#Чтение данных

AI_Tcells <- read_csv(
  "../../raw_data/AI_Tcells_для ЕА - Sheet1.csv",
  locale = locale(decimal_mark = ","),  # указываем, что десятичный разделитель - запятая
  show_col_types = FALSE
)

glimpse(AI_Tcells)
## Rows: 37,884
## Columns: 5
## $ ID         <dbl> 50, 69, 58, 2, 52, 42, 44, 1, 31, 49, 34, 33, 8, 6, 46, 27,…
## $ Time_OS    <dbl> 663, 503, 257, 434, 792, 363, 391, 786, 469, 447, 473, 559,…
## $ cGVHD_time <dbl> NA, 203, NA, 134, NA, NA, NA, NA, NA, 186, NA, NA, 203, 165…
## $ Names      <chr> "+180_ПЕР.КРОВЬ/4_TFH", "+180_ПЕР.КРОВЬ/4_TFH", "+180_ПЕР.К…
## $ Abs_Value  <dbl> 127.34533, 99.38984, 91.87249, 77.06436, 76.47210, 72.00345…
sum(is.na(AI_Tcells$Abs_Value))
## [1] 0

#Редактирование данных

AI_Tcells_data <- AI_Tcells %>%
  mutate(Analysis_day = str_extract(Names, "^[^_]+")) %>% # Извлекаем часть до первого "_" 
  mutate(Сell_population = str_extract(Names, "(?<=\\/).*")) %>% # Извлекаем все после "/"
  select(ID, Analysis_day, Сell_population, everything()) %>% # Перемещаем извлеченные данные в начало
  separate_rows(Analysis_day, sep = ",") %>% # Создаем новые строки, если несколько значений разделены запятыми
  mutate(Analysis_day = str_trim(Analysis_day))


AI_Tcells_data <- AI_Tcells_data %>%
  mutate(cGVHD_present = ifelse(is.na(AI_Tcells_data$cGVHD_time), 0, 1))

AI_Tcells_data <- AI_Tcells_data %>%
  mutate(cGVHD_present = factor(cGVHD_present, levels = c(0, 1), labels = c("No", "Yes")))

AI_Tcells_data <- AI_Tcells_data %>%
  mutate(across(c(Analysis_day, Сell_population), ~ factor(.)))

glimpse(AI_Tcells_data)
## Rows: 37,884
## Columns: 8
## $ ID              <dbl> 50, 69, 58, 2, 52, 42, 44, 1, 31, 49, 34, 33, 8, 6, 46…
## $ Analysis_day    <fct> +180, +180, +180, +180, +180, +180, +180, +180, +180, …
## $ Сell_population <fct> 4_TFH, 4_TFH, 4_TFH, 4_TFH, 4_TFH, 4_TFH, 4_TFH, 4_TFH…
## $ Time_OS         <dbl> 663, 503, 257, 434, 792, 363, 391, 786, 469, 447, 473,…
## $ cGVHD_time      <dbl> NA, 203, NA, 134, NA, NA, NA, NA, NA, 186, NA, NA, 203…
## $ Names           <chr> "+180_ПЕР.КРОВЬ/4_TFH", "+180_ПЕР.КРОВЬ/4_TFH", "+180_…
## $ Abs_Value       <dbl> 127.34533, 99.38984, 91.87249, 77.06436, 76.47210, 72.…
## $ cGVHD_present   <fct> No, Yes, No, Yes, No, No, No, No, No, Yes, No, No, Yes…
AI_Tcells_filtered <- AI_Tcells_data %>%
  mutate(
    Analysis_time = ifelse(
      str_detect(Analysis_day, "^ДЕНЬ\\sХРРТПХ\\s\\+180$"), cGVHD_time + 180,
      ifelse(
        str_detect(Analysis_day, "^ДЕНЬ\\sХРРТПХ\\s\\+90$"), cGVHD_time + 90,
        ifelse(
          str_detect(Analysis_day, "^ДЕНЬ\\sХРРТПХ\\s\\+60$"), cGVHD_time + 60,
          ifelse(
            str_detect(Analysis_day, "^ДЕНЬ\\sХРРТПХ\\s\\+30$"), cGVHD_time + 30,
            ifelse(
              str_detect(Analysis_day, "^ДЕНЬ\\sХРРТПХ$"), cGVHD_time,
              ifelse(
                str_detect(Analysis_day, "^\\+180$"), 180,
                ifelse(
                  str_detect(Analysis_day, "^\\+90$"), 90,
                  ifelse(
                    str_detect(Analysis_day, "^\\+60$"), 60,
                    ifelse(
                      str_detect(Analysis_day, "^\\+30$"), 30,
                      ifelse(
                        str_detect(Analysis_day, "^\\+365$"), 365, NA_real_
                      )))))))))))

 AI_Tcells_filtered <- AI_Tcells_filtered  %>%
  filter(Analysis_day != "+30" & Analysis_day != "+60")
 
  AI_Tcells_filtered <- AI_Tcells_filtered %>%
  filter(!(Analysis_time == 180 & !is.na(cGVHD_time) & cGVHD_time < 180))
                   
AI_Tcells_filtered <- AI_Tcells_filtered %>%
  select(ID, Time_OS, cGVHD_present, cGVHD_time, Analysis_day, Analysis_time, Сell_population, Abs_Value)

AI_Tcells_filtered <- AI_Tcells_filtered %>%
  arrange(ID, Analysis_time)

AI_Tcells_filtered <- AI_Tcells_filtered %>%
  mutate(across(c(Time_OS, cGVHD_time, Analysis_time), ~ factor(.)))

glimpse(AI_Tcells_filtered)
## Rows: 34,440
## Columns: 8
## $ ID              <dbl> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, …
## $ Time_OS         <fct> 786, 786, 786, 786, 786, 786, 786, 786, 786, 786, 786,…
## $ cGVHD_present   <fct> No, No, No, No, No, No, No, No, No, No, No, No, No, No…
## $ cGVHD_time      <fct> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
## $ Analysis_day    <fct> +90, +90, +90, +90, +90, +90, +90, +90, +90, +90, +90,…
## $ Analysis_time   <fct> 90, 90, 90, 90, 90, 90, 90, 90, 90, 90, 90, 90, 90, 90…
## $ Сell_population <fct> 4_TFH, 4_TH1, 4_TH17, 4_Th17TO1, 4_TH2, 4_TH22, 4+ (IM…
## $ Abs_Value       <dbl> 45.32738173, 7.89113186, 14.20660985, 3.33781372, 7.56…

#Описательные статистики

statistics <- list(
  
          `_Количество субъектов` = ~length(.x) %>% as.character(),
          `_Количество (есть данные)` = ~sum(!is.na(.x)) %>% as.character(),
          `_Нет данных` = ~sum(is.na(.x)) %>% as.character(),
          `_Ср. знач.` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", mean(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
          `_Станд. отклон.` = ~ifelse(sum(!is.na(.x)) < 3, "Н/П*", sd(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
          `_95% ДИ для среднего` = ~{
    n <- sum(!is.na(.x))
    ifelse(n < 3, "Н/П*", 
           paste0(round(mean(.x, na.rm = TRUE) - 1.96 * sd(.x, na.rm = TRUE) / sqrt(n), 2), " - ", round(mean(.x, na.rm = TRUE) + 1.96 * sd(.x, na.rm = TRUE) / sqrt(n), 2))
    )
  },
          `_мин. - макс.` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", paste0(min(.x, na.rm = TRUE) %>% round(2), " - ", max(.x, na.rm = TRUE) %>% round(2))),
          `_Медиана` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", median(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
          `_Q1 - Q3` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", paste0(quantile(.x, 0.25, na.rm = TRUE) %>% round(2), " - ", quantile(.x, 0.75, na.rm = TRUE) %>% round(2)))
    )




#AI_Tcells_filtered %>%
 # select(`Analysis_day`, `Сell_population`, `cGVHD_present`, Abs_Value) %>%
  #group_by(`Analysis_day`, `Сell_population`, `cGVHD_present`) %>%
  #summarize(across(Abs_Value, statistics)) %>% # Применяем список statistics к Abs_Value
  #pivot_longer(cols = -c(`Analysis_day`, `Сell_population`, `cGVHD_present`)) %>%
  #separate(name, into = c("Variable", "Statistics"), sep = "__") %>%
  #pivot_wider(names_from = c(cGVHD_present, Statistics), values_from = value) %>%
  #arrange(Analysis_day, Сell_population) %>%
  #flextable() %>%
  #theme_box() %>%
  #align(align = "center", part = "all") %>%
  #merge_v(c("Analysis_day", "Сell_population"))



# Создаём функцию для t-теста
t_test_wrapper <- function(data, var) {
  # Проверяем достаточно ли данных в каждой группе
  n_yes <- sum(!is.na(data$Abs_Value[data$cGVHD_present == "Yes"]))
  n_no <- sum(!is.na(data$Abs_Value[data$cGVHD_present == "No"]))
  
  if(n_yes < 3 || n_no < 3) {
    return("Н/П*")
  }
  
  # Выполняем t-тест
  test_result <- try(
    t.test(Abs_Value ~ cGVHD_present, data = data)$p.value,
    silent = TRUE
  )
  
  if(inherits(test_result, "try-error")) {
    return("Ошибка")
  }
  
  return(as.character(round(test_result, 4)))
}

# Сначала соберем все p-values в отдельный датафрейм
p_values_df <- AI_Tcells_filtered %>%
  group_by(Analysis_day, Сell_population) %>%
  summarise(
    p_value = t_test_wrapper(cur_data(), Abs_Value),
    .groups = "drop"
  )
## Warning: There was 1 warning in `summarise()`.
## ℹ In argument: `p_value = t_test_wrapper(cur_data(), Abs_Value)`.
## ℹ In group 1: `Analysis_day = +180` and `Сell_population = 4_TFH`.
## Caused by warning:
## ! `cur_data()` was deprecated in dplyr 1.1.0.
## ℹ Please use `pick()` instead.
# Создаем вектор для хранения скорректированных p-values
p_values_df <- p_values_df %>%
  mutate(
    adj_p_value = p_value  # Сначала копируем исходные p-values
  )

# Находим индексы числовых p-values
numeric_indices <- !p_values_df$p_value %in% c("Н/П*", "Ошибка")

if(sum(numeric_indices) > 0) {
  # Конвертируем в числовой формат только валидные p-values
  numeric_p_values <- as.numeric(p_values_df$p_value[numeric_indices])
  
  # Применяем коррекцию только к числовым значениям
  adj_p_values <- p.adjust(numeric_p_values, method = "BH")
  
  # Обновляем только числовые значения в столбце adj_p_value
  p_values_df$adj_p_value[numeric_indices] <- as.character(round(adj_p_values, 4))
}

# Основной код для создания таблицы
result <- AI_Tcells_filtered %>%
  select(`Analysis_day`, `Сell_population`, `cGVHD_present`, Abs_Value) %>%
  group_by(`Analysis_day`, `Сell_population`, `cGVHD_present`) %>%
  summarize(across(Abs_Value, statistics), .groups = "drop") %>%
  pivot_longer(cols = -c(`Analysis_day`, `Сell_population`, `cGVHD_present`)) %>%
  separate(name, into = c("Variable", "Statistics"), sep = "__") %>%
  pivot_wider(names_from = c(cGVHD_present, Statistics), values_from = value) %>%
  # Присоединяем p-values
  left_join(p_values_df, by = c("Analysis_day", "Сell_population")) %>%
    rename(
    "t-test, p-value" = p_value,
    "t-test, adj p-value (BH)" = adj_p_value
  ) %>%
  # Создаём финальную таблицу
  arrange(Analysis_day, Сell_population) %>%
  flextable() %>%
  theme_box() %>%
  align(align = "center", part = "all") %>%
  merge_v(c("Analysis_day", "Сell_population"))

# Выводим таблицу
result

Analysis_day

Сell_population

Variable

No_Количество субъектов

No_Количество (есть данные)

No_Нет данных

No_Ср. знач.

No_Станд. отклон.

No_95% ДИ для среднего

No_мин. - макс.

No_Медиана

No_Q1 - Q3

Yes_Количество субъектов

Yes_Количество (есть данные)

Yes_Нет данных

Yes_Ср. знач.

Yes_Станд. отклон.

Yes_95% ДИ для среднего

Yes_мин. - макс.

Yes_Медиана

Yes_Q1 - Q3

t-test, p-value

t-test, adj p-value (BH)

+180

4_TFH

Abs_Value

28

28

0

45.23

28.19

34.79 - 55.67

8.17 - 127.35

40.6

22.45 - 65.56

14

14

0

37.18

27.83

22.6 - 51.76

2.96 - 99.39

35.05

15.51 - 48.27

0.3868

0.6866

4_TH1

Abs_Value

28

28

0

30.97

28.29

20.5 - 41.45

7.26 - 139.21

21.63

12.61 - 40.09

14

14

0

25.29

17.73

16 - 34.58

2.75 - 63.56

21.81

11.79 - 31.97

0.4314

0.7016

4_TH17

Abs_Value

28

28

0

16.23

10.05

12.51 - 19.95

2.89 - 50.55

15.11

10.46 - 18.16

14

14

0

21.45

18.56

11.73 - 31.17

4.26 - 64.57

14.3

7.63 - 31.94

0.3393

0.6781

4_Th17TO1

Abs_Value

28

28

0

4.72

3.18

3.54 - 5.89

1.1 - 13.48

3.96

2.45 - 5.84

14

14

0

5.4

4.28

3.15 - 7.64

0.37 - 14.28

4.01

2.13 - 8.88

0.6048

0.7822

4_TH2

Abs_Value

28

28

0

19.81

14.65

14.38 - 25.23

3.06 - 52.15

14.55

7.62 - 30.35

14

14

0

25.44

33.42

7.93 - 42.94

4.36 - 132.22

13.3

8.77 - 24.71

0.5558

0.7482

4_TH22

Abs_Value

28

28

0

5.43

4.37

3.82 - 7.05

0.11 - 17.53

4.44

2.27 - 6.29

14

14

0

7.12

7.42

3.23 - 11.01

0.6 - 23.07

2.51

1.43 - 12.46

0.4431

0.7032

4+

Abs_Value

28

28

0

86.07

70.15

60.08 - 112.05

5.3 - 282.24

67.56

40.39 - 98.89

14

14

0

127.74

115.12

67.43 - 188.04

30.9 - 465.64

81.58

54.97 - 183.63

0.2295

0.6781

4+ (IM STAT)

Abs_Value

28

28

0

76.11

63.83

52.47 - 99.75

4.58 - 261.9

59.63

31.36 - 88.74

14

14

0

111.92

111.9

53.3 - 170.54

31.06 - 463.87

67.8

49.95 - 149.55

0.282

0.6781

4+226+

Abs_Value

28

28

0

240.03

119.69

195.69 - 284.36

82.61 - 581.74

237.99

154.89 - 305.8

14

14

0

253.52

138.82

180.79 - 326.24

59.38 - 494.52

233.24

142.9 - 349.53

0.759

0.884

4+39+

Abs_Value

28

28

0

58.56

45.04

41.88 - 75.24

1.62 - 164.84

44.35

28.99 - 83.56

14

14

0

70.14

50.91

43.47 - 96.81

0.38 - 146.53

83.04

21.52 - 108.28

0.4776

0.7185

4+DR+

Abs_Value

28

28

0

118.21

78.19

89.25 - 147.17

18.11 - 386.46

103.52

62.43 - 147.72

14

14

0

88.68

61.64

56.39 - 120.97

2.7 - 196.42

90.06

39.97 - 120.04

0.1915

0.6781

4+PD-1-TIGIT-

Abs_Value

28

28

0

88.95

59.1

67.06 - 110.84

12.4 - 216.52

71.92

38.42 - 131.56

14

14

0

124.6

89.68

77.62 - 171.58

21.15 - 336.65

103.12

48.41 - 181.86

0.1936

0.6781

4+PD-1-TIGIT+

Abs_Value

28

28

0

8.59

6.57

6.16 - 11.02

0.33 - 26.88

7.44

3.72 - 12.65

14

14

0

12.15

11.99

5.87 - 18.44

1.08 - 42.09

7.08

3.75 - 14.78

0.3144

0.6781

4+PD-1+

Abs_Value

28

28

0

163.55

100.44

126.35 - 200.75

60.8 - 544

146.17

92.9 - 204.31

14

14

0

137.32

78.18

96.36 - 178.27

19.13 - 251.25

137.45

85.35 - 188.75

0.3595

0.6829

4+PD-1+TIGIT-

Abs_Value

28

28

0

82.11

47.24

64.61 - 99.61

24.66 - 231.24

70.6

42.83 - 113.14

14

14

0

69.48

41.05

47.97 - 90.98

11.98 - 141.31

71.58

41.53 - 92.15

0.379

0.6866

4+PD-1+TIGIT+

Abs_Value

28

28

0

81.44

60.21

59.14 - 103.75

23.47 - 312.76

70.14

36.23 - 104.1

14

14

0

67.84

41.86

45.91 - 89.77

6.97 - 118.9

74.09

34.46 - 107.46

0.3997

0.6866

4+TIGIT+

Abs_Value

28

28

0

90.03

62.5

66.88 - 113.18

27.22 - 316.38

78.85

39.78 - 118.18

14

14

0

80

50.5

53.54 - 106.45

8.05 - 142.11

83.98

37.28 - 128.03

0.5796

0.7625

4NV

Abs_Value

28

28

0

47.92

50.96

29.04 - 66.79

1.38 - 219.79

32.76

17.69 - 57.58

14

14

0

68.98

57.36

38.93 - 99.03

8.01 - 221.84

63.72

22.76 - 100.68

0.2563

0.6781

4NV(СТАР2)

Abs_Value

28

28

0

41.99

45.17

25.26 - 58.72

1.11 - 184.63

28.89

15.07 - 54.98

14

14

0

64.13

53.04

36.35 - 91.92

7.33 - 199

55.39

24.35 - 92.65

0.1941

0.6781

4NV_TH1

Abs_Value

28

28

0

2.34

3.55

1.02 - 3.65

0.01 - 18.64

1.69

0.55 - 2.22

14

14

0

5.4

7.87

1.28 - 9.52

0.26 - 31.18

3.5

0.99 - 5.44

0.1848

0.6781

4NV_TH17

Abs_Value

28

28

0

1.43

1.4

0.91 - 1.95

0.17 - 5.2

0.84

0.43 - 2.12

14

14

0

1.76

1.66

0.89 - 2.63

0.15 - 6.65

1.37

0.68 - 2.26

0.5269

0.739

4NV_Th17TO1

Abs_Value

28

28

0

0.16

0.19

0.09 - 0.23

0 - 0.76

0.09

0.04 - 0.17

14

14

0

0.44

0.69

0.08 - 0.8

0.03 - 2.7

0.2

0.1 - 0.46

0.1581

0.6781

4NV_TH2

Abs_Value

28

28

0

10

10.71

6.03 - 13.97

0.32 - 42.08

5.32

1.9 - 16.43

14

14

0

6.01

4.03

3.9 - 8.12

0.9 - 15.34

4.93

3.44 - 7.26

0.0898

0.6781

4NV_TH22

Abs_Value

28

28

0

0.12

0.13

0.07 - 0.17

0 - 0.47

0.05

0.03 - 0.19

14

14

0

0.2

0.22

0.08 - 0.31

0 - 0.85

0.16

0.05 - 0.24

0.2363

0.6781

4NV+226+

Abs_Value

28

28

0

34.27

40.56

19.24 - 49.29

1.04 - 182.46

25.68

11.13 - 43.23

14

14

0

55.97

47.49

31.1 - 80.85

6.77 - 176.27

47.59

19.76 - 79.5

0.1569

0.6781

4NV+39+

Abs_Value

28

28

0

1.13

1.41

0.61 - 1.66

0.01 - 6.53

0.59

0.27 - 1.45

14

14

0

2.25

2.81

0.78 - 3.72

0.05 - 10.36

1.6

0.35 - 2.53

0.1805

0.6781

4NV+DR+

Abs_Value

28

28

0

3.59

4.26

2.02 - 5.17

0.18 - 18.97

2.07

0.83 - 4.89

14

14

0

3.51

3.73

1.56 - 5.47

0.16 - 12.36

1.95

1.19 - 4.3

0.9487

0.9711

4NV+PD-1-TIGIT-

Abs_Value

28

28

0

37.82

41.89

22.3 - 53.33

0.89 - 162.97

26.57

10.46 - 51.5

14

14

0

57.92

49.73

31.87 - 83.97

6.57 - 183.96

52.16

20.83 - 83.48

0.207

0.6781

4NV+PD-1-TIGIT+

Abs_Value

28

28

0

1.06

1.51

0.5 - 1.62

0.07 - 5.24

0.41

0.13 - 1.22

14

14

0

1.77

2.27

0.58 - 2.96

0.08 - 8.38

0.69

0.41 - 2.19

0.3061

0.6781

4NV+PD-1+TIGIT-

Abs_Value

28

28

0

2.19

2.63

1.22 - 3.16

0.07 - 10.74

1.21

0.51 - 2.14

14

14

0

2.94

3.29

1.22 - 4.67

0.26 - 11.91

1.3

0.73 - 4.66

0.4625

0.7142

4NV+PD-1+TIGIT+

Abs_Value

28

28

0

0.92

1.16

0.49 - 1.35

0.07 - 6.02

0.64

0.15 - 1.11

14

14

0

1.5

1.45

0.74 - 2.26

0.06 - 4.55

1.06

0.43 - 1.72

0.2059

0.6781

4NV+PD1+

Abs_Value

28

28

0

3.11

3.54

1.8 - 4.42

0.15 - 16.77

2.1

0.94 - 3.82

14

14

0

4.44

4.28

2.2 - 6.69

0.49 - 15.18

2.53

1.15 - 6.58

0.3243

0.6781

4NV+TIGIT+

Abs_Value

28

28

0

1.98

2.4

1.09 - 2.87

0.15 - 10.91

1.18

0.46 - 2.38

14

14

0

3.27

3.41

1.48 - 5.06

0.14 - 12.48

1.97

1.02 - 4.53

0.221

0.6781

4ЕМ

Abs_Value

28

28

0

27.44

62.36

4.35 - 50.54

0.05 - 337.94

15.05

5.39 - 24.18

14

14

0

8.4

8.82

3.77 - 13.02

0.17 - 25.86

5.24

1.79 - 9.96

0.1238

0.6781

4ЕМ_TH1

Abs_Value

28

28

0

10.52

21.21

2.67 - 18.38

0 - 112.94

4.34

1.5 - 10.68

14

14

0

3.18

4.44

0.85 - 5.5

0.03 - 12.98

1.11

0.26 - 3.35

0.0886

0.6781

4ЕМ_TH17

Abs_Value

28

28

0

0.03

0.05

0.01 - 0.05

0 - 0.18

0.01

0 - 0.03

14

14

0

0.07

0.16

-0.01 - 0.15

0 - 0.59

0.01

0 - 0.04

0.3904

0.6866

4ЕМ_Th17TO1

Abs_Value

28

28

0

0.51

0.93

0.16 - 0.86

0 - 4.85

0.2

0.07 - 0.57

14

14

0

0.19

0.22

0.08 - 0.31

0 - 0.66

0.13

0.03 - 0.23

0.0996

0.6781

4ЕМ_TH2

Abs_Value

28

28

0

1.79

4.75

0.03 - 3.55

0 - 24.46

0.2

0.02 - 1.83

14

14

0

0.32

0.59

0.01 - 0.62

0.01 - 2.2

0.08

0.04 - 0.28

0.1176

0.6781

4ЕМ_TH22

Abs_Value

28

28

0

0.01

0.02

0 - 0.02

0 - 0.11

0

0 - 0.01

14

14

0

0.01

0.01

0 - 0.01

0 - 0.05

0

0 - 0

0.4551

0.7131

4ЕМ+226+

Abs_Value

28

28

0

131.59

96.96

95.68 - 167.5

29.52 - 477.35

86.56

66.35 - 180.01

14

14

0

105.55

69.84

68.96 - 142.13

22.39 - 224.92

90.27

45.45 - 150.7

0.3264

0.6781

4ЕМ+39+

Abs_Value

28

28

0

36.82

35.18

23.79 - 49.85

0.88 - 146.09

23.82

17.36 - 48.28

14

14

0

39.21

29.01

24.01 - 54.41

0.25 - 83.93

40.64

10.33 - 58.8

0.8168

0.9094

4ЕМ+DR+

Abs_Value

28

28

0

80.97

68.49

55.6 - 106.34

10.12 - 341.19

52.11

40.32 - 119.37

14

14

0

51.14

37.29

31.61 - 70.68

2.19 - 150.75

51.7

25.99 - 61.76

0.0754

0.6781

4ЕМ+PD1-TIGIT-

Abs_Value

28

28

0

26.19

17.91

19.56 - 32.83

2 - 69.84

21.04

12.78 - 37.04

14

14

0

28.45

24.11

15.82 - 41.08

2.07 - 74.3

23.78

8.55 - 37.9

0.76

0.884

4ЕМ+PD1-TIGIT+

Abs_Value

28

28

0

3.33

2.73

2.32 - 4.34

0.08 - 9.42

2.47

1.26 - 5.09

14

14

0

4.11

3.66

2.19 - 6.03

0.19 - 11.47

2.6

1.05 - 6.71

0.4911

0.7192

4ЕМ+PD1+

Abs_Value

28

28

0

109.28

90.94

75.59 - 142.96

26.74 - 465.38

74.09

54.15 - 143.28

14

14

0

78.12

49.93

51.96 - 104.27

15.86 - 159.29

77.61

40.3 - 96.23

0.16

0.6781

4ЕМ+PD1+TIGIT-

Abs_Value

28

28

0

56.89

40.09

42.04 - 71.73

12.43 - 175.98

44.68

27.37 - 76.23

14

14

0

40.42

25.27

27.18 - 53.65

7.04 - 85.23

38.63

20.38 - 56.75

0.113

0.6781

4ЕМ+PD1+TIGIT+

Abs_Value

28

28

0

52.39

54.96

32.03 - 72.75

13.52 - 289.4

39.84

18.79 - 77.5

14

14

0

37.7

27.66

23.21 - 52.19

4.8 - 89.86

29.72

15.62 - 55.48

0.2561

0.6781

4ЕМ+TIGIT+

Abs_Value

28

28

0

55.72

55.87

35.03 - 76.42

14.57 - 292.02

40.91

19.91 - 84.16

14

14

0

41.81

29.93

26.13 - 57.49

6.19 - 95.58

35.76

16.71 - 61.83

0.2999

0.6781

4ЕМTM

Abs_Value

28

28

0

138.8

99.73

101.86 - 175.74

30.94 - 480.41

105.39

68.28 - 188.97

14

14

0

110.67

71.84

73.04 - 148.31

23.66 - 228.74

94.42

48.98 - 159.67

0.303

0.6781

4СМ

Abs_Value

28

28

0

61.75

37.84

47.73 - 75.77

13.26 - 146.46

52.11

30.84 - 91.37

14

14

0

76.5

55.02

47.68 - 105.32

10.54 - 214.21

63.18

36.55 - 115.1

0.378

0.6866

4СМ(СТАР2)

Abs_Value

28

28

0

47.2

26.48

37.4 - 57.01

7.82 - 107.45

43.92

23.6 - 62.8

14

14

0

58.39

51.76

31.28 - 85.51

8.04 - 200.31

44.16

28.4 - 63.93

0.4575

0.7142

4СМ_TH1

Abs_Value

28

28

0

1.47

1.67

0.85 - 2.09

0.07 - 7.15

0.97

0.45 - 1.42

14

14

0

3.57

5.03

0.93 - 6.2

0.3 - 20.04

2.01

0.94 - 4

0.1503

0.6781

4СМ_TH17

Abs_Value

28

28

0

7.3

4.88

5.49 - 9.1

1.27 - 20.38

6.35

3.64 - 9.25

14

14

0

9.16

7.08

5.46 - 12.87

2.38 - 28.22

8.46

3.19 - 12.75

0.3861

0.6866

4СМ_Th17TO1

Abs_Value

28

28

0

0.49

0.49

0.31 - 0.67

0.04 - 2.29

0.34

0.2 - 0.55

14

14

0

0.96

1.18

0.34 - 1.58

0.04 - 4.47

0.57

0.24 - 0.97

0.1713

0.6781

4СМ_TH2

Abs_Value

28

28

0

4.52

3.7

3.15 - 5.89

0.45 - 18.22

3.69

1.93 - 6.35

14

14

0

7.16

7.96

2.99 - 11.33

1.8 - 29.39

3.6

2.62 - 5.96

0.2551

0.6781

4СМ_TH22

Abs_Value

28

28

0

0.64

0.59

0.43 - 0.86

0.02 - 2.89

0.47

0.28 - 0.88

14

14

0

1.13

1.03

0.59 - 1.67

0.08 - 3.27

0.91

0.44 - 1.5

0.1197

0.6781

4СМ+226+

Abs_Value

28

28

0

43.71

25.43

34.29 - 53.13

7.56 - 105.79

39.19

22.71 - 57.23

14

14

0

54.63

48.32

29.32 - 79.94

7.28 - 188.86

41.68

27.29 - 61.77

0.4392

0.7016

4СМ+39+

Abs_Value

28

28

0

13.31

11.75

8.96 - 17.66

0.11 - 41.64

9

5.26 - 21.33

14

14

0

20.63

22.13

9.04 - 32.22

0.05 - 75.65

13.68

6.29 - 27.45

0.2629

0.6781

4СМ+DR+

Abs_Value

28

28

0

14.05

12.11

9.56 - 18.53

1.83 - 40.68

7.66

5.74 - 22.38

14

14

0

15.17

18.57

5.44 - 24.9

0.29 - 56.48

5.82

3.97 - 19.91

0.8402

0.9146

4СМ+PD1-TIGIT-

Abs_Value

28

28

0

15.05

9.37

11.58 - 18.52

2.82 - 32.52

13.06

6.32 - 25.05

14

14

0

22.08

26.2

8.35 - 35.8

3.91 - 99.16

13.5

6.88 - 21.33

0.3464

0.6781

4СМ+PD1-TIGIT+

Abs_Value

28

28

0

2.23

2.09

1.45 - 3

0.09 - 7.53

1.54

0.52 - 2.95

14

14

0

3.38

4.01

1.28 - 5.49

0.15 - 15.02

1.9

1.02 - 4.37

0.3251

0.6781

4СМ+PD1+

Abs_Value

28

28

0

29.92

18.68

23 - 36.84

3.4 - 75.06

26.33

17.08 - 40.87

14

14

0

32.93

28.96

17.76 - 48.1

1.74 - 94.4

23.08

14.69 - 43.5

0.7278

0.8715

4СМ+PD1+TIGIT-

Abs_Value

28

28

0

11.7

7.17

9.05 - 14.36

2.06 - 26.13

9.96

6.8 - 14.44

14

14

0

12.4

10.65

6.83 - 17.98

1.38 - 31.91

8.2

4.81 - 16.08

0.8267

0.9094

4СМ+PD1+TIGIT+

Abs_Value

28

28

0

18.22

14.61

12.81 - 23.63

1.34 - 62.79

15.67

8.1 - 21.06

14

14

0

20.53

19.49

10.32 - 30.73

0.36 - 62.83

14.99

8.23 - 26.26

0.6996

0.8548

4СМ+TIGIT+

Abs_Value

28

28

0

20.45

16.09

14.48 - 26.41

1.79 - 69.48

16.63

10.12 - 28.13

14

14

0

23.91

22.07

12.35 - 35.47

0.54 - 73.37

18.51

9.93 - 31.86

0.6073

0.7822

4ТM_TH1

Abs_Value

28

28

0

12.31

11.97

7.87 - 16.74

1.94 - 55.53

9.77

3.97 - 14.73

14

14

0

6.96

3.66

5.04 - 8.88

1.3 - 14.41

7.44

4.52 - 8.95

0.0368

0.6781

4ТM_TH17

Abs_Value

28

28

0

6.86

4.9

5.04 - 8.67

0.9 - 22.86

5.87

3.72 - 8.31

14

14

0

9.69

12.24

3.28 - 16.1

0.94 - 44.13

5.29

2.16 - 8.55

0.4184

0.6976

4ТM_Th17TO1

Abs_Value

28

28

0

3.12

2.5

2.19 - 4.05

0.79 - 10.52

2.39

1.52 - 3.62

14

14

0

3.02

2.9

1.5 - 4.54

0.28 - 10.5

2.48

1.05 - 3.28

0.9136

0.956

4ТM_TH2

Abs_Value

28

28

0

2.51

1.95

1.79 - 3.24

0.6 - 8.26

1.85

1.07 - 3.5

14

14

0

9.55

22.23

-2.1 - 21.19

0.3 - 85.75

2.62

1.3 - 5.59

0.2583

0.6781

4ТM_TH22

Abs_Value

28

28

0

4.15

3.93

2.7 - 5.61

0.09 - 16.55

2.84

1.63 - 5.23

14

14

0

5.06

5.9

1.97 - 8.15

0.44 - 17.35

1.66

0.69 - 8.22

0.6107

0.7845

4ТREG

Abs_Value

28

28

0

2.75

3.7

1.38 - 4.12

0.02 - 16

1.38

0.9 - 2.78

14

14

0

4.35

5.5

1.47 - 7.23

0.12 - 14.85

1.4

0.74 - 7.52

0.3382

0.6781

4ТREG(СТАР2)

Abs_Value

28

28

0

90.87

75.13

63.04 - 118.69

6.1 - 296.08

68.88

41.46 - 106.71

14

14

0

130.77

113.81

71.16 - 190.39

33.78 - 462.62

81.71

57.83 - 189.89

0.2492

0.6781

4ТREG_TH1

Abs_Value

28

28

0

0.26

0.26

0.16 - 0.35

0 - 1.28

0.2

0.08 - 0.3

14

14

0

0.34

0.47

0.09 - 0.58

0.06 - 1.9

0.21

0.1 - 0.32

0.5511

0.7482

4ТREG_TH17

Abs_Value

28

28

0

3.91

3.31

2.69 - 5.14

0.31 - 12.56

2.76

1.86 - 4.74

14

14

0

6.68

8.57

2.19 - 11.16

1.2 - 33.26

3.34

1.93 - 7.31

0.2627

0.6781

4ТREG_Th17TO1

Abs_Value

28

28

0

0.13

0.31

0.02 - 0.25

0 - 1.66

0.06

0.03 - 0.13

14

14

0

0.13

0.18

0.04 - 0.23

0.02 - 0.63

0.05

0.03 - 0.18

0.9919

0.9959

4ТREG_TH2

Abs_Value

28

28

0

2.09

1.71

1.46 - 2.73

0.18 - 7.26

1.67

0.77 - 3.26

14

14

0

3.65

4.38

1.36 - 5.95

0.49 - 17.5

2.38

1.13 - 4.78

0.2189

0.6781

4ТREG_TH22

Abs_Value

28

28

0

3.11

3.04

1.99 - 4.24

0.3 - 12.42

2.39

1.25 - 3.74

14

14

0

3.93

5.42

1.09 - 6.77

0.35 - 21.16

1.78

1.02 - 4.67

0.6063

0.7822

4ТЕ

Abs_Value

28

28

0

6.72

8.07

3.74 - 9.71

0.05 - 26.78

3.24

1.24 - 9.35

14

14

0

13.5

18.66

3.72 - 23.27

0.19 - 58.83

4.9

1.72 - 12.7

0.213

0.6781

4ТЕ(СТАР2)

Abs_Value

28

28

0

31.02

19.78

23.69 - 38.34

8.86 - 75.37

26.45

13.85 - 44.23

14

14

0

39.2

30.52

23.21 - 55.19

3.55 - 106.79

41.45

13.83 - 56.32

0.3736

0.6866

4ТЕ_TH1

Abs_Value

28

28

0

2.42

3.41

1.15 - 3.68

0 - 13.95

0.63

0.27 - 3.19

14

14

0

3.48

5.58

0.55 - 6.4

0.01 - 16.37

1.35

0.21 - 2.73

0.5225

0.7387

4ТЕ_TH17

Abs_Value

28

28

0

0.01

0.01

0 - 0.01

0 - 0.05

0

0 - 0.01

14

14

0

0.07

0.24

-0.05 - 0.2

0 - 0.91

0

0 - 0.01

0.3494

0.6781

4ТЕ_Th17TO1

Abs_Value

28

28

0

0.09

0.13

0.04 - 0.14

0 - 0.51

0.02

0 - 0.14

14

14

0

0.34

0.77

-0.07 - 0.74

0 - 2.9

0.04

0 - 0.19

0.2571

0.6781

4ТЕ_TH2

Abs_Value

28

28

0

0.46

0.69

0.2 - 0.71

0 - 2.26

0.06

0.01 - 0.58

14

14

0

0.59

1.53

-0.21 - 1.39

0 - 5.84

0.14

0.03 - 0.29

0.7584

0.884

4ТЕ_TH22

Abs_Value

28

28

0

0.01

0.02

0 - 0.02

0 - 0.09

0

0 - 0.01

14

14

0

0.01

0.01

0 - 0.02

0 - 0.05

0.01

0 - 0.02

0.7002

0.8548

4ТЕ+226+

Abs_Value

28

28

0

28.62

18.94

21.61 - 35.64

5.39 - 69.68

23.92

13.41 - 41.25

14

14

0

35.9

28.65

20.89 - 50.9

3.23 - 101.25

34.74

13.45 - 52.71

0.4001

0.6866

4ТЕ+39+

Abs_Value

28

28

0

6.91

6.93

4.34 - 9.47

0.19 - 30.14

5.03

1.49 - 9.56

14

14

0

7.6

7.97

3.42 - 11.77

0.03 - 29.54

6.06

1.39 - 11.47

0.7852

0.8997

4ТЕ+DR+

Abs_Value

28

28

0

19.05

16.74

12.85 - 25.25

2.33 - 69.31

15.63

8.38 - 20.29

14

14

0

18.69

18.7

8.89 - 28.49

0.08 - 60.5

14.65

6.75 - 20.78

0.9522

0.9711

4ТЕ+PD-1-TIGIT-

Abs_Value

28

28

0

9.06

6.86

6.52 - 11.6

0.69 - 29.76

7.41

3.88 - 12.42

14

14

0

15.11

13.39

8.09 - 22.13

1.05 - 47.45

10.59

5.29 - 23.72

0.1309

0.6781

4ТЕ+PD-1-TIGIT+

Abs_Value

28

28

0

1.87

1.73

1.22 - 2.51

0.07 - 8.02

1.4

0.7 - 2.21

14

14

0

2.7

2.9

1.18 - 4.22

0.13 - 9.27

0.93

0.55 - 4.17

0.335

0.6781

4ТЕ+PD-1+

Abs_Value

28

28

0

20.09

15.55

14.33 - 25.85

4.6 - 58.48

15.83

8.96 - 25.92

14

14

0

21.39

19.12

11.37 - 31.4

0.77 - 67.28

18.59

6.5 - 26.82

0.8281

0.9094

4ТЕ+PD-1+TIGIT-

Abs_Value

28

28

0

11.17

10.71

7.2 - 15.14

1.41 - 39.92

6.31

4.63 - 12.94

14

14

0

13.62

14.7

5.92 - 21.32

0.44 - 55.01

9.37

4.15 - 16.57

0.5853

0.7646

4ТЕ+PD-1+TIGIT+

Abs_Value

28

28

0

8.92

6.9

6.37 - 11.48

1.92 - 25.95

6.34

4.22 - 11.45

14

14

0

7.77

7.08

4.06 - 11.47

0.33 - 22.79

5.5

1.8 - 12.24

0.6192

0.7904

4ТЕ+TIGIT+

Abs_Value

28

28

0

10.79

7.88

7.87 - 13.71

2.51 - 30.84

8.43

5.19 - 14.18

14

14

0

10.47

9.63

5.42 - 15.51

0.46 - 32.06

7.69

2.46 - 15.9

0.9148

0.956

4ТМ

Abs_Value

28

28

0

109.01

67.42

84.03 - 133.98

32.08 - 253.34

82.13

53.03 - 141.37

14

14

0

93.26

64.47

59.48 - 127.03

14.63 - 197.92

80.46

41.2 - 144.82

0.4687

0.718

8+

Abs_Value

28

28

0

622.09

563.47

413.38 - 830.81

31.86 - 2078.56

508.16

107.88 - 982.15

14

14

0

371.07

337.5

194.28 - 547.86

2.77 - 942.86

259.72

57.26 - 608.29

0.0799

0.6781

8+ (IM STAT)

Abs_Value

28

28

0

806.12

725.48

537.4 - 1074.84

40.65 - 2479.37

632.98

234.59 - 1142.94

14

14

0

472.41

437.65

243.15 - 701.67

3.11 - 1413.27

383.59

88.25 - 709.03

0.0718

0.6781

8+226+

Abs_Value

28

28

0

1002.67

905.76

667.17 - 1338.17

109.2 - 3905.17

724.17

336.58 - 1226.89

14

14

0

628.39

516.74

357.7 - 899.07

16.08 - 1833.29

558.95

189.54 - 973.48

0.0967

0.6781

8+39+

Abs_Value

28

28

0

179.05

399.93

30.91 - 327.19

2.21 - 2089.83

65.06

28.88 - 134.15

14

14

0

108.54

95.6

58.46 - 158.62

0.53 - 266.18

81.42

23.84 - 181.37

0.3833

0.6866

8+DR+

Abs_Value

28

28

0

821.88

776.49

534.26 - 1109.5

36.66 - 3420.38

664.31

204.99 - 1135.08

14

14

0

465.82

437.17

236.81 - 694.82

3.7 - 1528.67

351.66

136.04 - 604.53

0.065

0.6781

8+PD-1-TIGIT-

Abs_Value

28

28

0

325.57

336.9

200.78 - 450.36

22.38 - 1345.43

230.47

60.24 - 415.57

14

14

0

229.44

191.28

129.24 - 329.64

10.99 - 612.35

201.15

90.92 - 361.15

0.2462

0.6781

8+PD-1-TIGIT+

Abs_Value

28

28

0

361.91

450.75

194.95 - 528.87

9.64 - 1906.78

198.53

112.67 - 338.93

14

14

0

163.73

156.05

81.98 - 245.47

0.61 - 587.72

112.8

63.09 - 234.43

0.0436

0.6781

8+PD-1+

Abs_Value

28

28

0

411.44

357.34

279.08 - 543.8

50.77 - 1157.32

242.05

152.08 - 581.29

14

14

0

297.17

333.76

122.34 - 472.01

5.1 - 1050.36

159.01

59.23 - 468.65

0.3159

0.6781

8+PD-1+TIGIT-

Abs_Value

28

28

0

92.8

86.8

60.64 - 124.95

3.08 - 350.2

71.08

33.32 - 120.94

14

14

0

101.97

140.21

28.52 - 175.41

3.19 - 429.98

40.54

9.22 - 155.68

0.8251

0.9094

8+PD-1+TIGIT+

Abs_Value

28

28

0

318.65

299.61

207.67 - 429.62

46.78 - 1020.62

184.97

102.83 - 432.2

14

14

0

195.21

199.07

90.93 - 299.49

1.91 - 620.38

112.82

50.02 - 325.98

0.1207

0.6781

8+TIGIT+

Abs_Value

28

28

0

680.56

684.87

426.88 - 934.23

83.69 - 2694.32

445.34

208.98 - 860.66

14

14

0

358.94

319.1

191.78 - 526.09

2.52 - 917.19

249.08

109.73 - 599.54

0.0445

0.6781

8EMTM

Abs_Value

28

28

0

297.12

413.32

144.02 - 450.21

7.83 - 1882.93

118.32

33.55 - 468.12

14

14

0

108.26

114.49

48.29 - 168.24

1.35 - 336.64

47.26

26.7 - 176.25

0.0309

0.6781

8EMTM+226+

Abs_Value

28

28

0

262.72

393.38

117.01 - 408.43

7.18 - 1881.01

107.78

30.67 - 330.96

14

14

0

90.82

94.44

41.36 - 140.29

1.28 - 270.09

37.28

21.54 - 160.05

0.0358

0.6781

8EMTM+39+

Abs_Value

28

28

0

75.18

204.28

-0.48 - 150.85

0.15 - 979.7

13.33

3.81 - 46.74

14

14

0

32.61

38.02

12.69 - 52.52

0.1 - 115.58

11.44

5.54 - 57.22

0.2946

0.6781

8EMTM+DR+

Abs_Value

28

28

0

253.32

362.91

118.89 - 387.74

3.36 - 1678.23

111.52

23.45 - 398.7

14

14

0

89.85

96.75

39.17 - 140.53

0.6 - 266.01

40.98

18.71 - 127.09

0.0325

0.6781

8EMTM+PD-1-TIGIT-

Abs_Value

28

28

0

78.51

128.66

30.85 - 126.16

0.77 - 396.55

20.79

3.43 - 68.29

14

14

0

20.46

23.19

8.31 - 32.61

0.57 - 81.18

14.3

5.74 - 21.89

0.0277

0.6781

8EMTM+PD-1-TIGIT+

Abs_Value

28

28

0

80.36

173.57

16.07 - 144.65

0.65 - 878.14

26.76

4.11 - 51.64

14

14

0

19.34

28.41

4.46 - 34.22

0.06 - 105.56

7.53

4.44 - 20.2

0.08

0.6781

8EMTM+PD-1+

Abs_Value

28

28

0

138.25

190.06

67.85 - 208.65

2.76 - 628.57

55.93

23.94 - 121.89

14

14

0

68.46

80.08

26.51 - 110.41

0.72 - 222.51

27.74

13.79 - 80.99

0.103

0.6781

8EMTM+PD-1+TIGIT-

Abs_Value

28

28

0

29.59

41.13

14.36 - 44.83

0.58 - 176.22

11.82

4 - 44.68

14

14

0

20.55

29.3

5.2 - 35.9

0.5 - 91.63

6.05

2.11 - 25.21

0.4182

0.6976

8EMTM+PD-1+TIGIT+

Abs_Value

28

28

0

108.66

159.34

49.64 - 167.68

2.05 - 544.23

35.07

19.33 - 100.5

14

14

0

47.91

56.83

18.14 - 77.68

0.22 - 167.49

21.69

11.54 - 52.86

0.0797

0.6781

8EMTM+TIGIT+

Abs_Value

28

28

0

189.02

302.12

77.12 - 300.93

4.08 - 1330.49

66.41

23.7 - 205.97

14

14

0

67.25

82.58

23.99 - 110.51

0.28 - 273.06

29.94

16.68 - 82.47

0.0547

0.6781

8NV

Abs_Value

28

28

0

21.59

23.9

12.74 - 30.45

1.08 - 117.97

16.42

9.44 - 22.67

14

14

0

24.99

15.76

16.73 - 33.24

2.58 - 62.15

23.87

17.89 - 30.86

0.5859

0.7646

8NV(СТАР2)

Abs_Value

28

28

0

25.71

29.33

14.85 - 36.58

1.52 - 104.32

16.23

9.59 - 25.92

14

14

0

23.68

15.83

15.39 - 31.98

2.85 - 55.29

23.65

12.38 - 28.58

0.7728

0.8946

8NV+226+

Abs_Value

28

28

0

22.4

26.13

12.72 - 32.08

1.4 - 96.72

14.48

9.13 - 23.05

14

14

0

21.49

15.19

13.53 - 29.45

2.73 - 54.93

21.56

10.55 - 25.09

0.8881

0.9417

8NV+39+

Abs_Value

28

28

0

1.56

2.33

0.7 - 2.42

0.02 - 11.42

0.78

0.25 - 1.66

14

14

0

2.11

2.34

0.89 - 3.34

0.07 - 8.56

1.34

0.31 - 3.21

0.4782

0.7185

8NV+DR+

Abs_Value

28

28

0

6.17

10.12

2.42 - 9.91

0.12 - 49.7

2.7

1.26 - 4.71

14

14

0

3.34

2.64

1.96 - 4.72

0.26 - 7.84

2.29

1.05 - 5.31

0.1755

0.6781

8NV+PD-1-TIGIT-

Abs_Value

28

28

0

17.04

23.81

8.22 - 25.86

0.93 - 101.41

10.66

4.93 - 15.8

14

14

0

18.89

13.6

11.76 - 26.01

1.46 - 46.07

18.38

8.18 - 23.33

0.7507

0.884

8NV+PD-1-TIGIT+

Abs_Value

28

28

0

2.24

2.68

1.25 - 3.23

0.03 - 11.3

1.55

0.34 - 3.23

14

14

0

1.51

1.78

0.58 - 2.44

0.04 - 6.46

0.76

0.46 - 1.73

0.3

0.6781

8NV+PD-1+

Abs_Value

28

28

0

6.43

15.22

0.79 - 12.07

0.07 - 81.13

1.76

0.97 - 6.11

14

14

0

3.28

2.88

1.78 - 4.79

0.21 - 8.57

2.47

0.8 - 5.02

0.2988

0.6781

8NV+PD-1+TIGIT-

Abs_Value

28

28

0

2.57

6.54

0.15 - 5

0 - 33.28

0.59

0.23 - 1.48

14

14

0

1.62

2.37

0.38 - 2.86

0.03 - 8.09

0.6

0.17 - 1.4

0.4967

0.7192

8NV+PD-1+TIGIT+

Abs_Value

28

28

0

3.86

9.06

0.5 - 7.21

0.07 - 47.85

1.05

0.52 - 3.46

14

14

0

1.66

1.33

0.97 - 2.36

0.12 - 3.69

1.47

0.5 - 2.93

0.2197

0.6781

8NV+TIGIT+

Abs_Value

28

28

0

6.1

10.28

2.29 - 9.91

0.3 - 51.41

2.39

1.28 - 5.55

14

14

0

3.17

2.45

1.89 - 4.46

0.16 - 9.39

2.43

1.43 - 4.38

0.1633

0.6781

8TREG

Abs_Value

28

28

0

679.26

594.1

459.2 - 899.32

31.9 - 1960.13

525.99

129.72 - 1051.71

14

14

0

382.04

350.32

198.53 - 565.55

2.7 - 946.35

277.39

59.9 - 604.13

0.0489

0.6781

8ЕМ

Abs_Value

28

28

0

291.16

561.39

83.22 - 499.11

1.35 - 2912.66

125.79

31.89 - 295.25

14

14

0

90.19

129.54

22.33 - 158.05

0.67 - 462.87

36.63

12.78 - 100.3

0.0811

0.6781

8СМ

Abs_Value

28

28

0

11.52

12.63

6.84 - 16.2

0.38 - 54.12

7.33

2.43 - 14.43

14

14

0

9.54

9.95

4.33 - 14.75

0.18 - 31.81

6.55

1.76 - 14.02

0.5836

0.7646

8СМ(СТАР2)

Abs_Value

28

28

0

12.03

22.84

3.57 - 20.49

0.51 - 115.04

4.3

1.89 - 8.54

14

14

0

6.81

9.89

1.63 - 11.99

0.11 - 35.91

2.44

0.66 - 6.83

0.3087

0.6781

8СМ+226+

Abs_Value

28

28

0

10.52

21.31

2.63 - 18.42

0.44 - 108.09

3.47

1.75 - 5.99

14

14

0

5.24

7.02

1.56 - 8.91

0.11 - 25.41

2.05

0.61 - 5.89

0.2419

0.6781

8СМ+39+

Abs_Value

28

28

0

2.85

4.64

1.13 - 4.57

0.01 - 20.23

1.11

0.43 - 3.12

14

14

0

3.3

5.33

0.51 - 6.1

0.01 - 18.76

0.64

0.22 - 4.13

0.7908

0.9

8СМ+DR+

Abs_Value

28

28

0

9.66

17.15

3.31 - 16.02

0.24 - 80.54

2.92

1.56 - 6.47

14

14

0

5.39

9.41

0.46 - 10.32

0.03 - 34.59

1.62

0.36 - 4.96

0.3035

0.6781

8СМ+PD-1-TIGIT-

Abs_Value

28

28

0

3

6.6

0.55 - 5.44

0.05 - 32.39

0.87

0.29 - 1.87

14

14

0

1.37

2.12

0.26 - 2.48

0.07 - 8.16

0.49

0.27 - 1.5

0.2416

0.6781

8СМ+PD-1-TIGIT+

Abs_Value

28

28

0

1.91

3.44

0.64 - 3.18

0.04 - 14.86

0.7

0.37 - 1.31

14

14

0

1.23

1.53

0.43 - 2.04

0 - 4.15

0.36

0.1 - 2.61

0.3841

0.6866

8СМ+PD-1+

Abs_Value

28

28

0

7.12

14.26

1.84 - 12.4

0.05 - 71.03

2.34

0.96 - 4.64

14

14

0

4.21

8.1

-0.03 - 8.46

0.05 - 30.23

1.56

0.36 - 2.97

0.4047

0.6902

8СМ+PD-1+TIGIT-

Abs_Value

28

28

0

1.78

6.19

-0.52 - 4.07

0 - 33.01

0.26

0.16 - 0.61

14

14

0

0.61

1.47

-0.16 - 1.38

0 - 5.66

0.15

0.08 - 0.32

0.3502

0.6781

8СМ+PD-1+TIGIT+

Abs_Value

28

28

0

5.34

8.9

2.05 - 8.64

0.05 - 38.02

2.19

0.73 - 4.38

14

14

0

3.6

6.72

0.08 - 7.12

0.01 - 24.57

1.36

0.23 - 2.52

0.4838

0.7191

8СМ+TIGIT+

Abs_Value

28

28

0

7.25

11.51

2.99 - 11.52

0.4 - 49.64

2.65

1.25 - 5.84

14

14

0

4.84

7.96

0.67 - 9.01

0.01 - 28.72

1.75

0.32 - 5.24

0.4319

0.7016

8ТЕ

Abs_Value

28

28

0

559.44

510.22

370.45 - 748.43

21.49 - 1984.18

386.13

153.78 - 765.25

14

14

0

420.95

394.25

214.43 - 627.47

7.02 - 1388.56

342.96

112.41 - 593

0.3393

0.6781

8ТЕ(СТАР2)

Abs_Value

28

28

0

760.76

651.04

519.61 - 1001.91

85.43 - 2454.12

597.34

233.36 - 973.93

14

14

0

549.84

485.59

295.48 - 804.21

7.28 - 1753.87

466.62

147.37 - 857.41

0.2465

0.6781

8ТЕ+226+

Abs_Value

28

28

0

704.58

620.82

474.63 - 934.54

70.48 - 2224.98

536.59

198.58 - 886.97

14

14

0

509.43

457.91

269.56 - 749.3

7.03 - 1680.66

433.53

143.45 - 734.61

0.2577

0.6781

8ТЕ+39+

Abs_Value

28

28

0

99.09

204.61

23.3 - 174.88

1.13 - 1085.66

36.16

19.58 - 97.46

14

14

0

69.82

56.96

39.98 - 99.66

0.35 - 156.59

66.19

19.81 - 122.1

0.4859

0.7192

8ТЕ+DR+

Abs_Value

28

28

0

550.8

518.65

358.69 - 742.91

32.15 - 1885.95

371.81

169.71 - 755.01

14

14

0

366.48

382.45

166.14 - 566.82

2.71 - 1408.92

283.06

108.34 - 403.66

0.2018

0.6781

8ТЕ+PD-1-TIGIT-

Abs_Value

28

28

0

226.53

232.94

140.25 - 312.82

8.85 - 977.38

164.89

42.74 - 353.97

14

14

0

188.06

174.91

96.44 - 279.69

3.37 - 546.54

169.72

26.6 - 300.93

0.5531

0.7482

8ТЕ+PD-1-TIGIT+

Abs_Value

28

28

0

277.01

322.66

157.5 - 396.53

7.28 - 1118.76

123.53

75.39 - 287.87

14

14

0

141.13

133.62

71.14 - 211.13

0.49 - 476.45

94.63

53.31 - 192.7

0.0618

0.6781

8ТЕ+PD-1+

Abs_Value

28

28

0

257.22

242.24

167.49 - 346.94

17.31 - 1012.86

154.35

86.77 - 439.93

14

14

0

220.64

278.8

74.6 - 366.68

3.41 - 959.6

108.29

34.51 - 279.19

0.6797

0.8445

8ТЕ+PD-1+TIGIT-

Abs_Value

28

28

0

58.57

57.31

37.35 - 79.8

1.78 - 217.83

39.31

22.3 - 67.46

14

14

0

79.23

118.31

17.25 - 141.2

1.91 - 388.34

30.42

5.88 - 75.42

0.5453

0.7482

8ТЕ+PD-1+TIGIT+

Abs_Value

28

28

0

198.64

200.93

124.21 - 273.07

15.53 - 830.14

115.53

61.29 - 258.57

14

14

0

141.41

163.22

55.91 - 226.92

1.5 - 571.26

74.7

27.15 - 208.77

0.33

0.6781

8ТЕ+TIGIT+

Abs_Value

28

28

0

475.65

478.92

298.26 - 653.05

60.35 - 1948.91

252.29

153.4 - 603.44

14

14

0

282.55

260.54

146.07 - 419.03

1.99 - 818.99

211.43

85.61 - 488.13

0.0987

0.6781

8ТМ

Abs_Value

28

28

0

103.51

167.34

41.52 - 165.49

2.77 - 712.4

34.28

16.32 - 98.29

14

14

0

49.25

78.03

8.38 - 90.13

0.73 - 307.9

27.39

15.88 - 50.35

0.1599

0.6781

TREG_CM

Abs_Value

28

28

0

2.14

2.4

1.25 - 3.03

0.05 - 9.79

1.38

0.49 - 2.36

14

14

0

2.57

3.89

0.53 - 4.61

0.08 - 14.95

1.28

0.6 - 1.82

0.7069

0.8566

TREG_EMTM

Abs_Value

28

28

0

17.07

15.93

11.16 - 22.97

1.71 - 79.04

11.8

7.19 - 20.87

14

14

0

23.74

23.55

11.4 - 36.07

3.25 - 71.51

13.29

6.66 - 30.27

0.3508

0.6781

TREG_NV

Abs_Value

28

28

0

2.24

2.91

1.16 - 3.32

0.02 - 11.22

1.29

0.44 - 2.39

14

14

0

2.21

2.61

0.85 - 3.58

0.49 - 10.39

1.26

0.64 - 2.63

0.9759

0.9879

TREG_TE

Abs_Value

28

28

0

4.46

4.48

2.8 - 6.12

0.29 - 19.01

3.7

2.1 - 5.47

14

14

0

4.99

5.47

2.13 - 7.85

0.54 - 18.3

3.13

1.41 - 6.1

0.7545

0.884

TREG+226-TIGIT-

Abs_Value

28

28

0

1.91

2.28

1.07 - 2.76

0.06 - 11.41

1.39

0.6 - 2.11

14

14

0

1.4

1.22

0.76 - 2.05

0.31 - 4.01

1.07

0.42 - 1.65

0.3556

0.6781

TREG+226-TIGIT+

Abs_Value

28

28

0

6.74

8.02

3.76 - 9.71

0.18 - 38.6

5.2

2.3 - 7.67

14

14

0

7.97

7.25

4.17 - 11.76

1.07 - 20.55

4.6

2.36 - 11.54

0.6201

0.7904

TREG+226+

Abs_Value

28

28

0

17.57

14.26

12.28 - 22.85

2.11 - 72.09

13.14

8.74 - 23.1

14

14

0

24.28

23.94

11.73 - 36.82

3.56 - 75.66

15.56

8.02 - 25.79

0.3469

0.6781

TREG+226+TIGIT-

Abs_Value

28

28

0

2.66

2.05

1.9 - 3.43

0.72 - 9.99

2.19

1.3 - 3.23

14

14

0

2.42

1.96

1.39 - 3.45

0.39 - 6.34

1.77

0.79 - 3.59

0.7059

0.8566

TREG+226+TIGIT+

Abs_Value

28

28

0

14.9

12.92

10.12 - 19.69

1.18 - 66.55

11.55

7.27 - 20.12

14

14

0

21.86

22.38

10.14 - 33.58

3.17 - 69.85

14.16

5.8 - 24.61

0.296

0.6781

TREG+39+

Abs_Value

28

28

0

19.34

18.14

12.62 - 26.06

1.99 - 77.53

14.73

6.89 - 25.57

14

14

0

23.53

22.77

11.6 - 35.46

1.37 - 84.95

16.15

8.12 - 28.06

0.5548

0.7482

TREG+DR+

Abs_Value

28

28

0

18.53

15.12

12.93 - 24.13

1.78 - 70.63

14.35

9.08 - 24.63

14

14

0

24.48

24.67

11.56 - 37.41

2.12 - 76.07

14.29

6.38 - 26.68

0.4181

0.6976

TREG+PD-1+

Abs_Value

28

28

0

10.89

9.84

7.24 - 14.53

0.6 - 38.32

7.38

4.29 - 14.03

14

14

0

14.55

15.86

6.24 - 22.86

1.03 - 49.25

7.67

3.58 - 21.24

0.4391

0.7016

TREG+TIGIT+

Abs_Value

28

28

0

21.64

17.99

14.97 - 28.3

1.42 - 73.15

18.37

9.26 - 25.7

14

14

0

29.83

29.43

14.41 - 45.25

4.64 - 90.4

17.4

7.87 - 35.58

0.3518

0.6781

+365

4_TFH

Abs_Value

13

13

0

65.34

37.16

45.14 - 85.54

5.63 - 132.09

55.23

38.65 - 82.38

13

13

0

47.29

18.76

37.09 - 57.49

9.47 - 72.66

48.7

31.58 - 58.4

0.1356

0.6781

4_TH1

Abs_Value

13

13

0

64.63

39.03

43.42 - 85.85

9.91 - 143.83

54.59

38.59 - 83.06

13

13

0

51.88

51.35

23.97 - 79.8

4.31 - 161.95

30.9

24.11 - 47.41

0.4833

0.7191

4_TH17

Abs_Value

13

13

0

22.1

10.62

16.32 - 27.87

7.99 - 40.27

20.97

11.82 - 31.4

13

13

0

34.53

29.41

18.54 - 50.52

8.97 - 109.23

27.65

10.99 - 43.52

0.1721

0.6781

4_Th17TO1

Abs_Value

13

13

0

13.04

11.55

6.76 - 19.32

2.42 - 39.63

7.87

5.63 - 16.31

13

13

0

12.94

11.49

6.69 - 19.19

0.78 - 39.95

11.04

5.89 - 12.47

0.9829

0.9889

4_TH2

Abs_Value

13

13

0

16.53

8.19

12.08 - 20.98

6.89 - 32.23

12.56

10.25 - 22.2

13

13

0

30.97

23.54

18.18 - 43.77

2.45 - 80.42

22.23

14.68 - 46.11

0.0543

0.6781

4_TH22

Abs_Value

13

13

0

9.21

7.41

5.18 - 13.24

0.85 - 24.41

7.54

3.3 - 10.42

13

13

0

12.98

13.47

5.66 - 20.3

2.27 - 43.52

6.25

4.4 - 15.95

0.3877

0.6866

4+

Abs_Value

13

13

0

159.05

136.59

84.8 - 233.3

52.48 - 526.69

107.32

91.29 - 157.54

13

13

0

172.82

136.8

98.46 - 247.19

20.84 - 561.4

130.33

87.45 - 197.84

0.7994

0.9

4+ (IM STAT)

Abs_Value

13

13

0

137.87

118.1

73.67 - 202.07

31.83 - 437.37

99.83

69.48 - 153.93

13

13

0

148.86

129.99

78.19 - 219.52

34.32 - 535.83

107.92

75.74 - 188.69

0.8235

0.9094

4+226+

Abs_Value

13

13

0

434.09

215.97

316.69 - 551.5

148.12 - 908.92

418.16

322.85 - 569.2

13

13

0

367.91

194.37

262.25 - 473.57

151.09 - 689.45

315.14

175.04 - 503.96

0.4197

0.6976

4+39+

Abs_Value

13

13

0

72.82

50.19

45.54 - 100.1

1.86 - 157.32

60.9

38.64 - 114.42

13

13

0

74.42

74.23

34.07 - 114.77

3 - 294.7

60.08

35.85 - 82.73

0.9493

0.9711

4+DR+

Abs_Value

13

13

0

203.14

165.82

113 - 293.28

35.88 - 695.8

161.93

120.52 - 239.44

13

13

0

133.82

113.21

72.28 - 195.36

37.87 - 433.17

95.63

55.05 - 152.03

0.2268

0.6781

4+PD-1-TIGIT-

Abs_Value

13

13

0

165.45

107.03

107.26 - 223.63

21.66 - 409.4

156.17

91.71 - 213.7

13

13

0

185.55

122.99

118.69 - 252.41

24.56 - 339.45

150.3

79.8 - 326.94

0.6607

0.8271

4+PD-1-TIGIT+

Abs_Value

13

13

0

16.44

17.32

7.02 - 25.86

2.68 - 63.64

9.45

6.4 - 17.7

13

13

0

17.39

13.74

9.92 - 24.87

2.16 - 46.7

16.77

5.77 - 21.51

0.8777

0.9388

4+PD-1+

Abs_Value

13

13

0

272.3

172.15

178.72 - 365.88

68.05 - 718.28

212.65

175.68 - 364.54

13

13

0

196.05

112.02

135.15 - 256.95

83.25 - 411.97

154.89

113.41 - 227.46

0.1953

0.6781

4+PD-1+TIGIT-

Abs_Value

13

13

0

146.17

77.12

104.24 - 188.09

32.8 - 282.13

132.55

92.16 - 201.04

13

13

0

107.58

67.37

70.96 - 144.21

46.73 - 237.8

79.56

56.16 - 133.4

0.1872

0.6781

4+PD-1+TIGIT+

Abs_Value

13

13

0

126.13

107.17

67.88 - 184.39

35.25 - 436.15

83.52

68.11 - 152.21

13

13

0

88.47

54.2

59 - 117.93

30.53 - 233.4

75.33

55.61 - 113.02

0.2732

0.6781

4+TIGIT+

Abs_Value

13

13

0

142.57

121.53

76.51 - 208.64

43.18 - 499.79

99.63

74.52 - 168.55

13

13

0

105.86

60.23

73.12 - 138.6

32.86 - 256.89

101.96

75.38 - 140.76

0.3424

0.6781

4NV

Abs_Value

13

13

0

83.4

55.4

53.28 - 113.51

2.54 - 194.07

71.69

45.79 - 109.06

13

13

0

94.65

79.18

51.61 - 137.69

7.74 - 219.7

69.52

34.57 - 167.25

0.6788

0.8445

4NV(СТАР2)

Abs_Value

13

13

0

71.79

48.37

45.5 - 98.08

1.85 - 171.15

63.56

33.81 - 105.47

13

13

0

89.8

80.11

46.25 - 133.35

7.32 - 237.87

56.13

28.32 - 149.96

0.4959

0.7192

4NV_TH1

Abs_Value

13

13

0

4.35

3.03

2.7 - 6

0.17 - 12.15

4.03

2.45 - 5.59

13

13

0

7.88

9.31

2.82 - 12.95

0.56 - 30

3.45

0.75 - 7.62

0.2135

0.6781

4NV_TH17

Abs_Value

13

13

0

2.16

1.44

1.38 - 2.95

0.4 - 5.09

2.02

1.3 - 2.34

13

13

0

2.65

2.59

1.24 - 4.06

0.16 - 8.85

1.59

1.21 - 2.92

0.5581

0.7482

4NV_Th17TO1

Abs_Value

13

13

0

0.47

0.36

0.27 - 0.66

0.01 - 1.3

0.48

0.14 - 0.58

13

13

0

0.71

0.62

0.37 - 1.05

0.05 - 2.08

0.44

0.35 - 1.02

0.2427

0.6781

4NV_TH2

Abs_Value

13

13

0

5.6

4.78

3 - 8.2

0.5 - 15.38

3.94

2.56 - 7.64

13

13

0

6.66

4.7

4.1 - 9.22

0.21 - 13.51

6.09

2.92 - 10.3

0.573

0.7599

4NV_TH22

Abs_Value

13

13

0

0.19

0.18

0.09 - 0.29

0.02 - 0.61

0.1

0.07 - 0.35

13

13

0

0.21

0.21

0.1 - 0.33

0 - 0.63

0.12

0.06 - 0.3

0.7948

0.9

4NV+226+

Abs_Value

13

13

0

63.84

42.61

40.67 - 87

1.8 - 148.33

61.02

31.32 - 92.36

13

13

0

77.25

69.95

39.23 - 115.28

6.18 - 203.08

46.99

23.72 - 137.98

0.5615

0.7507

4NV+39+

Abs_Value

13

13

0

0.99

0.73

0.6 - 1.39

0.01 - 2.47

0.98

0.33 - 1.51

13

13

0

2.6

2.83

1.06 - 4.13

0.09 - 9.72

1.74

0.51 - 2.99

0.0686

0.6781

4NV+DR+

Abs_Value

13

13

0

4.45

4.54

1.98 - 6.91

0.32 - 17.75

2.89

1.89 - 6

13

13

0

6.1

4.37

3.72 - 8.47

0.24 - 15.82

4.32

4.05 - 7.56

0.3547

0.6781

4NV+PD-1-TIGIT-

Abs_Value

13

13

0

64.15

44.02

40.22 - 88.08

1.55 - 158.4

59.59

23.79 - 90.38

13

13

0

82.01

75.65

40.89 - 123.14

3.6 - 218.79

46.91

24.7 - 143.53

0.4708

0.718

4NV+PD-1-TIGIT+

Abs_Value

13

13

0

1.17

0.8

0.73 - 1.6

0.12 - 2.96

1.03

0.73 - 1.25

13

13

0

2.87

4.3

0.53 - 5.21

0.12 - 15.6

1.05

0.52 - 2.65

0.1853

0.6781

4NV+PD-1+TIGIT-

Abs_Value

13

13

0

4.79

6.39

1.31 - 8.27

0.06 - 24.15

3.42

0.79 - 6.07

13

13

0

2.71

1.97

1.64 - 3.78

0.5 - 6.2

1.72

1.22 - 4.6

0.2805

0.6781

4NV+PD-1+TIGIT+

Abs_Value

13

13

0

1.68

1.31

0.97 - 2.39

0.07 - 4.48

1.38

0.81 - 2.15

13

13

0

2.21

2.39

0.91 - 3.51

0.17 - 8.03

1.35

0.46 - 2.5

0.4905

0.7192

4NV+PD1+

Abs_Value

13

13

0

6.47

7.25

2.53 - 10.41

0.15 - 27.06

4.9

1.31 - 9.5

13

13

0

4.92

3.56

2.98 - 6.86

0.76 - 12.63

4.21

2.41 - 7

0.4985

0.7192

4NV+TIGIT+

Abs_Value

13

13

0

2.85

1.84

1.85 - 3.85

0.19 - 5.28

2.47

1.65 - 4.98

13

13

0

5.08

5.67

1.99 - 8.16

0.51 - 18.1

2.26

1.08 - 7.52

0.198

0.6781

4ЕМ

Abs_Value

13

13

0

83.51

154.98

-0.73 - 167.76

1.65 - 581.05

33.56

14.28 - 75.09

13

13

0

17.36

26.78

2.81 - 31.92

1.9 - 101.46

8.09

3.96 - 16.47

0.1538

0.6781

4ЕМ_TH1

Abs_Value

13

13

0

23.16

22.92

10.7 - 35.61

0.28 - 69.88

15.02

3.71 - 37.18

13

13

0

7.54

14.11

-0.13 - 15.21

0.01 - 52.73

3.07

1.65 - 6.09

0.0493

0.6781

4ЕМ_TH17

Abs_Value

13

13

0

0.03

0.03

0.01 - 0.05

0 - 0.09

0.02

0 - 0.05

13

13

0

0.03

0.06

0 - 0.06

0 - 0.21

0.01

0 - 0.02

0.923

0.9601

4ЕМ_Th17TO1

Abs_Value

13

13

0

1.88

2.85

0.33 - 3.43

0 - 8.02

0.32

0.14 - 1.18

13

13

0

0.24

0.32

0.07 - 0.42

0 - 1.11

0.14

0.05 - 0.22

0.0621

0.6781

4ЕМ_TH2

Abs_Value

13

13

0

0.39

0.4

0.17 - 0.61

0.03 - 1.27

0.2

0.1 - 0.69

13

13

0

0.34

0.6

0.01 - 0.67

0.01 - 2.26

0.12

0.08 - 0.23

0.8195

0.9094

4ЕМ_TH22

Abs_Value

13

13

0

0

0

0 - 0

0 - 0.01

0

0 - 0

13

13

0

0.01

0.04

-0.01 - 0.04

0 - 0.16

0

0 - 0

0.4002

0.6866

4ЕМ+226+

Abs_Value

13

13

0

241.9

173.33

147.68 - 336.12

62.6 - 660.98

192.43

126 - 371.99

13

13

0

156.43

96.58

103.93 - 208.93

36.18 - 318.08

115.17

96.39 - 232.48

0.1371

0.6781

4ЕМ+39+

Abs_Value

13

13

0

51.04

39.02

29.83 - 72.26

0.65 - 127.55

40.86

19.93 - 76.25

13

13

0

41.88

36.21

22.2 - 61.56

2.04 - 139.13

41.5

18.65 - 51.06

0.5408

0.7475

4ЕМ+DR+

Abs_Value

13

13

0

143.14

130.26

72.33 - 213.95

24.28 - 526.3

98.4

72.9 - 188.23

13

13

0

73.97

53.76

44.75 - 103.19

14.83 - 210.31

58.06

41.44 - 85.21

0.0958

0.6781

4ЕМ+PD1-TIGIT-

Abs_Value

13

13

0

59.16

70.32

20.93 - 97.39

6.26 - 270.35

39.84

11.7 - 71.22

13

13

0

44.32

43.87

20.47 - 68.16

8.74 - 154.67

34.94

10.44 - 48.14

0.5257

0.739

4ЕМ+PD1-TIGIT+

Abs_Value

13

13

0

7.95

12.5

1.15 - 14.75

0.32 - 45.6

2.72

1.4 - 8.4

13

13

0

6.49

8.26

2 - 10.98

0.59 - 31.87

4.02

2.89 - 6.55

0.728

0.8715

4ЕМ+PD1+

Abs_Value

13

13

0

180.81

135.5

107.15 - 254.46

43.74 - 548.64

137.64

103.09 - 195.8

13

13

0

115.38

69.07

77.83 - 152.93

26.83 - 264.13

96.95

75.64 - 122.6

0.1385

0.6781

4ЕМ+PD1+TIGIT-

Abs_Value

13

13

0

99.02

55.6

68.8 - 129.24

23.17 - 193.88

90.04

75.08 - 118.97

13

13

0

67.82

46.16

42.73 - 92.91

19.11 - 155.38

55.65

36.28 - 64.22

0.1331

0.6781

4ЕМ+PD1+TIGIT+

Abs_Value

13

13

0

81.79

88.52

33.66 - 129.91

20.57 - 354.76

58.89

33.68 - 100.01

13

13

0

47.56

30.46

31 - 64.12

7.72 - 133.76

45.49

34.65 - 52.2

0.2075

0.6781

4ЕМ+TIGIT+

Abs_Value

13

13

0

89.74

99.99

35.38 - 144.1

22.59 - 400.36

65.3

34 - 104.03

13

13

0

54.05

33.34

35.92 - 72.17

8.33 - 140.74

49.17

43.44 - 55.09

0.2414

0.6781

4ЕМTM

Abs_Value

13

13

0

247.92

174.89

152.85 - 342.99

72.79 - 665.46

195.97

127.24 - 388.28

13

13

0

166.18

102.77

110.32 - 222.05

37.63 - 337

124.63

100.11 - 239.49

0.1623

0.6781

4СМ

Abs_Value

13

13

0

82.66

50.33

55.3 - 110.01

18.35 - 207.67

82.63

42.12 - 89.44

13

13

0

103.94

71.91

64.85 - 143.03

15.91 - 260.46

97.48

45.2 - 151.85

0.3917

0.6866

4СМ(СТАР2)

Abs_Value

13

13

0

65.89

37.99

45.24 - 86.54

15.11 - 150.25

71.44

33.76 - 85.67

13

13

0

78.17

54.08

48.77 - 107.57

21.2 - 184.54

63.26

33.85 - 106.54

0.5101

0.7296

4СМ_TH1

Abs_Value

13

13

0

3.04

2.68

1.59 - 4.5

0.6 - 9.36

2.39

1.29 - 3.47

13

13

0

6.69

8.01

2.34 - 11.05

0.38 - 30.36

4.94

1.58 - 9.1

0.1408

0.6781

4СМ_TH17

Abs_Value

13

13

0

8.34

3.64

6.36 - 10.32

3.64 - 15.46

8.09

5.18 - 10.54

13

13

0

12.96

11.28

6.83 - 19.1

1.95 - 34.36

9.47

3.78 - 16.8

0.1806

0.6781

4СМ_Th17TO1

Abs_Value

13

13

0

1.34

1.07

0.76 - 1.92

0.21 - 3.08

1.16

0.56 - 1.82

13

13

0

2.43

2.17

1.25 - 3.61

0.19 - 8.34

2.34

1 - 2.67

0.1227

0.6781

4СМ_TH2

Abs_Value

13

13

0

4.14

2.3

2.89 - 5.4

1.33 - 7.78

3.88

2.09 - 6.68

13

13

0

11.09

12.08

4.52 - 17.65

1.16 - 45.88

8.49

1.29 - 12.84

0.0628

0.6781

4СМ_TH22

Abs_Value

13

13

0

1.19

1.56

0.34 - 2.04

0.11 - 5.84

0.58

0.35 - 1.17

13

13

0

2.43

3.58

0.48 - 4.38

0.06 - 13.33

0.87

0.72 - 3.09

0.2681

0.6781

4СМ+226+

Abs_Value

13

13

0

63.24

36.6

43.34 - 83.13

14.8 - 144.2

68.05

31.79 - 79.68

13

13

0

74.53

51.68

46.43 - 102.62

19.64 - 178.97

60.07

32.98 - 98.97

0.5272

0.739

4СМ+39+

Abs_Value

13

13

0

14.91

11.7

8.55 - 21.26

0.06 - 40.39

12.19

7.06 - 23.23

13

13

0

21.13

30.82

4.37 - 37.88

0.51 - 118.64

13.06

6.43 - 21.8

0.5064

0.7264

4СМ+DR+

Abs_Value

13

13

0

14.01

13.93

6.44 - 21.58

3.76 - 45.11

7.05

5.05 - 14.82

13

13

0

20.3

19.59

9.65 - 30.95

3.93 - 64.82

10.94

7.81 - 24.58

0.3556

0.6781

4СМ+PD1-TIGIT-

Abs_Value

13

13

0

20.25

14.14

12.57 - 27.94

4.29 - 55.03

18.98

7.57 - 25.24

13

13

0

27.33

20.43

16.22 - 38.43

2.11 - 68.44

22.11

12.3 - 37.2

0.3161

0.6781

4СМ+PD1-TIGIT+

Abs_Value

13

13

0

3.66

4.04

1.46 - 5.86

0.36 - 15.7

2.8

1.36 - 3.88

13

13

0

4.74

3.84

2.65 - 6.82

0.21 - 13.54

4.14

1.62 - 6.43

0.4918

0.7192

4СМ+PD1+

Abs_Value

13

13

0

41.98

30.47

25.41 - 58.54

9.99 - 123.91

42.49

20.33 - 50.99

13

13

0

46.1

35.48

26.81 - 65.39

3.36 - 122.72

37.27

22.3 - 73.22

0.7533

0.884

4СМ+PD1+TIGIT-

Abs_Value

13

13

0

16.12

9.75

10.82 - 21.42

3.23 - 31.56

17.02

6.71 - 24.01

13

13

0

17.93

14.88

9.84 - 26.02

1.56 - 55.65

13.15

8.49 - 25.36

0.7172

0.867

4СМ+PD1+TIGIT+

Abs_Value

13

13

0

25.86

22.41

13.68 - 38.04

5.36 - 92.35

26.08

10.22 - 29.56

13

13

0

28.18

21.56

16.45 - 39.9

1.8 - 67.07

20.7

16.4 - 42.34

0.7908

0.9

4СМ+TIGIT+

Abs_Value

13

13

0

29.52

23.78

16.6 - 42.45

6.2 - 97.93

28.45

12.82 - 35.43

13

13

0

32.91

24.07

19.83 - 46

4.81 - 74.86

22.06

20.58 - 48.77

0.7209

0.8691

4ТM_TH1

Abs_Value

13

13

0

23.31

14.47

15.45 - 31.18

3.7 - 54.39

19.8

12 - 27.68

13

13

0

17.67

22.34

5.53 - 29.81

0.31 - 88.8

12.46

6.04 - 17.61

0.4532

0.7124

4ТM_TH17

Abs_Value

13

13

0

10.76

7.93

6.45 - 15.07

1.32 - 26.41

6.78

5.51 - 14.52

13

13

0

17.44

20.5

6.3 - 28.58

2.44 - 68.85

11.71

5.53 - 16.7

0.2899

0.6781

4ТM_Th17TO1

Abs_Value

13

13

0

8.52

7.97

4.19 - 12.86

1.35 - 28.42

5.41

3.78 - 9.57

13

13

0

8.54

9.73

3.25 - 13.83

0.13 - 35.59

6.45

2.87 - 9.11

0.9959

0.9959

4ТM_TH2

Abs_Value

13

13

0

5.43

6.04

2.14 - 8.71

0.67 - 19.04

2.96

1.96 - 4.7

13

13

0

9.45

10.03

4 - 14.91

0.77 - 33.45

3.13

1.44 - 15.46

0.2299

0.6781

4ТM_TH22

Abs_Value

13

13

0

7.06

6.43

3.56 - 10.56

0.34 - 22.69

6.47

2.19 - 8.34

13

13

0

9.1

10.7

3.28 - 14.91

1.11 - 38.35

4.1

2.72 - 13.99

0.563

0.7507

4ТREG

Abs_Value

13

13

0

2.67

3.56

0.73 - 4.6

0.18 - 14.06

1.89

0.91 - 2.05

13

13

0

3.25

3.83

1.17 - 5.33

0.49 - 13.02

1.36

1.12 - 3.25

0.6927

0.8514

4ТREG(СТАР2)

Abs_Value

13

13

0

166.74

142.02

89.54 - 243.94

52.54 - 539.05

122.66

94.71 - 157.59

13

13

0

176.73

132

104.98 - 248.49

45.87 - 554.23

125.25

100.3 - 206.41

0.8542

0.9205

4ТREG_TH1

Abs_Value

13

13

0

0.34

0.18

0.25 - 0.44

0.12 - 0.68

0.26

0.23 - 0.45

13

13

0

0.36

0.37

0.16 - 0.56

0.09 - 1.26

0.19

0.14 - 0.39

0.8509

0.9201

4ТREG_TH17

Abs_Value

13

13

0

4.58

3.04

2.93 - 6.24

1.23 - 13.43

4.22

2.99 - 5.13

13

13

0

6.46

4.28

4.13 - 8.79

2.62 - 15.15

4.65

3.37 - 7.8

0.2109

0.6781

4ТREG_Th17TO1

Abs_Value

13

13

0

0.1

0.09

0.05 - 0.14

0.02 - 0.3

0.06

0.03 - 0.16

13

13

0

0.15

0.14

0.07 - 0.22

0 - 0.38

0.06

0.05 - 0.23

0.2956

0.6781

4ТREG_TH2

Abs_Value

13

13

0

2.41

1.05

1.84 - 2.99

1.11 - 4.61

2.24

1.58 - 3.13

13

13

0

2.79

1.48

1.99 - 3.59

1.05 - 6.08

3.1

1.6 - 3.72

0.462

0.7142

4ТREG_TH22

Abs_Value

13

13

0

6.66

9.3

1.6 - 11.71

0.91 - 36.5

4.71

1.83 - 7.21

13

13

0

5.61

4.82

2.98 - 8.23

1.59 - 16.79

3.95

3.02 - 5.3

0.7225

0.8691

4ТЕ

Abs_Value

13

13

0

25.68

28.83

10.01 - 41.35

0.7 - 97.53

14.36

5.41 - 36.71

13

13

0

21.25

36.25

1.54 - 40.95

0.66 - 114.7

6.81

1.17 - 15.4

0.7331

0.8733

4ТЕ(СТАР2)

Abs_Value

13

13

0

69.3

56.53

38.57 - 100.03

21.6 - 217.76

46.95

33.64 - 77.25

13

13

0

64.29

62.48

30.33 - 98.26

11.38 - 207.55

49.68

22.31 - 72.87

0.8323

0.91

4ТЕ_TH1

Abs_Value

13

13

0

6.79

6.41

3.31 - 10.27

0.05 - 20.2

3.66

1.66 - 10.59

13

13

0

7.37

15.9

-1.27 - 16.01

0.01 - 52.19

0.58

0.33 - 3.53

0.9044

0.9546

4ТЕ_TH17

Abs_Value

13

13

0

0.01

0.01

0 - 0.01

0 - 0.04

0

0 - 0.01

13

13

0

0.01

0.01

0 - 0.01

0 - 0.01

0.01

0 - 0.01

0.4966

0.7192

4ТЕ_Th17TO1

Abs_Value

13

13

0

0.19

0.26

0.05 - 0.33

0 - 0.76

0.05

0.02 - 0.21

13

13

0

0.13

0.23

0 - 0.25

0 - 0.78

0.02

0 - 0.15

0.5389

0.7475

4ТЕ_TH2

Abs_Value

13

13

0

0.2

0.24

0.07 - 0.33

0.01 - 0.83

0.11

0.04 - 0.35

13

13

0

0.44

0.72

0.05 - 0.82

0 - 2.33

0.16

0.03 - 0.27

0.2834

0.6781

4ТЕ_TH22

Abs_Value

13

13

0

0.01

0.01

0 - 0.02

0 - 0.05

0

0 - 0.02

13

13

0

0

0.01

0 - 0.01

0 - 0.02

0

0 - 0

0.2025

0.6781

4ТЕ+226+

Abs_Value

13

13

0

65.9

56.15

35.37 - 96.42

17.35 - 215.7

42.5

29.7 - 75.76

13

13

0

59.23

61.82

25.62 - 92.84

10.21 - 202.6

44.9

16.88 - 66.16

0.776

0.8962

4ТЕ+39+

Abs_Value

13

13

0

5.97

3.71

3.96 - 7.99

0.43 - 11.93

5.87

3.68 - 7.92

13

13

0

8.84

10.79

2.97 - 14.7

0.21 - 33.74

4.21

2.04 - 10.76

0.3801

0.6866

4ТЕ+DR+

Abs_Value

13

13

0

42.24

43.71

18.48 - 66

5.42 - 168.72

28.9

15.47 - 52.93

13

13

0

33.35

48.35

7.07 - 59.63

3.27 - 156.97

11.63

6.03 - 29.26

0.6274

0.7976

4ТЕ+PD-1-TIGIT-

Abs_Value

13

13

0

21.71

21.28

10.14 - 33.28

4.28 - 78.19

11.57

8.36 - 33.76

13

13

0

31.59

38.22

10.81 - 52.37

1.94 - 132.13

15.24

6.25 - 29.36

0.4258

0.7016

4ТЕ+PD-1-TIGIT+

Abs_Value

13

13

0

3.64

4.06

1.43 - 5.85

0.48 - 16.23

2.38

1.68 - 3.48

13

13

0

3.28

3.04

1.63 - 4.94

0.35 - 11.49

2.91

0.97 - 3.98

0.802

0.9009

4ТЕ+PD-1+

Abs_Value

13

13

0

43.94

41.38

21.45 - 66.44

5.49 - 162.5

35.01

19.7 - 60.4

13

13

0

29.42

25.64

15.48 - 43.36

4.99 - 90

15.98

11.62 - 37.85

0.2949

0.6781

4ТЕ+PD-1+TIGIT-

Abs_Value

13

13

0

26.62

24.8

13.14 - 40.11

2.04 - 86.28

19.27

8.78 - 45.33

13

13

0

19.02

19.62

8.35 - 29.69

1.62 - 67.21

10.7

5.15 - 25.97

0.395

0.6866

4ТЕ+PD-1+TIGIT+

Abs_Value

13

13

0

17.32

19.33

6.81 - 27.83

3.45 - 76.22

13.34

5.89 - 15.88

13

13

0

10.4

7.98

6.06 - 14.74

2.91 - 25.6

9.16

3.58 - 14.14

0.2503

0.6781

4ТЕ+TIGIT+

Abs_Value

13

13

0

20.96

23.17

8.36 - 33.56

6.37 - 92.45

14.32

7.06 - 18.99

13

13

0

13.68

10.38

8.04 - 19.33

3.26 - 34.28

10.04

4.92 - 17.05

0.3162

0.6781

4ТМ

Abs_Value

13

13

0

165.75

92.33

115.55 - 215.94

55.5 - 339.62

164.24

81.42 - 247.66

13

13

0

141.19

99.78

86.95 - 195.42

36.46 - 328.01

100.61

81.37 - 204.29

0.521

0.7387

8+

Abs_Value

13

13

0

973.01

747.72

566.54 - 1379.47

57.71 - 2452.07

696.99

568.49 - 1161.65

13

13

0

546.63

640.27

198.58 - 894.69

80.74 - 2238.8

261.13

202.41 - 598.49

0.1318

0.6781

8+ (IM STAT)

Abs_Value

13

13

0

1085.12

786.37

657.64 - 1512.59

70.67 - 2683.52

803.31

580.14 - 1328.08

13

13

0

682.26

755.81

271.4 - 1093.12

101.71 - 2673.64

370.08

238.86 - 856.27

0.1955

0.6781

8+226+

Abs_Value

13

13

0

1425.23

900.19

935.88 - 1914.58

104.01 - 3338.48

1387.98

879.96 - 1695.87

13

13

0

897.07

877.53

420.04 - 1374.1

239.21 - 3240.63

640.91

367.77 - 988.26

0.1429

0.6781

8+39+

Abs_Value

13

13

0

149.18

125.68

80.86 - 217.5

6.69 - 401.66

156.01

25.68 - 185.72

13

13

0

124.59

156.16

39.7 - 209.48

3.22 - 554.73

73.44

39.08 - 132.9

0.6625

0.8273

8+DR+

Abs_Value

13

13

0

974.76

581.03

658.91 - 1290.61

77.9 - 2000.24

936.64

510.81 - 1096.91

13

13

0

655.65

764.95

239.82 - 1071.49

43.35 - 2729.41

426.73

213.57 - 575.13

0.2435

0.6781

8+PD-1-TIGIT-

Abs_Value

13

13

0

507.33

502.02

234.43 - 780.23

38.12 - 1570.48

378.56

162 - 611.39

13

13

0

333.33

368.67

132.92 - 533.73

70.59 - 1371.15

188.7

106.63 - 341.99

0.3247

0.6781

8+PD-1-TIGIT+

Abs_Value

13

13

0

417.34

339.24

232.92 - 601.75

74.35 - 1183.71

385.59

155.15 - 548.77

13

13

0

350.04

412.25

125.94 - 574.14

10.16 - 1209.08

151.69

95.73 - 384

0.6537

0.8226

8+PD-1+

Abs_Value

13

13

0

558.18

542.33

263.36 - 852.99

49.89 - 2097

491.09

237.65 - 612.58

13

13

0

305.61

194.81

199.71 - 411.51

93.13 - 731.94

253.18

149.01 - 438.12

0.1348

0.6781

8+PD-1+TIGIT-

Abs_Value

13

13

0

185.76

205.22

74.2 - 297.32

9.05 - 678.2

96.85

71.47 - 262.8

13

13

0

96.17

103.78

39.75 - 152.58

10.94 - 364.07

60.93

36.55 - 101.92

0.1774

0.6781

8+PD-1+TIGIT+

Abs_Value

13

13

0

372.41

395.78

157.27 - 587.56

40.84 - 1584.15

337.51

134.58 - 412.25

13

13

0

209.44

130.02

138.76 - 280.12

47.09 - 434.48

141.45

123.92 - 304.44

0.1794

0.6781

8+TIGIT+

Abs_Value

13

13

0

789.75

541.86

495.19 - 1084.31

115.8 - 2034.4

738.06

518.85 - 986.73

13

13

0

559.48

510.03

282.22 - 836.74

57.24 - 1576.95

372.8

202.83 - 818.49

0.2756

0.6781

8EMTM

Abs_Value

13

13

0

347.92

377.57

142.67 - 553.16

47.77 - 1398.17

228.63

102.82 - 403.3

13

13

0

121.21

97.04

68.46 - 173.96

13.51 - 335.18

95.26

39.69 - 172.92

0.0553

0.6781

8EMTM+226+

Abs_Value

13

13

0

337.02

376.23

132.5 - 541.54

28.26 - 1379.5

194.8

96.04 - 400.41

13

13

0

103.51

83.81

57.95 - 149.07

9.76 - 283.7

83.19

35.2 - 160.55

0.0476

0.6781

8EMTM+39+

Abs_Value

13

13

0

48.82

39.13

27.55 - 70.09

0.18 - 109.55

59.12

5.97 - 71.91

13

13

0

21.96

19.26

11.49 - 32.43

0.97 - 52.65

22.44

4.66 - 39.32

0.0398

0.6781

8EMTM+DR+

Abs_Value

13

13

0

255.33

238.84

125.5 - 385.16

34.54 - 830.52

168.04

77.85 - 362.11

13

13

0

95.55

84.09

49.84 - 141.26

9.62 - 298.35

72.75

36.73 - 130.68

0.0381

0.6781

8EMTM+PD-1-TIGIT-

Abs_Value

13

13

0

139.91

302.81

-24.7 - 304.51

4.45 - 1106.11

38.89

21.54 - 55.16

13

13

0

31.53

32.99

13.6 - 49.47

3.23 - 96.46

18.1

11.17 - 41.75

0.2232

0.6781

8EMTM+PD-1-TIGIT+

Abs_Value

13

13

0

74.21

86.1

27.4 - 121.01

7.63 - 242.77

24.48

12.4 - 102.51

13

13

0

27.79

34.5

9.04 - 46.55

0.5 - 119.96

8.44

5.38 - 32.25

0.0904

0.6781

8EMTM+PD-1+

Abs_Value

13

13

0

133.8

119.06

69.08 - 198.52

26.27 - 466.71

113.35

50.13 - 177.14

13

13

0

61.88

40.26

40 - 83.77

9.78 - 119.51

46.3

25.86 - 100.57

0.0572

0.6781

8EMTM+PD-1+TIGIT-

Abs_Value

13

13

0

48.19

71.54

9.31 - 87.08

4.29 - 268.37

24.49

11.08 - 37.34

13

13

0

16.93

15.96

8.25 - 25.6

4.23 - 56.1

10.28

5.44 - 19.35

0.1477

0.6781

8EMTM+PD-1+TIGIT+

Abs_Value

13

13

0

85.61

60.36

52.8 - 118.42

18.92 - 198.34

51.77

42.13 - 115.72

13

13

0

44.95

33.54

26.72 - 63.19

5.55 - 107.53

34.48

20.57 - 61.05

0.0473

0.6781

8EMTM+TIGIT+

Abs_Value

13

13

0

159.81

106.94

101.68 - 217.95

28.09 - 300.85

188.17

51.37 - 267.22

13

13

0

72.75

63.36

38.31 - 107.19

6.05 - 220.12

65.96

25.68 - 91.65

0.0203

0.6781

8NV

Abs_Value

13

13

0

45.79

28.32

30.4 - 61.18

8.16 - 95.21

33.84

25.59 - 65.7

13

13

0

58.65

50.58

31.15 - 86.14

4.62 - 189.4

63.06

19.96 - 75.23

0.4339

0.7016

8NV(СТАР2)

Abs_Value

13

13

0

33.1

22.31

20.97 - 45.23

3.18 - 72.59

32.88

19.17 - 37.83

13

13

0

67.91

68.16

30.86 - 104.96

4.23 - 232.76

53.18

17.68 - 97.88

0.1012

0.6781

8NV+226+

Abs_Value

13

13

0

27.93

18.66

17.79 - 38.07

3.13 - 63.08

28.59

13.02 - 32.37

13

13

0

57.09

62.6

23.06 - 91.12

3.16 - 230.07

42.18

16.37 - 86.19

0.1296

0.6781

8NV+39+

Abs_Value

13

13

0

1.43

1.01

0.88 - 1.97

0.03 - 3.49

1.2

0.63 - 2.01

13

13

0

6.03

8.56

1.38 - 10.68

0.15 - 30.4

1.66

0.7 - 8.3

0.0776

0.6781

8NV+DR+

Abs_Value

13

13

0

2.85

1.73

1.91 - 3.79

0.61 - 5.76

3.32

1.55 - 3.99

13

13

0

12.46

20.78

1.17 - 23.76

0.52 - 79.65

6.78

2.29 - 11.12

0.122

0.6781

8NV+PD-1-TIGIT-

Abs_Value

13

13

0

26.32

19.51

15.71 - 36.93

1.66 - 66.52

23.52

13.57 - 31.19

13

13

0

46.66

61.95

12.99 - 80.34

1.58 - 223.18

27.39

5.68 - 64.64

0.2772

0.6781

8NV+PD-1-TIGIT+

Abs_Value

13

13

0

2.68

3.16

0.96 - 4.41

0.41 - 11.42

1.59

0.81 - 2.43

13

13

0

13.29

33.02

-4.65 - 31.24

0.08 - 122.5

4.44

0.7 - 7.9

0.2708

0.6781

8NV+PD-1+

Abs_Value

13

13

0

4.1

4

1.92 - 6.27

0.06 - 14.35

3.65

1.11 - 5.19

13

13

0

7.95

6.45

4.45 - 11.46

0.97 - 19.52

7.03

1.76 - 13.46

0.0818

0.6781

8NV+PD-1+TIGIT-

Abs_Value

13

13

0

1.92

2.63

0.49 - 3.35

0 - 9.29

1.1

0.26 - 2.14

13

13

0

2.55

4.08

0.33 - 4.76

0.01 - 12.11

0.95

0.33 - 1.92

0.6453

0.8141

8NV+PD-1+TIGIT+

Abs_Value

13

13

0

2.18

1.69

1.26 - 3.1

0.06 - 5.06

2.04

0.57 - 3.18

13

13

0

5.41

5.98

2.16 - 8.66

0.22 - 17.65

2.61

0.96 - 7.01

0.0823

0.6781

8NV+TIGIT+

Abs_Value

13

13

0

4.86

3.3

3.07 - 6.66

0.78 - 11.87

4.46

2.67 - 5.87

13

13

0

18.7

37.34

-1.59 - 39

0.34 - 140.04

7

2.51 - 15.5

0.2075

0.6781

8TREG

Abs_Value

13

13

0

965.31

737.01

564.66 - 1365.95

59.02 - 2419.83

706.42

583.47 - 1219.41

13

13

0

556.75

632.79

212.76 - 900.74

76.34 - 2160.15

285.5

205.13 - 632.61

0.1428

0.6781

8ЕМ

Abs_Value

13

13

0

311.07

295.94

150.2 - 471.94

24.53 - 949.3

173.01

112.84 - 509.36

13

13

0

94.72

105.65

37.29 - 152.15

9.71 - 355.83

43.06

20.95 - 153.4

0.0254

0.6781

8СМ

Abs_Value

13

13

0

15.13

15.6

6.65 - 23.61

1.96 - 50.29

7.37

6.27 - 22.09

13

13

0

30.87

44.13

6.88 - 54.86

1.67 - 142.48

10.98

7.36 - 18.61

0.2441

0.6781

8СМ(СТАР2)

Abs_Value

13

13

0

11.88

13.94

4.3 - 19.46

1.34 - 46.77

7.23

3.84 - 11.07

13

13

0

16.92

18.98

6.6 - 27.24

0.7 - 60.65

7.86

4.01 - 18.59

0.4483

0.7069

8СМ+226+

Abs_Value

13

13

0

10.47

12.38

3.74 - 17.2

1.34 - 39.93

6.41

3.65 - 8.63

13

13

0

12.1

13.57

4.72 - 19.47

0.67 - 48.69

5.72

3.42 - 14.13

0.7518

0.884

8СМ+39+

Abs_Value

13

13

0

3.33

5.24

0.48 - 6.18

0.01 - 19.68

1.82

0.38 - 2.84

13

13

0

6.07

12.52

-0.73 - 12.88

0.09 - 46.33

1.96

0.45 - 3.22

0.4763

0.7185

8СМ+DR+

Abs_Value

13

13

0

8.74

11.98

2.23 - 15.25

0.88 - 44.36

4.53

2.55 - 7.74

13

13

0

13.2

16.24

4.37 - 22.02

0.31 - 51.36

5.17

2.6 - 14.49

0.4346

0.7016

8СМ+PD-1-TIGIT-

Abs_Value

13

13

0

2.9

5.41

-0.04 - 5.84

0.16 - 20.49

1.44

0.48 - 2.54

13

13

0

1.96

1.61

1.08 - 2.84

0.4 - 5.04

1.23

0.74 - 3.13

0.5569

0.7482

8СМ+PD-1-TIGIT+

Abs_Value

13

13

0

2.07

2.82

0.54 - 3.6

0.33 - 11.01

1.15

0.76 - 2.16

13

13

0

2.86

3.64

0.88 - 4.84

0.03 - 10.87

1.04

0.69 - 2.58

0.5424

0.7475

8СМ+PD-1+

Abs_Value

13

13

0

6.91

11.09

0.87 - 12.94

0.1 - 42.6

3.62

2.28 - 6.34

13

13

0

12.1

14.82

4.04 - 20.16

0.27 - 50.7

4.48

3.17 - 15.62

0.3226

0.6781

8СМ+PD-1+TIGIT-

Abs_Value

13

13

0

0.93

1.19

0.28 - 1.57

0.01 - 3.85

0.47

0.36 - 0.73

13

13

0

0.97

1.09

0.38 - 1.57

0.02 - 3.03

0.37

0.36 - 1.87

0.9152

0.956

8СМ+PD-1+TIGIT+

Abs_Value

13

13

0

5.98

10.14

0.47 - 11.49

0.09 - 38.76

3.15

1.56 - 5.57

13

13

0

11.13

14.46

3.27 - 18.98

0.21 - 48.83

4.1

2.81 - 13.11

0.305

0.6781

8СМ+TIGIT+

Abs_Value

13

13

0

8.05

10.57

2.31 - 13.8

0.84 - 40.38

4.83

1.89 - 7.96

13

13

0

13.99

17.4

4.53 - 23.44

0.24 - 54.85

6.27

3.21 - 14.15

0.3057

0.6781

8ТЕ

Abs_Value

13

13

0

869.23

644.32

518.97 - 1219.49

48.7 - 2173

678.5

416.74 - 1057.9

13

13

0

606.45

793.52

175.08 - 1037.81

134.4 - 2935.15

219.33

198.73 - 688.04

0.3636

0.6856

8ТЕ(СТАР2)

Abs_Value

13

13

0

1088.37

788.89

659.52 - 1517.21

93.35 - 2737.76

862.07

555.03 - 1157.21

13

13

0

781.56

896.57

294.18 - 1268.94

166.03 - 3213.82

433.23

252.42 - 870.46

0.3637

0.6856

8ТЕ+226+

Abs_Value

13

13

0

1049.05

777.66

626.31 - 1471.8

61.08 - 2644.03

809.38

490.38 - 1109.6

13

13

0

723.53

873.45

248.72 - 1198.35

102.22 - 3154.74

330.69

241 - 755.51

0.3257

0.6781

8ТЕ+39+

Abs_Value

13

13

0

95.14

95.05

43.47 - 146.81

6 - 323.26

59.84

17.3 - 125.59

13

13

0

89.92

138.94

14.4 - 165.45

0.86 - 469.2

34.47

19.83 - 82.62

0.912

0.956

8ТЕ+DR+

Abs_Value

13

13

0

708.11

502.81

434.78 - 981.44

41.33 - 1775.21

735.53

301.99 - 890.82

13

13

0

533.66

738.23

132.35 - 934.97

21.59 - 2669.82

281.95

170.74 - 471.59

0.489

0.7192

8ТЕ+PD-1-TIGIT-

Abs_Value

13

13

0

337.96

331

158.02 - 517.9

15.42 - 1169.4

281.68

96.42 - 398.93

13

13

0

252.89

368.08

52.79 - 452.98

20.48 - 1323.33

90.82

75.37 - 235.12

0.5414

0.7475

8ТЕ+PD-1-TIGIT+

Abs_Value

13

13

0

336.82

282.52

183.24 - 490.4

55.35 - 990.18

230.35

129.05 - 524.75

13

13

0

305.71

393.99

91.53 - 519.88

9.5 - 1190.46

115.13

84.56 - 360.57

0.8192

0.9094

8ТЕ+PD-1+

Abs_Value

13

13

0

413.59

484.86

150.01 - 677.16

22.59 - 1901.19

292.97

194.23 - 413.6

13

13

0

222.97

188.23

120.64 - 325.29

35.09 - 700.03

158.31

79.05 - 286.81

0.2055

0.6781

8ТЕ+PD-1+TIGIT-

Abs_Value

13

13

0

134.91

151.57

52.51 - 217.3

3.74 - 471.95

77.76

39.32 - 156.96

13

13

0

75.64

97.57

22.6 - 128.69

5.67 - 353.82

34.83

20.61 - 91.8

0.2494

0.6781

8ТЕ+PD-1+TIGIT+

Abs_Value

13

13

0

278.68

365.98

79.73 - 477.63

17.97 - 1429.23

170.79

92.76 - 256.65

13

13

0

147.32

116.29

84.1 - 210.54

29.42 - 357.6

97.13

47.51 - 213.88

0.2372

0.6781

8ТЕ+TIGIT+

Abs_Value

13

13

0

615.5

501.71

342.77 - 888.24

73.32 - 1866.88

534.52

260.99 - 702.42

13

13

0

453.03

479.73

192.25 - 713.81

50.85 - 1536.67

255.67

138.62 - 699.97

0.4071

0.6902

8ТМ

Abs_Value

13

13

0

91.97

114.04

29.98 - 153.97

8.37 - 434.09

50.69

27.35 - 101.77

13

13

0

40.32

29.2

24.44 - 56.19

7.07 - 92.45

41.07

15.16 - 59.97

0.1366

0.6781

TREG_CM

Abs_Value

13

13

0

2.42

1.84

1.42 - 3.42

0.14 - 6.15

2.01

1.33 - 2.54

13

13

0

2.71

1.9

1.68 - 3.74

0.28 - 6.58

2.28

1.11 - 3.81

0.6901

0.8514

TREG_EMTM

Abs_Value

13

13

0

24.38

24.24

11.2 - 37.55

5.53 - 99.28

18.31

13.69 - 22.04

13

13

0

25.58

19.9

14.76 - 36.39

7.98 - 69.64

17.52

13.91 - 21.39

0.8914

0.9432

TREG_NV

Abs_Value

13

13

0

3.55

3.84

1.47 - 5.64

0.06 - 14.23

1.97

0.89 - 5.29

13

13

0

2.64

2.1

1.5 - 3.79

0.25 - 6.8

2.13

1.02 - 3.33

0.4631

0.7142

TREG_TE

Abs_Value

13

13

0

4.21

2.25

2.99 - 5.43

1.56 - 7.78

4.02

2.5 - 6.18

13

13

0

5.64

5.48

2.66 - 8.62

0.86 - 21.61

4.58

2.18 - 5.65

0.3977

0.6866

TREG+226-TIGIT-

Abs_Value

13

13

0

2.65

2.38

1.36 - 3.94

0.1 - 8.35

1.52

0.93 - 3.87

13

13

0

2.11

1.55

1.26 - 2.95

0.36 - 6.14

1.57

1.19 - 2.92

0.4981

0.7192

TREG+226-TIGIT+

Abs_Value

13

13

0

8.55

9.6

3.33 - 13.77

1.64 - 38.5

6.04

5.1 - 8.12

13

13

0

9.68

9.67

4.43 - 14.94

2.48 - 38.88

6.4

4.11 - 10.14

0.7663

0.8892

TREG+226+

Abs_Value

13

13

0

23.33

17.35

13.9 - 32.76

5.38 - 73.34

18.84

18.45 - 20.72

13

13

0

24.82

15.9

16.17 - 33.46

11.37 - 58.24

16.66

14.9 - 27.08

0.8218

0.9094

TREG+226+TIGIT-

Abs_Value

13

13

0

3.58

1.73

2.64 - 4.51

0.75 - 6.7

3.71

2.55 - 4.11

13

13

0

3.56

2.26

2.33 - 4.79

0.51 - 7.21

3.12

1.9 - 5.7

0.9829

0.9889

TREG+226+TIGIT+

Abs_Value

13

13

0

19.75

16.29

10.9 - 28.61

4.63 - 66.64

15.88

12.83 - 17.82

13

13

0

21.26

15.02

13.09 - 29.43

9.07 - 53.05

13.69

11.28 - 24.82

0.8088

0.9044

TREG+39+

Abs_Value

13

13

0

25.41

26.51

11 - 39.82

2.29 - 106.13

19.11

14.33 - 23.39

13

13

0

23.29

14.76

15.27 - 31.32

3.34 - 61.46

21.21

14.48 - 30.08

0.8044

0.9015

TREG+DR+

Abs_Value

13

13

0

22.98

20.31

11.94 - 34.02

5.52 - 82.63

17.99

13.55 - 21.67

13

13

0

26.36

22.63

14.06 - 38.66

9.15 - 87.97

19.48

11.7 - 26.27

0.6923

0.8514

TREG+PD-1+

Abs_Value

13

13

0

17.32

19.33

6.81 - 27.83

3.42 - 77.43

12.22

7.39 - 18.37

13

13

0

16.03

11.14

9.98 - 22.09

4.48 - 48.13

13.81

11.21 - 15.23

0.8377

0.9139

TREG+TIGIT+

Abs_Value

13

13

0

28.3

25.29

14.56 - 42.05

6.62 - 105.14

21.63

19.46 - 22.95

13

13

0

30.94

23.05

18.41 - 43.47

11.55 - 89.91

21.94

17.8 - 37.88

0.7833

0.8997

+90

4_TFH

Abs_Value

39

39

0

16.33

13.43

12.11 - 20.55

0 - 61.09

13.26

8.06 - 22.35

28

28

0

14.42

12.25

9.88 - 18.96

1.1 - 45.51

10.81

4.76 - 18.65

0.5483

0.7482

4_TH1

Abs_Value

39

39

0

35.1

96.74

4.74 - 65.47

0.16 - 608.2

10.47

5.84 - 24.35

28

28

0

17.24

24.14

8.3 - 26.19

0.03 - 113.81

9.26

4.29 - 17.68

0.2747

0.6781

4_TH17

Abs_Value

39

39

0

13.84

8.71

11.11 - 16.57

0.02 - 34.84

12.75

6.74 - 18.73

28

28

0

13.49

9.77

9.87 - 17.11

0.86 - 40.22

11.94

6.64 - 20.16

0.8803

0.9395

4_Th17TO1

Abs_Value

39

39

0

3.39

3.17

2.4 - 4.39

0.03 - 17.49

2.3

1.43 - 4.6

28

28

0

3.75

4.89

1.93 - 5.56

0.05 - 18.77

2.09

0.78 - 3.94

0.7375

0.8764

4_TH2

Abs_Value

39

39

0

13.04

22.22

6.06 - 20.01

0.02 - 143.45

8.78

5.17 - 13.6

28

28

0

13.67

9.99

9.97 - 17.37

0.58 - 37.81

10.16

6.22 - 19.3

0.8754

0.9383

4_TH22

Abs_Value

39

39

0

3.91

3.18

2.91 - 4.91

0 - 13.92

3.12

1.51 - 5.85

28

28

0

4.25

3.86

2.82 - 5.68

0.02 - 14.86

3.06

1.61 - 5.72

0.7032

0.8564

4+

Abs_Value

39

39

0

70.84

76.56

46.81 - 94.87

0.01 - 430.92

59.43

20.66 - 92.9

28

28

0

83.71

46.4

66.52 - 100.89

1.65 - 194.52

81.98

48.2 - 121.66

0.3964

0.6866

4+ (IM STAT)

Abs_Value

39

39

0

65.93

72.58

43.14 - 88.71

0 - 397.77

47.44

19.37 - 82.94

28

28

0

74.78

44.66

58.24 - 91.32

2.77 - 186.76

77.26

37.17 - 96.8

0.5398

0.7475

4+226+

Abs_Value

39

39

0

155.71

179.73

99.3 - 212.12

0.31 - 1046.46

128.08

68.58 - 160.33

28

28

0

132.45

73.4

105.26 - 159.64

16.89 - 269.89

131.07

76.06 - 166.98

0.4698

0.718

4+39+

Abs_Value

39

39

0

39.48

31.48

29.6 - 49.36

0.07 - 135.08

37.22

19.19 - 54.81

28

28

0

40.21

33.36

27.86 - 52.57

0.49 - 110.79

34.79

9.36 - 63.23

0.9278

0.963

4+DR+

Abs_Value

39

39

0

102.8

170.68

49.23 - 156.37

0.05 - 960.16

65.32

31.43 - 87.28

28

28

0

64.77

56.51

43.84 - 85.71

4.16 - 250.67

51.29

24.28 - 82.42

0.2011

0.6781

4+PD-1-TIGIT-

Abs_Value

39

39

0

48.64

34

37.97 - 59.31

0.03 - 131.28

34.59

25.53 - 75.58

28

28

0

55.29

44.79

38.69 - 71.88

6.67 - 166.24

41.71

22.29 - 76.75

0.5119

0.73

4+PD-1-TIGIT+

Abs_Value

39

39

0

8.16

24.25

0.55 - 15.77

0 - 154.31

3.78

1.76 - 6.59

28

28

0

4.87

3.39

3.61 - 6.12

0.25 - 12.65

3.76

2.29 - 7.19

0.4071

0.6902

4+PD-1+

Abs_Value

39

39

0

108.13

148.15

61.64 - 154.63

0.33 - 789.05

77.82

46.08 - 97.71

28

28

0

82.56

62.59

59.37 - 105.74

7.01 - 256.14

70.45

36.32 - 110.92

0.3389

0.6781

4+PD-1+TIGIT-

Abs_Value

39

39

0

55.79

53.07

39.14 - 72.45

0.28 - 262.81

35.44

26.29 - 61.74

28

28

0

47.04

40.36

32.09 - 61.98

3.7 - 176.04

35.9

21.62 - 63.3

0.4459

0.7054

4+PD-1+TIGIT+

Abs_Value

39

39

0

52.34

100.95

20.66 - 84.03

0.05 - 526.23

28.49

18 - 44.4

28

28

0

35.52

29.85

24.47 - 46.58

3.31 - 119.05

23.88

15.59 - 49.99

0.3309

0.6781

4+TIGIT+

Abs_Value

39

39

0

60.51

121.07

22.51 - 98.51

0.05 - 680.54

31.37

20.51 - 50.09

28

28

0

40.39

31.42

28.75 - 52.03

4.89 - 130.02

28.02

20.05 - 55.79

0.3264

0.6781

4NV

Abs_Value

39

39

0

17.03

15.12

12.28 - 21.78

0 - 55.9

12.73

6.44 - 21.38

28

28

0

28.77

26.38

19 - 38.55

3.15 - 110.75

18.27

8.39 - 39.7

0.0404

0.6781

4NV(СТАР2)

Abs_Value

39

39

0

15.95

15.14

11.2 - 20.7

0 - 54

10.42

6.42 - 18.05

28

28

0

26.63

24.08

17.71 - 35.55

4.36 - 99.11

18.69

7.91 - 35.34

0.0444

0.6781

4NV_TH1

Abs_Value

39

39

0

1.27

1.37

0.84 - 1.7

0 - 6.02

0.92

0.31 - 1.7

28

28

0

1.99

2.02

1.24 - 2.74

0.01 - 7.62

1.39

0.42 - 2.94

0.1094

0.6781

4NV_TH17

Abs_Value

39

39

0

0.59

0.58

0.41 - 0.77

0 - 2.9

0.41

0.18 - 0.81

28

28

0

0.92

0.76

0.64 - 1.2

0.12 - 3.24

0.68

0.45 - 1.19

0.0582

0.6781

4NV_Th17TO1

Abs_Value

39

39

0

0.11

0.12

0.08 - 0.15

0 - 0.43

0.07

0.02 - 0.17

28

28

0

0.21

0.25

0.12 - 0.3

0.01 - 1.08

0.12

0.04 - 0.24

0.0737

0.6781

4NV_TH2

Abs_Value

39

39

0

1.99

2.41

1.23 - 2.74

0 - 11.34

1.09

0.62 - 2.33

28

28

0

4.1

4.56

2.41 - 5.79

0.14 - 20.02

2.86

1.01 - 5.49

0.0312

0.6781

4NV_TH22

Abs_Value

39

39

0

0.05

0.08

0.03 - 0.08

0 - 0.32

0.02

0.01 - 0.06

28

28

0

0.09

0.12

0.05 - 0.14

0 - 0.55

0.04

0.01 - 0.15

0.1106

0.6781

4NV+226+

Abs_Value

39

39

0

13.74

13.09

9.63 - 17.84

0 - 43.3

9.21

6.11 - 15.8

28

28

0

23.13

21.19

15.28 - 30.98

3.48 - 85.04

16.11

7.06 - 29.98

0.044

0.6781

4NV+39+

Abs_Value

39

39

0

0.7

0.89

0.42 - 0.98

0 - 3.98

0.4

0.1 - 0.87

28

28

0

0.98

0.98

0.61 - 1.34

0.01 - 4.69

0.75

0.48 - 1.13

0.2396

0.6781

4NV+DR+

Abs_Value

39

39

0

1.96

3.25

0.94 - 2.98

0 - 17.28

0.83

0.41 - 1.75

28

28

0

1.75

1.95

1.03 - 2.47

0.25 - 10.14

1.16

0.7 - 1.82

0.7485

0.884

4NV+PD-1-TIGIT-

Abs_Value

39

39

0

14.19

14.36

9.69 - 18.7

0 - 47.46

9.27

4.44 - 17.37

28

28

0

24.61

23.7

15.84 - 33.39

2.32 - 98.02

16.98

6.11 - 33.64

0.0448

0.6781

4NV+PD-1-TIGIT+

Abs_Value

39

39

0

0.46

0.79

0.22 - 0.71

0 - 4.58

0.26

0.11 - 0.41

28

28

0

0.61

0.55

0.4 - 0.81

0.07 - 2.14

0.44

0.25 - 0.7

0.3928

0.6866

4NV+PD-1+TIGIT-

Abs_Value

39

39

0

0.87

1.14

0.51 - 1.23

0 - 4.56

0.35

0.23 - 0.96

28

28

0

0.93

0.76

0.65 - 1.21

0.1 - 3.04

0.72

0.34 - 1.24

0.7927

0.9

4NV+PD-1+TIGIT+

Abs_Value

39

39

0

0.42

0.56

0.25 - 0.6

0 - 2.84

0.19

0.08 - 0.57

28

28

0

0.48

0.35

0.35 - 0.61

0.05 - 1.27

0.4

0.23 - 0.62

0.5964

0.7763

4NV+PD1+

Abs_Value

39

39

0

1.29

1.54

0.81 - 1.77

0 - 6.69

0.63

0.33 - 1.84

28

28

0

1.41

0.95

1.06 - 1.76

0.25 - 3.76

1.16

0.64 - 1.95

0.6939

0.8514

4NV+TIGIT+

Abs_Value

39

39

0

0.88

1.11

0.54 - 1.23

0 - 5.34

0.5

0.24 - 1.04

28

28

0

1.08

0.76

0.8 - 1.37

0.19 - 3.42

0.91

0.5 - 1.39

0.3839

0.6866

4ЕМ

Abs_Value

39

39

0

29.18

89.5

1.09 - 57.27

0.01 - 428.8

3.42

0.63 - 16.48

28

28

0

7.64

17.2

1.27 - 14.01

0 - 67.92

0.8

0.19 - 3.72

0.1502

0.6781

4ЕМ_TH1

Abs_Value

39

39

0

11.29

43.51

-2.37 - 24.94

0 - 267.92

1.06

0.16 - 3.75

28

28

0

1.94

5.86

-0.23 - 4.11

0 - 30.53

0.2

0.03 - 0.92

0.1925

0.6781

4ЕМ_TH17

Abs_Value

39

39

0

0.07

0.19

0.01 - 0.13

0 - 0.9

0.01

0 - 0.03

28

28

0

0.01

0.03

0 - 0.02

0 - 0.15

0

0 - 0.01

0.0572

0.6781

4ЕМ_Th17TO1

Abs_Value

39

39

0

0.29

0.88

0.01 - 0.56

0 - 5.46

0.04

0.01 - 0.32

28

28

0

0.04

0.08

0.01 - 0.07

0 - 0.41

0.01

0 - 0.04

0.0894

0.6781

4ЕМ_TH2

Abs_Value

39

39

0

3.8

21.09

-2.81 - 10.42

0 - 131.99

0.08

0.02 - 0.43

28

28

0

0.3

0.62

0.07 - 0.53

0 - 2.67

0.03

0.01 - 0.2

0.3066

0.6781

4ЕМ_TH22

Abs_Value

39

39

0

0.01

0.03

0 - 0.02

0 - 0.15

0

0 - 0

28

28

0

0.01

0.01

0 - 0.01

0 - 0.05

0

0 - 0

0.3268

0.6781

4ЕМ+226+

Abs_Value

39

39

0

85.97

111.51

50.98 - 120.97

0.28 - 553.6

60.55

31.84 - 87.48

28

28

0

61.27

45.72

44.34 - 78.21

2.92 - 184.9

61.09

24.67 - 85.82

0.2184

0.6781

4ЕМ+39+

Abs_Value

39

39

0

23.58

18.88

17.65 - 29.5

0.07 - 70.57

22.61

9.99 - 38

28

28

0

21.36

18.22

14.61 - 28.11

0.36 - 65.22

19.28

3.74 - 34.53

0.6308

0.7999

4ЕМ+DR+

Abs_Value

39

39

0

64.34

103.15

31.97 - 96.71

0.05 - 497.18

41.66

22.69 - 54.93

28

28

0

39.41

37.3

25.59 - 53.22

1.61 - 158.94

31.55

12.09 - 55.55

0.1711

0.6781

4ЕМ+PD1-TIGIT-

Abs_Value

39

39

0

17.15

17.92

11.53 - 22.78

0.02 - 72.04

10.23

5.61 - 20.32

28

28

0

13.15

14.56

7.75 - 18.54

0.12 - 53.88

6.67

4.26 - 15.63

0.3174

0.6781

4ЕМ+PD1-TIGIT+

Abs_Value

39

39

0

3.48

10.15

0.29 - 6.66

0 - 64.16

1.27

0.67 - 2.64

28

28

0

1.74

1.51

1.18 - 2.3

0.03 - 5.22

1.22

0.61 - 2.92

0.2989

0.6781

4ЕМ+PD1+

Abs_Value

39

39

0

68.62

97.13

38.13 - 99.1

0.31 - 488.16

42.29

29.92 - 67.94

28

28

0

49.55

43.2

33.55 - 65.55

2.85 - 169.81

41.27

18.21 - 65.64

0.2824

0.6781

4ЕМ+PD1+TIGIT-

Abs_Value

39

39

0

36.22

35.42

25.1 - 47.33

0.26 - 163.47

25.02

16.2 - 42.8

28

28

0

29.95

28.72

19.32 - 40.59

1.55 - 118.87

21.16

10.76 - 39.53

0.4278

0.7016

4ЕМ+PD1+TIGIT+

Abs_Value

39

39

0

32.4

66.32

11.58 - 53.22

0.05 - 343.46

16.95

9.28 - 23.66

28

28

0

19.6

19.73

12.29 - 26.9

1.3 - 92.73

14.3

6.25 - 25.74

0.2611

0.6781

4ЕМ+TIGIT+

Abs_Value

39

39

0

35.88

73.29

12.88 - 58.88

0.05 - 349.01

18.54

10.11 - 26.96

28

28

0

21.34

20.59

13.71 - 28.97

1.44 - 97.96

18.46

6.9 - 26.92

0.2457

0.6781

4ЕМTM

Abs_Value

39

39

0

89.25

112.7

53.88 - 124.62

0.33 - 560.51

61.41

33.6 - 92.27

28

28

0

64.44

48.25

46.57 - 82.31

3.5 - 201.17

63.48

25.56 - 91.84

0.225

0.6781

4СМ

Abs_Value

39

39

0

31.42

22.37

24.4 - 38.44

0 - 119.97

27.94

16.69 - 46.26

28

28

0

40.08

23.5

31.38 - 48.79

5.35 - 88.59

43.11

17.54 - 53.18

0.1344

0.6781

4СМ(СТАР2)

Abs_Value

39

39

0

30.02

22.79

22.87 - 37.17

0 - 133.51

26.43

16.63 - 38.84

28

28

0

32.97

19.84

25.62 - 40.32

1.94 - 67.99

34.65

16.28 - 44.77

0.5747

0.7601

4СМ_TH1

Abs_Value

39

39

0

1.56

2.53

0.76 - 2.35

0 - 15.41

1.1

0.34 - 1.69

28

28

0

1.57

1.47

1.03 - 2.12

0 - 4.36

0.9

0.36 - 2.7

0.9785

0.9885

4СМ_TH17

Abs_Value

39

39

0

5.03

3.89

3.81 - 6.25

0 - 15.87

4.24

1.91 - 7.32

28

28

0

6.77

5.73

4.65 - 8.89

0.22 - 20.07

4.4

2 - 10.07

0.17

0.6781

4СМ_Th17TO1

Abs_Value

39

39

0

0.38

0.57

0.21 - 0.56

0 - 3.07

0.24

0.06 - 0.41

28

28

0

0.55

0.73

0.28 - 0.82

0.03 - 3.05

0.25

0.12 - 0.65

0.3224

0.6781

4СМ_TH2

Abs_Value

39

39

0

3.18

2.55

2.38 - 3.98

0 - 11.68

2.61

1.48 - 4.55

28

28

0

5.02

4.33

3.42 - 6.63

0.29 - 18.6

4.09

1.54 - 8.19

0.0505

0.6781

4СМ_TH22

Abs_Value

39

39

0

0.53

0.65

0.33 - 0.74

0 - 3.29

0.32

0.1 - 0.69

28

28

0

0.85

0.79

0.56 - 1.14

0.01 - 2.75

0.79

0.19 - 1.1

0.0902

0.6781

4СМ+226+

Abs_Value

39

39

0

27.75

21.33

21.06 - 34.45

0 - 125.07

23.75

15.53 - 36.02

28

28

0

30.78

18.69

23.86 - 37.71

1.86 - 63.84

32.53

15.09 - 40.76

0.5396

0.7475

4СМ+39+

Abs_Value

39

39

0

10.35

10.02

7.2 - 13.49

0 - 49.38

9.36

1.53 - 13.97

28

28

0

12.32

11.87

7.92 - 16.71

0.01 - 39.63

9.41

1.22 - 17.71

0.479

0.7185

4СМ+DR+

Abs_Value

39

39

0

14.08

20.69

7.59 - 20.58

0 - 127.35

9.85

5.25 - 13.14

28

28

0

11.9

10.78

7.91 - 15.89

0.25 - 41.83

8.12

3.91 - 16.05

0.5771

0.7612

4СМ+PD1-TIGIT-

Abs_Value

39

39

0

9.47

6.39

7.46 - 11.47

0 - 23.26

7.52

5.37 - 13.64

28

28

0

11.96

10.31

8.14 - 15.78

0.12 - 41.2

8.6

4.25 - 18.41

0.264

0.6781

4СМ+PD1-TIGIT+

Abs_Value

39

39

0

1.44

2.08

0.78 - 2.09

0 - 12.64

0.77

0.45 - 2.01

28

28

0

1.41

1.22

0.96 - 1.86

0.01 - 4.72

1.1

0.6 - 1.79

0.9483

0.9711

4СМ+PD1+

Abs_Value

39

39

0

19.12

18.7

13.25 - 24.99

0 - 111.86

16.09

9.77 - 23.86

28

28

0

19.6

14.8

14.12 - 25.08

0.46 - 61.96

17.76

10.26 - 23.57

0.9061

0.9546

4СМ+PD1+TIGIT-

Abs_Value

39

39

0

8.47

5.96

6.6 - 10.34

0 - 23.93

7.21

4.23 - 13.21

28

28

0

8.74

6.04

6.5 - 10.98

0.31 - 24.42

8.55

5.14 - 11.06

0.855

0.9205

4СМ+PD1+TIGIT+

Abs_Value

39

39

0

10.65

14.71

6.04 - 15.27

0 - 90.89

7.63

3.58 - 11.64

28

28

0

10.86

9.95

7.18 - 14.55

0.15 - 37.55

8.88

5.08 - 12.27

0.9441

0.9711

4СМ+TIGIT+

Abs_Value

39

39

0

12.09

16.62

6.87 - 17.31

0 - 103.53

9

4.03 - 13.68

28

28

0

12.28

10.32

8.45 - 16.1

0.27 - 38.44

10.69

5.63 - 14.57

0.9553

0.9711

4ТM_TH1

Abs_Value

39

39

0

12.66

19.35

6.58 - 18.73

0.14 - 107.61

5.15

2.95 - 13.84

28

28

0

9.75

16.05

3.8 - 15.69

0.01 - 69.74

3.11

1.28 - 9.12

0.5047

0.7261

4ТM_TH17

Abs_Value

39

39

0

7.59

5.69

5.8 - 9.37

0.02 - 20.47

5.91

3.82 - 10.49

28

28

0

5.4

4.24

3.83 - 6.97

0.07 - 17.72

4.87

2.86 - 7.51

0.0761

0.6781

4ТM_Th17TO1

Abs_Value

39

39

0

2.19

1.71

1.65 - 2.72

0.03 - 6.88

1.88

0.98 - 3.01

28

28

0

2.64

3.74

1.26 - 4.02

0 - 13.42

1.26

0.4 - 2.99

0.5522

0.7482

4ТM_TH2

Abs_Value

39

39

0

3.2

3.01

2.26 - 4.15

0.02 - 13.03

2.17

1.45 - 3.93

28

28

0

3.69

4.82

1.91 - 5.48

0.07 - 25.5

2.9

0.95 - 4.16

0.6371

0.8058

4ТM_TH22

Abs_Value

39

39

0

3.03

2.8

2.15 - 3.91

0 - 11.23

1.9

1.07 - 4.73

28

28

0

2.99

3.07

1.85 - 4.12

0 - 11.35

2.21

0.77 - 4.02

0.9515

0.9711

4ТREG

Abs_Value

39

39

0

1.24

1.42

0.79 - 1.69

0 - 5.79

0.69

0.23 - 1.75

28

28

0

2.41

6.03

0.18 - 4.64

0.03 - 32.72

1.27

0.48 - 2.01

0.3225

0.6781

4ТREG(СТАР2)

Abs_Value

39

39

0

73

75.81

49.2 - 96.79

0.01 - 424.27

59.76

24.03 - 94.33

28

28

0

85.58

47.59

67.95 - 103.2

1.89 - 193.24

83.08

45.45 - 117.11

0.4082

0.6902

4ТREG_TH1

Abs_Value

39

39

0

0.2

0.24

0.12 - 0.28

0 - 0.92

0.14

0.03 - 0.2

28

28

0

0.22

0.24

0.13 - 0.31

0 - 1

0.15

0.07 - 0.3

0.7316

0.8733

4ТREG_TH17

Abs_Value

39

39

0

2.82

2.61

2 - 3.64

0.01 - 11.98

1.98

0.91 - 4.27

28

28

0

3.49

3.54

2.17 - 4.8

0.06 - 15.96

2.59

1.19 - 4.07

0.4005

0.6866

4ТREG_Th17TO1

Abs_Value

39

39

0

0.07

0.1

0.04 - 0.1

0 - 0.44

0.04

0.01 - 0.08

28

28

0

0.1

0.14

0.05 - 0.15

0 - 0.47

0.04

0.02 - 0.1

0.3475

0.6781

4ТREG_TH2

Abs_Value

39

39

0

1.54

1.37

1.11 - 1.97

0 - 5.88

1.46

0.53 - 2.34

28

28

0

2.23

2.84

1.18 - 3.28

0.22 - 14.5

1.3

0.74 - 3.06

0.2427

0.6781

4ТREG_TH22

Abs_Value

39

39

0

1.69

2.05

1.05 - 2.33

0.01 - 11.04

1.01

0.55 - 2.04

28

28

0

1.82

1.85

1.14 - 2.51

0 - 8.31

1.47

0.4 - 2.49

0.7863

0.8997

4ТЕ

Abs_Value

39

39

0

11.59

46.78

-3.09 - 26.27

0.01 - 293.46

0.64

0.2 - 5.63

28

28

0

2.37

3.82

0.96 - 3.78

0.03 - 14.73

0.88

0.24 - 2.04

0.2278

0.6781

4ТЕ(СТАР2)

Abs_Value

39

39

0

27.59

51.5

11.43 - 43.76

0.03 - 310.52

13.13

6.43 - 23.4

28

28

0

17.96

16.22

11.95 - 23.97

1.53 - 73.6

12.4

8.11 - 26.72

0.279

0.6781

4ТЕ_TH1

Abs_Value

39

39

0

5.91

29.66

-3.4 - 15.22

0 - 185.79

0.13

0.02 - 1.02

28

28

0

0.47

1.02

0.09 - 0.85

0 - 4.5

0.14

0.01 - 0.33

0.2599

0.6781

4ТЕ_TH17

Abs_Value

39

39

0

0.01

0.03

0 - 0.02

0 - 0.17

0

0 - 0

28

28

0

0.01

0.02

0 - 0.01

0 - 0.07

0

0 - 0

0.4728

0.718

4ТЕ_Th17TO1

Abs_Value

39

39

0

0.13

0.65

-0.08 - 0.33

0 - 4.08

0.01

0 - 0.03

28

28

0

0.01

0.02

0 - 0.02

0 - 0.07

0

0 - 0.01

0.2706

0.6781

4ТЕ_TH2

Abs_Value

39

39

0

0.42

1.36

-0.01 - 0.84

0 - 6.25

0.01

0 - 0.12

28

28

0

0.08

0.13

0.04 - 0.13

0 - 0.51

0.02

0 - 0.12

0.1315

0.6781

4ТЕ_TH22

Abs_Value

39

39

0

0.01

0.01

0 - 0.01

0 - 0.06

0

0 - 0.01

28

28

0

0

0.01

0 - 0.01

0 - 0.05

0

0 - 0

0.4354

0.7016

4ТЕ+226+

Abs_Value

39

39

0

26.34

51.15

10.28 - 42.39

0.03 - 307.76

11.03

6.12 - 22.51

28

28

0

16.66

15.37

10.97 - 22.35

1.33 - 71.49

11.51

7.18 - 22.78

0.271

0.6781

4ТЕ+39+

Abs_Value

39

39

0

4.33

3.99

3.08 - 5.59

0 - 17.63

3.24

0.79 - 6.09

28

28

0

5.45

6.64

2.99 - 7.91

0.05 - 29.5

3.18

1.51 - 6.83

0.4309

0.7016

4ТЕ+DR+

Abs_Value

39

39

0

20.75

45.95

6.33 - 35.17

0 - 273.14

8.21

4.06 - 17.59

28

28

0

11.62

15.22

5.98 - 17.26

0.27 - 71.42

7.25

3.38 - 11.19

0.2534

0.6781

4ТЕ+PD-1-TIGIT-

Abs_Value

39

39

0

7.42

9.57

4.42 - 10.42

0 - 48.37

3.79

2.16 - 8.9

28

28

0

5.1

4.7

3.36 - 6.84

0.27 - 20.57

4.19

2.35 - 5.99

0.1945

0.6781

4ТЕ+PD-1-TIGIT+

Abs_Value

39

39

0

2.5

10.09

-0.67 - 5.67

0 - 63.72

0.68

0.29 - 1.27

28

28

0

1.05

0.99

0.68 - 1.42

0.02 - 4.29

0.78

0.36 - 1.29

0.3773

0.6866

4ТЕ+PD-1+

Abs_Value

39

39

0

17.67

35.09

6.66 - 28.68

0.02 - 198.43

7.84

3.82 - 16

28

28

0

11.81

14.43

6.47 - 17.16

0.53 - 65.87

7.14

3.15 - 12.28

0.3527

0.6781

4ТЕ+PD-1+TIGIT-

Abs_Value

39

39

0

9.85

14.26

5.38 - 14.33

0.02 - 68.31

3.85

2.12 - 11.01

28

28

0

7.28

9.7

3.69 - 10.88

0.31 - 45.47

3.94

1.99 - 7.31

0.3832

0.6866

4ТЕ+PD-1+TIGIT+

Abs_Value

39

39

0

7.82

22.22

0.84 - 14.79

0 - 130.12

2.71

1.56 - 4.95

28

28

0

4.53

5.52

2.49 - 6.58

0.23 - 21.97

2.11

1.41 - 5.09

0.3806

0.6866

4ТЕ+TIGIT+

Abs_Value

39

39

0

10.32

31.7

0.37 - 20.27

0 - 193.84

3.7

2.22 - 6.07

28

28

0

5.58

6.07

3.33 - 7.83

0.34 - 22.91

3.11

2.07 - 5.82

0.3679

0.6866

4ТМ

Abs_Value

39

39

0

68.73

44.83

54.66 - 82.8

0.29 - 206.37

59.16

36.36 - 89.43

28

28

0

60.2

43.52

44.08 - 76.32

2.7 - 156.95

59.02

21.18 - 93.81

0.4377

0.7016

8+

Abs_Value

39

39

0

338.23

532.81

171.01 - 505.45

3.6 - 2131.88

94.25

33.79 - 338.12

28

28

0

163.88

420.4

8.16 - 319.59

0.65 - 2174.4

32.02

7.98 - 107.38

0.1397

0.6781

8+ (IM STAT)

Abs_Value

39

39

0

367.88

552.6

194.44 - 541.31

3.93 - 2176.1

99.73

39.92 - 499.23

28

28

0

190.71

457.37

21.29 - 360.12

0.71 - 2351.17

40.68

13.82 - 116.25

0.1569

0.6781

8+226+

Abs_Value

39

39

0

470.53

618.71

276.35 - 664.71

19.73 - 2309.79

182.21

83.91 - 662.23

28

28

0

254.15

484.55

74.67 - 433.63

7.76 - 2484.23

93.15

40.59 - 227.28

0.1136

0.6781

8+39+

Abs_Value

39

39

0

50.88

78.12

26.36 - 75.39

0.09 - 418.95

23.41

8.89 - 61.49

28

28

0

47.44

107.14

7.75 - 87.13

0.2 - 562.33

12.38

3.76 - 49.88

0.8858

0.9413

8+DR+

Abs_Value

39

39

0

367.32

527.47

201.78 - 532.87

4.94 - 2168.46

142.83

62.61 - 414.98

28

28

0

216.12

474.09

40.51 - 391.73

2.26 - 2431.19

63.22

19.15 - 162.93

0.2241

0.6781

8+PD-1-TIGIT-

Abs_Value

39

39

0

135.49

198.3

73.25 - 197.72

5.63 - 815.7

39.97

17.51 - 139.58

28

28

0

76.66

134.27

26.93 - 126.39

1.36 - 704.51

40.59

10.93 - 84.58

0.1526

0.6781

8+PD-1-TIGIT+

Abs_Value

39

39

0

144.2

244.69

67.4 - 221

1.37 - 1271.22

31.04

10.46 - 209.95

28

28

0

65.97

141.78

13.46 - 118.49

1 - 719.74

15.57

7.8 - 62.55

0.1044

0.6781

8+PD-1+

Abs_Value

39

39

0

217.19

328.31

114.15 - 320.23

7.78 - 1736.81

95

38.06 - 229.28

28

28

0

133.94

258.59

38.15 - 229.72

1.8 - 1201.16

35.47

16.3 - 80.32

0.2504

0.6781

8+PD-1+TIGIT-

Abs_Value

39

39

0

71.54

104.23

38.83 - 104.25

1.45 - 448.19

26.52

4.16 - 106.41

28

28

0

41.87

87.52

9.45 - 74.29

0.7 - 428.96

12.39

3.78 - 32.22

0.2113

0.6781

8+PD-1+TIGIT+

Abs_Value

39

39

0

145.65

238.86

70.69 - 220.62

5.05 - 1288.62

68.95

21.04 - 122.68

28

28

0

92.07

178.77

25.85 - 158.28

0.99 - 772.2

19.64

11.2 - 49.28

0.2976

0.6781

8+TIGIT+

Abs_Value

39

39

0

289.85

431.67

154.37 - 425.33

6.42 - 1840.75

94.56

43.22 - 313.01

28

28

0

158.04

314.31

41.62 - 274.46

1.99 - 1491.94

43.96

19.14 - 109.1

0.1529

0.6781

8EMTM

Abs_Value

39

39

0

77.74

115.56

41.47 - 114

2.95 - 582.56

29.11

9.7 - 91.47

28

28

0

70.04

204.35

-5.65 - 145.73

0.4 - 1077.88

11.45

3.34 - 45.52

0.8582

0.9219

8EMTM+226+

Abs_Value

39

39

0

72.96

112.94

37.51 - 108.41

2.29 - 577.84

28.32

7.48 - 83.22

28

28

0

64.24

192.62

-7.11 - 135.59

0.36 - 1020.79

10.3

2.38 - 43.16

0.8312

0.91

8EMTM+39+

Abs_Value

39

39

0

14.47

23.42

7.12 - 21.82

0.04 - 99.93

4.62

1.73 - 15.46

28

28

0

15.07

51.88

-4.14 - 34.29

0.03 - 277.35

1.72

0.75 - 9.77

0.9544

0.9711

8EMTM+DR+

Abs_Value

39

39

0

64.68

100.49

33.15 - 96.22

1.79 - 474.38

25.43

8.16 - 71.87

28

28

0

62.31

194.49

-9.73 - 134.35

0.28 - 1026.67

6.98

1.25 - 30.94

0.9532

0.9711

8EMTM+PD-1-TIGIT-

Abs_Value

39

39

0

16.56

28.57

7.59 - 25.52

0.1 - 131.33

4.96

1.16 - 19.06

28

28

0

14.71

44.65

-1.83 - 31.25

0.1 - 237.98

2.42

0.29 - 9.52

0.8481

0.9196

8EMTM+PD-1-TIGIT+

Abs_Value

39

39

0

18.89

47.24

4.06 - 33.71

0.12 - 275.2

4.85

0.88 - 12.82

28

28

0

12.87

39.42

-1.74 - 27.47

0.04 - 206

0.93

0.23 - 7.56

0.5727

0.7599

8EMTM+PD-1+

Abs_Value

39

39

0

42.29

57.22

24.33 - 60.25

2.21 - 240.61

17.22

6.99 - 48.08

28

28

0

42.46

121.77

-2.64 - 87.57

0.27 - 633.9

6.11

1.59 - 25.15

0.9945

0.9959

8EMTM+PD-1+TIGIT-

Abs_Value

39

39

0

13

16.61

7.78 - 18.21

0.2 - 74.77

5.86

1.15 - 19.09

28

28

0

13.87

44.21

-2.5 - 30.25

0.08 - 235.25

2.36

0.47 - 7.78

0.9209

0.9599

8EMTM+PD-1+TIGIT+

Abs_Value

39

39

0

29.3

44.1

15.46 - 43.14

0.71 - 188.94

11.73

3.71 - 27.49

28

28

0

28.59

79.29

-0.78 - 57.96

0.12 - 398.65

3.64

1.15 - 13.56

0.9662

0.9801

8EMTM+TIGIT+

Abs_Value

39

39

0

48.18

86.13

21.15 - 75.22

0.83 - 464.14

17.79

5.39 - 42.69

28

28

0

41.46

118.34

-2.38 - 85.29

0.16 - 604.65

4.85

1.71 - 21.19

0.799

0.9

8NV

Abs_Value

39

39

0

7.64

9.28

4.73 - 10.56

0.02 - 46.45

5.08

1.98 - 8.98

28

28

0

11.62

11.65

7.31 - 15.94

0.67 - 55.43

7.91

5.17 - 17.08

0.1405

0.6781

8NV(СТАР2)

Abs_Value

39

39

0

9.6

11.35

6.04 - 13.16

0.03 - 49.35

5.19

2.26 - 10.73

28

28

0

11.25

10.66

7.3 - 15.19

1.05 - 48.26

6.76

4.77 - 14.25

0.5468

0.7482

8NV+226+

Abs_Value

39

39

0

8.68

10.74

5.31 - 12.05

0.03 - 49.26

4.68

1.99 - 10.06

28

28

0

9.91

9.3

6.47 - 13.36

0.95 - 40.2

5.96

4.28 - 12.51

0.6174

0.7904

8NV+39+

Abs_Value

39

39

0

0.6

0.97

0.29 - 0.9

0 - 5.17

0.3

0.06 - 0.64

28

28

0

0.67

0.81

0.36 - 0.97

0.01 - 3.73

0.44

0.13 - 0.8

0.7558

0.884

8NV+DR+

Abs_Value

39

39

0

2.56

4.43

1.17 - 3.96

0.01 - 16.54

0.66

0.3 - 1.9

28

28

0

1.37

2.02

0.62 - 2.12

0.03 - 9.92

0.6

0.44 - 1.22

0.1426

0.6781

8NV+PD-1-TIGIT-

Abs_Value

39

39

0

7.04

9.42

4.09 - 10

0 - 43.98

3.81

1.03 - 8.78

28

28

0

9.61

10.56

5.7 - 13.52

0.23 - 47.12

5.74

3.06 - 12.31

0.3088

0.6781

8NV+PD-1-TIGIT+

Abs_Value

39

39

0

1.11

1.92

0.51 - 1.72

0 - 9.21

0.49

0.22 - 0.85

28

28

0

0.73

0.83

0.42 - 1.03

0.05 - 3.77

0.46

0.23 - 0.72

0.2655

0.6781

8NV+PD-1+

Abs_Value

39

39

0

1.45

2.12

0.78 - 2.11

0.02 - 10

0.52

0.2 - 1.5

28

28

0

0.91

1.11

0.5 - 1.32

0.05 - 3.96

0.44

0.23 - 1.06

0.1836

0.6781

8NV+PD-1+TIGIT-

Abs_Value

39

39

0

0.5

0.92

0.21 - 0.79

0 - 4.91

0.15

0.03 - 0.5

28

28

0

0.31

0.36

0.18 - 0.45

0 - 1.26

0.2

0.08 - 0.4

0.2527

0.6781

8NV+PD-1+TIGIT+

Abs_Value

39

39

0

0.95

1.35

0.52 - 1.37

0.01 - 5.16

0.39

0.15 - 1.12

28

28

0

0.6

0.89

0.27 - 0.92

0.04 - 3.31

0.25

0.17 - 0.38

0.2056

0.6781

8NV+TIGIT+

Abs_Value

39

39

0

2.06

3.05

1.1 - 3.02

0.01 - 12.72

0.88

0.45 - 2.26

28

28

0

1.32

1.63

0.72 - 1.93

0.11 - 6.55

0.64

0.46 - 1.05

0.2063

0.6781

8TREG

Abs_Value

39

39

0

334.51

529.5

168.33 - 500.7

3.32 - 2109.36

93.76

33.11 - 326.8

28

28

0

166.61

430.63

7.1 - 326.11

0.67 - 2227.15

31.77

8.02 - 102.77

0.158

0.6781

8ЕМ

Abs_Value

39

39

0

79.03

128.38

38.73 - 119.32

0.46 - 668.2

28.95

7.36 - 99.94

28

28

0

67.68

206.05

-8.64 - 144

0.11 - 1084.06

7.04

1.01 - 34.8

0.7979

0.9

8СМ

Abs_Value

39

39

0

2.88

6.14

0.95 - 4.81

0.01 - 37.25

0.94

0.56 - 2.43

28

28

0

5.32

12.63

0.64 - 9.99

0.08 - 67.57

2.36

0.34 - 5.01

0.351

0.6781

8СМ(СТАР2)

Abs_Value

39

39

0

6

19.68

-0.18 - 12.17

0.02 - 118.92

1.16

0.72 - 3.09

28

28

0

3.83

5.57

1.77 - 5.9

0.02 - 19.92

1.88

0.27 - 4.27

0.5181

0.7367

8СМ+226+

Abs_Value

39

39

0

5.61

19.33

-0.46 - 11.67

0.02 - 118.25

1.08

0.6 - 2.93

28

28

0

3.33

4.75

1.57 - 5.09

0.02 - 16.84

1.68

0.22 - 3.34

0.483

0.7191

8СМ+39+

Abs_Value

39

39

0

0.93

1.62

0.43 - 1.44

0 - 9.34

0.47

0.18 - 0.76

28

28

0

1.27

1.93

0.55 - 1.98

0 - 6.95

0.2

0.07 - 1.77

0.4626

0.7142

8СМ+DR+

Abs_Value

39

39

0

5.16

17.97

-0.48 - 10.8

0.01 - 107.27

0.96

0.51 - 2.09

28

28

0

2.81

5.22

0.87 - 4.74

0.01 - 19.49

0.69

0.13 - 1.93

0.4428

0.7032

8СМ+PD-1-TIGIT-

Abs_Value

39

39

0

1.23

2.88

0.32 - 2.13

0 - 15.65

0.25

0.11 - 0.88

28

28

0

1.12

1.58

0.54 - 1.71

0 - 5.79

0.49

0.11 - 1.24

0.8486

0.9196

8СМ+PD-1-TIGIT+

Abs_Value

39

39

0

2.1

9.31

-0.83 - 5.02

0 - 58.16

0.2

0.1 - 0.58

28

28

0

0.69

1.18

0.25 - 1.12

0 - 5.17

0.2

0.05 - 0.61

0.3555

0.6781

8СМ+PD-1+

Abs_Value

39

39

0

2.67

7.9

0.2 - 5.15

0.02 - 45.11

0.74

0.28 - 1.51

28

28

0

2.03

3.93

0.57 - 3.48

0.01 - 15.63

0.52

0.1 - 1.43

0.6598

0.8271

8СМ+PD-1+TIGIT-

Abs_Value

39

39

0

0.68

1.95

0.07 - 1.29

0 - 9.81

0.15

0.03 - 0.35

28

28

0

0.49

1

0.12 - 0.86

0.01 - 4.45

0.11

0.04 - 0.38

0.6059

0.7822

8СМ+PD-1+TIGIT+

Abs_Value

39

39

0

1.99

6.19

0.05 - 3.94

0.01 - 37.26

0.62

0.21 - 1.18

28

28

0

1.53

2.99

0.43 - 2.64

0 - 11.18

0.39

0.06 - 1.08

0.6889

0.8514

8СМ+TIGIT+

Abs_Value

39

39

0

4.09

15.41

-0.75 - 8.93

0.01 - 95.42

0.8

0.34 - 1.64

28

28

0

2.22

3.86

0.79 - 3.65

0 - 12.71

0.7

0.13 - 2.13

0.4714

0.718

8ТЕ

Abs_Value

39

39

0

340.55

488.28

187.3 - 493.79

4.38 - 1891.65

72.89

27.04 - 523.74

28

28

0

135.07

228.34

50.49 - 219.65

0.46 - 1033.99

42.13

12.61 - 131.19

0.0251

0.6781

8ТЕ(СТАР2)

Abs_Value

39

39

0

399.82

532.76

232.61 - 567.03

7.72 - 2117.62

121.61

53.59 - 623.55

28

28

0

190.71

317.08

73.26 - 308.16

2.04 - 1520.64

74.98

26.84 - 165.62

0.0492

0.6781

8ТЕ+226+

Abs_Value

39

39

0

380.04

511.32

219.56 - 540.51

6.99 - 1998.95

102.32

50.26 - 599.53

28

28

0

176.1

299.7

65.09 - 287.11

1.84 - 1441.91

61.81

24.47 - 147.36

0.0447

0.6781

8ТЕ+39+

Abs_Value

39

39

0

34.3

57.18

16.35 - 52.25

0.05 - 321.3

13.22

3.65 - 43.95

28

28

0

30.36

56.92

9.27 - 51.44

0.07 - 278.04

7.6

2.95 - 34.51

0.781

0.8997

8ТЕ+DR+

Abs_Value

39

39

0

291.49

426.01

157.79 - 425.2

2.61 - 1916.64

93.22

40.64 - 361.39

28

28

0

149.34

282.01

44.88 - 253.8

1.18 - 1379.51

39.48

15.08 - 122

0.1054

0.6781

8ТЕ+PD-1-TIGIT-

Abs_Value

39

39

0

109.69

170.26

56.25 - 163.13

2.07 - 692.88

26.6

9.18 - 117.4

28

28

0

50.89

89.3

17.81 - 83.97

0.56 - 459.76

20.6

5.05 - 62.44

0.0716

0.6781

8ТЕ+PD-1-TIGIT+

Abs_Value

39

39

0

121.05

193.14

60.43 - 181.66

0.99 - 921.44

24.4

8.44 - 190.13

28

28

0

51.55

101.85

13.82 - 89.27

0.45 - 504.62

14.1

4.74 - 55.63

0.0612

0.6781

8ТЕ+PD-1+

Abs_Value

39

39

0

169.08

280.68

80.99 - 257.17

3.69 - 1526.37

67.37

26.03 - 170.51

28

28

0

88.27

149.38

32.94 - 143.6

1.03 - 556.25

29.97

12.58 - 69.83

0.1331

0.6781

8ТЕ+PD-1+TIGIT-

Abs_Value

39

39

0

56.8

90.76

28.31 - 85.28

0.82 - 403.46

18.56

2.45 - 72.41

28

28

0

27.18

48.92

9.06 - 45.3

0.47 - 190.87

7.59

2.07 - 25.75

0.0906

0.6781

8ТЕ+PD-1+TIGIT+

Abs_Value

39

39

0

112.28

201.35

49.09 - 175.48

2.85 - 1122.91

47.52

13.89 - 97.11

28

28

0

61.09

106.19

21.76 - 100.43

0.56 - 365.38

14.54

8.69 - 41.59

0.1827

0.6781

8ТЕ+TIGIT+

Abs_Value

39

39

0

233.33

346.67

124.53 - 342.13

3.84 - 1498.44

77.37

26.2 - 269.88

28

28

0

112.64

198.57

39.09 - 186.19

1.01 - 870

29.7

14.87 - 94.69

0.0765

0.6781

8ТМ

Abs_Value

39

39

0

20.92

28

12.13 - 29.7

0.43 - 149.26

12.18

4.59 - 22.53

28

28

0

20.26

37.21

6.47 - 34.04

0.34 - 179.51

5.25

1.36 - 17.61

0.9375

0.9711

TREG_CM

Abs_Value

39

39

0

0.81

0.88

0.54 - 1.09

0 - 4.33

0.5

0.26 - 1.08

28

28

0

1.48

2.72

0.47 - 2.49

0.02 - 14.66

0.92

0.32 - 1.56

0.2223

0.6781

TREG_EMTM

Abs_Value

39

39

0

8.82

8.27

6.22 - 11.41

0.05 - 40.11

7.21

2.95 - 12.43

28

28

0

11.9

17.5

5.42 - 18.38

0.05 - 93.26

6.51

3.01 - 13.22

0.3923

0.6866

TREG_NV

Abs_Value

39

39

0

0.93

0.89

0.65 - 1.21

0 - 3.03

0.71

0.21 - 1.47

28

28

0

1.21

0.82

0.91 - 1.52

0.01 - 3.4

1.13

0.63 - 1.75

0.1786

0.6781

TREG_TE

Abs_Value

39

39

0

2.37

1.78

1.81 - 2.93

0 - 6.11

2.06

1.15 - 3.5

28

28

0

3.04

2.65

2.06 - 4.02

0.19 - 8.97

2.17

0.97 - 4.09

0.2505

0.6781

TREG+226-TIGIT-

Abs_Value

39

39

0

0.85

0.78

0.61 - 1.1

0 - 2.66

0.63

0.17 - 1.39

28

28

0

0.88

0.74

0.61 - 1.15

0.04 - 3.18

0.69

0.34 - 1.18

0.8825

0.9398

TREG+226-TIGIT+

Abs_Value

39

39

0

3.39

3.18

2.39 - 4.39

0.01 - 13.35

2.67

0.95 - 4.88

28

28

0

4.62

7.57

1.82 - 7.43

0.22 - 40.78

2.82

1.46 - 4.13

0.4216

0.6984

TREG+226+

Abs_Value

39

39

0

8.82

7.4

6.49 - 11.14

0.04 - 38.28

9.02

3.48 - 11.72

28

28

0

12.15

14.13

6.92 - 17.38

0.85 - 72.45

7.91

3.79 - 14.59

0.2615

0.6781

TREG+226+TIGIT-

Abs_Value

39

39

0

1.36

1.22

0.98 - 1.75

0.01 - 4.82

0.92

0.52 - 1.82

28

28

0

1.67

1.7

1.04 - 2.3

0.06 - 7.96

1.15

0.6 - 1.92

0.413

0.6959

TREG+226+TIGIT+

Abs_Value

39

39

0

7.46

6.55

5.4 - 9.51

0.02 - 33.46

6.06

2.41 - 10.44

28

28

0

10.48

13.51

5.47 - 15.48

0.25 - 70.7

6.52

3.05 - 13.06

0.2811

0.6781

TREG+39+

Abs_Value

39

39

0

9.7

9.56

6.7 - 12.7

0.03 - 45.27

6.69

3.41 - 11.8

28

28

0

13.81

20.79

6.11 - 21.52

0.18 - 111.4

8.3

3.67 - 15.91

0.336

0.6781

TREG+DR+

Abs_Value

39

39

0

9.7

8.49

7.03 - 12.36

0.02 - 39.81

8.49

3.47 - 13.01

28

28

0

13.29

19.64

6.01 - 20.56

0.59 - 105.25

8.1

3.56 - 14.05

0.3701

0.6866

TREG+PD-1+

Abs_Value

39

39

0

4.45

3.85

3.25 - 5.66

0.04 - 18.35

3.67

1.4 - 6.2

28

28

0

7.17

13.16

2.29 - 12.04

0.13 - 69.61

3.88

1.6 - 7.43

0.2978

0.6781

TREG+TIGIT+

Abs_Value

39

39

0

10.84

9.27

7.93 - 13.75

0.03 - 42.48

10.53

3.55 - 14.81

28

28

0

15.1

20.74

7.42 - 22.78

0.47 - 111.49

9.01

5.36 - 17.63

0.3169

0.6781

ДЕНЬ ХРРТПХ

4_TFH

Abs_Value

25

25

0

46.78

39.66

31.24 - 62.33

3.66 - 168.34

34.25

19.83 - 64.77

Н/П*

Н/П*

4_TH1

Abs_Value

25

25

0

28.17

17.06

21.49 - 34.86

2.66 - 65.39

29.97

13.25 - 43.17

Н/П*

Н/П*

4_TH17

Abs_Value

25

25

0

23.29

13.52

17.99 - 28.59

6.68 - 64.57

22.22

12.65 - 29.78

Н/П*

Н/П*

4_Th17TO1

Abs_Value

25

25

0

6.06

5.4

3.95 - 8.18

0.56 - 23.85

3.82

2.86 - 8.1

Н/П*

Н/П*

4_TH2

Abs_Value

25

25

0

24.18

26.58

13.76 - 34.6

3.39 - 132.22

18.42

6.59 - 29.27

Н/П*

Н/П*

4_TH22

Abs_Value

25

25

0

9.62

7.61

6.64 - 12.61

0.26 - 32.21

8.69

4.42 - 13.49

Н/П*

Н/П*

4+

Abs_Value

25

25

0

123.28

57.09

100.9 - 145.65

16.38 - 237.04

115.81

79.15 - 170.15

Н/П*

Н/П*

4+ (IM STAT)

Abs_Value

25

25

0

97.67

44.6

80.19 - 115.15

13.95 - 188.96

87.06

67.78 - 126.32

Н/П*

Н/П*

4+226+

Abs_Value

25

25

0

284.34

122.79

236.2 - 332.47

44.53 - 608.12

278.03

201.64 - 345.8

Н/П*

Н/П*

4+39+

Abs_Value

25

25

0

85.6

65.58

59.89 - 111.31

1.02 - 286.69

76.43

53.19 - 108.3

Н/П*

Н/П*

4+DR+

Abs_Value

25

25

0

133.94

87.87

99.5 - 168.39

24.34 - 400.84

100.49

65.24 - 183.02

Н/П*

Н/П*

4+PD-1-TIGIT-

Abs_Value

25

25

0

109.61

70.62

81.92 - 137.29

11.55 - 243.96

96.09

49.56 - 150.68

Н/П*

Н/П*

4+PD-1-TIGIT+

Abs_Value

25

25

0

11.95

10.29

7.91 - 15.98

0.92 - 41.1

7.95

3.98 - 17.77

Н/П*

Н/П*

4+PD-1+

Abs_Value

25

25

0

182.38

99.2

143.5 - 221.27

33.38 - 484.17

145.59

109.23 - 237.38

Н/П*

Н/П*

4+PD-1+TIGIT-

Abs_Value

25

25

0

100.64

63.31

75.83 - 125.46

20.2 - 286.07

76.64

62.96 - 141.45

Н/П*

Н/П*

4+PD-1+TIGIT+

Abs_Value

25

25

0

81.74

43.96

64.51 - 98.97

13.19 - 198.1

79.59

47.71 - 110.6

Н/П*

Н/П*

4+TIGIT+

Abs_Value

25

25

0

93.69

50.24

73.99 - 113.38

14.67 - 216.64

95.41

52.98 - 120.07

Н/П*

Н/П*

4NV

Abs_Value

25

25

0

59.45

55.09

37.86 - 81.05

4.48 - 237.61

41.58

22.62 - 88.96

Н/П*

Н/П*

4NV(СТАР2)

Abs_Value

25

25

0

53.26

52.95

32.5 - 74.02

3.89 - 222.55

32.64

13.42 - 88.36

Н/П*

Н/П*

4NV_TH1

Abs_Value

25

25

0

3.11

2.72

2.05 - 4.18

0.07 - 9.51

2.24

0.8 - 4.69

Н/П*

Н/П*

4NV_TH17

Abs_Value

25

25

0

1.55

1.46

0.98 - 2.12

0.21 - 7.19

1.07

0.67 - 2.07

Н/П*

Н/П*

4NV_Th17TO1

Abs_Value

25

25

0

0.29

0.27

0.19 - 0.4

0.01 - 0.98

0.18

0.08 - 0.47

Н/П*

Н/П*

4NV_TH2

Abs_Value

25

25

0

5.15

4.7

3.31 - 7

0.31 - 17.87

4.14

1.2 - 7.06

Н/П*

Н/П*

4NV_TH22

Abs_Value

25

25

0

0.33

0.63

0.09 - 0.58

0 - 2.8

0.14

0.02 - 0.23

Н/П*

Н/П*

4NV+226+

Abs_Value

25

25

0

47.3

50.15

27.64 - 66.96

3.83 - 221.43

31.18

10.03 - 73.8

Н/П*

Н/П*

4NV+39+

Abs_Value

25

25

0

1.82

2.11

0.99 - 2.64

0.01 - 8.35

1.27

0.52 - 2.01

Н/П*

Н/П*

4NV+DR+

Abs_Value

25

25

0

5.64

9.28

2 - 9.27

0.3 - 37.06

1.76

0.72 - 4.8

Н/П*

Н/П*

4NV+PD-1-TIGIT-

Abs_Value

25

25

0

47.97

50.69

28.1 - 67.84

2.87 - 213.68

29.51

11.05 - 80.14

Н/П*

Н/П*

4NV+PD-1-TIGIT+

Abs_Value

25

25

0

1.28

1.33

0.76 - 1.8

0.07 - 4.54

0.82

0.23 - 1.88

Н/П*

Н/П*

4NV+PD-1+TIGIT-

Abs_Value

25

25

0

2.66

2.35

1.74 - 3.58

0.06 - 8.51

2.16

0.7 - 4.62

Н/П*

Н/П*

4NV+PD-1+TIGIT+

Abs_Value

25

25

0

1.34

1.3

0.83 - 1.85

0 - 4.85

0.89

0.43 - 1.66

Н/П*

Н/П*

4NV+PD1+

Abs_Value

25

25

0

4

3.45

2.65 - 5.36

0.09 - 13.36

3.04

1.59 - 6.34

Н/П*

Н/П*

4NV+TIGIT+

Abs_Value

25

25

0

2.63

2.37

1.7 - 3.56

0.25 - 9.38

1.69

0.89 - 4

Н/П*

Н/П*

4ЕМ

Abs_Value

25

25

0

15.22

19.1

7.73 - 22.71

0.09 - 72.83

9.43

2.27 - 17.96

Н/П*

Н/П*

4ЕМ_TH1

Abs_Value

25

25

0

3.81

5.49

1.66 - 5.96

0.02 - 22.18

0.97

0.49 - 5.17

Н/П*

Н/П*

4ЕМ_TH17

Abs_Value

25

25

0

0.06

0.13

0.01 - 0.11

0 - 0.59

0.01

0 - 0.04

Н/П*

Н/П*

4ЕМ_Th17TO1

Abs_Value

25

25

0

0.12

0.18

0.05 - 0.19

0 - 0.62

0.04

0.01 - 0.13

Н/П*

Н/П*

4ЕМ_TH2

Abs_Value

25

25

0

0.61

1.02

0.21 - 1.01

0 - 4.75

0.14

0.04 - 0.82

Н/П*

Н/П*

4ЕМ_TH22

Abs_Value

25

25

0

0.01

0.03

0 - 0.02

0 - 0.13

0

0 - 0.01

Н/П*

Н/П*

4ЕМ+226+

Abs_Value

25

25

0

132.71

80.8

101.04 - 164.39

14.74 - 377.13

111.79

84.69 - 160.46

Н/П*

Н/П*

4ЕМ+39+

Abs_Value

25

25

0

50

45.87

32.01 - 67.98

0.71 - 224.9

45.43

20.01 - 70.49

Н/П*

Н/П*

4ЕМ+DR+

Abs_Value

25

25

0

78.78

58.01

56.04 - 101.52

10.43 - 286.47

68.2

44.3 - 88.66

Н/П*

Н/П*

4ЕМ+PD1-TIGIT-

Abs_Value

25

25

0

25.76

20.32

17.79 - 33.73

2.51 - 88.41

27.57

7.35 - 35.72

Н/П*

Н/П*

4ЕМ+PD1-TIGIT+

Abs_Value

25

25

0

4.14

5.03

2.17 - 6.11

0.34 - 23.64

2.5

1.05 - 4.75

Н/П*

Н/П*

4ЕМ+PD1+

Abs_Value

25

25

0

108.73

71.45

80.73 - 136.74

13.21 - 337.48

97.98

58.91 - 132.51

Н/П*

Н/П*

4ЕМ+PD1+TIGIT-

Abs_Value

25

25

0

63.06

44.82

45.49 - 80.63

7.96 - 196.34

51.81

33.43 - 77.66

Н/П*

Н/П*

4ЕМ+PD1+TIGIT+

Abs_Value

25

25

0

45.67

32.49

32.94 - 58.41

5.26 - 141.13

35.6

20.06 - 64.51

Н/П*

Н/П*

4ЕМ+TIGIT+

Abs_Value

25

25

0

49.81

35.48

35.9 - 63.72

5.74 - 149.98

39.47

21.38 - 64.84

Н/П*

Н/П*

4ЕМTM

Abs_Value

25

25

0

138.63

83

106.1 - 171.17

16.21 - 387.82

118.34

88.22 - 172.43

Н/П*

Н/П*

4СМ

Abs_Value

25

25

0

78.18

48

59.37 - 97

11.92 - 198.01

73.12

43.13 - 103.34

Н/П*

Н/П*

4СМ(СТАР2)

Abs_Value

25

25

0

59.67

36.54

45.35 - 73.99

2.49 - 132.74

61.2

36.49 - 76.35

Н/П*

Н/П*

4СМ_TH1

Abs_Value

25

25

0

3.24

2.9

2.1 - 4.38

0.16 - 10.97

2.47

1.01 - 4.11

Н/П*

Н/П*

4СМ_TH17

Abs_Value

25

25

0

9.24

5.27

7.18 - 11.31

1.77 - 19.65

9.32

4.72 - 13.61

Н/П*

Н/П*

4СМ_Th17TO1

Abs_Value

25

25

0

0.99

1.06

0.58 - 1.41

0.07 - 4.84

0.7

0.25 - 1.41

Н/П*

Н/П*

4СМ_TH2

Abs_Value

25

25

0

6.96

7.36

4.07 - 9.84

0.79 - 29.39

4.68

2.11 - 7.6

Н/П*

Н/П*

4СМ_TH22

Abs_Value

25

25

0

1.65

1.92

0.9 - 2.4

0.03 - 7.43

1.02

0.52 - 1.23

Н/П*

Н/П*

4СМ+226+

Abs_Value

25

25

0

56.59

34.4

43.1 - 70.07

2.12 - 125.18

57.79

33.85 - 71.78

Н/П*

Н/П*

4СМ+39+

Abs_Value

25

25

0

18.81

15.5

12.73 - 24.89

0.07 - 49.53

15.95

3.9 - 35.62

Н/П*

Н/П*

4СМ+DR+

Abs_Value

25

25

0

18.62

15.78

12.43 - 24.8

0.13 - 54.42

13.43

6.54 - 28.21

Н/П*

Н/П*

4СМ+PD1-TIGIT-

Abs_Value

25

25

0

19.47

16.23

13.11 - 25.83

0.75 - 58.09

16.18

6.62 - 29.33

Н/П*

Н/П*

4СМ+PD1-TIGIT+

Abs_Value

25

25

0

2.82

2.62

1.8 - 3.85

0.03 - 8.27

1.65

0.74 - 5.23

Н/П*

Н/П*

4СМ+PD1+

Abs_Value

25

25

0

37.38

23.64

28.11 - 46.65

0.25 - 85.43

34.06

18.31 - 51.53

Н/П*

Н/П*

4СМ+PD1+TIGIT-

Abs_Value

25

25

0

16.56

12.88

11.51 - 21.61

0.11 - 53.01

11.48

8.77 - 21.87

Н/П*

Н/П*

4СМ+PD1+TIGIT+

Abs_Value

25

25

0

20.82

12.6

15.88 - 25.76

0.14 - 43.85

22.44

8.69 - 29.97

Н/П*

Н/П*

4СМ+TIGIT+

Abs_Value

25

25

0

23.64

13.8

18.23 - 29.05

0.29 - 46.52

26.56

10.49 - 34.71

Н/П*

Н/П*

4ТM_TH1

Abs_Value

25

25

0

13.08

9.46

9.38 - 16.79

1.35 - 30.38

9.27

4.69 - 20.15

Н/П*

Н/П*

4ТM_TH17

Abs_Value

25

25

0

11.34

10.3

7.3 - 15.38

1.71 - 44.13

7.67

5.11 - 11.72

Н/П*

Н/П*

4ТM_Th17TO1

Abs_Value

25

25

0

3.97

4.14

2.34 - 5.59

0.27 - 18.81

2.41

1.67 - 4.26

Н/П*

Н/П*

4ТM_TH2

Abs_Value

25

25

0

9.21

17.57

2.33 - 16.1

0.45 - 85.75

4.09

2.14 - 8.69

Н/П*

Н/П*

4ТM_TH22

Abs_Value

25

25

0

6.69

6.49

4.14 - 9.23

0.16 - 30.35

4.96

2.64 - 8.68

Н/П*

Н/П*

4ТREG

Abs_Value

25

25

0

4.55

4.75

2.69 - 6.42

0.17 - 15.12

2.33

1.41 - 5.5

Н/П*

Н/П*

4ТREG(СТАР2)

Abs_Value

25

25

0

124.67

57.17

102.25 - 147.08

17.21 - 253.28

119.85

81.78 - 149.18

Н/П*

Н/П*

4ТREG_TH1

Abs_Value

25

25

0

0.31

0.21

0.22 - 0.39

0 - 0.83

0.23

0.17 - 0.41

Н/П*

Н/П*

4ТREG_TH17

Abs_Value

25

25

0

6.35

6.5

3.8 - 8.9

0.56 - 33.26

4.59

2.68 - 6.76

Н/П*

Н/П*

4ТREG_Th17TO1

Abs_Value

25

25

0

0.11

0.12

0.07 - 0.16

0 - 0.41

0.06

0.02 - 0.16

Н/П*

Н/П*

4ТREG_TH2

Abs_Value

25

25

0

3.47

3.49

2.11 - 4.84

0.25 - 17.5

2.55

1.61 - 3.8

Н/П*

Н/П*

4ТREG_TH22

Abs_Value

25

25

0

5.76

6.51

3.2 - 8.31

0.28 - 27.55

3.6

1.78 - 7.3

Н/П*

Н/П*

4ТЕ

Abs_Value

25

25

0

11.9

17.25

5.14 - 18.66

0.09 - 58.86

4.5

0.69 - 12.45

Н/П*

Н/П*

4ТЕ(СТАР2)

Abs_Value

25

25

0

50.4

40.13

34.67 - 66.13

7.25 - 172.13

43.71

18.43 - 63.13

Н/П*

Н/П*

4ТЕ_TH1

Abs_Value

25

25

0

2.02

3.2

0.76 - 3.27

0.01 - 10.1

0.52

0.13 - 1.84

Н/П*

Н/П*

4ТЕ_TH17

Abs_Value

25

25

0

0.02

0.04

0.01 - 0.04

0 - 0.16

0

0 - 0.03

Н/П*

Н/П*

4ТЕ_Th17TO1

Abs_Value

25

25

0

0.08

0.16

0.02 - 0.15

0 - 0.61

0.01

0 - 0.06

Н/П*

Н/П*

4ТЕ_TH2

Abs_Value

25

25

0

0.73

1.98

-0.04 - 1.51

0 - 9.46

0.07

0.01 - 0.35

Н/П*

Н/П*

4ТЕ_TH22

Abs_Value

25

25

0

0.01

0.01

0 - 0.01

0 - 0.07

0

0 - 0.01

Н/П*

Н/П*

4ТЕ+226+

Abs_Value

25

25

0

46.05

37.07

31.52 - 60.59

4.81 - 157.81

34.32

16.83 - 55.87

Н/П*

Н/П*

4ТЕ+39+

Abs_Value

25

25

0

14.6

20.15

6.7 - 22.5

0.22 - 95.56

9.76

2.35 - 17.25

Н/П*

Н/П*

4ТЕ+DR+

Abs_Value

25

25

0

30.46

30.03

18.69 - 42.23

1.44 - 116.89

20.47

8.45 - 44.76

Н/П*

Н/П*

4ТЕ+PD-1-TIGIT-

Abs_Value

25

25

0

15.13

14.11

9.6 - 20.66

2.1 - 56.74

10.33

5.61 - 18.87

Н/П*

Н/П*

4ТЕ+PD-1-TIGIT+

Abs_Value

25

25

0

3.58

4.89

1.66 - 5.49

0.12 - 23.61

2.14

0.94 - 3.94

Н/П*

Н/П*

4ТЕ+PD-1+

Abs_Value

25

25

0

31.69

27.12

21.06 - 42.32

3.94 - 91.79

23.98

10.09 - 46.99

Н/П*

Н/П*

4ТЕ+PD-1+TIGIT-

Abs_Value

25

25

0

18.29

16.74

11.73 - 24.85

1.07 - 61.87

9.57

5.85 - 25.01

Н/П*

Н/П*

4ТЕ+PD-1+TIGIT+

Abs_Value

25

25

0

13.4

13.04

8.29 - 18.51

1.84 - 53.98

7.5

4.05 - 19.89

Н/П*

Н/П*

4ТЕ+TIGIT+

Abs_Value

25

25

0

16.98

17.1

10.27 - 23.68

2.16 - 77.59

9.52

5.84 - 22.91

Н/П*

Н/П*

4ТМ

Abs_Value

25

25

0

126.88

66

101 - 152.75

21.41 - 291.47

116.87

85.67 - 147

Н/П*

Н/П*

8+

Abs_Value

25

25

0

498.65

380.89

349.34 - 647.96

1.92 - 1531.11

465.29

212.98 - 655.91

Н/П*

Н/П*

8+ (IM STAT)

Abs_Value

25

25

0

631.78

466.48

448.92 - 814.64

2.46 - 1698.96

591.33

265.98 - 867.29

Н/П*

Н/П*

8+226+

Abs_Value

25

25

0

814.06

535.69

604.07 - 1024.05

19.37 - 1852.8

729.4

398.53 - 1197.61

Н/П*

Н/П*

8+39+

Abs_Value

25

25

0

129.07

99.17

90.2 - 167.95

0.32 - 376.08

118.53

39.62 - 192.09

Н/П*

Н/П*

8+DR+

Abs_Value

25

25

0

651.17

434.05

481.02 - 821.32

13.26 - 1528.67

612.95

326.33 - 927.99

Н/П*

Н/П*

8+PD-1-TIGIT-

Abs_Value

25

25

0

248.99

224.98

160.79 - 337.18

3.06 - 946.44

216.46

92.27 - 271.42

Н/П*

Н/П*

8+PD-1-TIGIT+

Abs_Value

25

25

0

245.52

230.44

155.18 - 335.85

2.47 - 1005.42

192.22

72.97 - 331.8

Н/П*

Н/П*

8+PD-1+

Abs_Value

25

25

0

407.97

320.62

282.28 - 533.65

15.39 - 1058.56

284.89

148.47 - 599.28

Н/П*

Н/П*

8+PD-1+TIGIT-

Abs_Value

25

25

0

134.3

139

79.81 - 188.79

1.56 - 459.85

88.41

25.85 - 205.09

Н/П*

Н/П*

8+PD-1+TIGIT+

Abs_Value

25

25

0

273.67

208.59

191.9 - 355.44

10.91 - 761.58

216.27

111.37 - 411.76

Н/П*

Н/П*

8+TIGIT+

Abs_Value

25

25

0

519.19

361.77

377.37 - 661

13.76 - 1510.56

440.22

286.58 - 740.07

Н/П*

Н/П*

8EMTM

Abs_Value

25

25

0

153.27

133.38

100.98 - 205.56

1.17 - 410.17

107.03

55.31 - 248.39

Н/П*

Н/П*

8EMTM+226+

Abs_Value

25

25

0

131.1

115.53

85.81 - 176.39

0.94 - 359.16

91.21

32.65 - 222.03

Н/П*

Н/П*

8EMTM+39+

Abs_Value

25

25

0

33.29

37.04

18.77 - 47.81

0.19 - 141.21

23.35

3.51 - 49.02

Н/П*

Н/П*

8EMTM+DR+

Abs_Value

25

25

0

127.59

109.66

84.6 - 170.57

0.88 - 335.96

89.9

51 - 214.35

Н/П*

Н/П*

8EMTM+PD-1-TIGIT-

Abs_Value

25

25

0

30.74

38.35

15.71 - 45.78

0.1 - 179.93

19.92

7.51 - 44.09

Н/П*

Н/П*

8EMTM+PD-1-TIGIT+

Abs_Value

25

25

0

30.4

37.31

15.78 - 45.03

0.16 - 117.39

12.39

6.97 - 47.2

Н/П*

Н/П*

8EMTM+PD-1+

Abs_Value

25

25

0

92.12

83.1

59.55 - 124.7

0.9 - 285.03

57.46

30.15 - 154.36

Н/П*

Н/П*

8EMTM+PD-1+TIGIT-

Abs_Value

25

25

0

29.46

31.22

17.22 - 41.71

0.17 - 100.3

16.91

4.9 - 39.89

Н/П*

Н/П*

8EMTM+PD-1+TIGIT+

Abs_Value

25

25

0

62.66

60.31

39.02 - 86.3

0.73 - 237.56

42.98

13.9 - 97.09

Н/П*

Н/П*

8EMTM+TIGIT+

Abs_Value

25

25

0

93.06

89.71

57.89 - 128.23

0.9 - 307.05

57.53

21.15 - 129.95

Н/П*

Н/П*

8NV

Abs_Value

25

25

0

33.21

33.93

19.91 - 46.51

0.67 - 133.23

21.08

13.74 - 46.67

Н/П*

Н/П*

8NV(СТАР2)

Abs_Value

25

25

0

27.96

36.41

13.69 - 42.24

1.05 - 179.03

16.26

10.73 - 29.41

Н/П*

Н/П*

8NV+226+

Abs_Value

25

25

0

24.54

34.6

10.98 - 38.11

0.95 - 177.03

15.01

8.92 - 27.06

Н/П*

Н/П*

8NV+39+

Abs_Value

25

25

0

1.92

1.63

1.28 - 2.56

0.01 - 5.99

1.53

0.58 - 2.96

Н/П*

Н/П*

8NV+DR+

Abs_Value

25

25

0

6.24

10.17

2.25 - 10.23

0.38 - 48.85

2.94

1.04 - 5.9

Н/П*

Н/П*

8NV+PD-1-TIGIT-

Abs_Value

25

25

0

19.4

34.27

5.97 - 32.83

0.23 - 174.66

11.05

4.45 - 20.75

Н/П*

Н/П*

8NV+PD-1-TIGIT+

Abs_Value

25

25

0

3.48

8.65

0.09 - 6.87

0 - 42.43

0.86

0.41 - 2.46

Н/П*

Н/П*

8NV+PD-1+

Abs_Value

25

25

0

5.08

7.31

2.22 - 7.95

0.23 - 28.31

2.74

0.51 - 4.76

Н/П*

Н/П*

8NV+PD-1+TIGIT-

Abs_Value

25

25

0

1.03

1.39

0.49 - 1.58

0.01 - 5.9

0.61

0.2 - 1.38

Н/П*

Н/П*

8NV+PD-1+TIGIT+

Abs_Value

25

25

0

4.05

6.73

1.41 - 6.69

0.21 - 27.87

1.99

0.42 - 3.22

Н/П*

Н/П*

8NV+TIGIT+

Abs_Value

25

25

0

7.53

14.75

1.75 - 13.31

0.34 - 70.3

3.4

1.15 - 5.16

Н/П*

Н/П*

8TREG

Abs_Value

25

25

0

493.78

393.53

339.52 - 648.05

1.91 - 1599.38

417.54

205.29 - 666.09

Н/П*

Н/П*

8ЕМ

Abs_Value

25

25

0

140.54

128.18

90.3 - 190.79

0.54 - 545.89

110.91

33.4 - 214.98

Н/П*

Н/П*

8СМ

Abs_Value

25

25

0

17.95

24.9

8.19 - 27.71

0.11 - 105.04

8.58

2.52 - 17.67

Н/П*

Н/П*

8СМ(СТАР2)

Abs_Value

25

25

0

13.52

19.22

5.98 - 21.05

0.09 - 72.63

6.1

0.61 - 16.26

Н/П*

Н/П*

8СМ+226+

Abs_Value

25

25

0

10.31

13.06

5.2 - 15.43

0.09 - 45.56

5.66

0.57 - 14.18

Н/П*

Н/П*

8СМ+39+

Abs_Value

25

25

0

3.82

5.9

1.5 - 6.13

0.02 - 27.07

1.25

0.22 - 5.33

Н/П*

Н/П*

8СМ+DR+

Abs_Value

25

25

0

11.17

17.18

4.43 - 17.9

0.04 - 66.63

3.76

0.49 - 13.92

Н/П*

Н/П*

8СМ+PD-1-TIGIT-

Abs_Value

25

25

0

2.36

4.33

0.66 - 4.06

0.01 - 19.15

1.08

0.24 - 1.78

Н/П*

Н/П*

8СМ+PD-1-TIGIT+

Abs_Value

25

25

0

3.03

5.92

0.71 - 5.35

0.01 - 20.43

0.68

0.14 - 1.28

Н/П*

Н/П*

8СМ+PD-1+

Abs_Value

25

25

0

8.13

12.1

3.39 - 12.87

0.04 - 47.52

2.83

0.56 - 10.63

Н/П*

Н/П*

8СМ+PD-1+TIGIT-

Abs_Value

25

25

0

0.87

1.26

0.37 - 1.36

0.01 - 4.51

0.39

0.09 - 0.98

Н/П*

Н/П*

8СМ+PD-1+TIGIT+

Abs_Value

25

25

0

7.26

11.71

2.67 - 11.85

0.03 - 47.06

2.6

0.47 - 9.47

Н/П*

Н/П*

8СМ+TIGIT+

Abs_Value

25

25

0

10.29

16.53

3.81 - 16.77

0.05 - 67.49

3.33

0.5 - 11.66

Н/П*

Н/П*

8ТЕ

Abs_Value

25

25

0

526.75

392.68

372.82 - 680.68

6.82 - 1431.59

493.67

225.49 - 711.59

Н/П*

Н/П*

8ТЕ(СТАР2)

Abs_Value

25

25

0

704.23

474.15

518.36 - 890.1

9.74 - 1753.87

671.37

292.51 - 1022.83

Н/П*

Н/П*

8ТЕ+226+

Abs_Value

25

25

0

645.4

455.86

466.71 - 824.1

9.12 - 1680.66

581.45

261.89 - 979.95

Н/П*

Н/П*

8ТЕ+39+

Abs_Value

25

25

0

88.98

65.87

63.16 - 114.8

0.09 - 223.92

77.45

22.4 - 137.03

Н/П*

Н/П*

8ТЕ+DR+

Abs_Value

25

25

0

504.45

358.36

363.97 - 644.93

5.03 - 1408.92

489.78

214.85 - 707.77

Н/П*

Н/П*

8ТЕ+PD-1-TIGIT-

Abs_Value

25

25

0

195.18

190

120.7 - 269.66

2.48 - 718.37

161.26

68.44 - 228.42

Н/П*

Н/П*

8ТЕ+PD-1-TIGIT+

Abs_Value

25

25

0

207.54

191.78

132.36 - 282.71

1.65 - 830

165.2

64.29 - 316.92

Н/П*

Н/П*

8ТЕ+PD-1+

Abs_Value

25

25

0

301.51

262.45

198.63 - 404.39

5.61 - 959.6

209.97

111.48 - 427.65

Н/П*

Н/П*

8ТЕ+PD-1+TIGIT-

Abs_Value

25

25

0

103.07

115.9

57.64 - 148.5

1.36 - 388.34

52.08

15.99 - 159.29

Н/П*

Н/П*

8ТЕ+PD-1+TIGIT+

Abs_Value

25

25

0

198.44

163.25

134.45 - 262.44

3.52 - 571.26

139.35

75.68 - 315.01

Н/П*

Н/П*

8ТЕ+TIGIT+

Abs_Value

25

25

0

405.98

282.45

295.26 - 516.7

5.17 - 1145.01

322.14

207.82 - 585.29

Н/П*

Н/П*

8ТМ

Abs_Value

25

25

0

60

52.55

39.4 - 80.6

1.16 - 174.35

46.8

15.99 - 80.83

Н/П*

Н/П*

TREG_CM

Abs_Value

25

25

0

2.85

3.16

1.61 - 4.09

0.08 - 14.1

1.69

0.82 - 5.02

Н/П*

Н/П*

TREG_EMTM

Abs_Value

25

25

0

26.47

20.09

18.6 - 34.35

1.78 - 71.51

18.06

12.84 - 38.69

Н/П*

Н/П*

TREG_NV

Abs_Value

25

25

0

2.08

1.86

1.35 - 2.81

0 - 5.4

1.27

0.52 - 3.17

Н/П*

Н/П*

TREG_TE

Abs_Value

25

25

0

7.28

6.07

4.9 - 9.67

0.53 - 26.44

6.27

2.86 - 10.36

Н/П*

Н/П*

TREG+226-TIGIT-

Abs_Value

25

25

0

1.62

1.28

1.12 - 2.12

0.12 - 4.76

1.5

0.65 - 2.33

Н/П*

Н/П*

TREG+226-TIGIT+

Abs_Value

25

25

0

9.08

7.58

6.11 - 12.05

0.46 - 26.78

7.51

3.39 - 12.27

Н/П*

Н/П*

TREG+226+

Abs_Value

25

25

0

28.24

19.1

20.76 - 35.73

2.27 - 67.09

23.95

14.49 - 38.08

Н/П*

Н/П*

TREG+226+TIGIT-

Abs_Value

25

25

0

3.15

1.96

2.38 - 3.92

0.49 - 6.55

3.21

1.26 - 4.58

Н/П*

Н/П*

TREG+226+TIGIT+

Abs_Value

25

25

0

25.1

17.57

18.21 - 31.98

1.77 - 60.99

20.4

12.88 - 33.39

Н/П*

Н/П*

TREG+39+

Abs_Value

25

25

0

28.72

19.78

20.97 - 36.48

1.42 - 83.91

24.01

17.28 - 37.7

Н/П*

Н/П*

TREG+DR+

Abs_Value

25

25

0

30.1

21.09

21.84 - 38.37

2.28 - 75.55

26.18

14.64 - 46.59

Н/П*

Н/П*

TREG+PD-1+

Abs_Value

25

25

0

17.15

13.87

11.71 - 22.58

0.47 - 49.25

13.78

6.67 - 21.27

Н/П*

Н/П*

TREG+TIGIT+

Abs_Value

25

25

0

34.18

23.64

24.91 - 43.45

2.24 - 85.67

28.53

17.3 - 48.19

Н/П*

Н/П*

ДЕНЬ ХРРТПХ +180

4_TFH

Abs_Value

8

8

0

58.53

30.95

37.08 - 79.97

4.33 - 100.17

64.6

47.58 - 74.95

Н/П*

Н/П*

4_TH1

Abs_Value

8

8

0

52.88

45.82

21.12 - 84.63

5.76 - 139.51

36.23

26.33 - 62.23

Н/П*

Н/П*

4_TH17

Abs_Value

8

8

0

38.59

34.42

14.74 - 62.45

2.67 - 109.23

29.75

15.91 - 48.75

Н/П*

Н/П*

4_Th17TO1

Abs_Value

8

8

0

13.55

11.87

5.32 - 21.78

0.52 - 39.95

11.73

8.79 - 14.84

Н/П*

Н/П*

4_TH2

Abs_Value

8

8

0

27.12

24.59

10.08 - 44.16

3.71 - 80.42

17.94

14.69 - 28.01

Н/П*

Н/П*

4_TH22

Abs_Value

8

8

0

16.82

15.81

5.86 - 27.77

0.47 - 43.52

13.74

4.49 - 23.15

Н/П*

Н/П*

4+

Abs_Value

8

8

0

205.27

137.06

110.3 - 300.25

27.34 - 489.56

190.56

125.9 - 246.2

Н/П*

Н/П*

4+ (IM STAT)

Abs_Value

8

8

0

174.71

118.7

92.46 - 256.97

21.35 - 418.46

161.61

105.77 - 208.22

Н/П*

Н/П*

4+226+

Abs_Value

8

8

0

432.98

214.56

284.3 - 581.66

58.67 - 689.45

488.08

298.46 - 546.5

Н/П*

Н/П*

4+39+

Abs_Value

8

8

0

114.8

142.15

16.29 - 213.3

6.16 - 379.73

55.9

20.16 - 143.57

Н/П*

Н/П*

4+DR+

Abs_Value

8

8

0

197.76

167.54

81.66 - 313.86

6.74 - 444.36

163.5

72.37 - 295.08

Н/П*

Н/П*

4+PD-1-TIGIT-

Abs_Value

8

8

0

206.19

112.04

128.55 - 283.83

31.34 - 339.45

224.31

130.99 - 288.22

Н/П*

Н/П*

4+PD-1-TIGIT+

Abs_Value

8

8

0

16.48

11.95

8.21 - 24.76

2.07 - 40.26

17.21

7.4 - 20.31

Н/П*

Н/П*

4+PD-1+

Abs_Value

8

8

0

238.14

155.46

130.41 - 345.87

26.44 - 477.88

228.22

126.89 - 358.38

Н/П*

Н/П*

4+PD-1+TIGIT-

Abs_Value

8

8

0

148.9

112.95

70.63 - 227.18

15.97 - 335.51

125.94

65.84 - 232.62

Н/П*

Н/П*

4+PD-1+TIGIT+

Abs_Value

8

8

0

89.24

47.33

56.44 - 122.03

10.47 - 142.37

104.53

57.68 - 125.2

Н/П*

Н/П*

4+TIGIT+

Abs_Value

8

8

0

105.72

51.47

70.05 - 141.39

12.54 - 150.32

124.1

89.31 - 142.76

Н/П*

Н/П*

4NV

Abs_Value

8

8

0

93.17

65.58

47.73 - 138.61

19.14 - 205.24

71.98

45.66 - 143.14

Н/П*

Н/П*

4NV(СТАР2)

Abs_Value

8

8

0

87.06

67.44

40.32 - 133.8

15.78 - 204.98

75.64

29.46 - 122.75

Н/П*

Н/П*

4NV_TH1

Abs_Value

8

8

0

6.12

5.65

2.21 - 10.04

0.75 - 18.23

5.36

2.44 - 7.52

Н/П*

Н/П*

4NV_TH17

Abs_Value

8

8

0

1.8

0.86

1.21 - 2.4

0.5 - 2.92

1.57

1.29 - 2.59

Н/П*

Н/П*

4NV_Th17TO1

Abs_Value

8

8

0

0.61

0.34

0.38 - 0.85

0.09 - 1.14

0.55

0.43 - 0.78

Н/П*

Н/П*

4NV_TH2

Abs_Value

8

8

0

4.96

3.85

2.29 - 7.63

1.43 - 13.51

4.14

2.61 - 5.87

Н/П*

Н/П*

4NV_TH22

Abs_Value

8

8

0

0.14

0.2

0 - 0.28

0 - 0.63

0.08

0.03 - 0.13

Н/П*

Н/П*

4NV+226+

Abs_Value

8

8

0

76.75

65.59

31.3 - 122.2

15.45 - 203.08

56.76

25.71 - 109.58

Н/П*

Н/П*

4NV+39+

Abs_Value

8

8

0

2.28

3.15

0.09 - 4.46

0.09 - 9.72

1.37

0.51 - 2.32

Н/П*

Н/П*

4NV+DR+

Abs_Value

8

8

0

6.77

4.31

3.78 - 9.76

0.2 - 11.36

7.33

3.62 - 10.86

Н/П*

Н/П*

4NV+PD-1-TIGIT-

Abs_Value

8

8

0

79.19

64.15

34.73 - 123.64

14.59 - 193.32

66.91

27.72 - 106.01

Н/П*

Н/П*

4NV+PD-1-TIGIT+

Abs_Value

8

8

0

1.66

1.64

0.52 - 2.8

0.35 - 5.35

1.06

0.8 - 1.67

Н/П*

Н/П*

4NV+PD-1+TIGIT-

Abs_Value

8

8

0

4.6

5.7

0.65 - 8.55

0.4 - 17.59

3.03

1.04 - 5.15

Н/П*

Н/П*

4NV+PD-1+TIGIT+

Abs_Value

8

8

0

1.62

1.45

0.62 - 2.62

0.17 - 4.37

1.73

0.25 - 2.24

Н/П*

Н/П*

4NV+PD1+

Abs_Value

8

8

0

6.21

6.46

1.74 - 10.69

0.59 - 19.7

4.91

1.24 - 8.58

Н/П*

Н/П*

4NV+TIGIT+

Abs_Value

8

8

0

3.28

2.72

1.39 - 5.16

0.62 - 7.58

2.76

1.01 - 4.46

Н/П*

Н/П*

4ЕМ

Abs_Value

8

8

0

22.52

34.85

-1.63 - 46.68

1.83 - 101.46

7.62

3.66 - 18.69

Н/П*

Н/П*

4ЕМ_TH1

Abs_Value

8

8

0

10.41

17.96

-2.04 - 22.85

0.23 - 52.73

2.65

1.26 - 8.81

Н/П*

Н/П*

4ЕМ_TH17

Abs_Value

8

8

0

0.02

0.03

-0.01 - 0.04

0 - 0.1

0.01

0 - 0.01

Н/П*

Н/П*

4ЕМ_Th17TO1

Abs_Value

8

8

0

0.1

0.07

0.05 - 0.15

0 - 0.2

0.1

0.05 - 0.15

Н/П*

Н/П*

4ЕМ_TH2

Abs_Value

8

8

0

0.47

0.76

-0.05 - 1

0.02 - 2.26

0.13

0.07 - 0.5

Н/П*

Н/П*

4ЕМ_TH22

Abs_Value

8

8

0

0

0

0 - 0

0 - 0.01

0

0 - 0

Н/П*

Н/П*

4ЕМ+226+

Abs_Value

8

8

0

213.97

149.24

110.55 - 317.39

23.82 - 444.2

247.06

80.19 - 304.9

Н/П*

Н/П*

4ЕМ+39+

Abs_Value

8

8

0

77.91

110.06

1.65 - 154.18

3.69 - 325.68

35.53

8.19 - 86.25

Н/П*

Н/П*

4ЕМ+DR+

Abs_Value

8

8

0

129.31

120.6

45.74 - 212.88

5.04 - 373.34

118.88

40.25 - 160.95

Н/П*

Н/П*

4ЕМ+PD1-TIGIT-

Abs_Value

8

8

0

61.31

55.08

23.14 - 99.47

6.25 - 154.67

56.62

9.86 - 91.88

Н/П*

Н/П*

4ЕМ+PD1-TIGIT+

Abs_Value

8

8

0

7.01

10.31

-0.13 - 14.16

0.61 - 31.87

3.91

1.77 - 6.35

Н/П*

Н/П*

4ЕМ+PD1+

Abs_Value

8

8

0

153.48

114.77

73.95 - 233.01

17.49 - 364.92

160.65

71.44 - 203.18

Н/П*

Н/П*

4ЕМ+PD1+TIGIT-

Abs_Value

8

8

0

103.85

87.77

43.03 - 164.67

10.35 - 266.71

97.4

31.99 - 150

Н/П*

Н/П*

4ЕМ+PD1+TIGIT+

Abs_Value

8

8

0

49.63

30.49

28.5 - 70.76

7.14 - 98.21

54.21

36.04 - 63.49

Н/П*

Н/П*

4ЕМ+TIGIT+

Abs_Value

8

8

0

56.64

34.43

32.79 - 80.5

7.75 - 100.36

61.16

38.96 - 78.79

Н/П*

Н/П*

4ЕМTM

Abs_Value

8

8

0

221.8

153.13

115.69 - 327.92

24.35 - 452.24

261.67

83.92 - 313.95

Н/П*

Н/П*

4СМ

Abs_Value

8

8

0

105.82

85.55

46.53 - 165.1

13.53 - 260.46

90.77

53.74 - 132.89

Н/П*

Н/П*

4СМ(СТАР2)

Abs_Value

8

8

0

83.32

59.93

41.78 - 124.85

10.93 - 184.54

67.98

49.57 - 116.93

Н/П*

Н/П*

4СМ_TH1

Abs_Value

8

8

0

5.01

3.72

2.43 - 7.59

0.38 - 10.83

5.21

2.47 - 6.57

Н/П*

Н/П*

4СМ_TH17

Abs_Value

8

8

0

12.73

11.95

4.45 - 21.01

1.07 - 34.36

8.51

5.91 - 15.66

Н/П*

Н/П*

4СМ_Th17TO1

Abs_Value

8

8

0

2.1

1.47

1.08 - 3.11

0.06 - 4.39

1.89

1.23 - 3.02

Н/П*

Н/П*

4СМ_TH2

Abs_Value

8

8

0

10.33

14.82

0.06 - 20.6

1.12 - 45.88

5.88

2.99 - 7.9

Н/П*

Н/П*

4СМ_TH22

Abs_Value

8

8

0

2.49

4.52

-0.65 - 5.62

0.17 - 13.33

0.55

0.33 - 1.69

Н/П*

Н/П*

4СМ+226+

Abs_Value

8

8

0

79.57

57.71

39.58 - 119.56

10.84 - 178.97

64.6

47.28 - 109.65

Н/П*

Н/П*

4СМ+39+

Abs_Value

8

8

0

24.52

39.26

-2.68 - 51.73

0.7 - 118.64

10.4

3.23 - 23.72

Н/П*

Н/П*

4СМ+DR+

Abs_Value

8

8

0

25.78

24.1

9.08 - 42.48

0.72 - 64.82

18.55

9.27 - 36.47

Н/П*

Н/П*

4СМ+PD1-TIGIT-

Abs_Value

8

8

0

28.9

21.97

13.68 - 44.13

6.03 - 68.44

20.78

14.22 - 39.45

Н/П*

Н/П*

4СМ+PD1-TIGIT+

Abs_Value

8

8

0

4.4

3.18

2.2 - 6.6

0.45 - 8.85

4.32

1.57 - 6.77

Н/П*

Н/П*

4СМ+PD1+

Abs_Value

8

8

0

50.01

39.97

22.31 - 77.71

3.36 - 122.72

44.08

25.57 - 73.81

Н/П*

Н/П*

4СМ+PD1+TIGIT-

Abs_Value

8

8

0

22.23

17.51

10.09 - 34.36

1.56 - 55.65

21.54

11.54 - 29.87

Н/П*

Н/П*

4СМ+PD1+TIGIT+

Abs_Value

8

8

0

27.78

23.32

11.62 - 43.95

1.8 - 67.07

20.45

14.02 - 44.31

Н/П*

Н/П*

4СМ+TIGIT+

Abs_Value

8

8

0

32.18

26.02

14.15 - 50.22

2.3 - 74.86

22.93

17.51 - 51.35

Н/П*

Н/П*

4ТM_TH1

Abs_Value

8

8

0

19.51

19.98

5.67 - 33.35

0.88 - 65.78

14.44

10.42 - 21.14

Н/П*

Н/П*

4ТM_TH17

Abs_Value

8

8

0

22.44

25.21

4.97 - 39.91

0.98 - 68.85

13.68

5.06 - 27.62

Н/П*

Н/П*

4ТM_Th17TO1

Abs_Value

8

8

0

9.76

11.07

2.09 - 17.43

0.18 - 35.59

6.91

5.21 - 9.69

Н/П*

Н/П*

4ТM_TH2

Abs_Value

8

8

0

8.68

11.09

0.99 - 16.37

0.78 - 33.45

4.33

1.8 - 9.67

Н/П*

Н/П*

4ТM_TH22

Abs_Value

8

8

0

12.51

12.63

3.75 - 21.26

0.22 - 38.35

9.62

3.27 - 17.13

Н/П*

Н/П*

4ТREG

Abs_Value

8

8

0

3.38

3.33

1.08 - 5.69

0.52 - 9.96

2.06

1.18 - 4.33

Н/П*

Н/П*

4ТREG(СТАР2)

Abs_Value

8

8

0

204.35

131.83

112.99 - 295.7

27.24 - 474.51

195.64

124.48 - 241.62

Н/П*

Н/П*

4ТREG_TH1

Abs_Value

8

8

0

0.35

0.25

0.17 - 0.52

0.1 - 0.82

0.29

0.14 - 0.44

Н/П*

Н/П*

4ТREG_TH17

Abs_Value

8

8

0

7.31

5.37

3.59 - 11.03

1.01 - 15.15

5.27

3.34 - 12.25

Н/П*

Н/П*

4ТREG_Th17TO1

Abs_Value

8

8

0

0.14

0.13

0.05 - 0.22

0.03 - 0.33

0.06

0.04 - 0.24

Н/П*

Н/П*

4ТREG_TH2

Abs_Value

8

8

0

2.82

1.72

1.62 - 4.01

1.04 - 6.08

2.8

1.28 - 3.61

Н/П*

Н/П*

4ТREG_TH22

Abs_Value

8

8

0

7.11

5.87

3.04 - 11.17

0.61 - 16.79

5.23

3.58 - 9.37

Н/П*

Н/П*

4ТЕ

Abs_Value

8

8

0

20.66

39.04

-6.39 - 47.71

0.47 - 114.7

3.04

0.82 - 20.35

Н/П*

Н/П*

4ТЕ(СТАР2)

Abs_Value

8

8

0

66.94

63.13

23.19 - 110.68

8.27 - 207.55

60.47

23.6 - 74.9

Н/П*

Н/П*

4ТЕ_TH1

Abs_Value

8

8

0

7.58

18.08

-4.94 - 20.11

0.15 - 52.19

0.8

0.3 - 2.5

Н/П*

Н/П*

4ТЕ_TH17

Abs_Value

8

8

0

0.01

0.01

0 - 0.01

0 - 0.01

0

0 - 0.01

Н/П*

Н/П*

4ТЕ_Th17TO1

Abs_Value

8

8

0

0.04

0.05

0 - 0.07

0 - 0.15

0.02

0 - 0.04

Н/П*

Н/П*

4ТЕ_TH2

Abs_Value

8

8

0

0.56

0.89

-0.06 - 1.18

0 - 2.33

0.11

0.01 - 0.64

Н/П*

Н/П*

4ТЕ_TH22

Abs_Value

8

8

0

0

0

0 - 0

0 - 0.01

0

0 - 0

Н/П*

Н/П*

4ТЕ+226+

Abs_Value

8

8

0

61.16

62.06

18.15 - 104.16

8.06 - 202.6

51.87

19 - 66.98

Н/П*

Н/П*

4ТЕ+39+

Abs_Value

8

8

0

9.82

12.1

1.43 - 18.2

0.46 - 33.74

3.66

1.87 - 13.89

Н/П*

Н/П*

4ТЕ+DR+

Abs_Value

8

8

0

35.56

50.84

0.32 - 70.79

0.75 - 156.97

25

4.98 - 31.35

Н/П*

Н/П*

4ТЕ+PD-1-TIGIT-

Abs_Value

8

8

0

35.93

43.64

5.7 - 66.17

4.15 - 132.13

20.84

7.97 - 38.36

Н/П*

Н/П*

4ТЕ+PD-1-TIGIT+

Abs_Value

8

8

0

3.27

1.93

1.93 - 4.61

0.39 - 6.11

3.42

2.52 - 4.23

Н/П*

Н/П*

4ТЕ+PD-1+

Abs_Value

8

8

0

27.73

21.67

12.72 - 42.75

3.73 - 69.3

23.92

12.48 - 38.56

Н/П*

Н/П*

4ТЕ+PD-1+TIGIT-

Abs_Value

8

8

0

17.95

16.1

6.79 - 29.11

2.56 - 50.24

15.05

5 - 25.28

Н/П*

Н/П*

4ТЕ+PD-1+TIGIT+

Abs_Value

8

8

0

9.78

7.1

4.86 - 14.7

1.17 - 20.13

9.12

4.04 - 13.67

Н/П*

Н/П*

4ТЕ+TIGIT+

Abs_Value

8

8

0

13.05

8.5

7.16 - 18.94

1.56 - 25.17

12.54

7.22 - 18.44

Н/П*

Н/П*

4ТМ

Abs_Value

8

8

0

197.18

140.24

100 - 294.36

17.69 - 412.31

221.7

76.18 - 269.6

Н/П*

Н/П*

8+

Abs_Value

8

8

0

523.34

519.66

163.23 - 883.44

59.76 - 1524.17

277.21

193.35 - 719.8

Н/П*

Н/П*

8+ (IM STAT)

Abs_Value

8

8

0

644.48

596.98

230.79 - 1058.16

79.31 - 1806.25

379.1

320.21 - 790.62

Н/П*

Н/П*

8+226+

Abs_Value

8

8

0

874.92

701.97

388.48 - 1361.36

127.09 - 2191.35

644.85

432.11 - 1059.39

Н/П*

Н/П*

8+39+

Abs_Value

8

8

0

133.28

177.9

10 - 256.55

6.21 - 554.73

90.88

36.72 - 131.09

Н/П*

Н/П*

8+DR+

Abs_Value

8

8

0

623.87

537.07

251.69 - 996.04

31.3 - 1792.18

448.68

399.48 - 668.98

Н/П*

Н/П*

8+PD-1-TIGIT-

Abs_Value

8

8

0

308.48

285.61

110.56 - 506.39

49.48 - 800.45

220.15

94.66 - 424.06

Н/П*

Н/П*

8+PD-1-TIGIT+

Abs_Value

8

8

0

327.41

389.55

57.47 - 597.36

7.25 - 1202.9

218.74

86.19 - 402.2

Н/П*

Н/П*

8+PD-1+

Abs_Value

8

8

0

361.17

212.11

214.18 - 508.16

75.83 - 699.18

393.45

178.08 - 489.96

Н/П*

Н/П*

8+PD-1+TIGIT-

Abs_Value

8

8

0

83.59

67.58

36.76 - 130.42

21.48 - 241.24

67

48.28 - 87.75

Н/П*

Н/П*

8+PD-1+TIGIT+

Abs_Value

8

8

0

277.58

166.02

162.53 - 392.63

29.43 - 457.94

313.32

127.01 - 423.77

Н/П*

Н/П*

8+TIGIT+

Abs_Value

8

8

0

604.99

480.7

271.89 - 938.1

36.68 - 1567.95

426.9

346.35 - 842.55

Н/П*

Н/П*

8EMTM

Abs_Value

8

8

0

157.47

116.33

76.86 - 238.09

20.06 - 335.18

141.63

55.89 - 238.23

Н/П*

Н/П*

8EMTM+226+

Abs_Value

8

8

0

134.77

98.65

66.41 - 203.14

17.63 - 283.7

122.32

48.9 - 208.61

Н/П*

Н/П*

8EMTM+39+

Abs_Value

8

8

0

23.39

19.6

9.81 - 36.97

0.97 - 52.74

23.57

4.09 - 39.48

Н/П*

Н/П*

8EMTM+DR+

Abs_Value

8

8

0

125.15

96.78

58.09 - 192.22

8.01 - 298.35

118.77

46.34 - 167.33

Н/П*

Н/П*

8EMTM+PD-1-TIGIT-

Abs_Value

8

8

0

40.68

37.73

14.54 - 66.83

4.5 - 95.71

29.93

7.39 - 69.84

Н/П*

Н/П*

8EMTM+PD-1-TIGIT+

Abs_Value

8

8

0

34.07

42.71

4.47 - 63.67

0.84 - 119.96

17.86

3.85 - 44.74

Н/П*

Н/П*

8EMTM+PD-1+

Abs_Value

8

8

0

82.72

49.41

48.48 - 116.96

14.72 - 164.57

91.68

42.91 - 105.3

Н/П*

Н/П*

8EMTM+PD-1+TIGIT-

Abs_Value

8

8

0

20.07

12.58

11.35 - 28.78

7.32 - 39.52

16.06

11.7 - 24.89

Н/П*

Н/П*

8EMTM+PD-1+TIGIT+

Abs_Value

8

8

0

62.65

40.44

34.63 - 90.68

7.4 - 125.68

67.48

30.29 - 84.25

Н/П*

Н/П*

8EMTM+TIGIT+

Abs_Value

8

8

0

96.72

74.19

45.31 - 148.14

8.24 - 220.12

86.84

34.65 - 150.96

Н/П*

Н/П*

8NV

Abs_Value

8

8

0

58.05

57.22

18.41 - 97.7

8.51 - 189.4

38.1

29.77 - 65.86

Н/П*

Н/П*

8NV(СТАР2)

Abs_Value

8

8

0

62.09

73.13

11.41 - 112.77

4.23 - 232.76

49.11

19.27 - 60.6

Н/П*

Н/П*

8NV+226+

Abs_Value

8

8

0

55.11

73.03

4.5 - 105.72

3.16 - 230.07

39.17

16.6 - 50.78

Н/П*

Н/П*

8NV+39+

Abs_Value

8

8

0

4.26

5.01

0.79 - 7.73

0.15 - 12.88

2.24

0.88 - 5.74

Н/П*

Н/П*

8NV+DR+

Abs_Value

8

8

0

7.12

4.48

4.01 - 10.22

0.28 - 14.07

7.08

5.08 - 9.53

Н/П*

Н/П*

8NV+PD-1-TIGIT-

Abs_Value

8

8

0

50.51

73.06

-0.12 - 101.14

1.58 - 223.18

31.16

6.06 - 46.52

Н/П*

Н/П*

8NV+PD-1-TIGIT+

Abs_Value

8

8

0

2.95

3.36

0.62 - 5.28

0.22 - 10.07

1.38

0.69 - 4.48

Н/П*

Н/П*

8NV+PD-1+

Abs_Value

8

8

0

8.63

6.89

3.86 - 13.41

0.97 - 19.85

5.91

4.14 - 14.06

Н/П*

Н/П*

8NV+PD-1+TIGIT-

Abs_Value

8

8

0

4.43

5.63

0.52 - 8.33

0.01 - 14.25

1.89

0.41 - 6.52

Н/П*

Н/П*

8NV+PD-1+TIGIT+

Abs_Value

8

8

0

4.21

3.64

1.69 - 6.73

0.67 - 11.23

3.44

1.25 - 5.95

Н/П*

Н/П*

8NV+TIGIT+

Abs_Value

8

8

0

7.16

5.53

3.32 - 10.99

0.89 - 17.04

6.64

2.49 - 9.86

Н/П*

Н/П*

8TREG

Abs_Value

8

8

0

545.21

535.4

174.2 - 916.22

63.17 - 1610.29

285.52

252.25 - 701.11

Н/П*

Н/П*

8ЕМ

Abs_Value

8

8

0

126.1

115.45

46.1 - 206.11

11.85 - 355.83

107.95

44.1 - 171.12

Н/П*

Н/П*

8СМ

Abs_Value

8

8

0

25.41

36.82

-0.1 - 50.93

1.27 - 101.48

8.12

4.79 - 25.98

Н/П*

Н/П*

8СМ(СТАР2)

Abs_Value

8

8

0

17.73

22.04

2.46 - 33.01

1.08 - 60.65

7.6

2.54 - 24.44

Н/П*

Н/П*

8СМ+226+

Abs_Value

8

8

0

12.44

16.05

1.32 - 23.56

0.99 - 48.69

6.15

2.15 - 15.5

Н/П*

Н/П*

8СМ+39+

Abs_Value

8

8

0

7.04

15.93

-4 - 18.07

0.16 - 46.33

1.44

0.35 - 3.16

Н/П*

Н/П*

8СМ+DR+

Abs_Value

8

8

0

14.92

19.56

1.36 - 28.47

0.37 - 51.36

5.17

2.11 - 20.71

Н/П*

Н/П*

8СМ+PD-1-TIGIT-

Abs_Value

8

8

0

1.63

1.3

0.73 - 2.53

0.27 - 3.93

1.31

0.61 - 2.23

Н/П*

Н/П*

8СМ+PD-1-TIGIT+

Abs_Value

8

8

0

2.56

3.87

-0.12 - 5.24

0.1 - 10.87

0.92

0.41 - 2.29

Н/П*

Н/П*

8СМ+PD-1+

Abs_Value

8

8

0

13.54

17.72

1.26 - 25.82

0.32 - 50.7

5.37

1.99 - 18.71

Н/П*

Н/П*

8СМ+PD-1+TIGIT-

Abs_Value

8

8

0

0.83

0.89

0.21 - 1.45

0.07 - 2.5

0.39

0.3 - 1.15

Н/П*

Н/П*

8СМ+PD-1+TIGIT+

Abs_Value

8

8

0

12.71

17.22

0.78 - 24.64

0.25 - 48.83

4.73

1.69 - 16.73

Н/П*

Н/П*

8СМ+TIGIT+

Abs_Value

8

8

0

15.27

20.33

1.19 - 29.36

0.38 - 54.85

5.65

1.91 - 20.23

Н/П*

Н/П*

8ТЕ

Abs_Value

8

8

0

526.81

519.95

166.5 - 887.11

93.48 - 1482.15

311.25

217.77 - 578.75

Н/П*

Н/П*

8ТЕ(СТАР2)

Abs_Value

8

8

0

758.43

674.09

291.31 - 1225.55

102.52 - 2054.76

434.61

392.31 - 1019.77

Н/П*

Н/П*

8ТЕ+226+

Abs_Value

8

8

0

671.96

634.86

232.03 - 1111.89

99.94 - 1884.09

365.53

285.22 - 895.47

Н/П*

Н/П*

8ТЕ+39+

Abs_Value

8

8

0

98.34

153.1

-7.75 - 204.43

3.31 - 469.2

52.07

22.93 - 83.65

Н/П*

Н/П*

8ТЕ+DR+

Abs_Value

8

8

0

476.4

443.49

169.08 - 783.72

22.67 - 1449.4

347.41

254.15 - 533.69

Н/П*

Н/П*

8ТЕ+PD-1-TIGIT-

Abs_Value

8

8

0

215.55

257.1

37.39 - 393.71

27.26 - 700.86

96.41

53.34 - 261.11

Н/П*

Н/П*

8ТЕ+PD-1-TIGIT+

Abs_Value

8

8

0

287.16

348.87

45.41 - 528.92

6.1 - 1067.1

161.64

80.81 - 375.23

Н/П*

Н/П*

8ТЕ+PD-1+

Abs_Value

8

8

0

255.71

174.09

135.07 - 376.35

56.75 - 510.33

280.27

73.87 - 389.33

Н/П*

Н/П*

8ТЕ+PD-1+TIGIT-

Abs_Value

8

8

0

58.3

58.42

17.81 - 98.78

9.24 - 196.26

45.46

31.28 - 55.95

Н/П*

Н/П*

8ТЕ+PD-1+TIGIT+

Abs_Value

8

8

0

197.42

137.47

102.15 - 292.68

20.98 - 357.6

223.55

55.71 - 318.96

Н/П*

Н/П*

8ТЕ+TIGIT+

Abs_Value

8

8

0

484.58

411.65

199.32 - 769.84

27.07 - 1300.32

334.3

235.14 - 721.94

Н/П*

Н/П*

8ТМ

Abs_Value

8

8

0

60.95

59.05

20.03 - 101.87

5.98 - 184.39

45.83

15.25 - 85.13

Н/П*

Н/П*

TREG_CM

Abs_Value

8

8

0

3.13

2.18

1.62 - 4.64

0.39 - 6.58

3.11

1.67 - 4.65

Н/П*

Н/П*

TREG_EMTM

Abs_Value

8

8

0

29.53

23.85

13 - 46.06

6.83 - 69.64

18.05

12.58 - 49.74

Н/П*

Н/П*

TREG_NV

Abs_Value

8

8

0

3.25

2.28

1.67 - 4.83

0.25 - 6.33

3.11

1.52 - 5.23

Н/П*

Н/П*

TREG_TE

Abs_Value

8

8

0

7.23

7.34

2.15 - 12.32

0.92 - 21.61

4.92

1.87 - 9.42

Н/П*

Н/П*

TREG+226-TIGIT-

Abs_Value

8

8

0

3.02

2.09

1.58 - 4.47

0.34 - 6.14

2.75

1.39 - 4.23

Н/П*

Н/П*

TREG+226-TIGIT+

Abs_Value

8

8

0

11.51

12.13

3.1 - 19.91

1.18 - 38.88

8.41

4.02 - 13.26

Н/П*

Н/П*

TREG+226+

Abs_Value

8

8

0

28.74

20.29

14.68 - 42.8

7.4 - 58.24

20.17

14.48 - 43.06

Н/П*

Н/П*

TREG+226+TIGIT-

Abs_Value

8

8

0

4.69

2.41

3.02 - 6.36

0.65 - 7.21

5.74

2.69 - 6.14

Н/П*

Н/П*

TREG+226+TIGIT+

Abs_Value

8

8

0

24.05

18.56

11.2 - 36.91

6.75 - 51.84

16.08

10.13 - 36.09

Н/П*

Н/П*

TREG+39+

Abs_Value

8

8

0

26.13

18.4

13.38 - 38.88

6.67 - 62.29

24.03

11.41 - 33.36

Н/П*

Н/П*

TREG+DR+

Abs_Value

8

8

0

30.35

28.97

10.28 - 50.42

4.17 - 87.97

17.23

11.06 - 44.75

Н/П*

Н/П*

TREG+PD-1+

Abs_Value

8

8

0

18.73

16.12

7.57 - 29.9

4.48 - 54.08

14.55

9.46 - 19.64

Н/П*

Н/П*

TREG+TIGIT+

Abs_Value

8

8

0

35.56

28.98

15.48 - 55.65

7.94 - 89.91

23.42

15.76 - 51.2

Н/П*

Н/П*

ДЕНЬ ХРРТПХ +30

4_TFH

Abs_Value

15

15

0

41.42

35.22

23.59 - 59.25

1.88 - 144.19

34.77

19.59 - 48.2

Н/П*

Н/П*

4_TH1

Abs_Value

15

15

0

18.7

11.35

12.96 - 24.44

0.66 - 34.4

17.15

9.34 - 28.6

Н/П*

Н/П*

4_TH17

Abs_Value

15

15

0

27.05

22.76

15.53 - 38.57

3.09 - 89.01

29.2

9.12 - 34.98

Н/П*

Н/П*

4_Th17TO1

Abs_Value

15

15

0

5.5

5

2.97 - 8.03

0.12 - 17.42

3.34

2.54 - 6.4

Н/П*

Н/П*

4_TH2

Abs_Value

15

15

0

32.35

34.88

14.7 - 50

2.05 - 117.68

19.15

12.1 - 29.88

Н/П*

Н/П*

4_TH22

Abs_Value

15

15

0

10.2

8.13

6.09 - 14.32

0.28 - 25.4

8.22

4.08 - 16.88

Н/П*

Н/П*

4+

Abs_Value

15

15

0

113.45

77.06

74.45 - 152.44

12.27 - 279.76

115.34

52.55 - 137.07

Н/П*

Н/П*

4+ (IM STAT)

Abs_Value

15

15

0

83.06

47.94

58.8 - 107.32

4.93 - 174.05

94.04

49.17 - 113.02

Н/П*

Н/П*

4+226+

Abs_Value

15

15

0

258.58

149.29

183.03 - 334.13

16.9 - 520.8

261.93

133.57 - 367.46

Н/П*

Н/П*

4+39+

Abs_Value

15

15

0

60.66

49.31

35.7 - 85.61

7.34 - 160.47

51.07

18.09 - 98.84

Н/П*

Н/П*

4+DR+

Abs_Value

15

15

0

84.97

62.79

53.19 - 116.74

9.79 - 265.5

83.23

48.31 - 108.22

Н/П*

Н/П*

4+PD-1-TIGIT-

Abs_Value

15

15

0

126.96

82.73

85.1 - 168.83

5.65 - 256.76

136.66

45.58 - 192.53

Н/П*

Н/П*

4+PD-1-TIGIT+

Abs_Value

15

15

0

9.1

6.8

5.66 - 12.55

0.42 - 23.61

6.58

4.12 - 14.19

Н/П*

Н/П*

4+PD-1+

Abs_Value

15

15

0

141.17

92.6

94.31 - 188.03

11.98 - 315.97

130.18

76.11 - 198.25

Н/П*

Н/П*

4+PD-1+TIGIT-

Abs_Value

15

15

0

75.02

49.16

50.14 - 99.89

7.35 - 183.9

75.16

37.11 - 95.98

Н/П*

Н/П*

4+PD-1+TIGIT+

Abs_Value

15

15

0

66.15

46.61

42.57 - 89.74

4.63 - 152.42

45.69

36.49 - 103.46

Н/П*

Н/П*

4+TIGIT+

Abs_Value

15

15

0

75.26

51.98

48.95 - 101.56

5.05 - 169.73

56.34

40.61 - 112.97

Н/П*

Н/П*

4NV

Abs_Value

15

15

0

68.83

57.06

39.95 - 97.71

4.02 - 183.37

52.65

22.6 - 99.81

Н/П*

Н/П*

4NV(СТАР2)

Abs_Value

15

15

0

61.97

55.34

33.97 - 89.98

3.41 - 181.45

44.3

19.68 - 93.27

Н/П*

Н/П*

4NV_TH1

Abs_Value

15

15

0

3.96

3.53

2.18 - 5.75

0.17 - 10.34

2.83

0.67 - 6.5

Н/П*

Н/П*

4NV_TH17

Abs_Value

15

15

0

2.14

1.92

1.17 - 3.11

0.28 - 6.27

1.46

0.75 - 2.59

Н/П*

Н/П*

4NV_Th17TO1

Abs_Value

15

15

0

0.38

0.41

0.17 - 0.59

0.01 - 1.64

0.31

0.08 - 0.53

Н/П*

Н/П*

4NV_TH2

Abs_Value

15

15

0

7.94

7.05

4.37 - 11.51

0.44 - 23.62

5.43

1.83 - 14.44

Н/П*

Н/П*

4NV_TH22

Abs_Value

15

15

0

0.12

0.14

0.05 - 0.19

0 - 0.49

0.09

0.02 - 0.14

Н/П*

Н/П*

4NV+226+

Abs_Value

15

15

0

55.53

50.79

29.83 - 81.23

3.06 - 175.11

39.74

17.39 - 84.16

Н/П*

Н/П*

4NV+39+

Abs_Value

15

15

0

1.75

2.76

0.35 - 3.14

0.01 - 11.3

1.08

0.37 - 1.7

Н/П*

Н/П*

4NV+DR+

Abs_Value

15

15

0

3.23

3.9

1.26 - 5.2

0.15 - 13.12

1.81

1.05 - 2.84

Н/П*

Н/П*

4NV+PD-1-TIGIT-

Abs_Value

15

15

0

58.02

53.13

31.13 - 84.9

2.88 - 176.14

41.17

17.05 - 88.71

Н/П*

Н/П*

4NV+PD-1-TIGIT+

Abs_Value

15

15

0

1.07

1.18

0.47 - 1.66

0.08 - 4.15

0.68

0.23 - 1.59

Н/П*

Н/П*

4NV+PD-1+TIGIT-

Abs_Value

15

15

0

2.03

2.76

0.64 - 3.43

0.09 - 11.35

1.28

0.72 - 2.04

Н/П*

Н/П*

4NV+PD-1+TIGIT+

Abs_Value

15

15

0

0.86

0.73

0.49 - 1.22

0.08 - 2.32

0.66

0.43 - 1.16

Н/П*

Н/П*

4NV+PD1+

Abs_Value

15

15

0

2.89

3.29

1.22 - 4.56

0.17 - 13.68

1.81

1.35 - 3.46

Н/П*

Н/П*

4NV+TIGIT+

Abs_Value

15

15

0

1.92

1.87

0.98 - 2.87

0.16 - 6.48

1.36

0.74 - 2.73

Н/П*

Н/П*

4ЕМ

Abs_Value

15

15

0

8.01

9.16

3.37 - 12.65

0.03 - 29.57

3.27

2.21 - 14.05

Н/П*

Н/П*

4ЕМ_TH1

Abs_Value

15

15

0

1.58

1.93

0.6 - 2.55

0.01 - 6.46

1.04

0.52 - 1.68

Н/П*

Н/П*

4ЕМ_TH17

Abs_Value

15

15

0

0.14

0.47

-0.1 - 0.38

0 - 1.83

0

0 - 0.03

Н/П*

Н/П*

4ЕМ_Th17TO1

Abs_Value

15

15

0

0.09

0.13

0.02 - 0.16

0 - 0.54

0.06

0.01 - 0.09

Н/П*

Н/П*

4ЕМ_TH2

Abs_Value

15

15

0

1.2

3.96

-0.8 - 3.2

0.01 - 15.48

0.08

0.04 - 0.29

Н/П*

Н/П*

4ЕМ_TH22

Abs_Value

15

15

0

0

0.01

0 - 0.01

0 - 0.02

0

0 - 0

Н/П*

Н/П*

4ЕМ+226+

Abs_Value

15

15

0

117.34

79.32

77.19 - 157.48

6.84 - 253.96

92.56

50.54 - 178.57

Н/П*

Н/П*

4ЕМ+39+

Abs_Value

15

15

0

37.54

33.1

20.79 - 54.29

4.45 - 111.55

28.6

11.75 - 57.97

Н/П*

Н/П*

4ЕМ+DR+

Abs_Value

15

15

0

57.12

45.75

33.97 - 80.27

4.57 - 188.94

47.84

28.28 - 73.33

Н/П*

Н/П*

4ЕМ+PD1-TIGIT-

Abs_Value

15

15

0

32.35

27.25

18.56 - 46.13

0.6 - 91.12

36.85

8.89 - 47.51

Н/П*

Н/П*

4ЕМ+PD1-TIGIT+

Abs_Value

15

15

0

3.44

2.85

2 - 4.88

0.08 - 9.64

2.2

1.27 - 5.62

Н/П*

Н/П*

4ЕМ+PD1+

Abs_Value

15

15

0

87.7

57.65

58.53 - 116.87

6.41 - 195.8

79.37

42.57 - 133.07

Н/П*

Н/П*

4ЕМ+PD1+TIGIT-

Abs_Value

15

15

0

48.54

31.01

32.84 - 64.23

4.01 - 115.09

45.93

23.82 - 71.85

Н/П*

Н/П*

4ЕМ+PD1+TIGIT+

Abs_Value

15

15

0

39.16

28.54

24.72 - 53.61

2.39 - 80.71

28.76

15.72 - 70.77

Н/П*

Н/П*

4ЕМ+TIGIT+

Abs_Value

15

15

0

42.6

30.6

27.12 - 58.09

2.47 - 88.33

29.75

17.11 - 74.95

Н/П*

Н/П*

4ЕМTM

Abs_Value

15

15

0

123.49

83.06

81.45 - 165.52

7.08 - 263.87

97.56

55.67 - 186.59

Н/П*

Н/П*

4СМ

Abs_Value

15

15

0

72.69

52.49

46.12 - 99.25

6.84 - 182.94

64.37

31.44 - 103.84

Н/П*

Н/П*

4СМ(СТАР2)

Abs_Value

15

15

0

59.44

43.19

37.59 - 81.3

3.79 - 156.19

53.43

30.31 - 83.44

Н/П*

Н/П*

4СМ_TH1

Abs_Value

15

15

0

2.57

2.12

1.5 - 3.64

0.18 - 6.72

2.27

0.7 - 3.4

Н/П*

Н/П*

4СМ_TH17

Abs_Value

15

15

0

10.25

7.2

6.61 - 13.89

1.53 - 20.35

10.12

3.42 - 16.88

Н/П*

Н/П*

4СМ_Th17TO1

Abs_Value

15

15

0

1.09

1.3

0.44 - 1.75

0.04 - 4.95

0.57

0.5 - 1.03

Н/П*

Н/П*

4СМ_TH2

Abs_Value

15

15

0

7.94

10.63

2.56 - 13.32

0.53 - 43.16

5.73

1.69 - 8.08

Н/П*

Н/П*

4СМ_TH22

Abs_Value

15

15

0

1.21

1.35

0.52 - 1.89

0.09 - 5.05

0.66

0.21 - 1.6

Н/П*

Н/П*

4СМ+226+

Abs_Value

15

15

0

56.63

41.5

35.63 - 77.64

3.54 - 150.99

51.16

28.19 - 79.37

Н/П*

Н/П*

4СМ+39+

Abs_Value

15

15

0

16.23

16.63

7.81 - 24.65

0.32 - 63.2

15.74

4.09 - 21.21

Н/П*

Н/П*

4СМ+DR+

Abs_Value

15

15

0

11.87

9.36

7.13 - 16.61

0.74 - 30.47

11.86

4.41 - 16.27

Н/П*

Н/П*

4СМ+PD1-TIGIT-

Abs_Value

15

15

0

23.04

16.45

14.71 - 31.36

0.98 - 52.58

23.91

7.34 - 33.86

Н/П*

Н/П*

4СМ+PD1-TIGIT+

Abs_Value

15

15

0

2.64

2.07

1.59 - 3.69

0.1 - 6.56

2.19

0.98 - 3.81

Н/П*

Н/П*

4СМ+PD1+

Abs_Value

15

15

0

33.77

29.24

18.97 - 48.57

2.28 - 112.1

25.79

15.5 - 40.13

Н/П*

Н/П*

4СМ+PD1+TIGIT-

Abs_Value

15

15

0

14.41

12.54

8.06 - 20.76

1.16 - 43.45

10.48

6.3 - 19.55

Н/П*

Н/П*

4СМ+PD1+TIGIT+

Abs_Value

15

15

0

19.36

17.82

10.34 - 28.38

1.13 - 68.65

14.97

9.62 - 21.95

Н/П*

Н/П*

4СМ+TIGIT+

Abs_Value

15

15

0

22

19.34

12.21 - 31.79

1.33 - 75.21

16.36

13.43 - 24.87

Н/П*

Н/П*

4ТM_TH1

Abs_Value

15

15

0

6.89

5.17

4.28 - 9.51

0.2 - 15.48

5.33

3.2 - 10.96

Н/П*

Н/П*

4ТM_TH17

Abs_Value

15

15

0

13.31

15.17

5.64 - 20.99

0.71 - 55.73

10.63

3.85 - 13.15

Н/П*

Н/П*

4ТM_Th17TO1

Abs_Value

15

15

0

3.4

3.05

1.85 - 4.94

0.05 - 9.26

2.18

1.5 - 4.78

Н/П*

Н/П*

4ТM_TH2

Abs_Value

15

15

0

13.23

22.12

2.04 - 24.43

0.25 - 77.73

3.24

1.25 - 10.52

Н/П*

Н/П*

4ТM_TH22

Abs_Value

15

15

0

7.99

7.02

4.43 - 11.54

0.09 - 23.06

5.64

2.71 - 13.79

Н/П*

Н/П*

4ТREG

Abs_Value

15

15

0

4.6

4.45

2.35 - 6.85

0.4 - 16.67

3.82

1.9 - 5.07

Н/П*

Н/П*

4ТREG(СТАР2)

Abs_Value

15

15

0

115.61

78.89

75.68 - 155.53

12.1 - 286.85

117.64

52.03 - 141.84

Н/П*

Н/П*

4ТREG_TH1

Abs_Value

15

15

0

0.29

0.22

0.17 - 0.4

0.01 - 0.75

0.25

0.11 - 0.48

Н/П*

Н/П*

4ТREG_TH17

Abs_Value

15

15

0

7.04

7.91

3.04 - 11.05

0.53 - 24.8

3.6

2.5 - 6.65

Н/П*

Н/П*

4ТREG_Th17TO1

Abs_Value

15

15

0

0.1

0.11

0.05 - 0.15

0 - 0.34

0.06

0.02 - 0.16

Н/П*

Н/П*

4ТREG_TH2

Abs_Value

15

15

0

4.32

5.41

1.59 - 7.06

0.18 - 18.49

2.52

1.77 - 3.33

Н/П*

Н/П*

4ТREG_TH22

Abs_Value

15

15

0

6.24

5.63

3.39 - 9.09

0.48 - 19.57

5

1.79 - 7.33

Н/П*

Н/П*

4ТЕ

Abs_Value

15

15

0

5.88

8.77

1.44 - 10.32

0.02 - 33.66

3.33

0.28 - 7.82

Н/П*

Н/П*

4ТЕ(СТАР2)

Abs_Value

15

15

0

31.57

20.83

21.03 - 42.11

3.14 - 68.2

27.41

20.69 - 43.27

Н/П*

Н/П*

4ТЕ_TH1

Abs_Value

15

15

0

1.51

2.07

0.47 - 2.56

0.01 - 6.53

0.37

0.06 - 2.29

Н/П*

Н/П*

4ТЕ_TH17

Abs_Value

15

15

0

0.01

0.03

0 - 0.02

0 - 0.1

0

0 - 0.01

Н/П*

Н/П*

4ТЕ_Th17TO1

Abs_Value

15

15

0

0.05

0.08

0.01 - 0.1

0 - 0.26

0.01

0 - 0.08

Н/П*

Н/П*

4ТЕ_TH2

Abs_Value

15

15

0

0.14

0.18

0.05 - 0.23

0 - 0.61

0.07

0 - 0.23

Н/П*

Н/П*

4ТЕ_TH22

Abs_Value

15

15

0

0.01

0.02

0 - 0.02

0 - 0.06

0

0 - 0.01

Н/П*

Н/П*

4ТЕ+226+

Abs_Value

15

15

0

28.47

18.77

18.97 - 37.97

2.9 - 61.52

24.82

18.55 - 41

Н/П*

Н/П*

4ТЕ+39+

Abs_Value

15

15

0

5.25

3.92

3.26 - 7.23

0.69 - 13.77

4.75

1.81 - 7.46

Н/П*

Н/П*

4ТЕ+DR+

Abs_Value

15

15

0

12.88

9.8

7.92 - 17.84

0.58 - 35.94

11.91

4.58 - 18.14

Н/П*

Н/П*

4ТЕ+PD-1-TIGIT-

Abs_Value

15

15

0

12.52

10.11

7.4 - 17.63

0.87 - 37.08

10.68

7.43 - 14.06

Н/П*

Н/П*

4ТЕ+PD-1-TIGIT+

Abs_Value

15

15

0

1.89

1.74

1.01 - 2.77

0.07 - 7.04

1.41

0.78 - 2.42

Н/П*

Н/П*

4ТЕ+PD-1+

Abs_Value

15

15

0

17.17

12.94

10.62 - 23.72

1.5 - 42.91

15.16

8.07 - 20.76

Н/П*

Н/П*

4ТЕ+PD-1+TIGIT-

Abs_Value

15

15

0

10.15

8.57

5.81 - 14.49

0.74 - 31.83

7.39

4 - 15.3

Н/П*

Н/П*

4ТЕ+PD-1+TIGIT+

Abs_Value

15

15

0

7.01

5.67

4.14 - 9.88

0.76 - 22.71

6.36

4.24 - 7.37

Н/П*

Н/П*

4ТЕ+TIGIT+

Abs_Value

15

15

0

8.9

7.28

5.22 - 12.59

0.88 - 29.75

7.6

5.02 - 10.38

Н/П*

Н/П*

4ТМ

Abs_Value

15

15

0

110.74

77.46

71.54 - 149.94

5 - 226.12

88.73

45.16 - 173.91

Н/П*

Н/П*

8+

Abs_Value

15

15

0

454.96

301.52

302.37 - 607.55

23.55 - 922.88

549.84

163.75 - 673.27

Н/П*

Н/П*

8+ (IM STAT)

Abs_Value

15

15

0

585.72

390.28

388.21 - 783.23

24.94 - 1331.74

688.88

220.35 - 851.78

Н/П*

Н/П*

8+226+

Abs_Value

15

15

0

735.7

486.29

489.6 - 981.79

38.86 - 1789.01

825.43

303.22 - 983.5

Н/П*

Н/П*

8+39+

Abs_Value

15

15

0

114.39

114.56

56.41 - 172.36

16.66 - 357.72

41.29

24.39 - 183.7

Н/П*

Н/П*

8+DR+

Abs_Value

15

15

0

575.11

408.95

368.15 - 782.06

42.24 - 1466.62

593.7

229.91 - 684.66

Н/П*

Н/П*

8+PD-1-TIGIT-

Abs_Value

15

15

0

251.97

184.25

158.73 - 345.21

11.27 - 622.7

261.4

86.93 - 385.69

Н/П*

Н/П*

8+PD-1-TIGIT+

Abs_Value

15

15

0

242.39

172.19

155.25 - 329.53

8.34 - 526.18

205.45

92.47 - 382.59

Н/П*

Н/П*

8+PD-1+

Abs_Value

15

15

0

354.74

310.4

197.66 - 511.83

17.27 - 1087.66

309.38

134.94 - 539.92

Н/П*

Н/П*

8+PD-1+TIGIT-

Abs_Value

15

15

0

123.02

146.03

49.11 - 196.92

2.82 - 534.79

60.17

29.02 - 171.1

Н/П*

Н/П*

8+PD-1+TIGIT+

Abs_Value

15

15

0

231.73

193.18

133.96 - 329.49

14.46 - 610.79

129.1

105.33 - 354.03

Н/П*

Н/П*

8+TIGIT+

Abs_Value

15

15

0

474.11

307.19

318.66 - 629.57

37.05 - 948.67

494.17

217.71 - 739.83

Н/П*

Н/П*

8EMTM

Abs_Value

15

15

0

129.44

92.83

82.46 - 176.42

1.08 - 323.39

126.6

59.22 - 174.2

Н/П*

Н/П*

8EMTM+226+

Abs_Value

15

15

0

102.37

66.2

68.87 - 135.87

0.93 - 235.61

114.55

49.95 - 145.93

Н/П*

Н/П*

8EMTM+39+

Abs_Value

15

15

0

27.9

31.46

11.98 - 43.82

0.67 - 104.21

14.41

5.84 - 41.03

Н/П*

Н/П*

8EMTM+DR+

Abs_Value

15

15

0

104.25

73.16

67.22 - 141.27

0.9 - 274.76

100.99

55.05 - 136.05

Н/П*

Н/П*

8EMTM+PD-1-TIGIT-

Abs_Value

15

15

0

23.96

15.74

15.99 - 31.93

0.14 - 48.43

28.99

10.71 - 32.49

Н/П*

Н/П*

8EMTM+PD-1-TIGIT+

Abs_Value

15

15

0

27.07

30.9

11.43 - 42.71

0.05 - 97

13.96

6.64 - 40.15

Н/П*

Н/П*

8EMTM+PD-1+

Abs_Value

15

15

0

78.41

59.13

48.49 - 108.34

0.88 - 195.42

71.52

43.76 - 92.46

Н/П*

Н/П*

8EMTM+PD-1+TIGIT-

Abs_Value

15

15

0

23.48

20.37

13.17 - 33.79

0.31 - 69.43

19.83

6.65 - 34.68

Н/П*

Н/П*

8EMTM+PD-1+TIGIT+

Abs_Value

15

15

0

54.93

47.52

30.88 - 78.98

0.58 - 163.69

42.61

29.39 - 68.04

Н/П*

Н/П*

8EMTM+TIGIT+

Abs_Value

15

15

0

82

74.15

44.47 - 119.53

0.63 - 226.09

54.58

32.91 - 131.91

Н/П*

Н/П*

8NV

Abs_Value

15

15

0

32.09

27.63

18.11 - 46.08

4.86 - 82.24

20.92

9.56 - 48.01

Н/П*

Н/П*

8NV(СТАР2)

Abs_Value

15

15

0

34.3

28.76

19.74 - 48.85

2.72 - 93.55

24.99

6.57 - 58.3

Н/П*

Н/П*

8NV+226+

Abs_Value

15

15

0

29.83

25.73

16.8 - 42.85

2.36 - 87.03

24.46

5.45 - 49.76

Н/П*

Н/П*

8NV+39+

Abs_Value

15

15

0

3.41

4.89

0.93 - 5.88

0 - 17.8

1.14

0.37 - 4.4

Н/П*

Н/П*

8NV+DR+

Abs_Value

15

15

0

5.06

6

2.02 - 8.09

0.27 - 21.82

2.96

1.32 - 5.7

Н/П*

Н/П*

8NV+PD-1-TIGIT-

Abs_Value

15

15

0

27.14

26.38

13.79 - 40.49

0.86 - 90.53

19.82

5.58 - 46.88

Н/П*

Н/П*

8NV+PD-1-TIGIT+

Abs_Value

15

15

0

2.26

2.32

1.08 - 3.43

0.19 - 8.04

1.63

0.54 - 3.45

Н/П*

Н/П*

8NV+PD-1+

Abs_Value

15

15

0

4.9

7.29

1.21 - 8.59

0.09 - 25.44

1.31

0.74 - 5.67

Н/П*

Н/П*

8NV+PD-1+TIGIT-

Abs_Value

15

15

0

1.18

1.9

0.22 - 2.14

0.01 - 6.86

0.32

0.09 - 1.31

Н/П*

Н/П*

8NV+PD-1+TIGIT+

Abs_Value

15

15

0

3.71

5.8

0.78 - 6.65

0.08 - 21.78

1.01

0.62 - 4.05

Н/П*

Н/П*

8NV+TIGIT+

Abs_Value

15

15

0

5.97

6.65

2.61 - 9.34

0.35 - 25.67

3.22

1.54 - 8.12

Н/П*

Н/П*

8TREG

Abs_Value

15

15

0

445.89

292.69

297.77 - 594.01

20.46 - 892.2

544.62

162.87 - 665.11

Н/П*

Н/П*

8ЕМ

Abs_Value

15

15

0

92.33

61.79

61.06 - 123.6

0.5 - 229.56

93.55

43.05 - 128.36

Н/П*

Н/П*

8СМ

Abs_Value

15

15

0

21.45

27.26

7.65 - 35.24

0.61 - 77.79

8.32

4.62 - 24.69

Н/П*

Н/П*

8СМ(СТАР2)

Abs_Value

15

15

0

18.25

24.46

5.87 - 30.62

0.4 - 85.81

7.24

2.61 - 25.28

Н/П*

Н/П*

8СМ+226+

Abs_Value

15

15

0

12.81

17.04

4.18 - 21.43

0.36 - 60.98

6.43

2.05 - 15.28

Н/П*

Н/П*

8СМ+39+

Abs_Value

15

15

0

6.38

10.39

1.12 - 11.64

0.12 - 32.91

1.15

0.4 - 6.79

Н/П*

Н/П*

8СМ+DR+

Abs_Value

15

15

0

14.68

19.65

4.74 - 24.63

0.17 - 63.4

4.51

2.17 - 22.39

Н/П*

Н/П*

8СМ+PD-1-TIGIT-

Abs_Value

15

15

0

2.85

3.95

0.85 - 4.85

0.03 - 15.83

1.77

0.64 - 2.93

Н/П*

Н/П*

8СМ+PD-1-TIGIT+

Abs_Value

15

15

0

3.4

4.78

0.99 - 5.82

0.07 - 18.1

1.05

0.32 - 5.38

Н/П*

Н/П*

8СМ+PD-1+

Abs_Value

15

15

0

11.99

16.71

3.53 - 20.45

0.15 - 51.89

4

1.51 - 15.08

Н/П*

Н/П*

8СМ+PD-1+TIGIT-

Abs_Value

15

15

0

1.24

1.7

0.38 - 2.1

0.02 - 6.29

0.57

0.13 - 1.91

Н/П*

Н/П*

8СМ+PD-1+TIGIT+

Abs_Value

15

15

0

10.75

15.28

3.02 - 18.49

0.12 - 48.73

2.14

1.38 - 13.8

Н/П*

Н/П*

8СМ+TIGIT+

Abs_Value

15

15

0

14.16

19.6

4.24 - 24.08

0.2 - 66.83

4.86

2.03 - 20.16

Н/П*

Н/П*

8ТЕ

Abs_Value

15

15

0

481.07

361.97

297.88 - 664.25

6.43 - 1353.64

461.4

190.67 - 655.26

Н/П*

Н/П*

8ТЕ(СТАР2)

Abs_Value

15

15

0

664.73

461.52

431.16 - 898.29

56.16 - 1732.27

718.48

241.65 - 862.68

Н/П*

Н/П*

8ТЕ+226+

Abs_Value

15

15

0

588.82

441.14

365.57 - 812.07

33.24 - 1657.11

649.69

210.33 - 738.66

Н/П*

Н/П*

8ТЕ+39+

Abs_Value

15

15

0

76.43

77.61

37.16 - 115.71

12.62 - 275.32

36.22

15.97 - 128.88

Н/П*

Н/П*

8ТЕ+DR+

Abs_Value

15

15

0

450.51

368.94

263.8 - 637.22

39.8 - 1367.91

434.18

172.47 - 533.54

Н/П*

Н/П*

8ТЕ+PD-1-TIGIT-

Abs_Value

15

15

0

197.21

165.31

113.55 - 280.86

7.02 - 566.21

180.62

47.02 - 306.88

Н/П*

Н/П*

8ТЕ+PD-1-TIGIT+

Abs_Value

15

15

0

208.78

145.39

135.2 - 282.36

7.47 - 439.67

188.42

79.03 - 308.92

Н/П*

Н/П*

8ТЕ+PD-1+

Abs_Value

15

15

0

258.74

270.88

121.66 - 395.82

15.97 - 1004.7

215.94

72.21 - 321.98

Н/П*

Н/П*

8ТЕ+PD-1+TIGIT-

Abs_Value

15

15

0

97.06

132.41

30.05 - 164.06

2.47 - 498.86

43.16

15.49 - 123.69

Н/П*

Н/П*

8ТЕ+PD-1+TIGIT+

Abs_Value

15

15

0

161.68

155.73

82.87 - 240.5

13.5 - 505.84

83.47

58.05 - 198.7

Н/П*

Н/П*

8ТЕ+TIGIT+

Abs_Value

15

15

0

370.46

242.29

247.85 - 493.08

30.75 - 687.19

449

158.04 - 566.74

Н/П*

Н/П*

8ТМ

Abs_Value

15

15

0

59.34

51.96

33.04 - 85.64

1.32 - 166.73

42.86

21.57 - 82.19

Н/П*

Н/П*

TREG_CM

Abs_Value

15

15

0

2.08

1.6

1.27 - 2.89

0.16 - 5.88

1.61

0.95 - 3.23

Н/П*

Н/П*

TREG_EMTM

Abs_Value

15

15

0

29.34

25.6

16.39 - 42.3

1.8 - 84.82

25.51

11.82 - 34.09

Н/П*

Н/П*

TREG_NV

Abs_Value

15

15

0

1.88

1.65

1.04 - 2.71

0.08 - 4.93

1.29

0.54 - 3.14

Н/П*

Н/П*

TREG_TE

Abs_Value

15

15

0

4.65

3.51

2.87 - 6.42

0.61 - 11.35

3.75

2.05 - 5.65

Н/П*

Н/П*

TREG+226-TIGIT-

Abs_Value

15

15

0

1.81

1.59

1 - 2.62

0.1 - 5.34

1.12

1.01 - 2.25

Н/П*

Н/П*

TREG+226-TIGIT+

Abs_Value

15

15

0

7.69

6.68

4.31 - 11.07

0.59 - 26.4

5.69

3.99 - 11.05

Н/П*

Н/П*

TREG+226+

Abs_Value

15

15

0

28.52

23.47

16.64 - 40.4

2.17 - 75.68

24.5

13.63 - 29.7

Н/П*

Н/П*

TREG+226+TIGIT-

Abs_Value

15

15

0

2.89

1.74

2.01 - 3.77

0.17 - 7.07

3.06

1.71 - 3.51

Н/П*

Н/П*

TREG+226+TIGIT+

Abs_Value

15

15

0

25.63

22.38

14.3 - 36.96

2 - 69.16

21.31

10.97 - 26.56

Н/П*

Н/П*

TREG+39+

Abs_Value

15

15

0

25.07

18.82

15.55 - 34.6

2.7 - 79.85

18.08

15.1 - 30.32

Н/П*

Н/П*

TREG+DR+

Abs_Value

15

15

0

29.17

24.94

16.55 - 41.79

2.49 - 88.09

23.93

13.72 - 33.11

Н/П*

Н/П*

TREG+PD-1+

Abs_Value

15

15

0

18.76

20.3

8.49 - 29.03

1.91 - 63.74

7.76

5.51 - 20.16

Н/П*

Н/П*

TREG+TIGIT+

Abs_Value

15

15

0

33.32

27.8

19.25 - 47.39

2.59 - 95.01

29.17

14.94 - 37.72

Н/П*

Н/П*

ДЕНЬ ХРРТПХ +60

4_TFH

Abs_Value

11

11

0

28.68

15.62

19.45 - 37.91

3.33 - 54.11

28.46

19.56 - 37.1

Н/П*

Н/П*

4_TH1

Abs_Value

11

11

0

35.88

30.33

17.95 - 53.81

4.85 - 102.42

24.35

17.37 - 50.66

Н/П*

Н/П*

4_TH17

Abs_Value

11

11

0

16.99

8.94

11.71 - 22.27

5.06 - 31.95

14.47

11.07 - 22.14

Н/П*

Н/П*

4_Th17TO1

Abs_Value

11

11

0

5.93

3.78

3.7 - 8.16

0.57 - 14.51

5.47

3.56 - 8.08

Н/П*

Н/П*

4_TH2

Abs_Value

11

11

0

23.51

26.51

7.84 - 39.18

3.06 - 91.26

12.68

8.27 - 24.48

Н/П*

Н/П*

4_TH22

Abs_Value

11

11

0

7.43

7.7

2.87 - 11.98

0.89 - 23.85

4.44

1.81 - 8.44

Н/П*

Н/П*

4+

Abs_Value

11

11

0

143.45

110.14

78.36 - 208.54

18.83 - 343.47

103.46

76.62 - 181.02

Н/П*

Н/П*

4+ (IM STAT)

Abs_Value

11

11

0

107.12

91.74

52.91 - 161.34

9 - 338.01

96.04

49.64 - 120.74

Н/П*

Н/П*

4+226+

Abs_Value

11

11

0

295.97

201.02

177.18 - 414.77

52.17 - 682.45

246.62

161.27 - 388.47

Н/П*

Н/П*

4+39+

Abs_Value

11

11

0

56.6

45.2

29.89 - 83.31

4.61 - 145.64

66.4

16.69 - 76.04

Н/П*

Н/П*

4+DR+

Abs_Value

11

11

0

88.9

67.23

49.17 - 128.63

8.23 - 193.07

71.11

34.8 - 139.33

Н/П*

Н/П*

4+PD-1-TIGIT-

Abs_Value

11

11

0

169.02

167.56

70 - 268.04

14.91 - 537.94

125.88

45.31 - 244.85

Н/П*

Н/П*

4+PD-1-TIGIT+

Abs_Value

11

11

0

10.29

9.13

4.89 - 15.68

0.63 - 31.44

8.82

3.66 - 14.76

Н/П*

Н/П*

4+PD-1+

Abs_Value

11

11

0

138.29

71.58

95.99 - 180.59

31.78 - 262.8

132.83

96.83 - 170.43

Н/П*

Н/П*

4+PD-1+TIGIT-

Abs_Value

11

11

0

83.27

52.91

52.01 - 114.54

23.07 - 198.47

79.56

45.64 - 98.1

Н/П*

Н/П*

4+PD-1+TIGIT+

Abs_Value

11

11

0

55.01

24.32

40.64 - 69.39

8.71 - 95.48

53.46

45.38 - 69.83

Н/П*

Н/П*

4+TIGIT+

Abs_Value

11

11

0

65.3

30.88

47.05 - 83.55

9.38 - 126.92

64.95

55 - 74.97

Н/П*

Н/П*

4NV

Abs_Value

11

11

0

94

128.87

17.84 - 170.15

6.21 - 420.64

45.02

11.53 - 100.8

Н/П*

Н/П*

4NV(СТАР2)

Abs_Value

11

11

0

97.76

149.09

9.65 - 185.86

1.3 - 510.77

49.15

8.92 - 96.81

Н/П*

Н/П*

4NV_TH1

Abs_Value

11

11

0

6.91

9.37

1.37 - 12.44

0.25 - 29.1

3.44

0.76 - 7.04

Н/П*

Н/П*

4NV_TH17

Abs_Value

11

11

0

1.98

1.99

0.8 - 3.16

0.16 - 6.19

1.44

0.51 - 2.58

Н/П*

Н/П*

4NV_Th17TO1

Abs_Value

11

11

0

0.69

0.68

0.28 - 1.09

0 - 1.82

0.46

0.1 - 1.17

Н/П*

Н/П*

4NV_TH2

Abs_Value

11

11

0

8.76

13.32

0.89 - 16.63

0.21 - 40.56

2.29

1.3 - 7.28

Н/П*

Н/П*

4NV_TH22

Abs_Value

11

11

0

0.15

0.19

0.04 - 0.27

0 - 0.62

0.06

0.03 - 0.18

Н/П*

Н/П*

4NV+226+

Abs_Value

11

11

0

87.24

146.03

0.94 - 173.54

1.18 - 502.6

42.25

7.16 - 82.61

Н/П*

Н/П*

4NV+39+

Abs_Value

11

11

0

1.66

1.79

0.6 - 2.72

0.02 - 4.32

0.51

0.12 - 3.09

Н/П*

Н/П*

4NV+DR+

Abs_Value

11

11

0

2.91

2.8

1.25 - 4.56

0.06 - 7.64

3.2

0.27 - 4.87

Н/П*

Н/П*

4NV+PD-1-TIGIT-

Abs_Value

11

11

0

91.34

140.61

8.25 - 174.44

1.08 - 481.6

45.15

7.96 - 89.58

Н/П*

Н/П*

4NV+PD-1-TIGIT+

Abs_Value

11

11

0

2.58

3.72

0.37 - 4.78

0 - 11.49

1.13

0.18 - 2.86

Н/П*

Н/П*

4NV+PD-1+TIGIT-

Abs_Value

11

11

0

2.39

3.59

0.27 - 4.51

0.15 - 12.43

1.02

0.42 - 2.62

Н/П*

Н/П*

4NV+PD-1+TIGIT+

Abs_Value

11

11

0

1.45

1.57

0.52 - 2.37

0.03 - 5.24

1.15

0.28 - 2.18

Н/П*

Н/П*

4NV+PD1+

Abs_Value

11

11

0

3.84

5.01

0.88 - 6.8

0.21 - 17.68

2.86

0.75 - 4.59

Н/П*

Н/П*

4NV+TIGIT+

Abs_Value

11

11

0

4.02

5.04

1.05 - 7

0.03 - 16.74

2.98

0.44 - 4.8

Н/П*

Н/П*

4ЕМ

Abs_Value

11

11

0

23.6

38.73

0.72 - 46.49

0.38 - 135.76

6.94

4.53 - 24.3

Н/П*

Н/П*

4ЕМ_TH1

Abs_Value

11

11

0

8.99

12.65

1.52 - 16.47

0.08 - 41.51

3.69

0.85 - 12.85

Н/П*

Н/П*

4ЕМ_TH17

Abs_Value

11

11

0

0.02

0.03

0 - 0.04

0 - 0.11

0.01

0 - 0.04

Н/П*

Н/П*

4ЕМ_Th17TO1

Abs_Value

11

11

0

0.18

0.21

0.05 - 0.3

0.01 - 0.61

0.05

0.03 - 0.32

Н/П*

Н/П*

4ЕМ_TH2

Abs_Value

11

11

0

1.32

3.66

-0.85 - 3.48

0.01 - 12.33

0.23

0.1 - 0.35

Н/П*

Н/П*

4ЕМ_TH22

Abs_Value

11

11

0

0

0

0 - 0.01

0 - 0.01

0

0 - 0.01

Н/П*

Н/П*

4ЕМ+226+

Abs_Value

11

11

0

112.6

58.93

77.78 - 147.43

36.25 - 233.28

115.17

67.72 - 144.4

Н/П*

Н/П*

4ЕМ+39+

Abs_Value

11

11

0

33.27

23.41

19.43 - 47.11

3.55 - 66.1

32.47

14.72 - 53.53

Н/П*

Н/П*

4ЕМ+DR+

Abs_Value

11

11

0

59.19

49.1

30.17 - 88.21

7.54 - 169.88

45.31

22.39 - 86.64

Н/П*

Н/П*

4ЕМ+PD1-TIGIT-

Abs_Value

11

11

0

29.45

24.24

15.13 - 43.78

5.75 - 67.06

17.26

11.39 - 49.37

Н/П*

Н/П*

4ЕМ+PD1-TIGIT+

Abs_Value

11

11

0

2.69

1.88

1.58 - 3.8

0.32 - 5.74

3.05

0.98 - 4.2

Н/П*

Н/П*

4ЕМ+PD1+

Abs_Value

11

11

0

84.6

55

52.1 - 117.11

28.52 - 229.28

75.61

50.19 - 100.5

Н/П*

Н/П*

4ЕМ+PD1+TIGIT-

Abs_Value

11

11

0

54.13

44.26

27.97 - 80.29

21.05 - 175.37

43.85

24.53 - 62.18

Н/П*

Н/П*

4ЕМ+PD1+TIGIT+

Abs_Value

11

11

0

30.47

13.79

22.32 - 38.62

7.43 - 53.91

31.76

23.22 - 34.75

Н/П*

Н/П*

4ЕМ+TIGIT+

Abs_Value

11

11

0

33.16

13.77

25.02 - 41.29

7.96 - 54.23

35.86

25.41 - 39.15

Н/П*

Н/П*

4ЕМTM

Abs_Value

11

11

0

116.74

58.8

81.99 - 151.5

39.04 - 235.35

118.96

70.64 - 149.95

Н/П*

Н/П*

4СМ

Abs_Value

11

11

0

82.27

64.92

43.9 - 120.63

6.36 - 204.91

96.73

26.33 - 114.43

Н/П*

Н/П*

4СМ(СТАР2)

Abs_Value

11

11

0

65.12

54.23

33.07 - 97.16

5.4 - 150.09

69.58

12.28 - 95.96

Н/П*

Н/П*

4СМ_TH1

Abs_Value

11

11

0

4.48

6.89

0.4 - 8.55

0.17 - 24.29

2.37

1.2 - 3.37

Н/П*

Н/П*

4СМ_TH17

Abs_Value

11

11

0

7.88

6.56

4 - 11.76

1.54 - 20.3

4.17

2.85 - 12.14

Н/П*

Н/П*

4СМ_Th17TO1

Abs_Value

11

11

0

1.69

1.82

0.61 - 2.76

0.01 - 5.86

1

0.51 - 2.18

Н/П*

Н/П*

4СМ_TH2

Abs_Value

11

11

0

8.01

11.02

1.5 - 14.52

0.84 - 37.81

2.11

1.93 - 9.41

Н/П*

Н/П*

4СМ_TH22

Abs_Value

11

11

0

1.64

2.41

0.22 - 3.07

0.02 - 7.61

0.49

0.24 - 2.1

Н/П*

Н/П*

4СМ+226+

Abs_Value

11

11

0

61.44

51.86

30.79 - 92.08

4.91 - 144.32

63.53

11.59 - 91.57

Н/П*

Н/П*

4СМ+39+

Abs_Value

11

11

0

15.09

17.6

4.69 - 25.49

0.26 - 50.51

6.36

0.91 - 24.68

Н/П*

Н/П*

4СМ+DR+

Abs_Value

11

11

0

11.87

11.99

4.78 - 18.96

0.3 - 29.76

4.52

3.34 - 23.4

Н/П*

Н/П*

4СМ+PD1-TIGIT-

Abs_Value

11

11

0

30.48

28.97

13.36 - 47.6

2.17 - 79.64

31.41

4.29 - 50.23

Н/П*

Н/П*

4СМ+PD1-TIGIT+

Abs_Value

11

11

0

2.83

3.02

1.05 - 4.62

0.04 - 9.53

2.72

0.64 - 3.35

Н/П*

Н/П*

4СМ+PD1+

Abs_Value

11

11

0

31.8

25.92

16.48 - 47.12

1.57 - 63.6

29.07

8.04 - 60.52

Н/П*

Н/П*

4СМ+PD1+TIGIT-

Abs_Value

11

11

0

15.07

13.01

7.38 - 22.76

1.16 - 38.18

11.31

4.11 - 26.82

Н/П*

Н/П*

4СМ+PD1+TIGIT+

Abs_Value

11

11

0

16.73

13.91

8.51 - 24.95

0.41 - 38.43

14.64

3.93 - 27.2

Н/П*

Н/П*

4СМ+TIGIT+

Abs_Value

11

11

0

19.56

16.53

9.79 - 29.33

0.45 - 47.95

18.23

4.45 - 29.99

Н/П*

Н/П*

4ТM_TH1

Abs_Value

11

11

0

8.94

6.31

5.21 - 12.67

2.22 - 23.42

9.6

3.4 - 11.51

Н/П*

Н/П*

4ТM_TH17

Abs_Value

11

11

0

6.69

3.22

4.79 - 8.6

0.67 - 12.4

7.05

5.08 - 7.62

Н/П*

Н/П*

4ТM_Th17TO1

Abs_Value

11

11

0

2.81

1.95

1.66 - 3.97

0.49 - 6.92

2.57

1.31 - 4.11

Н/П*

Н/П*

4ТM_TH2

Abs_Value

11

11

0

3.88

3.58

1.76 - 5.99

0.65 - 10.5

2.91

1.32 - 4.89

Н/П*

Н/П*

4ТM_TH22

Abs_Value

11

11

0

5.01

5.46

1.78 - 8.23

0.36 - 15.88

2.75

1.41 - 5.73

Н/П*

Н/П*

4ТREG

Abs_Value

11

11

0

5.7

5.55

2.42 - 8.98

0.16 - 18.58

5.59

1.05 - 7.72

Н/П*

Н/П*

4ТREG(СТАР2)

Abs_Value

11

11

0

141.67

106.82

78.54 - 204.79

19.25 - 336.13

98.26

74.19 - 184.1

Н/П*

Н/П*

4ТREG_TH1

Abs_Value

11

11

0

0.44

0.39

0.21 - 0.68

0.05 - 1.08

0.37

0.12 - 0.74

Н/П*

Н/П*

4ТREG_TH17

Abs_Value

11

11

0

3.75

2.39

2.34 - 5.17

0.91 - 8.42

3.65

2.01 - 5.1

Н/П*

Н/П*

4ТREG_Th17TO1

Abs_Value

11

11

0

0.2

0.15

0.11 - 0.28

0.01 - 0.39

0.18

0.06 - 0.33

Н/П*

Н/П*

4ТREG_TH2

Abs_Value

11

11

0

2.9

2.9

1.18 - 4.61

0.31 - 8.68

1.15

0.9 - 4.55

Н/П*

Н/П*

4ТREG_TH22

Abs_Value

11

11

0

3.71

3.64

1.56 - 5.86

0.7 - 11.45

2.16

1.2 - 5.39

Н/П*

Н/П*

4ТЕ

Abs_Value

11

11

0

9.12

11.87

2.11 - 16.14

0.42 - 41.3

4.96

1.38 - 12.13

Н/П*

Н/П*

4ТЕ(СТАР2)

Abs_Value

11

11

0

29.57

20.51

17.45 - 41.69

5.39 - 74.77

24.32

19.09 - 31.91

Н/П*

Н/П*

4ТЕ_TH1

Abs_Value

11

11

0

3.99

7.86

-0.65 - 8.64

0.16 - 27.05

0.94

0.23 - 3.48

Н/П*

Н/П*

4ТЕ_TH17

Abs_Value

11

11

0

0.01

0.01

0 - 0.01

0 - 0.03

0

0 - 0.01

Н/П*

Н/П*

4ТЕ_Th17TO1

Abs_Value

11

11

0

0.21

0.56

-0.12 - 0.54

0 - 1.89

0.01

0 - 0.06

Н/П*

Н/П*

4ТЕ_TH2

Abs_Value

11

11

0

0.25

0.4

0.01 - 0.49

0 - 1.33

0.11

0.03 - 0.22

Н/П*

Н/П*

4ТЕ_TH22

Abs_Value

11

11

0

0.01

0.02

0 - 0.02

0 - 0.06

0

0 - 0.01

Н/П*

Н/П*

4ТЕ+226+

Abs_Value

11

11

0

27.32

19.92

15.55 - 39.09

4.64 - 73.35

22.18

16.86 - 29.79

Н/П*

Н/П*

4ТЕ+39+

Abs_Value

11

11

0

5.06

6.29

1.34 - 8.78

0.56 - 20.16

2.04

1.27 - 5.28

Н/П*

Н/П*

4ТЕ+DR+

Abs_Value

11

11

0

14.02

14.93

5.2 - 22.85

0.32 - 51.79

10.36

3.21 - 18.85

Н/П*

Н/П*

4ТЕ+PD-1-TIGIT-

Abs_Value

11

11

0

11.75

8.82

6.54 - 16.96

3.69 - 28.88

8.21

5.44 - 13.73

Н/П*

Н/П*

4ТЕ+PD-1-TIGIT+

Abs_Value

11

11

0

1.44

1.34

0.65 - 2.23

0.1 - 3.76

1.3

0.37 - 2.13

Н/П*

Н/П*

4ТЕ+PD-1+

Abs_Value

11

11

0

16.39

12.56

8.97 - 23.81

1.16 - 45.19

15.93

7.48 - 22.66

Н/П*

Н/П*

4ТЕ+PD-1+TIGIT-

Abs_Value

11

11

0

10.92

10.16

4.92 - 16.92

0.66 - 35.88

6.17

4.48 - 15.07

Н/П*

Н/П*

4ТЕ+PD-1+TIGIT+

Abs_Value

11

11

0

5.47

3.87

3.18 - 7.75

0.5 - 12.65

3.33

2.97 - 7.54

Н/П*

Н/П*

4ТЕ+TIGIT+

Abs_Value

11

11

0

6.9

5.09

3.9 - 9.91

0.6 - 16.41

5.24

3.37 - 9.19

Н/П*

Н/П*

4ТМ

Abs_Value

11

11

0

83.29

28.69

66.34 - 100.24

36.54 - 131.83

82.01

63.66 - 105.58

Н/П*

Н/П*

8+

Abs_Value

11

11

0

578.84

685.07

173.99 - 983.69

30 - 2195.9

217.02

159.23 - 742.49

Н/П*

Н/П*

8+ (IM STAT)

Abs_Value

11

11

0

734.51

779.31

273.97 - 1195.06

32.41 - 2619.95

392.04

231.98 - 846.94

Н/П*

Н/П*

8+226+

Abs_Value

11

11

0

926.56

884.39

403.92 - 1449.2

46.34 - 3173.45

512.62

396.99 - 1064.24

Н/П*

Н/П*

8+39+

Abs_Value

11

11

0

110.84

179.27

4.89 - 216.78

8.23 - 628.04

47.55

32.28 - 73.58

Н/П*

Н/П*

8+DR+

Abs_Value

11

11

0

714.36

823.08

227.95 - 1200.77

71.6 - 2878.79

332.58

275.06 - 883.81

Н/П*

Н/П*

8+PD-1-TIGIT-

Abs_Value

11

11

0

402.69

397.54

167.76 - 637.62

11.43 - 1404.23

233.57

196.53 - 526.23

Н/П*

Н/П*

8+PD-1-TIGIT+

Abs_Value

11

11

0

191.36

216.53

63.4 - 319.32

22.57 - 615.13

126.36

51.13 - 197.78

Н/П*

Н/П*

8+PD-1+

Abs_Value

11

11

0

403.19

372.5

183.06 - 623.32

38.01 - 1266.83

251.83

164.33 - 556.48

Н/П*

Н/П*

8+PD-1+TIGIT-

Abs_Value

11

11

0

198.03

216.01

70.37 - 325.68

3.48 - 749.39

118.32

62.39 - 249.91

Н/П*

Н/П*

8+PD-1+TIGIT+

Abs_Value

11

11

0

205.16

164.35

108.04 - 302.29

34.52 - 517.43

128.21

90.21 - 306.57

Н/П*

Н/П*

8+TIGIT+

Abs_Value

11

11

0

396.52

349.93

189.72 - 603.32

62.49 - 1118.31

272

161.54 - 486.27

Н/П*

Н/П*

8EMTM

Abs_Value

11

11

0

156.08

149.71

67.61 - 244.55

4.67 - 481.44

104.12

57 - 203.48

Н/П*

Н/П*

8EMTM+226+

Abs_Value

11

11

0

142.66

141.53

59.02 - 226.3

2.47 - 469.49

100.18

51.53 - 171.7

Н/П*

Н/П*

8EMTM+39+

Abs_Value

11

11

0

21.87

24.79

7.22 - 36.51

0.5 - 82.84

10.76

3.92 - 33.37

Н/П*

Н/П*

8EMTM+DR+

Abs_Value

11

11

0

124.38

130.01

47.55 - 201.21

4.32 - 412.87

79.07

45.46 - 128.94

Н/П*

Н/П*

8EMTM+PD-1-TIGIT-

Abs_Value

11

11

0

41.89

36.39

20.38 - 63.4

0.24 - 123.49

27.51

18.51 - 52.01

Н/П*

Н/П*

8EMTM+PD-1-TIGIT+

Abs_Value

11

11

0

15.38

20.08

3.52 - 27.25

0.18 - 61.97

7.82

2.29 - 19.7

Н/П*

Н/П*

8EMTM+PD-1+

Abs_Value

11

11

0

98.81

113.49

31.74 - 165.88

4.25 - 396.29

56.28

33.81 - 121.02

Н/П*

Н/П*

8EMTM+PD-1+TIGIT-

Abs_Value

11

11

0

48.74

57.28

14.89 - 82.59

0.45 - 196.08

30.56

13.74 - 63.82

Н/П*

Н/П*

8EMTM+PD-1+TIGIT+

Abs_Value

11

11

0

50.07

57.79

15.92 - 84.22

3.8 - 200.2

36.49

10.63 - 63.03

Н/П*

Н/П*

8EMTM+TIGIT+

Abs_Value

11

11

0

65.45

70.67

23.68 - 107.21

3.98 - 226.37

39.85

12.86 - 86.24

Н/П*

Н/П*

8NV

Abs_Value

11

11

0

35.12

34.31

14.84 - 55.39

3.36 - 103.28

16.56

7.3 - 57.15

Н/П*

Н/П*

8NV(СТАР2)

Abs_Value

11

11

0

54.65

62.03

18 - 91.31

0.85 - 214.03

54.6

8.61 - 74.13

Н/П*

Н/П*

8NV+226+

Abs_Value

11

11

0

48.04

58.86

13.26 - 82.83

0.83 - 205.18

47.85

6.01 - 60.43

Н/П*

Н/П*

8NV+39+

Abs_Value

11

11

0

4.06

5.8

0.63 - 7.49

0.13 - 14.96

0.8

0.41 - 6.58

Н/П*

Н/П*

8NV+DR+

Abs_Value

11

11

0

7.23

6.4

3.44 - 11.01

0.46 - 16.71

4.59

2.16 - 13.91

Н/П*

Н/П*

8NV+PD-1-TIGIT-

Abs_Value

11

11

0

43.46

59.83

8.11 - 78.82

0.2 - 208.28

37.74

5.12 - 57.46

Н/П*

Н/П*

8NV+PD-1-TIGIT+

Abs_Value

11

11

0

4.24

6.3

0.52 - 7.97

0 - 21.7

1.52

0.42 - 5.46

Н/П*

Н/П*

8NV+PD-1+

Abs_Value

11

11

0

6.95

6.26

3.25 - 10.64

0.24 - 19.42

4.65

2.4 - 9.42

Н/П*

Н/П*

8NV+PD-1+TIGIT-

Abs_Value

11

11

0

2.24

2.66

0.67 - 3.81

0 - 8.15

0.95

0.33 - 3.06

Н/П*

Н/П*

8NV+PD-1+TIGIT+

Abs_Value

11

11

0

4.71

4.68

1.94 - 7.47

0.24 - 12.49

2.25

1.27 - 8.82

Н/П*

Н/П*

8NV+TIGIT+

Abs_Value

11

11

0

8.95

9.6

3.28 - 14.62

0.41 - 29.4

3.77

1.65 - 16.06

Н/П*

Н/П*

8TREG

Abs_Value

11

11

0

596

680.43

193.88 - 998.11

29.13 - 2207.38

265.06

199.18 - 720.62

Н/П*

Н/П*

8ЕМ

Abs_Value

11

11

0

142.53

143.35

57.82 - 227.24

4.7 - 435.49

74.23

36.04 - 199.55

Н/П*

Н/П*

8СМ

Abs_Value

11

11

0

13.49

15.47

4.35 - 22.64

0.6 - 51.2

7.36

2.34 - 21.35

Н/П*

Н/П*

8СМ(СТАР2)

Abs_Value

11

11

0

8.6

9.75

2.84 - 14.37

0.04 - 33.96

4.01

2.63 - 12.02

Н/П*

Н/П*

8СМ+226+

Abs_Value

11

11

0

5.99

5.4

2.79 - 9.18

0.04 - 16.8

3.55

2.09 - 8.3

Н/П*

Н/П*

8СМ+39+

Abs_Value

11

11

0

1.55

1.93

0.41 - 2.69

0.02 - 5.23

0.87

0.17 - 2.06

Н/П*

Н/П*

8СМ+DR+

Abs_Value

11

11

0

6.71

8.7

1.57 - 11.85

0.02 - 30.43

3.64

1.84 - 8.99

Н/П*

Н/П*

8СМ+PD-1-TIGIT-

Abs_Value

11

11

0

1.88

2.22

0.56 - 3.19

0.02 - 7.08

0.78

0.29 - 2.73

Н/П*

Н/П*

8СМ+PD-1-TIGIT+

Abs_Value

11

11

0

1.44

2.54

-0.06 - 2.94

0 - 8.77

0.41

0.12 - 1.6

Н/П*

Н/П*

8СМ+PD-1+

Abs_Value

11

11

0

5.28

6.19

1.62 - 8.94

0.02 - 21.78

3.17

1.73 - 7.04

Н/П*

Н/П*

8СМ+PD-1+TIGIT-

Abs_Value

11

11

0

0.77

0.64

0.39 - 1.14

0 - 2.18

0.82

0.24 - 0.98

Н/П*

Н/П*

8СМ+PD-1+TIGIT+

Abs_Value

11

11

0

4.51

6.04

0.94 - 8.09

0.01 - 21.05

2.23

1.12 - 5.47

Н/П*

Н/П*

8СМ+TIGIT+

Abs_Value

11

11

0

5.96

8.52

0.92 - 10.99

0.01 - 29.82

3.21

1.28 - 6.63

Н/П*

Н/П*

8ТЕ

Abs_Value

11

11

0

622.8

761.49

172.78 - 1072.81

23.09 - 2714.05

306.64

199.77 - 658.64

Н/П*

Н/П*

8ТЕ(СТАР2)

Abs_Value

11

11

0

759.66

830.66

268.77 - 1250.55

88.95 - 2905.58

391.48

268.78 - 855.84

Н/П*

Н/П*

8ТЕ+226+

Abs_Value

11

11

0

714.93

813.85

233.98 - 1195.88

37.92 - 2858.44

332.25

262.61 - 814.62

Н/П*

Н/П*

8ТЕ+39+

Abs_Value

11

11

0

74.62

137.84

-6.84 - 156.08

7.19 - 479.15

18.13

15.25 - 46.38

Н/П*

Н/П*

8ТЕ+DR+

Abs_Value

11

11

0

562.06

750.18

118.74 - 1005.39

66.62 - 2623.56

243.25

155.56 - 645.34

Н/П*

Н/П*

8ТЕ+PD-1-TIGIT-

Abs_Value

11

11

0

311.97

376.13

89.69 - 534.25

5.08 - 1283.87

141.19

96.18 - 427.02

Н/П*

Н/П*

8ТЕ+PD-1-TIGIT+

Abs_Value

11

11

0

166.89

194.49

51.96 - 281.83

17.28 - 551.54

100.26

43.13 - 159.9

Н/П*

Н/П*

8ТЕ+PD-1+

Abs_Value

11

11

0

280.8

304.9

100.61 - 460.98

33.55 - 1070.17

158.31

80.8 - 424.72

Н/П*

Н/П*

8ТЕ+PD-1+TIGIT-

Abs_Value

11

11

0

144.03

192.95

30 - 258.05

3.04 - 682.96

61.42

39.01 - 193.3

Н/П*

Н/П*

8ТЕ+PD-1+TIGIT+

Abs_Value

11

11

0

136.77

120.68

65.45 - 208.09

23.32 - 387.21

66.51

40.69 - 225.04

Н/П*

Н/П*

8ТЕ+TIGIT+

Abs_Value

11

11

0

303.66

292.71

130.68 - 476.65

42.68 - 938.75

228.72

82.7 - 354

Н/П*

Н/П*

8ТМ

Abs_Value

11

11

0

33.69

24.31

19.32 - 48.05

5.82 - 76

26.42

14.67 - 52.75

Н/П*

Н/П*

TREG_CM

Abs_Value

11

11

0

3.15

3.31

1.2 - 5.11

0.14 - 9.47

1.57

0.48 - 5.12

Н/П*

Н/П*

TREG_EMTM

Abs_Value

11

11

0

26.34

17.66

15.9 - 36.78

5.79 - 53.46

22.45

10.29 - 42.3

Н/П*

Н/П*

TREG_NV

Abs_Value

11

11

0

3

2.92

1.28 - 4.73

0.01 - 7.25

1.78

0.46 - 5.58

Н/П*

Н/П*

TREG_TE

Abs_Value

11

11

0

4.08

3.56

1.98 - 6.18

0.26 - 10.4

2.85

1.02 - 7.13

Н/П*

Н/П*

TREG+226-TIGIT-

Abs_Value

11

11

0

1.84

1.28

1.08 - 2.59

0.2 - 4.49

1.73

0.89 - 2.34

Н/П*

Н/П*

TREG+226-TIGIT+

Abs_Value

11

11

0

8.56

6.91

4.47 - 12.64

0.73 - 19.26

7.93

2.12 - 13.51

Н/П*

Н/П*

TREG+226+

Abs_Value

11

11

0

26.66

17.13

16.54 - 36.79

5.33 - 51.13

24.99

13.42 - 38.48

Н/П*

Н/П*

TREG+226+TIGIT-

Abs_Value

11

11

0

3.05

1.72

2.04 - 4.07

0.95 - 6.15

3.59

1.37 - 4.12

Н/П*

Н/П*

TREG+226+TIGIT+

Abs_Value

11

11

0

23.61

16.25

14 - 33.21

4.36 - 47.29

23.7

9.63 - 34.4

Н/П*

Н/П*

TREG+39+

Abs_Value

11

11

0

24.66

19.74

13 - 36.33

5.68 - 68.05

19.08

12.11 - 26.92

Н/П*

Н/П*

TREG+DR+

Abs_Value

11

11

0

26.32

19.69

14.68 - 37.95

4.39 - 59.8

25.66

7.96 - 41.74

Н/П*

Н/П*

TREG+PD-1+

Abs_Value

11

11

0

17.43

13.77

9.29 - 25.57

4.68 - 47.96

16.01

6.75 - 18.88

Н/П*

Н/П*

TREG+TIGIT+

Abs_Value

11

11

0

32.16

22.25

19.02 - 45.31

5.35 - 66.55

29.06

12.43 - 50.36

Н/П*

Н/П*

ДЕНЬ ХРРТПХ +90

4_TFH

Abs_Value

16

16

0

35.35

23.89

23.64 - 47.05

3.11 - 96.06

28.78

21.76 - 50.15

Н/П*

Н/П*

4_TH1

Abs_Value

16

16

0

31.21

29.23

16.89 - 45.54

1.9 - 112.66

21.99

15.62 - 32.29

Н/П*

Н/П*

4_TH17

Abs_Value

16

16

0

24.13

15.61

16.48 - 31.78

6.93 - 58.39

19.17

12.69 - 32.93

Н/П*

Н/П*

4_Th17TO1

Abs_Value

16

16

0

6.09

4.39

3.94 - 8.24

0.23 - 16.13

4.89

3.51 - 8.74

Н/П*

Н/П*

4_TH2

Abs_Value

16

16

0

27.11

18.08

18.25 - 35.97

8.43 - 76.49

20.94

14.14 - 35.85

Н/П*

Н/П*

4_TH22

Abs_Value

16

16

0

9.15

7.62

5.42 - 12.88

0.67 - 23.59

6.45

3.86 - 12.08

Н/П*

Н/П*

4+

Abs_Value

16

16

0

132.22

82.34

91.87 - 172.56

20.84 - 298.94

110.26

66.25 - 190.14

Н/П*

Н/П*

4+ (IM STAT)

Abs_Value

16

16

0

103.84

67.1

70.96 - 136.72

34.32 - 275.92

98.9

52.08 - 129.82

Н/П*

Н/П*

4+226+

Abs_Value

16

16

0

287.69

154.08

212.19 - 363.19

87.94 - 576.94

257.19

176.03 - 410.75

Н/П*

Н/П*

4+39+

Abs_Value

16

16

0

55.03

60.37

25.45 - 84.61

1.04 - 246.85

41.24

21.45 - 62.04

Н/П*

Н/П*

4+DR+

Abs_Value

16

16

0

93.94

80.53

54.48 - 133.4

25.31 - 271.33

51.07

39.47 - 108.97

Н/П*

Н/П*

4+PD-1-TIGIT-

Abs_Value

16

16

0

141.1

95.38

94.36 - 187.84

37.81 - 332.69

131.49

64.39 - 171.18

Н/П*

Н/П*

4+PD-1-TIGIT+

Abs_Value

16

16

0

11.6

10.85

6.29 - 16.92

1.69 - 46.7

7.74

5.22 - 15.71

Н/П*

Н/П*

4+PD-1+

Abs_Value

16

16

0

155.06

104.07

104.07 - 206.05

30.06 - 400.09

125.63

86.15 - 191.77

Н/П*

Н/П*

4+PD-1+TIGIT-

Abs_Value

16

16

0

85.42

58.08

56.96 - 113.88

15.87 - 247.58

68.49

50 - 101.27

Н/П*

Н/П*

4+PD-1+TIGIT+

Abs_Value

16

16

0

69.64

53.87

43.24 - 96.04

14.19 - 235.06

56.25

37.41 - 90.5

Н/П*

Н/П*

4+TIGIT+

Abs_Value

16

16

0

81.25

58.37

52.65 - 109.85

19.56 - 252.76

72.45

40.14 - 98.27

Н/П*

Н/П*

4NV

Abs_Value

16

16

0

85.71

81.73

45.66 - 125.76

13.04 - 299.61

53.86

31.77 - 101.04

Н/П*

Н/П*

4NV(СТАР2)

Abs_Value

16

16

0

80.63

80.6

41.14 - 120.12

6.3 - 304.68

47.43

30.78 - 103.91

Н/П*

Н/П*

4NV_TH1

Abs_Value

16

16

0

5.61

7.86

1.76 - 9.46

0.57 - 30

2.05

0.92 - 6.64

Н/П*

Н/П*

4NV_TH17

Abs_Value

16

16

0

2.48

2.38

1.31 - 3.64

0.27 - 8.85

1.77

0.71 - 3.14

Н/П*

Н/П*

4NV_Th17TO1

Abs_Value

16

16

0

0.54

0.61

0.24 - 0.84

0.04 - 2.08

0.34

0.1 - 0.82

Н/П*

Н/П*

4NV_TH2

Abs_Value

16

16

0

9.6

13.38

3.04 - 16.16

0.58 - 57.11

5.97

3.75 - 10.43

Н/П*

Н/П*

4NV_TH22

Abs_Value

16

16

0

0.18

0.14

0.11 - 0.25

0.02 - 0.54

0.16

0.11 - 0.2

Н/П*

Н/П*

4NV+226+

Abs_Value

16

16

0

73.83

78.87

35.18 - 112.47

4.85 - 302.56

41.42

23.72 - 96.07

Н/П*

Н/П*

4NV+39+

Abs_Value

16

16

0

1.88

2.22

0.79 - 2.96

0.05 - 8

1.49

0.31 - 2.26

Н/П*

Н/П*

4NV+DR+

Abs_Value

16

16

0

5.04

4.84

2.67 - 7.41

0.13 - 15.82

3.55

1.77 - 6.32

Н/П*

Н/П*

4NV+PD-1-TIGIT-

Abs_Value

16

16

0

73.63

76.16

36.31 - 110.95

3.6 - 289.92

41.78

27.61 - 96.54

Н/П*

Н/П*

4NV+PD-1-TIGIT+

Abs_Value

16

16

0

2.24

3.68

0.44 - 4.05

0.04 - 15.6

1.2

0.96 - 1.83

Н/П*

Н/П*

4NV+PD-1+TIGIT-

Abs_Value

16

16

0

2.88

2.51

1.65 - 4.11

0.07 - 9.06

1.81

0.99 - 4.26

Н/П*

Н/П*

4NV+PD-1+TIGIT+

Abs_Value

16

16

0

1.87

1.83

0.97 - 2.77

0.08 - 6.13

1.14

0.63 - 2.24

Н/П*

Н/П*

4NV+PD1+

Abs_Value

16

16

0

4.75

4.08

2.75 - 6.75

0.16 - 15.19

3.55

1.84 - 6.1

Н/П*

Н/П*

4NV+TIGIT+

Abs_Value

16

16

0

4.11

4.54

1.89 - 6.34

0.13 - 18.1

2.45

1.63 - 4.05

Н/П*

Н/П*

4ЕМ

Abs_Value

16

16

0

22.06

50.17

-2.52 - 46.64

0.23 - 203.95

4.06

2.05 - 16.96

Н/П*

Н/П*

4ЕМ_TH1

Abs_Value

16

16

0

3.88

5.53

1.17 - 6.59

0 - 19.39

1.69

0.2 - 4.23

Н/П*

Н/П*

4ЕМ_TH17

Abs_Value

16

16

0

0.04

0.07

0.01 - 0.08

0 - 0.23

0.01

0 - 0.03

Н/П*

Н/П*

4ЕМ_Th17TO1

Abs_Value

16

16

0

0.19

0.33

0.03 - 0.35

0 - 1.11

0.06

0.01 - 0.17

Н/П*

Н/П*

4ЕМ_TH2

Abs_Value

16

16

0

1.01

2.41

-0.16 - 2.19

0 - 9.23

0.11

0.02 - 0.26

Н/П*

Н/П*

4ЕМ_TH22

Abs_Value

16

16

0

0.03

0.07

-0.01 - 0.06

0 - 0.23

0

0 - 0

Н/П*

Н/П*

4ЕМ+226+

Abs_Value

16

16

0

121.53

79.15

82.75 - 160.31

19.75 - 301.44

123.64

52.94 - 142.43

Н/П*

Н/П*

4ЕМ+39+

Abs_Value

16

16

0

30.98

34.27

14.19 - 47.78

0.63 - 139.31

22.37

9.01 - 43.25

Н/П*

Н/П*

4ЕМ+DR+

Abs_Value

16

16

0

55.87

47.67

32.51 - 79.23

9.62 - 166.88

40.96

19.64 - 71.61

Н/П*

Н/П*

4ЕМ+PD1-TIGIT-

Abs_Value

16

16

0

31.07

26.51

18.08 - 44.06

1.02 - 100.32

27.71

13.49 - 35.59

Н/П*

Н/П*

4ЕМ+PD1-TIGIT+

Abs_Value

16

16

0

3.8

3.45

2.11 - 5.49

0.11 - 12.17

2.57

1.75 - 4.65

Н/П*

Н/П*

4ЕМ+PD1+

Abs_Value

16

16

0

93.56

72.96

57.81 - 129.31

12.61 - 285.99

91.29

38.83 - 108.13

Н/П*

Н/П*

4ЕМ+PD1+TIGIT-

Abs_Value

16

16

0

54.83

45.16

32.7 - 76.96

7.13 - 195.03

52.87

21.85 - 62.98

Н/П*

Н/П*

4ЕМ+PD1+TIGIT+

Abs_Value

16

16

0

38.73

32.29

22.91 - 54.55

4.47 - 125.93

36.34

15.02 - 46.71

Н/П*

Н/П*

4ЕМ+TIGIT+

Abs_Value

16

16

0

42.53

33.2

26.26 - 58.8

5.34 - 130.53

43.38

16.63 - 52.8

Н/П*

Н/П*

4ЕМTM

Abs_Value

16

16

0

128.43

80.9

88.79 - 168.07

20.66 - 302.94

135.97

56.8 - 149.8

Н/П*

Н/П*

4СМ

Abs_Value

16

16

0

70.16

37.67

51.7 - 88.61

25.35 - 151.85

63.9

42.04 - 98.93

Н/П*

Н/П*

4СМ(СТАР2)

Abs_Value

16

16

0

52.13

25.48

39.64 - 64.61

21.2 - 101.25

47.97

31.82 - 65.94

Н/П*

Н/П*

4СМ_TH1

Abs_Value

16

16

0

3.4

3.07

1.89 - 4.91

0.29 - 9.26

1.83

0.93 - 5.51

Н/П*

Н/П*

4СМ_TH17

Abs_Value

16

16

0

10.37

7.08

6.9 - 13.84

1.95 - 31.31

8.81

6.44 - 12.39

Н/П*

Н/П*

4СМ_Th17TO1

Abs_Value

16

16

0

1.16

0.95

0.69 - 1.63

0.11 - 2.67

1.06

0.23 - 1.75

Н/П*

Н/П*

4СМ_TH2

Abs_Value

16

16

0

7.03

4.75

4.7 - 9.36

1.16 - 18.38

6.35

3.74 - 9.61

Н/П*

Н/П*

4СМ_TH22

Abs_Value

16

16

0

1.55

1.51

0.81 - 2.29

0.03 - 4.89

0.84

0.61 - 2.35

Н/П*

Н/П*

4СМ+226+

Abs_Value

16

16

0

49.62

24.87

37.44 - 61.81

19.64 - 97.29

45.45

30.02 - 62.62

Н/П*

Н/П*

4СМ+39+

Abs_Value

16

16

0

12.83

10.42

7.72 - 17.93

0.16 - 33.92

11.07

6.71 - 18.46

Н/П*

Н/П*

4СМ+DR+

Abs_Value

16

16

0

10.1

6.87

6.74 - 13.47

1.2 - 24.58

8.29

5.28 - 12.93

Н/П*

Н/П*

4СМ+PD1-TIGIT-

Abs_Value

16

16

0

19.96

12.91

13.63 - 26.28

2.11 - 50.45

21

11.18 - 27.37

Н/П*

Н/П*

4СМ+PD1-TIGIT+

Abs_Value

16

16

0

3.18

3.19

1.62 - 4.75

0.21 - 13.54

2.63

1.15 - 4.08

Н/П*

Н/П*

4СМ+PD1+

Abs_Value

16

16

0

28.99

15.2

21.54 - 36.44

9.67 - 60.98

25.05

18.68 - 37.73

Н/П*

Н/П*

4СМ+PD1+TIGIT-

Abs_Value

16

16

0

11.22

5.06

8.74 - 13.71

3.55 - 20.95

9.83

7.28 - 14.47

Н/П*

Н/П*

4СМ+PD1+TIGIT+

Abs_Value

16

16

0

17.76

11.18

12.28 - 23.24

6.08 - 44.81

14.8

8.86 - 24

Н/П*

Н/П*

4СМ+TIGIT+

Abs_Value

16

16

0

20.95

12.85

14.65 - 27.24

7.81 - 49.68

17.47

10.61 - 27.82

Н/П*

Н/П*

4ТM_TH1

Abs_Value

16

16

0

12.57

13.68

5.87 - 19.28

0.08 - 43.91

5.73

4.91 - 14.5

Н/П*

Н/П*

4ТM_TH17

Abs_Value

16

16

0

10.27

7.78

6.46 - 14.08

0.84 - 27.7

7.96

4.34 - 13.61

Н/П*

Н/П*

4ТM_Th17TO1

Abs_Value

16

16

0

3.66

3.12

2.13 - 5.19

0.05 - 10.67

2.76

1.66 - 4.3

Н/П*

Н/П*

4ТM_TH2

Abs_Value

16

16

0

7.39

7.76

3.59 - 11.2

0.56 - 30.18

4.11

1.81 - 11.18

Н/П*

Н/П*

4ТM_TH22

Abs_Value

16

16

0

6.38

5.58

3.64 - 9.11

0.12 - 17.72

4.12

2.47 - 9.31

Н/П*

Н/П*

4ТREG

Abs_Value

16

16

0

2.77

3.73

0.94 - 4.59

0.04 - 13.02

1.12

0.55 - 2.67

Н/П*

Н/П*

4ТREG(СТАР2)

Abs_Value

16

16

0

138.47

81.61

98.48 - 178.45

45.87 - 308.22

118.87

72.38 - 194.27

Н/П*

Н/П*

4ТREG_TH1

Abs_Value

16

16

0

0.37

0.5

0.13 - 0.62

0.02 - 1.73

0.21

0.07 - 0.31

Н/П*

Н/П*

4ТREG_TH17

Abs_Value

16

16

0

4.3

3.2

2.73 - 5.87

0.86 - 13.28

3.51

1.97 - 5.48

Н/П*

Н/П*

4ТREG_Th17TO1

Abs_Value

16

16

0

0.14

0.16

0.06 - 0.22

0 - 0.49

0.05

0.02 - 0.25

Н/П*

Н/П*

4ТREG_TH2

Abs_Value

16

16

0

2.72

1.4

2.03 - 3.41

0.32 - 6.34

2.86

1.58 - 3.38

Н/П*

Н/П*

4ТREG_TH22

Abs_Value

16

16

0

3.67

2.57

2.41 - 4.93

0.84 - 9.32

3.37

1.45 - 5.51

Н/П*

Н/П*

4ТЕ

Abs_Value

16

16

0

12.11

23.09

0.8 - 23.43

0.1 - 86.7

1.66

0.64 - 8.96

Н/П*

Н/П*

4ТЕ(СТАР2)

Abs_Value

16

16

0

46.28

52.68

20.47 - 72.1

10.54 - 179.15

24.72

18.15 - 46.09

Н/П*

Н/П*

4ТЕ_TH1

Abs_Value

16

16

0

2.93

7.7

-0.85 - 6.7

0 - 31.37

0.55

0.13 - 1.75

Н/П*

Н/П*

4ТЕ_TH17

Abs_Value

16

16

0

0

0.01

0 - 0.01

0 - 0.02

0

0 - 0.01

Н/П*

Н/П*

4ТЕ_Th17TO1

Abs_Value

16

16

0

0.09

0.2

0 - 0.19

0 - 0.78

0.01

0 - 0.06

Н/П*

Н/П*

4ТЕ_TH2

Abs_Value

16

16

0

0.25

0.52

0 - 0.51

0 - 2.03

0.05

0.01 - 0.17

Н/П*

Н/П*

4ТЕ_TH22

Abs_Value

16

16

0

0

0.01

0 - 0.01

0 - 0.02

0

0 - 0

Н/П*

Н/П*

4ТЕ+226+

Abs_Value

16

16

0

42.58

49.68

18.24 - 66.92

9.58 - 174.69

20.95

15.78 - 41.84

Н/П*

Н/П*

4ТЕ+39+

Abs_Value

16

16

0

9.58

19.21

0.17 - 18.99

0.11 - 76.01

2.69

1.1 - 6.23

Н/П*

Н/П*

4ТЕ+DR+

Abs_Value

16

16

0

23.14

34.36

6.3 - 39.97

1.71 - 119.56

11.25

3.25 - 19.01

Н/П*

Н/П*

4ТЕ+PD-1-TIGIT-

Abs_Value

16

16

0

15.74

18.58

6.63 - 24.84

1.05 - 77.66

8.83

6.01 - 16.42

Н/П*

Н/П*

4ТЕ+PD-1-TIGIT+

Abs_Value

16

16

0

2.38

2.93

0.95 - 3.82

0.25 - 11.49

1.42

0.72 - 2.58

Н/П*

Н/П*

4ТЕ+PD-1+

Abs_Value

16

16

0

28.16

35.29

10.87 - 45.46

4.45 - 126.54

12.85

9.84 - 22.45

Н/П*

Н/П*

4ТЕ+PD-1+TIGIT-

Abs_Value

16

16

0

16.67

19.57

7.08 - 26.26

1.62 - 67.21

9.04

4.03 - 15.46

Н/П*

Н/П*

4ТЕ+PD-1+TIGIT+

Abs_Value

16

16

0

11.49

19

2.18 - 20.8

1.41 - 78.88

4.87

3.31 - 9.58

Н/П*

Н/П*

4ТЕ+TIGIT+

Abs_Value

16

16

0

13.88

20.94

3.62 - 24.14

2.14 - 85.88

6.14

4.09 - 12.22

Н/П*

Н/П*

4ТМ

Abs_Value

16

16

0

104.08

71.19

69.2 - 138.97

10.27 - 315

108.35

52.94 - 121.85

Н/П*

Н/П*

8+

Abs_Value

16

16

0

483.96

570.83

204.26 - 763.67

14.73 - 2238.8

304.59

68.25 - 709.26

Н/П*

Н/П*

8+ (IM STAT)

Abs_Value

16

16

0

609.74

665.61

283.6 - 935.89

16.62 - 2673.64

442.06

114.75 - 887.6

Н/П*

Н/П*

8+226+

Abs_Value

16

16

0

753.82

776.41

373.38 - 1134.26

86.91 - 3240.63

557.23

173.53 - 1009.04

Н/П*

Н/П*

8+39+

Abs_Value

16

16

0

96.16

122.44

36.16 - 156.15

2.61 - 428.13

46.94

19.91 - 114.27

Н/П*

Н/П*

8+DR+

Abs_Value

16

16

0

541.38

669.73

213.22 - 869.55

40.55 - 2729.41

332.49

144.84 - 628.19

Н/П*

Н/П*

8+PD-1-TIGIT-

Abs_Value

16

16

0

270.21

320.05

113.39 - 427.03

41.92 - 1371.15

169.76

91.78 - 323.43

Н/П*

Н/П*

8+PD-1-TIGIT+

Abs_Value

16

16

0

240.55

333.54

77.12 - 403.98

11.7 - 1209.08

116.12

27.43 - 225.26

Н/П*

Н/П*

8+PD-1+

Abs_Value

16

16

0

350.72

343.07

182.62 - 518.83

32.61 - 1231.92

257.6

106.43 - 493.01

Н/П*

Н/П*

8+PD-1+TIGIT-

Abs_Value

16

16

0

110.21

118.56

52.12 - 168.3

9.56 - 367.72

50.18

38.78 - 140.79

Н/П*

Н/П*

8+PD-1+TIGIT+

Abs_Value

16

16

0

240.51

275.68

105.43 - 375.59

17.7 - 1097.55

156.79

52.92 - 320.3

Н/П*

Н/П*

8+TIGIT+

Abs_Value

16

16

0

481.06

475.3

248.17 - 713.96

38.2 - 1576.95

282.64

65.8 - 759

Н/П*

Н/П*

8EMTM

Abs_Value

16

16

0

107.4

93.5

61.58 - 153.21

2.31 - 329.24

89.66

36.53 - 145.89

Н/П*

Н/П*

8EMTM+226+

Abs_Value

16

16

0

89.77

87.29

47 - 132.55

1.94 - 322.53

62.82

26.16 - 124.81

Н/П*

Н/П*

8EMTM+39+

Abs_Value

16

16

0

16.13

17.42

7.6 - 24.67

0.51 - 52.65

11.57

1.72 - 23.43

Н/П*

Н/П*

8EMTM+DR+

Abs_Value

16

16

0

79.14

65.23

47.18 - 111.11

2.13 - 212.97

66.93

28.12 - 116.1

Н/П*

Н/П*

8EMTM+PD-1-TIGIT-

Abs_Value

16

16

0

23.65

28.49

9.69 - 37.61

0.73 - 96.46

11.24

4.44 - 31.65

Н/П*

Н/П*

8EMTM+PD-1-TIGIT+

Abs_Value

16

16

0

17.07

20.91

6.83 - 27.32

0.22 - 81.95

7.77

3.49 - 27

Н/П*

Н/П*

8EMTM+PD-1+

Abs_Value

16

16

0

66.67

62.9

35.85 - 97.49

1.36 - 255.69

62.14

21.09 - 87.57

Н/П*

Н/П*

8EMTM+PD-1+TIGIT-

Abs_Value

16

16

0

22.19

27.96

8.48 - 35.89

0.69 - 110.4

13.72

6.74 - 21.03

Н/П*

Н/П*

8EMTM+PD-1+TIGIT+

Abs_Value

16

16

0

44.49

43.02

23.41 - 65.56

0.67 - 145.3

31.84

10.28 - 62.94

Н/П*

Н/П*

8EMTM+TIGIT+

Abs_Value

16

16

0

61.56

55.9

34.17 - 88.95

0.89 - 170.16

40.89

15.83 - 105.25

Н/П*

Н/П*

8NV

Abs_Value

16

16

0

45.74

44.53

23.93 - 67.56

9.18 - 184.51

26.4

17.5 - 61.65

Н/П*

Н/П*

8NV(СТАР2)

Abs_Value

16

16

0

54.54

70.98

19.76 - 89.32

3.34 - 298.83

32.85

16.66 - 59.43

Н/П*

Н/П*

8NV+226+

Abs_Value

16

16

0

49.02

69.71

14.87 - 83.18

2.97 - 293.94

30.66

15.35 - 51.92

Н/П*

Н/П*

8NV+39+

Abs_Value

16

16

0

3.23

3.32

1.6 - 4.85

0.06 - 10.69

2.17

0.62 - 4.34

Н/П*

Н/П*

8NV+DR+

Abs_Value

16

16

0

5.83

4.64

3.56 - 8.11

0.39 - 16.08

3.75

2.54 - 8.79

Н/П*

Н/П*

8NV+PD-1-TIGIT-

Abs_Value

16

16

0

45

69.44

10.98 - 79.03

0.89 - 288.77

25.56

10.96 - 41.48

Н/П*

Н/П*

8NV+PD-1-TIGIT+

Abs_Value

16

16

0

2.6

2.33

1.46 - 3.74

0.08 - 7.9

1.9

0.73 - 4.47

Н/П*

Н/П*

8NV+PD-1+

Abs_Value

16

16

0

6.94

6.77

3.62 - 10.26

0.58 - 25.65

4.93

2.43 - 8.52

Н/П*

Н/П*

8NV+PD-1+TIGIT-

Abs_Value

16

16

0

2.75

3.28

1.15 - 4.36

0.02 - 11.05

1.5

0.69 - 3.46

Н/П*

Н/П*

8NV+PD-1+TIGIT+

Abs_Value

16

16

0

4.19

4.73

1.87 - 6.5

0.56 - 17.13

2.56

1.14 - 4.17

Н/П*

Н/П*

8NV+TIGIT+

Abs_Value

16

16

0

6.78

5.99

3.85 - 9.72

1.52 - 19.73

3.92

2.49 - 9.77

Н/П*

Н/П*

8TREG

Abs_Value

16

16

0

476.38

546.46

208.61 - 744.14

14 - 2160.15

322.51

70.53 - 695.58

Н/П*

Н/П*

8ЕМ

Abs_Value

16

16

0

101.04

118.3

43.08 - 159.01

2.96 - 350.98

40.04

20.01 - 173.13

Н/П*

Н/П*

8СМ

Abs_Value

16

16

0

18.78

35.01

1.62 - 35.93

0.71 - 142.48

8.33

4.18 - 11.2

Н/П*

Н/П*

8СМ(СТАР2)

Abs_Value

16

16

0

10.74

13.16

4.29 - 17.19

1.43 - 45.99

6.28

5.32 - 8.71

Н/П*

Н/П*

8СМ+226+

Abs_Value

16

16

0

7.26

7.43

3.62 - 10.9

1.17 - 27.65

5.09

4.2 - 6.31

Н/П*

Н/П*

8СМ+39+

Abs_Value

16

16

0

2.72

3.64

0.94 - 4.51

0.08 - 12.25

1.63

0.49 - 3.06

Н/П*

Н/П*

8СМ+DR+

Abs_Value

16

16

0

8.28

10.55

3.11 - 13.45

0.95 - 40.03

4.7

3.28 - 6.65

Н/П*

Н/П*

8СМ+PD-1-TIGIT-

Abs_Value

16

16

0

1.48

1.19

0.9 - 2.07

0.09 - 5.04

1.24

1.01 - 1.78

Н/П*

Н/П*

8СМ+PD-1-TIGIT+

Abs_Value

16

16

0

2

2.86

0.6 - 3.4

0.04 - 9.71

1

0.54 - 1.45

Н/П*

Н/П*

8СМ+PD-1+

Abs_Value

16

16

0

7.26

9.89

2.42 - 12.11

1.14 - 36.67

3.64

2.17 - 5.64

Н/П*

Н/П*

8СМ+PD-1+TIGIT-

Abs_Value

16

16

0

0.8

0.82

0.4 - 1.2

0.1 - 3.03

0.43

0.35 - 0.86

Н/П*

Н/П*

8СМ+PD-1+TIGIT+

Abs_Value

16

16

0

6.46

9.66

1.73 - 11.2

0.84 - 35.27

2.98

1.75 - 5.14

Н/П*

Н/П*

8СМ+TIGIT+

Abs_Value

16

16

0

8.46

12.34

2.41 - 14.5

0.93 - 43.35

4.12

2.65 - 6.7

Н/П*

Н/П*

8ТЕ

Abs_Value

16

16

0

501.34

697.27

159.67 - 843

27.81 - 2935.15

315.6

112.05 - 556.57

Н/П*

Н/П*

8ТЕ(СТАР2)

Abs_Value

16

16

0

685.6

784.62

301.14 - 1070.06

35.46 - 3213.82

506

156.46 - 979.83

Н/П*

Н/П*

8ТЕ+226+

Abs_Value

16

16

0

605.32

757.57

234.11 - 976.53

34.55 - 3154.74

352.23

150.77 - 781.62

Н/П*

Н/П*

8ТЕ+39+

Abs_Value

16

16

0

73.58

111.95

18.72 - 128.44

1.13 - 386.23

25.52

8.98 - 82.36

Н/П*

Н/П*

8ТЕ+DR+

Abs_Value

16

16

0

447.63

655.54

126.41 - 768.84

20.58 - 2669.82

240.49

106.37 - 478.6

Н/П*

Н/П*

8ТЕ+PD-1-TIGIT-

Abs_Value

16

16

0

199.55

318.56

43.46 - 355.65

9.04 - 1323.33

86.53

44.16 - 243.13

Н/П*

Н/П*

8ТЕ+PD-1-TIGIT+

Abs_Value

16

16

0

216.44

317.94

60.65 - 372.23

9.38 - 1190.46

94.42

24.2 - 195.52

Н/П*

Н/П*

8ТЕ+PD-1+

Abs_Value

16

16

0

269.6

303.31

120.98 - 418.23

16.39 - 1104.9

170.5

66.27 - 358.79

Н/П*

Н/П*

8ТЕ+PD-1+TIGIT-

Abs_Value

16

16

0

84.52

100.53

35.26 - 133.78

5.34 - 353.82

34.82

24.87 - 116.83

Н/П*

Н/П*

8ТЕ+PD-1+TIGIT+

Abs_Value

16

16

0

185.09

244.63

65.22 - 304.95

11.05 - 987.9

106.95

40.06 - 235.62

Н/П*

Н/П*

8ТЕ+TIGIT+

Abs_Value

16

16

0

401.52

438.75

186.54 - 616.51

20.43 - 1536.67

234.01

54.74 - 587.2

Н/П*

Н/П*

8ТМ

Abs_Value

16

16

0

43.72

58.64

14.98 - 72.45

0.57 - 244.32

21.85

10.88 - 60.22

Н/П*

Н/П*

TREG_CM

Abs_Value

16

16

0

1.83

1.04

1.32 - 2.34

0.19 - 3.86

1.63

1.35 - 2.2

Н/П*

Н/П*

TREG_EMTM

Abs_Value

16

16

0

19.2

16.73

11 - 27.4

3.24 - 57.99

16.19

6.39 - 22.43

Н/П*

Н/П*

TREG_NV

Abs_Value

16

16

0

2.59

2.52

1.35 - 3.82

0.22 - 7.96

1.22

0.91 - 3.92

Н/П*

Н/П*

TREG_TE

Abs_Value

16

16

0

4.87

8.07

0.92 - 8.82

0.35 - 33.62

2.28

1.42 - 4.96

Н/П*

Н/П*

TREG+226-TIGIT-

Abs_Value

16

16

0

1.77

1.68

0.95 - 2.59

0.09 - 5.76

1.37

0.45 - 2.28

Н/П*

Н/П*

TREG+226-TIGIT+

Abs_Value

16

16

0

6.18

6.1

3.2 - 9.17

0.38 - 18.95

4.4

1.76 - 8.88

Н/П*

Н/П*

TREG+226+

Abs_Value

16

16

0

20.48

17.47

11.92 - 29.04

3.74 - 64.06

15.48

7.87 - 26.26

Н/П*

Н/П*

TREG+226+TIGIT-

Abs_Value

16

16

0

2.6

1.7

1.77 - 3.44

0.37 - 5.6

2.62

0.91 - 3.75

Н/П*

Н/П*

TREG+226+TIGIT+

Abs_Value

16

16

0

17.88

16.73

9.68 - 26.08

3.37 - 58.46

11.88

6.05 - 24.33

Н/П*

Н/П*

TREG+39+

Abs_Value

16

16

0

20.12

20.89

9.88 - 30.35

3.52 - 76.71

12.83

6.64 - 23.81

Н/П*

Н/П*

TREG+DR+

Abs_Value

16

16

0

18.52

17.96

9.72 - 27.32

3.45 - 67.02

16.88

6.22 - 20.21

Н/П*

Н/П*

TREG+PD-1+

Abs_Value

16

16

0

13.74

14.23

6.77 - 20.71

2.61 - 48.13

9.94

4.29 - 14.6

Н/П*

Н/П*

TREG+TIGIT+

Abs_Value

16

16

0

24.06

21.65

13.46 - 34.67

3.75 - 77.23

18.29

7.78 - 31.58

Н/П*

Н/П*

В таблицах столбцы No- для тех, у кого не развилось cGVHD, Yes - у кого развилось

Описательная таблица только для дня анализа 90

# Те же статистики 
statistics <- list(
  `_Количество субъектов` = ~length(.x) %>% as.character(),
  `_Количество (есть данные)` = ~sum(!is.na(.x)) %>% as.character(),
  `_Нет данных` = ~sum(is.na(.x)) %>% as.character(),
  `_Ср. знач.` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", mean(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
  `_Станд. отклон.` = ~ifelse(sum(!is.na(.x)) < 3, "Н/П*", sd(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
  `_95% ДИ для среднего` = ~{
    n <- sum(!is.na(.x))
    ifelse(n < 3, "Н/П*", 
           paste0(round(mean(.x, na.rm = TRUE) - 1.96 * sd(.x, na.rm = TRUE) / sqrt(n), 2), " - ", round(mean(.x, na.rm = TRUE) + 1.96 * sd(.x, na.rm = TRUE) / sqrt(n), 2))
    )
  },
  `_мин. - макс.` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", paste0(min(.x, na.rm = TRUE) %>% round(2), " - ", max(.x, na.rm = TRUE) %>% round(2))),
  `_Медиана` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", median(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
  `_Q1 - Q3` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", paste0(quantile(.x, 0.25, na.rm = TRUE) %>% round(2), " - ", quantile(.x, 0.75, na.rm = TRUE) %>% round(2)))
)

# Фильтруем данные только для +90 дней
AI_Tcells_90 <- AI_Tcells_filtered %>%
  filter(Analysis_day == "+90")

# Функция для t-теста 
t_test_wrapper <- function(data, var) {
  n_yes <- sum(!is.na(data$Abs_Value[data$cGVHD_present == "Yes"]))
  n_no <- sum(!is.na(data$Abs_Value[data$cGVHD_present == "No"]))
  
  if(n_yes < 3 || n_no < 3) {
    return("Н/П*")
  }
  
  test_result <- try(
    t.test(Abs_Value ~ cGVHD_present, data = data)$p.value,
    silent = TRUE
  )
  
  if(inherits(test_result, "try-error")) {
    return("Ошибка")
  }
  
  return(as.character(round(test_result, 4)))
}

# Собираем p-values только для данных 90-го дня
p_values_df_90 <- AI_Tcells_90 %>%
  group_by(Сell_population) %>%
  summarise(
    p_value = t_test_wrapper(cur_data(), Abs_Value),
    .groups = "drop"
  )

# Корректируем p-values
p_values_df_90 <- p_values_df_90 %>%
  mutate(
    adj_p_value = p_value
  )

# Находим индексы числовых p-values
numeric_indices <- !p_values_df_90$p_value %in% c("Н/П*", "Ошибка")

if(sum(numeric_indices) > 0) {
  numeric_p_values <- as.numeric(p_values_df_90$p_value[numeric_indices])
  adj_p_values <- p.adjust(numeric_p_values, method = "BH")
  p_values_df_90$adj_p_value[numeric_indices] <- as.character(round(adj_p_values, 4))
}

# Создаем финальную таблицу
result_90 <- AI_Tcells_90 %>%
  select(`Сell_population`, `cGVHD_present`, Abs_Value) %>%
  group_by(`Сell_population`, `cGVHD_present`) %>%
  summarize(across(Abs_Value, statistics), .groups = "drop") %>%
  pivot_longer(cols = -c(`Сell_population`, `cGVHD_present`)) %>%
  separate(name, into = c("Variable", "Statistics"), sep = "__") %>%
  pivot_wider(names_from = c(cGVHD_present, Statistics), values_from = value) %>%
  # Присоединяем p-values
  left_join(p_values_df_90, by = c("Сell_population")) %>%
  rename(
    "t-test, p-value" = p_value,
    "t-test, adj p-value (BH)" = adj_p_value
  ) %>%
  # Создаём финальную таблицу
  arrange(Сell_population) %>%
  flextable() %>%
  theme_box() %>%
  align(align = "center", part = "all")

# Выводим таблицу
result_90

Сell_population

Variable

No_Количество субъектов

No_Количество (есть данные)

No_Нет данных

No_Ср. знач.

No_Станд. отклон.

No_95% ДИ для среднего

No_мин. - макс.

No_Медиана

No_Q1 - Q3

Yes_Количество субъектов

Yes_Количество (есть данные)

Yes_Нет данных

Yes_Ср. знач.

Yes_Станд. отклон.

Yes_95% ДИ для среднего

Yes_мин. - макс.

Yes_Медиана

Yes_Q1 - Q3

t-test, p-value

t-test, adj p-value (BH)

4_TFH

Abs_Value

39

39

0

16.33

13.43

12.11 - 20.55

0 - 61.09

13.26

8.06 - 22.35

28

28

0

14.42

12.25

9.88 - 18.96

1.1 - 45.51

10.81

4.76 - 18.65

0.5483

0.7484

4_TH1

Abs_Value

39

39

0

35.1

96.74

4.74 - 65.47

0.16 - 608.2

10.47

5.84 - 24.35

28

28

0

17.24

24.14

8.3 - 26.19

0.03 - 113.81

9.26

4.29 - 17.68

0.2747

0.6696

4_TH17

Abs_Value

39

39

0

13.84

8.71

11.11 - 16.57

0.02 - 34.84

12.75

6.74 - 18.73

28

28

0

13.49

9.77

9.87 - 17.11

0.86 - 40.22

11.94

6.64 - 20.16

0.8803

0.9621

4_Th17TO1

Abs_Value

39

39

0

3.39

3.17

2.4 - 4.39

0.03 - 17.49

2.3

1.43 - 4.6

28

28

0

3.75

4.89

1.93 - 5.56

0.05 - 18.77

2.09

0.78 - 3.94

0.7375

0.8959

4_TH2

Abs_Value

39

39

0

13.04

22.22

6.06 - 20.01

0.02 - 143.45

8.78

5.17 - 13.6

28

28

0

13.67

9.99

9.97 - 17.37

0.58 - 37.81

10.16

6.22 - 19.3

0.8754

0.9621

4_TH22

Abs_Value

39

39

0

3.91

3.18

2.91 - 4.91

0 - 13.92

3.12

1.51 - 5.85

28

28

0

4.25

3.86

2.82 - 5.68

0.02 - 14.86

3.06

1.61 - 5.72

0.7032

0.8671

4+

Abs_Value

39

39

0

70.84

76.56

46.81 - 94.87

0.01 - 430.92

59.43

20.66 - 92.9

28

28

0

83.71

46.4

66.52 - 100.89

1.65 - 194.52

81.98

48.2 - 121.66

0.3964

0.6762

4+ (IM STAT)

Abs_Value

39

39

0

65.93

72.58

43.14 - 88.71

0 - 397.77

47.44

19.37 - 82.94

28

28

0

74.78

44.66

58.24 - 91.32

2.77 - 186.76

77.26

37.17 - 96.8

0.5398

0.7484

4+226+

Abs_Value

39

39

0

155.71

179.73

99.3 - 212.12

0.31 - 1046.46

128.08

68.58 - 160.33

28

28

0

132.45

73.4

105.26 - 159.64

16.89 - 269.89

131.07

76.06 - 166.98

0.4698

0.6986

4+39+

Abs_Value

39

39

0

39.48

31.48

29.6 - 49.36

0.07 - 135.08

37.22

19.19 - 54.81

28

28

0

40.21

33.36

27.86 - 52.57

0.49 - 110.79

34.79

9.36 - 63.23

0.9278

0.9731

4+DR+

Abs_Value

39

39

0

102.8

170.68

49.23 - 156.37

0.05 - 960.16

65.32

31.43 - 87.28

28

28

0

64.77

56.51

43.84 - 85.71

4.16 - 250.67

51.29

24.28 - 82.42

0.2011

0.6696

4+PD-1-TIGIT-

Abs_Value

39

39

0

48.64

34

37.97 - 59.31

0.03 - 131.28

34.59

25.53 - 75.58

28

28

0

55.29

44.79

38.69 - 71.88

6.67 - 166.24

41.71

22.29 - 76.75

0.5119

0.73

4+PD-1-TIGIT+

Abs_Value

39

39

0

8.16

24.25

0.55 - 15.77

0 - 154.31

3.78

1.76 - 6.59

28

28

0

4.87

3.39

3.61 - 6.12

0.25 - 12.65

3.76

2.29 - 7.19

0.4071

0.6762

4+PD-1+

Abs_Value

39

39

0

108.13

148.15

61.64 - 154.63

0.33 - 789.05

77.82

46.08 - 97.71

28

28

0

82.56

62.59

59.37 - 105.74

7.01 - 256.14

70.45

36.32 - 110.92

0.3389

0.6696

4+PD-1+TIGIT-

Abs_Value

39

39

0

55.79

53.07

39.14 - 72.45

0.28 - 262.81

35.44

26.29 - 61.74

28

28

0

47.04

40.36

32.09 - 61.98

3.7 - 176.04

35.9

21.62 - 63.3

0.4459

0.6834

4+PD-1+TIGIT+

Abs_Value

39

39

0

52.34

100.95

20.66 - 84.03

0.05 - 526.23

28.49

18 - 44.4

28

28

0

35.52

29.85

24.47 - 46.58

3.31 - 119.05

23.88

15.59 - 49.99

0.3309

0.6696

4+TIGIT+

Abs_Value

39

39

0

60.51

121.07

22.51 - 98.51

0.05 - 680.54

31.37

20.51 - 50.09

28

28

0

40.39

31.42

28.75 - 52.03

4.89 - 130.02

28.02

20.05 - 55.79

0.3264

0.6696

4NV

Abs_Value

39

39

0

17.03

15.12

12.28 - 21.78

0 - 55.9

12.73

6.44 - 21.38

28

28

0

28.77

26.38

19 - 38.55

3.15 - 110.75

18.27

8.39 - 39.7

0.0404

0.6696

4NV(СТАР2)

Abs_Value

39

39

0

15.95

15.14

11.2 - 20.7

0 - 54

10.42

6.42 - 18.05

28

28

0

26.63

24.08

17.71 - 35.55

4.36 - 99.11

18.69

7.91 - 35.34

0.0444

0.6696

4NV_TH1

Abs_Value

39

39

0

1.27

1.37

0.84 - 1.7

0 - 6.02

0.92

0.31 - 1.7

28

28

0

1.99

2.02

1.24 - 2.74

0.01 - 7.62

1.39

0.42 - 2.94

0.1094

0.6696

4NV_TH17

Abs_Value

39

39

0

0.59

0.58

0.41 - 0.77

0 - 2.9

0.41

0.18 - 0.81

28

28

0

0.92

0.76

0.64 - 1.2

0.12 - 3.24

0.68

0.45 - 1.19

0.0582

0.6696

4NV_Th17TO1

Abs_Value

39

39

0

0.11

0.12

0.08 - 0.15

0 - 0.43

0.07

0.02 - 0.17

28

28

0

0.21

0.25

0.12 - 0.3

0.01 - 1.08

0.12

0.04 - 0.24

0.0737

0.6696

4NV_TH2

Abs_Value

39

39

0

1.99

2.41

1.23 - 2.74

0 - 11.34

1.09

0.62 - 2.33

28

28

0

4.1

4.56

2.41 - 5.79

0.14 - 20.02

2.86

1.01 - 5.49

0.0312

0.6696

4NV_TH22

Abs_Value

39

39

0

0.05

0.08

0.03 - 0.08

0 - 0.32

0.02

0.01 - 0.06

28

28

0

0.09

0.12

0.05 - 0.14

0 - 0.55

0.04

0.01 - 0.15

0.1106

0.6696

4NV+226+

Abs_Value

39

39

0

13.74

13.09

9.63 - 17.84

0 - 43.3

9.21

6.11 - 15.8

28

28

0

23.13

21.19

15.28 - 30.98

3.48 - 85.04

16.11

7.06 - 29.98

0.044

0.6696

4NV+39+

Abs_Value

39

39

0

0.7

0.89

0.42 - 0.98

0 - 3.98

0.4

0.1 - 0.87

28

28

0

0.98

0.98

0.61 - 1.34

0.01 - 4.69

0.75

0.48 - 1.13

0.2396

0.6696

4NV+DR+

Abs_Value

39

39

0

1.96

3.25

0.94 - 2.98

0 - 17.28

0.83

0.41 - 1.75

28

28

0

1.75

1.95

1.03 - 2.47

0.25 - 10.14

1.16

0.7 - 1.82

0.7485

0.9026

4NV+PD-1-TIGIT-

Abs_Value

39

39

0

14.19

14.36

9.69 - 18.7

0 - 47.46

9.27

4.44 - 17.37

28

28

0

24.61

23.7

15.84 - 33.39

2.32 - 98.02

16.98

6.11 - 33.64

0.0448

0.6696

4NV+PD-1-TIGIT+

Abs_Value

39

39

0

0.46

0.79

0.22 - 0.71

0 - 4.58

0.26

0.11 - 0.41

28

28

0

0.61

0.55

0.4 - 0.81

0.07 - 2.14

0.44

0.25 - 0.7

0.3928

0.6762

4NV+PD-1+TIGIT-

Abs_Value

39

39

0

0.87

1.14

0.51 - 1.23

0 - 4.56

0.35

0.23 - 0.96

28

28

0

0.93

0.76

0.65 - 1.21

0.1 - 3.04

0.72

0.34 - 1.24

0.7927

0.9228

4NV+PD-1+TIGIT+

Abs_Value

39

39

0

0.42

0.56

0.25 - 0.6

0 - 2.84

0.19

0.08 - 0.57

28

28

0

0.48

0.35

0.35 - 0.61

0.05 - 1.27

0.4

0.23 - 0.62

0.5964

0.7825

4NV+PD1+

Abs_Value

39

39

0

1.29

1.54

0.81 - 1.77

0 - 6.69

0.63

0.33 - 1.84

28

28

0

1.41

0.95

1.06 - 1.76

0.25 - 3.76

1.16

0.64 - 1.95

0.6939

0.8621

4NV+TIGIT+

Abs_Value

39

39

0

0.88

1.11

0.54 - 1.23

0 - 5.34

0.5

0.24 - 1.04

28

28

0

1.08

0.76

0.8 - 1.37

0.19 - 3.42

0.91

0.5 - 1.39

0.3839

0.6762

4ЕМ

Abs_Value

39

39

0

29.18

89.5

1.09 - 57.27

0.01 - 428.8

3.42

0.63 - 16.48

28

28

0

7.64

17.2

1.27 - 14.01

0 - 67.92

0.8

0.19 - 3.72

0.1502

0.6696

4ЕМ_TH1

Abs_Value

39

39

0

11.29

43.51

-2.37 - 24.94

0 - 267.92

1.06

0.16 - 3.75

28

28

0

1.94

5.86

-0.23 - 4.11

0 - 30.53

0.2

0.03 - 0.92

0.1925

0.6696

4ЕМ_TH17

Abs_Value

39

39

0

0.07

0.19

0.01 - 0.13

0 - 0.9

0.01

0 - 0.03

28

28

0

0.01

0.03

0 - 0.02

0 - 0.15

0

0 - 0.01

0.0572

0.6696

4ЕМ_Th17TO1

Abs_Value

39

39

0

0.29

0.88

0.01 - 0.56

0 - 5.46

0.04

0.01 - 0.32

28

28

0

0.04

0.08

0.01 - 0.07

0 - 0.41

0.01

0 - 0.04

0.0894

0.6696

4ЕМ_TH2

Abs_Value

39

39

0

3.8

21.09

-2.81 - 10.42

0 - 131.99

0.08

0.02 - 0.43

28

28

0

0.3

0.62

0.07 - 0.53

0 - 2.67

0.03

0.01 - 0.2

0.3066

0.6696

4ЕМ_TH22

Abs_Value

39

39

0

0.01

0.03

0 - 0.02

0 - 0.15

0

0 - 0

28

28

0

0.01

0.01

0 - 0.01

0 - 0.05

0

0 - 0

0.3268

0.6696

4ЕМ+226+

Abs_Value

39

39

0

85.97

111.51

50.98 - 120.97

0.28 - 553.6

60.55

31.84 - 87.48

28

28

0

61.27

45.72

44.34 - 78.21

2.92 - 184.9

61.09

24.67 - 85.82

0.2184

0.6696

4ЕМ+39+

Abs_Value

39

39

0

23.58

18.88

17.65 - 29.5

0.07 - 70.57

22.61

9.99 - 38

28

28

0

21.36

18.22

14.61 - 28.11

0.36 - 65.22

19.28

3.74 - 34.53

0.6308

0.8082

4ЕМ+DR+

Abs_Value

39

39

0

64.34

103.15

31.97 - 96.71

0.05 - 497.18

41.66

22.69 - 54.93

28

28

0

39.41

37.3

25.59 - 53.22

1.61 - 158.94

31.55

12.09 - 55.55

0.1711

0.6696

4ЕМ+PD1-TIGIT-

Abs_Value

39

39

0

17.15

17.92

11.53 - 22.78

0.02 - 72.04

10.23

5.61 - 20.32

28

28

0

13.15

14.56

7.75 - 18.54

0.12 - 53.88

6.67

4.26 - 15.63

0.3174

0.6696

4ЕМ+PD1-TIGIT+

Abs_Value

39

39

0

3.48

10.15

0.29 - 6.66

0 - 64.16

1.27

0.67 - 2.64

28

28

0

1.74

1.51

1.18 - 2.3

0.03 - 5.22

1.22

0.61 - 2.92

0.2989

0.6696

4ЕМ+PD1+

Abs_Value

39

39

0

68.62

97.13

38.13 - 99.1

0.31 - 488.16

42.29

29.92 - 67.94

28

28

0

49.55

43.2

33.55 - 65.55

2.85 - 169.81

41.27

18.21 - 65.64

0.2824

0.6696

4ЕМ+PD1+TIGIT-

Abs_Value

39

39

0

36.22

35.42

25.1 - 47.33

0.26 - 163.47

25.02

16.2 - 42.8

28

28

0

29.95

28.72

19.32 - 40.59

1.55 - 118.87

21.16

10.76 - 39.53

0.4278

0.6834

4ЕМ+PD1+TIGIT+

Abs_Value

39

39

0

32.4

66.32

11.58 - 53.22

0.05 - 343.46

16.95

9.28 - 23.66

28

28

0

19.6

19.73

12.29 - 26.9

1.3 - 92.73

14.3

6.25 - 25.74

0.2611

0.6696

4ЕМ+TIGIT+

Abs_Value

39

39

0

35.88

73.29

12.88 - 58.88

0.05 - 349.01

18.54

10.11 - 26.96

28

28

0

21.34

20.59

13.71 - 28.97

1.44 - 97.96

18.46

6.9 - 26.92

0.2457

0.6696

4ЕМTM

Abs_Value

39

39

0

89.25

112.7

53.88 - 124.62

0.33 - 560.51

61.41

33.6 - 92.27

28

28

0

64.44

48.25

46.57 - 82.31

3.5 - 201.17

63.48

25.56 - 91.84

0.225

0.6696

4СМ

Abs_Value

39

39

0

31.42

22.37

24.4 - 38.44

0 - 119.97

27.94

16.69 - 46.26

28

28

0

40.08

23.5

31.38 - 48.79

5.35 - 88.59

43.11

17.54 - 53.18

0.1344

0.6696

4СМ(СТАР2)

Abs_Value

39

39

0

30.02

22.79

22.87 - 37.17

0 - 133.51

26.43

16.63 - 38.84

28

28

0

32.97

19.84

25.62 - 40.32

1.94 - 67.99

34.65

16.28 - 44.77

0.5747

0.7633

4СМ_TH1

Abs_Value

39

39

0

1.56

2.53

0.76 - 2.35

0 - 15.41

1.1

0.34 - 1.69

28

28

0

1.57

1.47

1.03 - 2.12

0 - 4.36

0.9

0.36 - 2.7

0.9785

0.9845

4СМ_TH17

Abs_Value

39

39

0

5.03

3.89

3.81 - 6.25

0 - 15.87

4.24

1.91 - 7.32

28

28

0

6.77

5.73

4.65 - 8.89

0.22 - 20.07

4.4

2 - 10.07

0.17

0.6696

4СМ_Th17TO1

Abs_Value

39

39

0

0.38

0.57

0.21 - 0.56

0 - 3.07

0.24

0.06 - 0.41

28

28

0

0.55

0.73

0.28 - 0.82

0.03 - 3.05

0.25

0.12 - 0.65

0.3224

0.6696

4СМ_TH2

Abs_Value

39

39

0

3.18

2.55

2.38 - 3.98

0 - 11.68

2.61

1.48 - 4.55

28

28

0

5.02

4.33

3.42 - 6.63

0.29 - 18.6

4.09

1.54 - 8.19

0.0505

0.6696

4СМ_TH22

Abs_Value

39

39

0

0.53

0.65

0.33 - 0.74

0 - 3.29

0.32

0.1 - 0.69

28

28

0

0.85

0.79

0.56 - 1.14

0.01 - 2.75

0.79

0.19 - 1.1

0.0902

0.6696

4СМ+226+

Abs_Value

39

39

0

27.75

21.33

21.06 - 34.45

0 - 125.07

23.75

15.53 - 36.02

28

28

0

30.78

18.69

23.86 - 37.71

1.86 - 63.84

32.53

15.09 - 40.76

0.5396

0.7484

4СМ+39+

Abs_Value

39

39

0

10.35

10.02

7.2 - 13.49

0 - 49.38

9.36

1.53 - 13.97

28

28

0

12.32

11.87

7.92 - 16.71

0.01 - 39.63

9.41

1.22 - 17.71

0.479

0.701

4СМ+DR+

Abs_Value

39

39

0

14.08

20.69

7.59 - 20.58

0 - 127.35

9.85

5.25 - 13.14

28

28

0

11.9

10.78

7.91 - 15.89

0.25 - 41.83

8.12

3.91 - 16.05

0.5771

0.7633

4СМ+PD1-TIGIT-

Abs_Value

39

39

0

9.47

6.39

7.46 - 11.47

0 - 23.26

7.52

5.37 - 13.64

28

28

0

11.96

10.31

8.14 - 15.78

0.12 - 41.2

8.6

4.25 - 18.41

0.264

0.6696

4СМ+PD1-TIGIT+

Abs_Value

39

39

0

1.44

2.08

0.78 - 2.09

0 - 12.64

0.77

0.45 - 2.01

28

28

0

1.41

1.22

0.96 - 1.86

0.01 - 4.72

1.1

0.6 - 1.79

0.9483

0.9731

4СМ+PD1+

Abs_Value

39

39

0

19.12

18.7

13.25 - 24.99

0 - 111.86

16.09

9.77 - 23.86

28

28

0

19.6

14.8

14.12 - 25.08

0.46 - 61.96

17.76

10.26 - 23.57

0.9061

0.9731

4СМ+PD1+TIGIT-

Abs_Value

39

39

0

8.47

5.96

6.6 - 10.34

0 - 23.93

7.21

4.23 - 13.21

28

28

0

8.74

6.04

6.5 - 10.98

0.31 - 24.42

8.55

5.14 - 11.06

0.855

0.9574

4СМ+PD1+TIGIT+

Abs_Value

39

39

0

10.65

14.71

6.04 - 15.27

0 - 90.89

7.63

3.58 - 11.64

28

28

0

10.86

9.95

7.18 - 14.55

0.15 - 37.55

8.88

5.08 - 12.27

0.9441

0.9731

4СМ+TIGIT+

Abs_Value

39

39

0

12.09

16.62

6.87 - 17.31

0 - 103.53

9

4.03 - 13.68

28

28

0

12.28

10.32

8.45 - 16.1

0.27 - 38.44

10.69

5.63 - 14.57

0.9553

0.9731

4ТM_TH1

Abs_Value

39

39

0

12.66

19.35

6.58 - 18.73

0.14 - 107.61

5.15

2.95 - 13.84

28

28

0

9.75

16.05

3.8 - 15.69

0.01 - 69.74

3.11

1.28 - 9.12

0.5047

0.7261

4ТM_TH17

Abs_Value

39

39

0

7.59

5.69

5.8 - 9.37

0.02 - 20.47

5.91

3.82 - 10.49

28

28

0

5.4

4.24

3.83 - 6.97

0.07 - 17.72

4.87

2.86 - 7.51

0.0761

0.6696

4ТM_Th17TO1

Abs_Value

39

39

0

2.19

1.71

1.65 - 2.72

0.03 - 6.88

1.88

0.98 - 3.01

28

28

0

2.64

3.74

1.26 - 4.02

0 - 13.42

1.26

0.4 - 2.99

0.5522

0.7484

4ТM_TH2

Abs_Value

39

39

0

3.2

3.01

2.26 - 4.15

0.02 - 13.03

2.17

1.45 - 3.93

28

28

0

3.69

4.82

1.91 - 5.48

0.07 - 25.5

2.9

0.95 - 4.16

0.6371

0.81

4ТM_TH22

Abs_Value

39

39

0

3.03

2.8

2.15 - 3.91

0 - 11.23

1.9

1.07 - 4.73

28

28

0

2.99

3.07

1.85 - 4.12

0 - 11.35

2.21

0.77 - 4.02

0.9515

0.9731

4ТREG

Abs_Value

39

39

0

1.24

1.42

0.79 - 1.69

0 - 5.79

0.69

0.23 - 1.75

28

28

0

2.41

6.03

0.18 - 4.64

0.03 - 32.72

1.27

0.48 - 2.01

0.3225

0.6696

4ТREG(СТАР2)

Abs_Value

39

39

0

73

75.81

49.2 - 96.79

0.01 - 424.27

59.76

24.03 - 94.33

28

28

0

85.58

47.59

67.95 - 103.2

1.89 - 193.24

83.08

45.45 - 117.11

0.4082

0.6762

4ТREG_TH1

Abs_Value

39

39

0

0.2

0.24

0.12 - 0.28

0 - 0.92

0.14

0.03 - 0.2

28

28

0

0.22

0.24

0.13 - 0.31

0 - 1

0.15

0.07 - 0.3

0.7316

0.8954

4ТREG_TH17

Abs_Value

39

39

0

2.82

2.61

2 - 3.64

0.01 - 11.98

1.98

0.91 - 4.27

28

28

0

3.49

3.54

2.17 - 4.8

0.06 - 15.96

2.59

1.19 - 4.07

0.4005

0.6762

4ТREG_Th17TO1

Abs_Value

39

39

0

0.07

0.1

0.04 - 0.1

0 - 0.44

0.04

0.01 - 0.08

28

28

0

0.1

0.14

0.05 - 0.15

0 - 0.47

0.04

0.02 - 0.1

0.3475

0.6701

4ТREG_TH2

Abs_Value

39

39

0

1.54

1.37

1.11 - 1.97

0 - 5.88

1.46

0.53 - 2.34

28

28

0

2.23

2.84

1.18 - 3.28

0.22 - 14.5

1.3

0.74 - 3.06

0.2427

0.6696

4ТREG_TH22

Abs_Value

39

39

0

1.69

2.05

1.05 - 2.33

0.01 - 11.04

1.01

0.55 - 2.04

28

28

0

1.82

1.85

1.14 - 2.51

0 - 8.31

1.47

0.4 - 2.49

0.7863

0.9228

4ТЕ

Abs_Value

39

39

0

11.59

46.78

-3.09 - 26.27

0.01 - 293.46

0.64

0.2 - 5.63

28

28

0

2.37

3.82

0.96 - 3.78

0.03 - 14.73

0.88

0.24 - 2.04

0.2278

0.6696

4ТЕ(СТАР2)

Abs_Value

39

39

0

27.59

51.5

11.43 - 43.76

0.03 - 310.52

13.13

6.43 - 23.4

28

28

0

17.96

16.22

11.95 - 23.97

1.53 - 73.6

12.4

8.11 - 26.72

0.279

0.6696

4ТЕ_TH1

Abs_Value

39

39

0

5.91

29.66

-3.4 - 15.22

0 - 185.79

0.13

0.02 - 1.02

28

28

0

0.47

1.02

0.09 - 0.85

0 - 4.5

0.14

0.01 - 0.33

0.2599

0.6696

4ТЕ_TH17

Abs_Value

39

39

0

0.01

0.03

0 - 0.02

0 - 0.17

0

0 - 0

28

28

0

0.01

0.02

0 - 0.01

0 - 0.07

0

0 - 0

0.4728

0.6986

4ТЕ_Th17TO1

Abs_Value

39

39

0

0.13

0.65

-0.08 - 0.33

0 - 4.08

0.01

0 - 0.03

28

28

0

0.01

0.02

0 - 0.02

0 - 0.07

0

0 - 0.01

0.2706

0.6696

4ТЕ_TH2

Abs_Value

39

39

0

0.42

1.36

-0.01 - 0.84

0 - 6.25

0.01

0 - 0.12

28

28

0

0.08

0.13

0.04 - 0.13

0 - 0.51

0.02

0 - 0.12

0.1315

0.6696

4ТЕ_TH22

Abs_Value

39

39

0

0.01

0.01

0 - 0.01

0 - 0.06

0

0 - 0.01

28

28

0

0

0.01

0 - 0.01

0 - 0.05

0

0 - 0

0.4354

0.6834

4ТЕ+226+

Abs_Value

39

39

0

26.34

51.15

10.28 - 42.39

0.03 - 307.76

11.03

6.12 - 22.51

28

28

0

16.66

15.37

10.97 - 22.35

1.33 - 71.49

11.51

7.18 - 22.78

0.271

0.6696

4ТЕ+39+

Abs_Value

39

39

0

4.33

3.99

3.08 - 5.59

0 - 17.63

3.24

0.79 - 6.09

28

28

0

5.45

6.64

2.99 - 7.91

0.05 - 29.5

3.18

1.51 - 6.83

0.4309

0.6834

4ТЕ+DR+

Abs_Value

39

39

0

20.75

45.95

6.33 - 35.17

0 - 273.14

8.21

4.06 - 17.59

28

28

0

11.62

15.22

5.98 - 17.26

0.27 - 71.42

7.25

3.38 - 11.19

0.2534

0.6696

4ТЕ+PD-1-TIGIT-

Abs_Value

39

39

0

7.42

9.57

4.42 - 10.42

0 - 48.37

3.79

2.16 - 8.9

28

28

0

5.1

4.7

3.36 - 6.84

0.27 - 20.57

4.19

2.35 - 5.99

0.1945

0.6696

4ТЕ+PD-1-TIGIT+

Abs_Value

39

39

0

2.5

10.09

-0.67 - 5.67

0 - 63.72

0.68

0.29 - 1.27

28

28

0

1.05

0.99

0.68 - 1.42

0.02 - 4.29

0.78

0.36 - 1.29

0.3773

0.6762

4ТЕ+PD-1+

Abs_Value

39

39

0

17.67

35.09

6.66 - 28.68

0.02 - 198.43

7.84

3.82 - 16

28

28

0

11.81

14.43

6.47 - 17.16

0.53 - 65.87

7.14

3.15 - 12.28

0.3527

0.6701

4ТЕ+PD-1+TIGIT-

Abs_Value

39

39

0

9.85

14.26

5.38 - 14.33

0.02 - 68.31

3.85

2.12 - 11.01

28

28

0

7.28

9.7

3.69 - 10.88

0.31 - 45.47

3.94

1.99 - 7.31

0.3832

0.6762

4ТЕ+PD-1+TIGIT+

Abs_Value

39

39

0

7.82

22.22

0.84 - 14.79

0 - 130.12

2.71

1.56 - 4.95

28

28

0

4.53

5.52

2.49 - 6.58

0.23 - 21.97

2.11

1.41 - 5.09

0.3806

0.6762

4ТЕ+TIGIT+

Abs_Value

39

39

0

10.32

31.7

0.37 - 20.27

0 - 193.84

3.7

2.22 - 6.07

28

28

0

5.58

6.07

3.33 - 7.83

0.34 - 22.91

3.11

2.07 - 5.82

0.3679

0.6762

4ТМ

Abs_Value

39

39

0

68.73

44.83

54.66 - 82.8

0.29 - 206.37

59.16

36.36 - 89.43

28

28

0

60.2

43.52

44.08 - 76.32

2.7 - 156.95

59.02

21.18 - 93.81

0.4377

0.6834

8+

Abs_Value

39

39

0

338.23

532.81

171.01 - 505.45

3.6 - 2131.88

94.25

33.79 - 338.12

28

28

0

163.88

420.4

8.16 - 319.59

0.65 - 2174.4

32.02

7.98 - 107.38

0.1397

0.6696

8+ (IM STAT)

Abs_Value

39

39

0

367.88

552.6

194.44 - 541.31

3.93 - 2176.1

99.73

39.92 - 499.23

28

28

0

190.71

457.37

21.29 - 360.12

0.71 - 2351.17

40.68

13.82 - 116.25

0.1569

0.6696

8+226+

Abs_Value

39

39

0

470.53

618.71

276.35 - 664.71

19.73 - 2309.79

182.21

83.91 - 662.23

28

28

0

254.15

484.55

74.67 - 433.63

7.76 - 2484.23

93.15

40.59 - 227.28

0.1136

0.6696

8+39+

Abs_Value

39

39

0

50.88

78.12

26.36 - 75.39

0.09 - 418.95

23.41

8.89 - 61.49

28

28

0

47.44

107.14

7.75 - 87.13

0.2 - 562.33

12.38

3.76 - 49.88

0.8858

0.9621

8+DR+

Abs_Value

39

39

0

367.32

527.47

201.78 - 532.87

4.94 - 2168.46

142.83

62.61 - 414.98

28

28

0

216.12

474.09

40.51 - 391.73

2.26 - 2431.19

63.22

19.15 - 162.93

0.2241

0.6696

8+PD-1-TIGIT-

Abs_Value

39

39

0

135.49

198.3

73.25 - 197.72

5.63 - 815.7

39.97

17.51 - 139.58

28

28

0

76.66

134.27

26.93 - 126.39

1.36 - 704.51

40.59

10.93 - 84.58

0.1526

0.6696

8+PD-1-TIGIT+

Abs_Value

39

39

0

144.2

244.69

67.4 - 221

1.37 - 1271.22

31.04

10.46 - 209.95

28

28

0

65.97

141.78

13.46 - 118.49

1 - 719.74

15.57

7.8 - 62.55

0.1044

0.6696

8+PD-1+

Abs_Value

39

39

0

217.19

328.31

114.15 - 320.23

7.78 - 1736.81

95

38.06 - 229.28

28

28

0

133.94

258.59

38.15 - 229.72

1.8 - 1201.16

35.47

16.3 - 80.32

0.2504

0.6696

8+PD-1+TIGIT-

Abs_Value

39

39

0

71.54

104.23

38.83 - 104.25

1.45 - 448.19

26.52

4.16 - 106.41

28

28

0

41.87

87.52

9.45 - 74.29

0.7 - 428.96

12.39

3.78 - 32.22

0.2113

0.6696

8+PD-1+TIGIT+

Abs_Value

39

39

0

145.65

238.86

70.69 - 220.62

5.05 - 1288.62

68.95

21.04 - 122.68

28

28

0

92.07

178.77

25.85 - 158.28

0.99 - 772.2

19.64

11.2 - 49.28

0.2976

0.6696

8+TIGIT+

Abs_Value

39

39

0

289.85

431.67

154.37 - 425.33

6.42 - 1840.75

94.56

43.22 - 313.01

28

28

0

158.04

314.31

41.62 - 274.46

1.99 - 1491.94

43.96

19.14 - 109.1

0.1529

0.6696

8EMTM

Abs_Value

39

39

0

77.74

115.56

41.47 - 114

2.95 - 582.56

29.11

9.7 - 91.47

28

28

0

70.04

204.35

-5.65 - 145.73

0.4 - 1077.88

11.45

3.34 - 45.52

0.8582

0.9574

8EMTM+226+

Abs_Value

39

39

0

72.96

112.94

37.51 - 108.41

2.29 - 577.84

28.32

7.48 - 83.22

28

28

0

64.24

192.62

-7.11 - 135.59

0.36 - 1020.79

10.3

2.38 - 43.16

0.8312

0.9533

8EMTM+39+

Abs_Value

39

39

0

14.47

23.42

7.12 - 21.82

0.04 - 99.93

4.62

1.73 - 15.46

28

28

0

15.07

51.88

-4.14 - 34.29

0.03 - 277.35

1.72

0.75 - 9.77

0.9544

0.9731

8EMTM+DR+

Abs_Value

39

39

0

64.68

100.49

33.15 - 96.22

1.79 - 474.38

25.43

8.16 - 71.87

28

28

0

62.31

194.49

-9.73 - 134.35

0.28 - 1026.67

6.98

1.25 - 30.94

0.9532

0.9731

8EMTM+PD-1-TIGIT-

Abs_Value

39

39

0

16.56

28.57

7.59 - 25.52

0.1 - 131.33

4.96

1.16 - 19.06

28

28

0

14.71

44.65

-1.83 - 31.25

0.1 - 237.98

2.42

0.29 - 9.52

0.8481

0.9574

8EMTM+PD-1-TIGIT+

Abs_Value

39

39

0

18.89

47.24

4.06 - 33.71

0.12 - 275.2

4.85

0.88 - 12.82

28

28

0

12.87

39.42

-1.74 - 27.47

0.04 - 206

0.93

0.23 - 7.56

0.5727

0.7633

8EMTM+PD-1+

Abs_Value

39

39

0

42.29

57.22

24.33 - 60.25

2.21 - 240.61

17.22

6.99 - 48.08

28

28

0

42.46

121.77

-2.64 - 87.57

0.27 - 633.9

6.11

1.59 - 25.15

0.9945

0.9945

8EMTM+PD-1+TIGIT-

Abs_Value

39

39

0

13

16.61

7.78 - 18.21

0.2 - 74.77

5.86

1.15 - 19.09

28

28

0

13.87

44.21

-2.5 - 30.25

0.08 - 235.25

2.36

0.47 - 7.78

0.9209

0.9731

8EMTM+PD-1+TIGIT+

Abs_Value

39

39

0

29.3

44.1

15.46 - 43.14

0.71 - 188.94

11.73

3.71 - 27.49

28

28

0

28.59

79.29

-0.78 - 57.96

0.12 - 398.65

3.64

1.15 - 13.56

0.9662

0.9781

8EMTM+TIGIT+

Abs_Value

39

39

0

48.18

86.13

21.15 - 75.22

0.83 - 464.14

17.79

5.39 - 42.69

28

28

0

41.46

118.34

-2.38 - 85.29

0.16 - 604.65

4.85

1.71 - 21.19

0.799

0.9228

8NV

Abs_Value

39

39

0

7.64

9.28

4.73 - 10.56

0.02 - 46.45

5.08

1.98 - 8.98

28

28

0

11.62

11.65

7.31 - 15.94

0.67 - 55.43

7.91

5.17 - 17.08

0.1405

0.6696

8NV(СТАР2)

Abs_Value

39

39

0

9.6

11.35

6.04 - 13.16

0.03 - 49.35

5.19

2.26 - 10.73

28

28

0

11.25

10.66

7.3 - 15.19

1.05 - 48.26

6.76

4.77 - 14.25

0.5468

0.7484

8NV+226+

Abs_Value

39

39

0

8.68

10.74

5.31 - 12.05

0.03 - 49.26

4.68

1.99 - 10.06

28

28

0

9.91

9.3

6.47 - 13.36

0.95 - 40.2

5.96

4.28 - 12.51

0.6174

0.7973

8NV+39+

Abs_Value

39

39

0

0.6

0.97

0.29 - 0.9

0 - 5.17

0.3

0.06 - 0.64

28

28

0

0.67

0.81

0.36 - 0.97

0.01 - 3.73

0.44

0.13 - 0.8

0.7558

0.9048

8NV+DR+

Abs_Value

39

39

0

2.56

4.43

1.17 - 3.96

0.01 - 16.54

0.66

0.3 - 1.9

28

28

0

1.37

2.02

0.62 - 2.12

0.03 - 9.92

0.6

0.44 - 1.22

0.1426

0.6696

8NV+PD-1-TIGIT-

Abs_Value

39

39

0

7.04

9.42

4.09 - 10

0 - 43.98

3.81

1.03 - 8.78

28

28

0

9.61

10.56

5.7 - 13.52

0.23 - 47.12

5.74

3.06 - 12.31

0.3088

0.6696

8NV+PD-1-TIGIT+

Abs_Value

39

39

0

1.11

1.92

0.51 - 1.72

0 - 9.21

0.49

0.22 - 0.85

28

28

0

0.73

0.83

0.42 - 1.03

0.05 - 3.77

0.46

0.23 - 0.72

0.2655

0.6696

8NV+PD-1+

Abs_Value

39

39

0

1.45

2.12

0.78 - 2.11

0.02 - 10

0.52

0.2 - 1.5

28

28

0

0.91

1.11

0.5 - 1.32

0.05 - 3.96

0.44

0.23 - 1.06

0.1836

0.6696

8NV+PD-1+TIGIT-

Abs_Value

39

39

0

0.5

0.92

0.21 - 0.79

0 - 4.91

0.15

0.03 - 0.5

28

28

0

0.31

0.36

0.18 - 0.45

0 - 1.26

0.2

0.08 - 0.4

0.2527

0.6696

8NV+PD-1+TIGIT+

Abs_Value

39

39

0

0.95

1.35

0.52 - 1.37

0.01 - 5.16

0.39

0.15 - 1.12

28

28

0

0.6

0.89

0.27 - 0.92

0.04 - 3.31

0.25

0.17 - 0.38

0.2056

0.6696

8NV+TIGIT+

Abs_Value

39

39

0

2.06

3.05

1.1 - 3.02

0.01 - 12.72

0.88

0.45 - 2.26

28

28

0

1.32

1.63

0.72 - 1.93

0.11 - 6.55

0.64

0.46 - 1.05

0.2063

0.6696

8TREG

Abs_Value

39

39

0

334.51

529.5

168.33 - 500.7

3.32 - 2109.36

93.76

33.11 - 326.8

28

28

0

166.61

430.63

7.1 - 326.11

0.67 - 2227.15

31.77

8.02 - 102.77

0.158

0.6696

8ЕМ

Abs_Value

39

39

0

79.03

128.38

38.73 - 119.32

0.46 - 668.2

28.95

7.36 - 99.94

28

28

0

67.68

206.05

-8.64 - 144

0.11 - 1084.06

7.04

1.01 - 34.8

0.7979

0.9228

8СМ

Abs_Value

39

39

0

2.88

6.14

0.95 - 4.81

0.01 - 37.25

0.94

0.56 - 2.43

28

28

0

5.32

12.63

0.64 - 9.99

0.08 - 67.57

2.36

0.34 - 5.01

0.351

0.6701

8СМ(СТАР2)

Abs_Value

39

39

0

6

19.68

-0.18 - 12.17

0.02 - 118.92

1.16

0.72 - 3.09

28

28

0

3.83

5.57

1.77 - 5.9

0.02 - 19.92

1.88

0.27 - 4.27

0.5181

0.7325

8СМ+226+

Abs_Value

39

39

0

5.61

19.33

-0.46 - 11.67

0.02 - 118.25

1.08

0.6 - 2.93

28

28

0

3.33

4.75

1.57 - 5.09

0.02 - 16.84

1.68

0.22 - 3.34

0.483

0.701

8СМ+39+

Abs_Value

39

39

0

0.93

1.62

0.43 - 1.44

0 - 9.34

0.47

0.18 - 0.76

28

28

0

1.27

1.93

0.55 - 1.98

0 - 6.95

0.2

0.07 - 1.77

0.4626

0.6986

8СМ+DR+

Abs_Value

39

39

0

5.16

17.97

-0.48 - 10.8

0.01 - 107.27

0.96

0.51 - 2.09

28

28

0

2.81

5.22

0.87 - 4.74

0.01 - 19.49

0.69

0.13 - 1.93

0.4428

0.6834

8СМ+PD-1-TIGIT-

Abs_Value

39

39

0

1.23

2.88

0.32 - 2.13

0 - 15.65

0.25

0.11 - 0.88

28

28

0

1.12

1.58

0.54 - 1.71

0 - 5.79

0.49

0.11 - 1.24

0.8486

0.9574

8СМ+PD-1-TIGIT+

Abs_Value

39

39

0

2.1

9.31

-0.83 - 5.02

0 - 58.16

0.2

0.1 - 0.58

28

28

0

0.69

1.18

0.25 - 1.12

0 - 5.17

0.2

0.05 - 0.61

0.3555

0.6701

8СМ+PD-1+

Abs_Value

39

39

0

2.67

7.9

0.2 - 5.15

0.02 - 45.11

0.74

0.28 - 1.51

28

28

0

2.03

3.93

0.57 - 3.48

0.01 - 15.63

0.52

0.1 - 1.43

0.6598

0.8324

8СМ+PD-1+TIGIT-

Abs_Value

39

39

0

0.68

1.95

0.07 - 1.29

0 - 9.81

0.15

0.03 - 0.35

28

28

0

0.49

1

0.12 - 0.86

0.01 - 4.45

0.11

0.04 - 0.38

0.6059

0.7886

8СМ+PD-1+TIGIT+

Abs_Value

39

39

0

1.99

6.19

0.05 - 3.94

0.01 - 37.26

0.62

0.21 - 1.18

28

28

0

1.53

2.99

0.43 - 2.64

0 - 11.18

0.39

0.06 - 1.08

0.6889

0.8621

8СМ+TIGIT+

Abs_Value

39

39

0

4.09

15.41

-0.75 - 8.93

0.01 - 95.42

0.8

0.34 - 1.64

28

28

0

2.22

3.86

0.79 - 3.65

0 - 12.71

0.7

0.13 - 2.13

0.4714

0.6986

8ТЕ

Abs_Value

39

39

0

340.55

488.28

187.3 - 493.79

4.38 - 1891.65

72.89

27.04 - 523.74

28

28

0

135.07

228.34

50.49 - 219.65

0.46 - 1033.99

42.13

12.61 - 131.19

0.0251

0.6696

8ТЕ(СТАР2)

Abs_Value

39

39

0

399.82

532.76

232.61 - 567.03

7.72 - 2117.62

121.61

53.59 - 623.55

28

28

0

190.71

317.08

73.26 - 308.16

2.04 - 1520.64

74.98

26.84 - 165.62

0.0492

0.6696

8ТЕ+226+

Abs_Value

39

39

0

380.04

511.32

219.56 - 540.51

6.99 - 1998.95

102.32

50.26 - 599.53

28

28

0

176.1

299.7

65.09 - 287.11

1.84 - 1441.91

61.81

24.47 - 147.36

0.0447

0.6696

8ТЕ+39+

Abs_Value

39

39

0

34.3

57.18

16.35 - 52.25

0.05 - 321.3

13.22

3.65 - 43.95

28

28

0

30.36

56.92

9.27 - 51.44

0.07 - 278.04

7.6

2.95 - 34.51

0.781

0.9228

8ТЕ+DR+

Abs_Value

39

39

0

291.49

426.01

157.79 - 425.2

2.61 - 1916.64

93.22

40.64 - 361.39

28

28

0

149.34

282.01

44.88 - 253.8

1.18 - 1379.51

39.48

15.08 - 122

0.1054

0.6696

8ТЕ+PD-1-TIGIT-

Abs_Value

39

39

0

109.69

170.26

56.25 - 163.13

2.07 - 692.88

26.6

9.18 - 117.4

28

28

0

50.89

89.3

17.81 - 83.97

0.56 - 459.76

20.6

5.05 - 62.44

0.0716

0.6696

8ТЕ+PD-1-TIGIT+

Abs_Value

39

39

0

121.05

193.14

60.43 - 181.66

0.99 - 921.44

24.4

8.44 - 190.13

28

28

0

51.55

101.85

13.82 - 89.27

0.45 - 504.62

14.1

4.74 - 55.63

0.0612

0.6696

8ТЕ+PD-1+

Abs_Value

39

39

0

169.08

280.68

80.99 - 257.17

3.69 - 1526.37

67.37

26.03 - 170.51

28

28

0

88.27

149.38

32.94 - 143.6

1.03 - 556.25

29.97

12.58 - 69.83

0.1331

0.6696

8ТЕ+PD-1+TIGIT-

Abs_Value

39

39

0

56.8

90.76

28.31 - 85.28

0.82 - 403.46

18.56

2.45 - 72.41

28

28

0

27.18

48.92

9.06 - 45.3

0.47 - 190.87

7.59

2.07 - 25.75

0.0906

0.6696

8ТЕ+PD-1+TIGIT+

Abs_Value

39

39

0

112.28

201.35

49.09 - 175.48

2.85 - 1122.91

47.52

13.89 - 97.11

28

28

0

61.09

106.19

21.76 - 100.43

0.56 - 365.38

14.54

8.69 - 41.59

0.1827

0.6696

8ТЕ+TIGIT+

Abs_Value

39

39

0

233.33

346.67

124.53 - 342.13

3.84 - 1498.44

77.37

26.2 - 269.88

28

28

0

112.64

198.57

39.09 - 186.19

1.01 - 870

29.7

14.87 - 94.69

0.0765

0.6696

8ТМ

Abs_Value

39

39

0

20.92

28

12.13 - 29.7

0.43 - 149.26

12.18

4.59 - 22.53

28

28

0

20.26

37.21

6.47 - 34.04

0.34 - 179.51

5.25

1.36 - 17.61

0.9375

0.9731

TREG_CM

Abs_Value

39

39

0

0.81

0.88

0.54 - 1.09

0 - 4.33

0.5

0.26 - 1.08

28

28

0

1.48

2.72

0.47 - 2.49

0.02 - 14.66

0.92

0.32 - 1.56

0.2223

0.6696

TREG_EMTM

Abs_Value

39

39

0

8.82

8.27

6.22 - 11.41

0.05 - 40.11

7.21

2.95 - 12.43

28

28

0

11.9

17.5

5.42 - 18.38

0.05 - 93.26

6.51

3.01 - 13.22

0.3923

0.6762

TREG_NV

Abs_Value

39

39

0

0.93

0.89

0.65 - 1.21

0 - 3.03

0.71

0.21 - 1.47

28

28

0

1.21

0.82

0.91 - 1.52

0.01 - 3.4

1.13

0.63 - 1.75

0.1786

0.6696

TREG_TE

Abs_Value

39

39

0

2.37

1.78

1.81 - 2.93

0 - 6.11

2.06

1.15 - 3.5

28

28

0

3.04

2.65

2.06 - 4.02

0.19 - 8.97

2.17

0.97 - 4.09

0.2505

0.6696

TREG+226-TIGIT-

Abs_Value

39

39

0

0.85

0.78

0.61 - 1.1

0 - 2.66

0.63

0.17 - 1.39

28

28

0

0.88

0.74

0.61 - 1.15

0.04 - 3.18

0.69

0.34 - 1.18

0.8825

0.9621

TREG+226-TIGIT+

Abs_Value

39

39

0

3.39

3.18

2.39 - 4.39

0.01 - 13.35

2.67

0.95 - 4.88

28

28

0

4.62

7.57

1.82 - 7.43

0.22 - 40.78

2.82

1.46 - 4.13

0.4216

0.6834

TREG+226+

Abs_Value

39

39

0

8.82

7.4

6.49 - 11.14

0.04 - 38.28

9.02

3.48 - 11.72

28

28

0

12.15

14.13

6.92 - 17.38

0.85 - 72.45

7.91

3.79 - 14.59

0.2615

0.6696

TREG+226+TIGIT-

Abs_Value

39

39

0

1.36

1.22

0.98 - 1.75

0.01 - 4.82

0.92

0.52 - 1.82

28

28

0

1.67

1.7

1.04 - 2.3

0.06 - 7.96

1.15

0.6 - 1.92

0.413

0.6773

TREG+226+TIGIT+

Abs_Value

39

39

0

7.46

6.55

5.4 - 9.51

0.02 - 33.46

6.06

2.41 - 10.44

28

28

0

10.48

13.51

5.47 - 15.48

0.25 - 70.7

6.52

3.05 - 13.06

0.2811

0.6696

TREG+39+

Abs_Value

39

39

0

9.7

9.56

6.7 - 12.7

0.03 - 45.27

6.69

3.41 - 11.8

28

28

0

13.81

20.79

6.11 - 21.52

0.18 - 111.4

8.3

3.67 - 15.91

0.336

0.6696

TREG+DR+

Abs_Value

39

39

0

9.7

8.49

7.03 - 12.36

0.02 - 39.81

8.49

3.47 - 13.01

28

28

0

13.29

19.64

6.01 - 20.56

0.59 - 105.25

8.1

3.56 - 14.05

0.3701

0.6762

TREG+PD-1+

Abs_Value

39

39

0

4.45

3.85

3.25 - 5.66

0.04 - 18.35

3.67

1.4 - 6.2

28

28

0

7.17

13.16

2.29 - 12.04

0.13 - 69.61

3.88

1.6 - 7.43

0.2978

0.6696

TREG+TIGIT+

Abs_Value

39

39

0

10.84

9.27

7.93 - 13.75

0.03 - 42.48

10.53

3.55 - 14.81

28

28

0

15.1

20.74

7.42 - 22.78

0.47 - 111.49

9.01

5.36 - 17.63

0.3169

0.6696

#Графики без логарифмирования

Без группировки, день 90

# 2. Построение графиков 
analysis_days <- c("+90")  # Фиксируем день +90
cell_populations <- unique(AI_Tcells_filtered$Сell_population)

# Функция для создания одного графика
create_plot <- function(day, cell_pop, data) {
  data_subset <- data %>%
    filter(Analysis_day == day, Сell_population == cell_pop)

  if (nrow(data_subset) > 0) {
    p <- ggplot(data_subset, aes(x = cGVHD_present, y = Abs_Value, fill = cGVHD_present)) +
      geom_boxplot() +
      ggpubr::stat_compare_means(method = "t.test", label.y = 0.8 * max(data_subset$Abs_Value, na.rm = TRUE), label.x = 1.5) +
      labs(title = paste("Abs_Value by cGVHD_present\n(Analysis_day =", day, ", Cell Pop =", cell_pop, ")"),
           x = "cGVHD_present", y = "Abs_Value") +
      theme_bw() +
      theme(axis.text.x = element_text(angle = 45, hjust = 1),
            plot.title = element_text(hjust = 0.5)) +
      scale_y_continuous(limits = function(x) {
        range_x <- max(x) - min(x)
        c(min(x) - 0.1 * range_x, max(x) + 0.1 * range_x)
      })
    
    return(p)
  } else {
    return(NULL) # Возвращаем NULL, если нет данных
  }
}

# Создание всех графиков
plots <- list()
for (cell_pop in cell_populations) {
  p <- create_plot("+90", cell_pop, AI_Tcells_filtered)
  if (!is.null(p)) {
    print(p)
    plots[[paste0("plot_90_", cell_pop)]] <- p
    #ggsave(paste0("plot_90_", cell_pop, ".png"), plot = p, width = 10, height = 7)
  }
}

Графики с логарифмированием

# 1. Добавление группирующей переменной для facet_wrap)
AI_Tcells_filtered_facet <- AI_Tcells_filtered %>%
  mutate(group = paste0("Group ", (as.numeric(Сell_population) -1) %/% 5 +1))


# 2. Построение графиков с использованием facet_wrap

analysis_days <- unique(AI_Tcells_filtered_facet$Analysis_day)
groups <- unique(AI_Tcells_filtered_facet$group)

for (day in analysis_days) {
  for (grp in groups) {
    data_subset <- AI_Tcells_filtered_facet %>%
      filter(Analysis_day == day, group == grp)

    if (nrow(data_subset) > 0) {
      # Логарифмирование значений Abs_Value
      data_subset <- data_subset %>%
        mutate(log_Abs_Value = log1p(Abs_Value)) # log1p для обработки нулей

       max_val <- max(data_subset$log_Abs_Value, na.rm = TRUE)

      p <- ggplot(data_subset, aes(x = cGVHD_present, y = log_Abs_Value, fill = cGVHD_present)) + 
        geom_boxplot() +
        ggpubr::stat_compare_means(method = "t.test", label.y = max_val - 0.1 * max_val) +
        labs(title = paste("log(Abs_Value + 1) by cGVHD_present\n(Analysis_day =", day, ", Group =", grp, ")"), 
             x = "cGVHD_present", y = "log(Abs_Value + 1)") + 
        theme_bw() +
        theme(axis.text.x = element_text(angle = 45, hjust = 1),
              plot.title = element_text(hjust = 0.5)) +
        facet_wrap(~Сell_population, scales = "free_x")

      print(p)
      #ggsave(paste0("plot_log_", day, "_group_", grp, ".png"), plot = p, width = 12, height = 8)
    }
  }
}

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

#GLM wide data

##Подготовка данных

data_day90 <- filter(AI_Tcells_filtered, Analysis_day == "+90")

data_day180 <- filter(AI_Tcells_filtered, Analysis_day == "+180")
data_wide_90 <- data_day90 %>%
  pivot_wider(names_from = Сell_population, values_from = Abs_Value)

data_90 <- data_wide_90 %>%
  select(-ID, -Time_OS, -cGVHD_time, -Analysis_day, -Analysis_time)


data_wide_180 <- data_day180 %>%
  pivot_wider(names_from = Сell_population, values_from = Abs_Value)

data_180 <- data_wide_180 %>%
  select(-ID, -Time_OS, -cGVHD_time, -Analysis_day, -Analysis_time)

Первая модель, aliased coefficients

model_90 <- glm(cGVHD_present ~ ., data = data_90, family = binomial)

# Модель для 180-го дня
model_180 <- glm(cGVHD_present ~ ., data = data_180, family = binomial)

summary(model_90)
## 
## Call:
## glm(formula = cGVHD_present ~ ., family = binomial, data = data_90)
## 
## Coefficients: (98 not defined because of singularities)
##                       Estimate Std. Error z value Pr(>|z|)
## (Intercept)         -2.478e+01  3.493e+05       0        1
## `4_TFH`              2.814e+00  1.169e+05       0        1
## `4_TH1`              1.197e+01  2.993e+05       0        1
## `4_TH17`            -2.102e+01  2.303e+05       0        1
## `4_Th17TO1`         -4.085e-01  1.115e+05       0        1
## `4_TH2`              6.069e+01  7.583e+05       0        1
## `4_TH22`             3.035e+01  3.068e+05       0        1
## `4+ (IM STAT)`      -2.700e+00  3.472e+04       0        1
## `4+`                 1.901e+00  2.483e+04       0        1
## `4+226+`            -9.562e+01  1.002e+06       0        1
## `4+39+`              8.119e+00  1.808e+05       0        1
## `4+DR+`             -6.441e+00  1.808e+05       0        1
## `4+PD-1+`            2.392e+09  4.572e+13       0        1
## `4+PD-1+TIGIT-`     -2.392e+09  4.572e+13       0        1
## `4+PD-1+TIGIT+`     -2.369e+08  5.477e+13       0        1
## `4+PD-1-TIGIT-`      7.296e+01  8.486e+05       0        1
## `4+PD-1-TIGIT+`      2.155e+09  8.382e+13       0        1
## `4+TIGIT+`          -2.155e+09  8.382e+13       0        1
## `4NV(СТАР2)`         3.651e+09  9.226e+13       0        1
## `4NV`               -1.696e+01  2.263e+05       0        1
## `4NV_TH1`           -4.673e+01  1.095e+06       0        1
## `4NV_TH17`          -6.398e+01  1.775e+06       0        1
## `4NV_Th17TO1`        8.650e+01  5.334e+06       0        1
## `4NV_TH2`           -3.296e+01  5.916e+05       0        1
## `4NV_TH22`           2.725e+02  2.957e+06       0        1
## `4NV+226+`           1.107e+02  1.253e+06       0        1
## `4NV+39+`            4.507e+01  1.144e+06       0        1
## `4NV+DR+`           -1.925e+01  5.060e+05       0        1
## `4NV+PD1+`           1.273e+09  6.849e+14       0        1
## `4NV+PD-1+TIGIT-`   -4.924e+09  6.852e+14       0        1
## `4NV+PD-1+TIGIT+`   -2.167e+11  3.916e+15       0        1
## `4NV+PD-1-TIGIT-`   -3.651e+09  9.226e+13       0        1
## `4NV+PD-1-TIGIT+`   -2.154e+11  4.110e+15       0        1
## `4NV+TIGIT+`         2.117e+11  4.058e+15       0        1
## `4ЕМ`               -7.693e+00  1.312e+05       0        1
## `4ЕМ_TH1`            9.051e+00  5.941e+05       0        1
## `4ЕМ_TH17`           6.029e+02  7.161e+06       0        1
## `4ЕМ_Th17TO1`        7.375e+01  2.839e+06       0        1
## `4ЕМ_TH2`           -4.820e+01  6.447e+05       0        1
## `4ЕМ_TH22`           2.975e+03  4.646e+07       0        1
## `4ЕМ+226+`           1.163e+02  1.340e+06       0        1
## `4ЕМ+39+`           -7.999e+00  1.989e+05       0        1
## `4ЕМ+DR+`            8.134e+00  2.964e+05       0        1
## `4ЕМ+PD1+`           1.167e+09  5.108e+13       0        1
## `4ЕМ+PD1+TIGIT-`    -8.231e+09  9.278e+13       0        1
## `4ЕМ+PD1+TIGIT+`    -5.654e+09  1.127e+14       0        1
## `4ЕМ+PD1-TIGIT-`    -7.064e+09  7.265e+13       0        1
## `4ЕМ+PD1-TIGIT+`    -4.487e+09  1.366e+14       0        1
## `4ЕМ+TIGIT+`        -2.578e+09  1.365e+14       0        1
## `4ЕМTM`              7.064e+09  7.265e+13       0        1
## `4СМ(СТАР2)`        -5.354e+09  1.173e+14       0        1
## `4СМ`               -1.240e+00  2.015e+05       0        1
## `4СМ_TH1`           -2.607e+01  1.087e+06       0        1
## `4СМ_TH17`           3.976e+01  7.140e+05       0        1
## `4СМ_Th17TO1`        9.995e+01  1.573e+06       0        1
## `4СМ_TH2`           -7.502e+01  9.984e+05       0        1
## `4СМ_TH22`          -3.550e+01  1.285e+06       0        1
## `4СМ+226+`           1.126e+02  1.124e+06       0        1
## `4СМ+39+`           -1.046e+01  2.979e+05       0        1
## `4СМ+DR+`            9.785e+00  1.619e+05       0        1
## `4СМ+PD1+`           5.137e+09  1.271e+14       0        1
## `4СМ+PD1+TIGIT-`     2.173e+08  9.713e+13       0        1
## `4СМ+PD1+TIGIT+`    -1.778e+10  2.012e+14       0        1
## `4СМ+PD1-TIGIT-`     5.354e+09  1.173e+14       0        1
## `4СМ+PD1-TIGIT+`    -1.264e+10  1.672e+14       0        1
## `4СМ+TIGIT+`         1.800e+10  2.468e+14       0        1
## `4ТM_TH1`           -1.488e+01  3.306e+05       0        1
## `4ТM_TH17`                  NA         NA      NA       NA
## `4ТM_Th17TO1`               NA         NA      NA       NA
## `4ТM_TH2`                   NA         NA      NA       NA
## `4ТM_TH22`                  NA         NA      NA       NA
## `4ТREG(СТАР2)`              NA         NA      NA       NA
## `4ТREG`                     NA         NA      NA       NA
## `4ТREG_TH1`                 NA         NA      NA       NA
## `4ТREG_TH17`                NA         NA      NA       NA
## `4ТREG_Th17TO1`             NA         NA      NA       NA
## `4ТREG_TH2`                 NA         NA      NA       NA
## `4ТREG_TH22`                NA         NA      NA       NA
## `4ТЕ(СТАР2)`                NA         NA      NA       NA
## `4ТЕ`                       NA         NA      NA       NA
## `4ТЕ_TH1`                   NA         NA      NA       NA
## `4ТЕ_TH17`                  NA         NA      NA       NA
## `4ТЕ_Th17TO1`               NA         NA      NA       NA
## `4ТЕ_TH2`                   NA         NA      NA       NA
## `4ТЕ_TH22`                  NA         NA      NA       NA
## `4ТЕ+226+`                  NA         NA      NA       NA
## `4ТЕ+39+`                   NA         NA      NA       NA
## `4ТЕ+DR+`                   NA         NA      NA       NA
## `4ТЕ+PD-1+`                 NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `4ТЕ+TIGIT+`                NA         NA      NA       NA
## `4ТМ`                       NA         NA      NA       NA
## `8+ (IM STAT)`              NA         NA      NA       NA
## `8+`                        NA         NA      NA       NA
## `8+226+`                    NA         NA      NA       NA
## `8+39+`                     NA         NA      NA       NA
## `8+DR+`                     NA         NA      NA       NA
## `8+PD-1+`                   NA         NA      NA       NA
## `8+PD-1+TIGIT-`             NA         NA      NA       NA
## `8+PD-1+TIGIT+`             NA         NA      NA       NA
## `8+PD-1-TIGIT-`             NA         NA      NA       NA
## `8+PD-1-TIGIT+`             NA         NA      NA       NA
## `8+TIGIT+`                  NA         NA      NA       NA
## `8EMTM`                     NA         NA      NA       NA
## `8EMTM+226+`                NA         NA      NA       NA
## `8EMTM+39+`                 NA         NA      NA       NA
## `8EMTM+DR+`                 NA         NA      NA       NA
## `8EMTM+PD-1+`               NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT+`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT+`         NA         NA      NA       NA
## `8EMTM+TIGIT+`              NA         NA      NA       NA
## `8NV(СТАР2)`                NA         NA      NA       NA
## `8NV`                       NA         NA      NA       NA
## `8NV+226+`                  NA         NA      NA       NA
## `8NV+39+`                   NA         NA      NA       NA
## `8NV+DR+`                   NA         NA      NA       NA
## `8NV+PD-1+`                 NA         NA      NA       NA
## `8NV+PD-1+TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1+TIGIT+`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT+`           NA         NA      NA       NA
## `8NV+TIGIT+`                NA         NA      NA       NA
## `8TREG`                     NA         NA      NA       NA
## `8ЕМ`                       NA         NA      NA       NA
## `8СМ(СТАР2)`                NA         NA      NA       NA
## `8СМ`                       NA         NA      NA       NA
## `8СМ+226+`                  NA         NA      NA       NA
## `8СМ+39+`                   NA         NA      NA       NA
## `8СМ+DR+`                   NA         NA      NA       NA
## `8СМ+PD-1+`                 NA         NA      NA       NA
## `8СМ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8СМ+TIGIT+`                NA         NA      NA       NA
## `8ТЕ(СТАР2)`                NA         NA      NA       NA
## `8ТЕ`                       NA         NA      NA       NA
## `8ТЕ+226+`                  NA         NA      NA       NA
## `8ТЕ+39+`                   NA         NA      NA       NA
## `8ТЕ+DR+`                   NA         NA      NA       NA
## `8ТЕ+PD-1+`                 NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8ТЕ+TIGIT+`                NA         NA      NA       NA
## `8ТМ`                       NA         NA      NA       NA
## TREG_CM                     NA         NA      NA       NA
## TREG_EMTM                   NA         NA      NA       NA
## TREG_NV                     NA         NA      NA       NA
## TREG_TE                     NA         NA      NA       NA
## `TREG+226+`                 NA         NA      NA       NA
## `TREG+226+TIGIT-`           NA         NA      NA       NA
## `TREG+226+TIGIT+`           NA         NA      NA       NA
## `TREG+226-TIGIT-`           NA         NA      NA       NA
## `TREG+226-TIGIT+`           NA         NA      NA       NA
## `TREG+39+`                  NA         NA      NA       NA
## `TREG+DR+`                  NA         NA      NA       NA
## `TREG+PD-1+`                NA         NA      NA       NA
## `TREG+TIGIT+`               NA         NA      NA       NA
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 9.1068e+01  on 66  degrees of freedom
## Residual deviance: 3.8871e-10  on  0  degrees of freedom
## AIC: 134
## 
## Number of Fisher Scoring iterations: 25
summary(model_180)
## 
## Call:
## glm(formula = cGVHD_present ~ ., family = binomial, data = data_180)
## 
## Coefficients: (123 not defined because of singularities)
##                       Estimate Std. Error z value Pr(>|z|)
## (Intercept)         -2.139e+01  8.538e+05       0        1
## `4_TFH`              9.432e-02  4.383e+04       0        1
## `4_TH1`              1.968e+00  5.945e+04       0        1
## `4_TH17`            -1.234e+00  1.196e+05       0        1
## `4_Th17TO1`         -2.081e+00  1.644e+05       0        1
## `4_TH2`             -3.419e+00  7.776e+04       0        1
## `4_TH22`             7.887e+00  2.891e+05       0        1
## `4+ (IM STAT)`      -4.519e-01  3.940e+04       0        1
## `4+`                 1.518e+00  3.746e+04       0        1
## `4+226+`            -3.920e+00  1.053e+05       0        1
## `4+39+`             -2.813e-01  1.057e+05       0        1
## `4+DR+`              4.347e-02  3.146e+04       0        1
## `4+PD-1+`           -9.565e+08  2.509e+13       0        1
## `4+PD-1+TIGIT-`      9.565e+08  2.509e+13       0        1
## `4+PD-1+TIGIT+`      1.508e+08  3.255e+13       0        1
## `4+PD-1-TIGIT-`      3.759e+00  1.165e+05       0        1
## `4+PD-1-TIGIT+`     -8.057e+08  1.597e+13       0        1
## `4+TIGIT+`           8.057e+08  1.597e+13       0        1
## `4NV(СТАР2)`         2.940e+09  4.100e+13       0        1
## `4NV`               -3.941e+00  1.597e+05       0        1
## `4NV_TH1`            1.105e+00  3.562e+05       0        1
## `4NV_TH17`          -5.061e+00  1.356e+06       0        1
## `4NV_Th17TO1`       -4.550e+01  6.278e+06       0        1
## `4NV_TH2`            2.648e+00  1.768e+05       0        1
## `4NV_TH22`          -1.653e+01  5.084e+06       0        1
## `4NV+226+`           5.451e+00  2.154e+05       0        1
## `4NV+39+`            3.068e+01  1.403e+06       0        1
## `4NV+DR+`            8.034e+00  1.962e+05       0        1
## `4NV+PD1+`          -4.005e+10  1.110e+15       0        1
## `4NV+PD-1+TIGIT-`    3.711e+10  1.086e+15       0        1
## `4NV+PD-1+TIGIT+`   -1.309e+10  1.119e+15       0        1
## `4NV+PD-1-TIGIT-`   -2.940e+09  4.100e+13       0        1
## `4NV+PD-1-TIGIT+`   -5.314e+10  1.279e+15       0        1
## `4NV+TIGIT+`         5.021e+10  1.249e+15       0        1
## `4ЕМ`               -1.272e+00  1.459e+05       0        1
## `4ЕМ_TH1`           -2.770e+00  2.901e+05       0        1
## `4ЕМ_TH17`           2.145e+02  1.343e+07       0        1
## `4ЕМ_Th17TO1`        1.317e+01  8.963e+05       0        1
## `4ЕМ_TH2`            2.101e+01  1.147e+06       0        1
## `4ЕМ_TH22`          -3.374e+03  6.507e+07       0        1
## `4ЕМ+226+`           1.086e+00  5.482e+04       0        1
## `4ЕМ+39+`           -6.593e-01  1.766e+05       0        1
## `4ЕМ+DR+`                   NA         NA      NA       NA
## `4ЕМ+PD1+`                  NA         NA      NA       NA
## `4ЕМ+PD1+TIGIT-`            NA         NA      NA       NA
## `4ЕМ+PD1+TIGIT+`            NA         NA      NA       NA
## `4ЕМ+PD1-TIGIT-`            NA         NA      NA       NA
## `4ЕМ+PD1-TIGIT+`            NA         NA      NA       NA
## `4ЕМ+TIGIT+`                NA         NA      NA       NA
## `4ЕМTM`                     NA         NA      NA       NA
## `4СМ(СТАР2)`                NA         NA      NA       NA
## `4СМ`                       NA         NA      NA       NA
## `4СМ_TH1`                   NA         NA      NA       NA
## `4СМ_TH17`                  NA         NA      NA       NA
## `4СМ_Th17TO1`               NA         NA      NA       NA
## `4СМ_TH2`                   NA         NA      NA       NA
## `4СМ_TH22`                  NA         NA      NA       NA
## `4СМ+226+`                  NA         NA      NA       NA
## `4СМ+39+`                   NA         NA      NA       NA
## `4СМ+DR+`                   NA         NA      NA       NA
## `4СМ+PD1+`                  NA         NA      NA       NA
## `4СМ+PD1+TIGIT-`            NA         NA      NA       NA
## `4СМ+PD1+TIGIT+`            NA         NA      NA       NA
## `4СМ+PD1-TIGIT-`            NA         NA      NA       NA
## `4СМ+PD1-TIGIT+`            NA         NA      NA       NA
## `4СМ+TIGIT+`                NA         NA      NA       NA
## `4ТM_TH1`                   NA         NA      NA       NA
## `4ТM_TH17`                  NA         NA      NA       NA
## `4ТM_Th17TO1`               NA         NA      NA       NA
## `4ТM_TH2`                   NA         NA      NA       NA
## `4ТM_TH22`                  NA         NA      NA       NA
## `4ТREG(СТАР2)`              NA         NA      NA       NA
## `4ТREG`                     NA         NA      NA       NA
## `4ТREG_TH1`                 NA         NA      NA       NA
## `4ТREG_TH17`                NA         NA      NA       NA
## `4ТREG_Th17TO1`             NA         NA      NA       NA
## `4ТREG_TH2`                 NA         NA      NA       NA
## `4ТREG_TH22`                NA         NA      NA       NA
## `4ТЕ(СТАР2)`                NA         NA      NA       NA
## `4ТЕ`                       NA         NA      NA       NA
## `4ТЕ_TH1`                   NA         NA      NA       NA
## `4ТЕ_TH17`                  NA         NA      NA       NA
## `4ТЕ_Th17TO1`               NA         NA      NA       NA
## `4ТЕ_TH2`                   NA         NA      NA       NA
## `4ТЕ_TH22`                  NA         NA      NA       NA
## `4ТЕ+226+`                  NA         NA      NA       NA
## `4ТЕ+39+`                   NA         NA      NA       NA
## `4ТЕ+DR+`                   NA         NA      NA       NA
## `4ТЕ+PD-1+`                 NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `4ТЕ+TIGIT+`                NA         NA      NA       NA
## `4ТМ`                       NA         NA      NA       NA
## `8+ (IM STAT)`              NA         NA      NA       NA
## `8+`                        NA         NA      NA       NA
## `8+226+`                    NA         NA      NA       NA
## `8+39+`                     NA         NA      NA       NA
## `8+DR+`                     NA         NA      NA       NA
## `8+PD-1+`                   NA         NA      NA       NA
## `8+PD-1+TIGIT-`             NA         NA      NA       NA
## `8+PD-1+TIGIT+`             NA         NA      NA       NA
## `8+PD-1-TIGIT-`             NA         NA      NA       NA
## `8+PD-1-TIGIT+`             NA         NA      NA       NA
## `8+TIGIT+`                  NA         NA      NA       NA
## `8EMTM`                     NA         NA      NA       NA
## `8EMTM+226+`                NA         NA      NA       NA
## `8EMTM+39+`                 NA         NA      NA       NA
## `8EMTM+DR+`                 NA         NA      NA       NA
## `8EMTM+PD-1+`               NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT+`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT+`         NA         NA      NA       NA
## `8EMTM+TIGIT+`              NA         NA      NA       NA
## `8NV(СТАР2)`                NA         NA      NA       NA
## `8NV`                       NA         NA      NA       NA
## `8NV+226+`                  NA         NA      NA       NA
## `8NV+39+`                   NA         NA      NA       NA
## `8NV+DR+`                   NA         NA      NA       NA
## `8NV+PD-1+`                 NA         NA      NA       NA
## `8NV+PD-1+TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1+TIGIT+`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT+`           NA         NA      NA       NA
## `8NV+TIGIT+`                NA         NA      NA       NA
## `8TREG`                     NA         NA      NA       NA
## `8ЕМ`                       NA         NA      NA       NA
## `8СМ(СТАР2)`                NA         NA      NA       NA
## `8СМ`                       NA         NA      NA       NA
## `8СМ+226+`                  NA         NA      NA       NA
## `8СМ+39+`                   NA         NA      NA       NA
## `8СМ+DR+`                   NA         NA      NA       NA
## `8СМ+PD-1+`                 NA         NA      NA       NA
## `8СМ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8СМ+TIGIT+`                NA         NA      NA       NA
## `8ТЕ(СТАР2)`                NA         NA      NA       NA
## `8ТЕ`                       NA         NA      NA       NA
## `8ТЕ+226+`                  NA         NA      NA       NA
## `8ТЕ+39+`                   NA         NA      NA       NA
## `8ТЕ+DR+`                   NA         NA      NA       NA
## `8ТЕ+PD-1+`                 NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8ТЕ+TIGIT+`                NA         NA      NA       NA
## `8ТМ`                       NA         NA      NA       NA
## TREG_CM                     NA         NA      NA       NA
## TREG_EMTM                   NA         NA      NA       NA
## TREG_NV                     NA         NA      NA       NA
## TREG_TE                     NA         NA      NA       NA
## `TREG+226+`                 NA         NA      NA       NA
## `TREG+226+TIGIT-`           NA         NA      NA       NA
## `TREG+226+TIGIT+`           NA         NA      NA       NA
## `TREG+226-TIGIT-`           NA         NA      NA       NA
## `TREG+226-TIGIT+`           NA         NA      NA       NA
## `TREG+39+`                  NA         NA      NA       NA
## `TREG+DR+`                  NA         NA      NA       NA
## `TREG+PD-1+`                NA         NA      NA       NA
## `TREG+TIGIT+`               NA         NA      NA       NA
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 5.3467e+01  on 41  degrees of freedom
## Residual deviance: 2.4369e-10  on  0  degrees of freedom
## AIC: 84
## 
## Number of Fisher Scoring iterations: 25

Диагностика

#{r} car::vif(model_90) car::vif(model_180)

#Корреляции

data_90_num <- data_90 %>%
  select(-cGVHD_present) 

data_90_cor <- cor(data_90_num)

corrplot(data_90_cor, method = "circle", type = "upper", tl.col = "black", tl.cex = 0.7)

corrplot(data_90_cor, method = 'number')

correlation_matrix <- cor(model.matrix(model_90))
## Warning in cor(model.matrix(model_90)): стандартное отклонение нулевое
# Визуализация тепловой карты

melted_cor <- reshape2::melt(correlation_matrix)

ggplot(data = melted_cor, aes(x = Var1, y = Var2, fill = value)) +
  geom_tile() +
  scale_fill_gradient2(low = "blue", mid = "white", high = "red") +  
  theme(axis.text.x = element_text(angle = 90, hjust = 1)) +  
  labs(title = "Матрица корреляций", fill = "Коэффициент корреляции")

#LASSO применяет L1-регуляризацию, которая добавляет штрафной член к функции потерь. Этот штраф уменьшает коэффициенты некоторых предикторов до нуля, эффективно исключая их из модели.

##90

# Подготовка данных: X - матрица предикторов, y - вектор отклика
X <- model.matrix(cGVHD_present ~ ., data = data_90)
y <- data_90$cGVHD_present

# Построение модели LASSO
lasso_model <- glmnet(X, y, family = "binomial", alpha = 1) # alpha = 1 для LASSO

# Выбор наилучшего lambda с помощью кросс-валидации
cv_lasso <- cv.glmnet(X, y, family = "binomial", alpha = 1)
best_lambda <- cv_lasso$lambda.min

# Модель с наилучшим lambda
lasso_model_best <- glmnet(X, y, family = "binomial", alpha = 1, lambda = best_lambda)

# Коэффициенты
coef(lasso_model_best)
## 166 x 1 sparse Matrix of class "dgCMatrix"
##                               s0
## (Intercept)         -0.352883859
## (Intercept)          .          
## `4_TFH`              .          
## `4_TH1`              .          
## `4_TH17`             .          
## `4_Th17TO1`          .          
## `4_TH2`              .          
## `4_TH22`             .          
## `4+ (IM STAT)`       .          
## `4+`                 .          
## `4+226+`             .          
## `4+39+`              .          
## `4+DR+`              .          
## `4+PD-1+`            .          
## `4+PD-1+TIGIT-`      .          
## `4+PD-1+TIGIT+`      .          
## `4+PD-1-TIGIT-`      .          
## `4+PD-1-TIGIT+`      .          
## `4+TIGIT+`           .          
## `4NV(СТАР2)`         .          
## `4NV`                .          
## `4NV_TH1`            .          
## `4NV_TH17`           .          
## `4NV_Th17TO1`        .          
## `4NV_TH2`            0.007483848
## `4NV_TH22`           .          
## `4NV+226+`           .          
## `4NV+39+`            .          
## `4NV+DR+`            .          
## `4NV+PD1+`           .          
## `4NV+PD-1+TIGIT-`    .          
## `4NV+PD-1+TIGIT+`    .          
## `4NV+PD-1-TIGIT-`    .          
## `4NV+PD-1-TIGIT+`    .          
## `4NV+TIGIT+`         .          
## `4ЕМ`                .          
## `4ЕМ_TH1`            .          
## `4ЕМ_TH17`           .          
## `4ЕМ_Th17TO1`        .          
## `4ЕМ_TH2`            .          
## `4ЕМ_TH22`           .          
## `4ЕМ+226+`           .          
## `4ЕМ+39+`            .          
## `4ЕМ+DR+`            .          
## `4ЕМ+PD1+`           .          
## `4ЕМ+PD1+TIGIT-`     .          
## `4ЕМ+PD1+TIGIT+`     .          
## `4ЕМ+PD1-TIGIT-`     .          
## `4ЕМ+PD1-TIGIT+`     .          
## `4ЕМ+TIGIT+`         .          
## `4ЕМTM`              .          
## `4СМ(СТАР2)`         .          
## `4СМ`                .          
## `4СМ_TH1`            .          
## `4СМ_TH17`           .          
## `4СМ_Th17TO1`        .          
## `4СМ_TH2`            .          
## `4СМ_TH22`           .          
## `4СМ+226+`           .          
## `4СМ+39+`            .          
## `4СМ+DR+`            .          
## `4СМ+PD1+`           .          
## `4СМ+PD1+TIGIT-`     .          
## `4СМ+PD1+TIGIT+`     .          
## `4СМ+PD1-TIGIT-`     .          
## `4СМ+PD1-TIGIT+`     .          
## `4СМ+TIGIT+`         .          
## `4ТM_TH1`            .          
## `4ТM_TH17`           .          
## `4ТM_Th17TO1`        .          
## `4ТM_TH2`            .          
## `4ТM_TH22`           .          
## `4ТREG(СТАР2)`       .          
## `4ТREG`              .          
## `4ТREG_TH1`          .          
## `4ТREG_TH17`         .          
## `4ТREG_Th17TO1`      .          
## `4ТREG_TH2`          .          
## `4ТREG_TH22`         .          
## `4ТЕ(СТАР2)`         .          
## `4ТЕ`                .          
## `4ТЕ_TH1`            .          
## `4ТЕ_TH17`           .          
## `4ТЕ_Th17TO1`        .          
## `4ТЕ_TH2`            .          
## `4ТЕ_TH22`           .          
## `4ТЕ+226+`           .          
## `4ТЕ+39+`            .          
## `4ТЕ+DR+`            .          
## `4ТЕ+PD-1+`          .          
## `4ТЕ+PD-1+TIGIT-`    .          
## `4ТЕ+PD-1+TIGIT+`    .          
## `4ТЕ+PD-1-TIGIT-`    .          
## `4ТЕ+PD-1-TIGIT+`    .          
## `4ТЕ+TIGIT+`         .          
## `4ТМ`                .          
## `8+ (IM STAT)`       .          
## `8+`                 .          
## `8+226+`             .          
## `8+39+`              .          
## `8+DR+`              .          
## `8+PD-1+`            .          
## `8+PD-1+TIGIT-`      .          
## `8+PD-1+TIGIT+`      .          
## `8+PD-1-TIGIT-`      .          
## `8+PD-1-TIGIT+`      .          
## `8+TIGIT+`           .          
## `8EMTM`              .          
## `8EMTM+226+`         .          
## `8EMTM+39+`          .          
## `8EMTM+DR+`          .          
## `8EMTM+PD-1+`        .          
## `8EMTM+PD-1+TIGIT-`  .          
## `8EMTM+PD-1+TIGIT+`  .          
## `8EMTM+PD-1-TIGIT-`  .          
## `8EMTM+PD-1-TIGIT+`  .          
## `8EMTM+TIGIT+`       .          
## `8NV(СТАР2)`         .          
## `8NV`                .          
## `8NV+226+`           .          
## `8NV+39+`            .          
## `8NV+DR+`            .          
## `8NV+PD-1+`          .          
## `8NV+PD-1+TIGIT-`    .          
## `8NV+PD-1+TIGIT+`    .          
## `8NV+PD-1-TIGIT-`    .          
## `8NV+PD-1-TIGIT+`    .          
## `8NV+TIGIT+`         .          
## `8TREG`              .          
## `8ЕМ`                .          
## `8СМ(СТАР2)`         .          
## `8СМ`                .          
## `8СМ+226+`           .          
## `8СМ+39+`            .          
## `8СМ+DR+`            .          
## `8СМ+PD-1+`          .          
## `8СМ+PD-1+TIGIT-`    .          
## `8СМ+PD-1+TIGIT+`    .          
## `8СМ+PD-1-TIGIT-`    .          
## `8СМ+PD-1-TIGIT+`    .          
## `8СМ+TIGIT+`         .          
## `8ТЕ(СТАР2)`         .          
## `8ТЕ`                .          
## `8ТЕ+226+`           .          
## `8ТЕ+39+`            .          
## `8ТЕ+DR+`            .          
## `8ТЕ+PD-1+`          .          
## `8ТЕ+PD-1+TIGIT-`    .          
## `8ТЕ+PD-1+TIGIT+`    .          
## `8ТЕ+PD-1-TIGIT-`    .          
## `8ТЕ+PD-1-TIGIT+`    .          
## `8ТЕ+TIGIT+`         .          
## `8ТМ`                .          
## TREG_CM              .          
## TREG_EMTM            .          
## TREG_NV              .          
## TREG_TE              .          
## `TREG+226+`          .          
## `TREG+226+TIGIT-`    .          
## `TREG+226+TIGIT+`    .          
## `TREG+226-TIGIT-`    .          
## `TREG+226-TIGIT+`    .          
## `TREG+39+`           .          
## `TREG+DR+`           .          
## `TREG+PD-1+`         .          
## `TREG+TIGIT+`        .

##180

# Подготовка данных: X - матрица предикторов, y - вектор отклика
X <- model.matrix(cGVHD_present ~ ., data = data_180)
y <- data_180$cGVHD_present

# Построение модели LASSO
lasso_model <- glmnet(X, y, family = "binomial", alpha = 1) # alpha = 1 для LASSO

# Выбор наилучшего lambda с помощью кросс-валидации
cv_lasso <- cv.glmnet(X, y, family = "binomial", alpha = 1)
best_lambda <- cv_lasso$lambda.min

# Модель с наилучшим lambda
lasso_model_best <- glmnet(X, y, family = "binomial", alpha = 1, lambda = best_lambda)

# Коэффициенты
coef(lasso_model_best)
## 166 x 1 sparse Matrix of class "dgCMatrix"
##                                s0
## (Intercept)         -6.931472e-01
## (Intercept)          .           
## `4_TFH`              .           
## `4_TH1`              .           
## `4_TH17`             .           
## `4_Th17TO1`          .           
## `4_TH2`              .           
## `4_TH22`             .           
## `4+ (IM STAT)`       .           
## `4+`                 .           
## `4+226+`             .           
## `4+39+`              .           
## `4+DR+`              .           
## `4+PD-1+`            .           
## `4+PD-1+TIGIT-`      .           
## `4+PD-1+TIGIT+`      .           
## `4+PD-1-TIGIT-`      .           
## `4+PD-1-TIGIT+`      .           
## `4+TIGIT+`           .           
## `4NV(СТАР2)`         .           
## `4NV`                .           
## `4NV_TH1`            .           
## `4NV_TH17`           .           
## `4NV_Th17TO1`        8.628088e-16
## `4NV_TH2`            .           
## `4NV_TH22`           .           
## `4NV+226+`           .           
## `4NV+39+`            .           
## `4NV+DR+`            .           
## `4NV+PD1+`           .           
## `4NV+PD-1+TIGIT-`    .           
## `4NV+PD-1+TIGIT+`    .           
## `4NV+PD-1-TIGIT-`    .           
## `4NV+PD-1-TIGIT+`    .           
## `4NV+TIGIT+`         .           
## `4ЕМ`                .           
## `4ЕМ_TH1`            .           
## `4ЕМ_TH17`           .           
## `4ЕМ_Th17TO1`        .           
## `4ЕМ_TH2`            .           
## `4ЕМ_TH22`           .           
## `4ЕМ+226+`           .           
## `4ЕМ+39+`            .           
## `4ЕМ+DR+`            .           
## `4ЕМ+PD1+`           .           
## `4ЕМ+PD1+TIGIT-`     .           
## `4ЕМ+PD1+TIGIT+`     .           
## `4ЕМ+PD1-TIGIT-`     .           
## `4ЕМ+PD1-TIGIT+`     .           
## `4ЕМ+TIGIT+`         .           
## `4ЕМTM`              .           
## `4СМ(СТАР2)`         .           
## `4СМ`                .           
## `4СМ_TH1`            .           
## `4СМ_TH17`           .           
## `4СМ_Th17TO1`        .           
## `4СМ_TH2`            .           
## `4СМ_TH22`           .           
## `4СМ+226+`           .           
## `4СМ+39+`            .           
## `4СМ+DR+`            .           
## `4СМ+PD1+`           .           
## `4СМ+PD1+TIGIT-`     .           
## `4СМ+PD1+TIGIT+`     .           
## `4СМ+PD1-TIGIT-`     .           
## `4СМ+PD1-TIGIT+`     .           
## `4СМ+TIGIT+`         .           
## `4ТM_TH1`            .           
## `4ТM_TH17`           .           
## `4ТM_Th17TO1`        .           
## `4ТM_TH2`            .           
## `4ТM_TH22`           .           
## `4ТREG(СТАР2)`       .           
## `4ТREG`              .           
## `4ТREG_TH1`          .           
## `4ТREG_TH17`         .           
## `4ТREG_Th17TO1`      .           
## `4ТREG_TH2`          .           
## `4ТREG_TH22`         .           
## `4ТЕ(СТАР2)`         .           
## `4ТЕ`                .           
## `4ТЕ_TH1`            .           
## `4ТЕ_TH17`           .           
## `4ТЕ_Th17TO1`        .           
## `4ТЕ_TH2`            .           
## `4ТЕ_TH22`           .           
## `4ТЕ+226+`           .           
## `4ТЕ+39+`            .           
## `4ТЕ+DR+`            .           
## `4ТЕ+PD-1+`          .           
## `4ТЕ+PD-1+TIGIT-`    .           
## `4ТЕ+PD-1+TIGIT+`    .           
## `4ТЕ+PD-1-TIGIT-`    .           
## `4ТЕ+PD-1-TIGIT+`    .           
## `4ТЕ+TIGIT+`         .           
## `4ТМ`                .           
## `8+ (IM STAT)`       .           
## `8+`                 .           
## `8+226+`             .           
## `8+39+`              .           
## `8+DR+`              .           
## `8+PD-1+`            .           
## `8+PD-1+TIGIT-`      .           
## `8+PD-1+TIGIT+`      .           
## `8+PD-1-TIGIT-`      .           
## `8+PD-1-TIGIT+`      .           
## `8+TIGIT+`           .           
## `8EMTM`              .           
## `8EMTM+226+`         .           
## `8EMTM+39+`          .           
## `8EMTM+DR+`          .           
## `8EMTM+PD-1+`        .           
## `8EMTM+PD-1+TIGIT-`  .           
## `8EMTM+PD-1+TIGIT+`  .           
## `8EMTM+PD-1-TIGIT-`  .           
## `8EMTM+PD-1-TIGIT+`  .           
## `8EMTM+TIGIT+`       .           
## `8NV(СТАР2)`         .           
## `8NV`                .           
## `8NV+226+`           .           
## `8NV+39+`            .           
## `8NV+DR+`            .           
## `8NV+PD-1+`          .           
## `8NV+PD-1+TIGIT-`    .           
## `8NV+PD-1+TIGIT+`    .           
## `8NV+PD-1-TIGIT-`    .           
## `8NV+PD-1-TIGIT+`    .           
## `8NV+TIGIT+`         .           
## `8TREG`              .           
## `8ЕМ`                .           
## `8СМ(СТАР2)`         .           
## `8СМ`                .           
## `8СМ+226+`           .           
## `8СМ+39+`            .           
## `8СМ+DR+`            .           
## `8СМ+PD-1+`          .           
## `8СМ+PD-1+TIGIT-`    .           
## `8СМ+PD-1+TIGIT+`    .           
## `8СМ+PD-1-TIGIT-`    .           
## `8СМ+PD-1-TIGIT+`    .           
## `8СМ+TIGIT+`         .           
## `8ТЕ(СТАР2)`         .           
## `8ТЕ`                .           
## `8ТЕ+226+`           .           
## `8ТЕ+39+`            .           
## `8ТЕ+DR+`            .           
## `8ТЕ+PD-1+`          .           
## `8ТЕ+PD-1+TIGIT-`    .           
## `8ТЕ+PD-1+TIGIT+`    .           
## `8ТЕ+PD-1-TIGIT-`    .           
## `8ТЕ+PD-1-TIGIT+`    .           
## `8ТЕ+TIGIT+`         .           
## `8ТМ`                .           
## TREG_CM              .           
## TREG_EMTM            .           
## TREG_NV              .           
## TREG_TE              .           
## `TREG+226+`          .           
## `TREG+226+TIGIT-`    .           
## `TREG+226+TIGIT+`    .           
## `TREG+226-TIGIT-`    .           
## `TREG+226-TIGIT+`    .           
## `TREG+39+`           .           
## `TREG+DR+`           .           
## `TREG+PD-1+`         .           
## `TREG+TIGIT+`        .

##несколько попыток отобрать предикторы в модель, везде aliased coefficient

model_90_filter <- glm(cGVHD_present ~ . - `4+ (IM STAT)` - `4+` - `4NV(СТАР2)` - `4NV` - `4ЕМ` - `4СМ(СТАР2)` - `4СМ` - `4ТREG(СТАР2)` - `4ТREG` - `4ТЕ(СТАР2)` - `4ТЕ` - `8+ (IM STAT)` - `8+` - `8EMTM` - `8NV(СТАР2)` - `8NV` - `8СМ(СТАР2)` - `8СМ` - `8ТЕ(СТАР2)` - `8ТЕ`, data = data_90, family = binomial)


summary(model_90_filter)
## 
## Call:
## glm(formula = cGVHD_present ~ . - `4+ (IM STAT)` - `4+` - `4NV(СТАР2)` - 
##     `4NV` - `4ЕМ` - `4СМ(СТАР2)` - `4СМ` - `4ТREG(СТАР2)` - 
##     `4ТREG` - `4ТЕ(СТАР2)` - `4ТЕ` - `8+ (IM STAT)` - 
##     `8+` - `8EMTM` - `8NV(СТАР2)` - `8NV` - `8СМ(СТАР2)` - 
##     `8СМ` - `8ТЕ(СТАР2)` - `8ТЕ`, family = binomial, 
##     data = data_90)
## 
## Coefficients: (78 not defined because of singularities)
##                       Estimate Std. Error z value Pr(>|z|)
## (Intercept)         -2.776e+01  3.605e+05       0        1
## `4_TFH`             -5.818e+00  8.031e+04       0        1
## `4_TH1`              2.656e+01  9.467e+05       0        1
## `4_TH17`            -9.898e+01  1.504e+06       0        1
## `4_Th17TO1`         -9.482e+01  5.141e+06       0        1
## `4_TH2`             -7.014e+01  7.237e+05       0        1
## `4_TH22`            -4.085e+00  4.450e+06       0        1
## `4+226+`             2.066e+01  1.107e+06       0        1
## `4+39+`              3.786e+01  9.003e+05       0        1
## `4+DR+`             -7.175e+00  1.271e+05       0        1
## `4+PD-1+`            1.388e+09  7.014e+13       0        1
## `4+PD-1+TIGIT-`     -1.388e+09  7.014e+13       0        1
## `4+PD-1+TIGIT+`     -2.926e+09  3.248e+13       0        1
## `4+PD-1-TIGIT-`     -2.752e+01  5.302e+05       0        1
## `4+PD-1-TIGIT+`     -1.538e+09  8.709e+13       0        1
## `4+TIGIT+`           1.538e+09  8.709e+13       0        1
## `4NV_TH1`           -8.685e+01  2.563e+06       0        1
## `4NV_TH17`           1.218e+02  1.464e+06       0        1
## `4NV_Th17TO1`        4.724e+02  1.482e+07       0        1
## `4NV_TH2`            7.191e+01  8.991e+05       0        1
## `4NV_TH22`          -3.069e+02  1.039e+07       0        1
## `4NV+226+`          -2.714e+01  1.126e+06       0        1
## `4NV+39+`            1.268e+01  2.072e+06       0        1
## `4NV+DR+`           -2.711e+00  1.230e+06       0        1
## `4NV+PD1+`          -1.076e+11  3.701e+15       0        1
## `4NV+PD-1+TIGIT-`    1.076e+11  3.701e+15       0        1
## `4NV+PD-1+TIGIT+`   -2.395e+11  1.201e+16       0        1
## `4NV+PD-1-TIGIT-`    3.541e+01  5.552e+05       0        1
## `4NV+PD-1-TIGIT+`   -3.471e+11  1.564e+16       0        1
## `4NV+TIGIT+`         3.471e+11  1.564e+16       0        1
## `4ЕМ_TH1`           -4.077e+01  1.075e+06       0        1
## `4ЕМ_TH17`          -1.992e+02  7.594e+06       0        1
## `4ЕМ_Th17TO1`        3.540e+02  6.738e+06       0        1
## `4ЕМ_TH2`            9.196e+01  1.220e+06       0        1
## `4ЕМ_TH22`           1.020e+03  9.990e+07       0        1
## `4ЕМ+226+`          -3.620e+01  1.314e+06       0        1
## `4ЕМ+39+`           -4.022e+01  8.473e+05       0        1
## `4ЕМ+DR+`            7.334e+00  3.289e+05       0        1
## `4ЕМ+PD1+`          -3.490e+09  7.280e+13       0        1
## `4ЕМ+PD1+TIGIT-`     1.190e+09  1.597e+14       0        1
## `4ЕМ+PD1+TIGIT+`     1.519e+09  2.640e+14       0        1
## `4ЕМ+PD1-TIGIT-`    -2.301e+09  1.057e+14       0        1
## `4ЕМ+PD1-TIGIT+`    -1.972e+09  2.074e+14       0        1
## `4ЕМ+TIGIT+`        -3.291e+08  1.137e+14       0        1
## `4ЕМTM`              2.301e+09  1.057e+14       0        1
## `4СМ_TH1`            1.176e+01  6.180e+05       0        1
## `4СМ_TH17`           1.031e+02  1.787e+06       0        1
## `4СМ_Th17TO1`        2.113e+01  2.776e+06       0        1
## `4СМ_TH2`            7.338e+01  7.548e+05       0        1
## `4СМ_TH22`           1.180e+02  1.024e+07       0        1
## `4СМ+226+`          -4.553e+01  1.911e+06       0        1
## `4СМ+39+`           -4.747e+01  1.396e+06       0        1
## `4СМ+DR+`           -9.300e-01  2.872e+05       0        1
## `4СМ+PD1+`           6.314e+09  2.271e+14       0        1
## `4СМ+PD1+TIGIT-`    -6.314e+09  2.271e+14       0        1
## `4СМ+PD1+TIGIT+`     2.295e+09  2.751e+14       0        1
## `4СМ+PD1-TIGIT-`     4.609e+01  1.600e+06       0        1
## `4СМ+PD1-TIGIT+`     8.609e+09  2.957e+14       0        1
## `4СМ+TIGIT+`        -8.609e+09  2.957e+14       0        1
## `4ТM_TH1`           -4.046e+01  1.141e+06       0        1
## `4ТM_TH17`           1.119e+02  1.767e+06       0        1
## `4ТM_Th17TO1`        1.064e+02  6.304e+06       0        1
## `4ТM_TH2`            6.166e+01  1.313e+06       0        1
## `4ТM_TH22`          -2.066e+01  5.232e+06       0        1
## `4ТREG_TH1`          3.298e+02  8.226e+06       0        1
## `4ТREG_TH17`         9.210e+00  7.521e+05       0        1
## `4ТREG_Th17TO1`     -5.297e+02  1.103e+07       0        1
## `4ТREG_TH2`                 NA         NA      NA       NA
## `4ТREG_TH22`                NA         NA      NA       NA
## `4ТЕ_TH1`                   NA         NA      NA       NA
## `4ТЕ_TH17`                  NA         NA      NA       NA
## `4ТЕ_Th17TO1`               NA         NA      NA       NA
## `4ТЕ_TH2`                   NA         NA      NA       NA
## `4ТЕ_TH22`                  NA         NA      NA       NA
## `4ТЕ+226+`                  NA         NA      NA       NA
## `4ТЕ+39+`                   NA         NA      NA       NA
## `4ТЕ+DR+`                   NA         NA      NA       NA
## `4ТЕ+PD-1+`                 NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `4ТЕ+TIGIT+`                NA         NA      NA       NA
## `4ТМ`                       NA         NA      NA       NA
## `8+226+`                    NA         NA      NA       NA
## `8+39+`                     NA         NA      NA       NA
## `8+DR+`                     NA         NA      NA       NA
## `8+PD-1+`                   NA         NA      NA       NA
## `8+PD-1+TIGIT-`             NA         NA      NA       NA
## `8+PD-1+TIGIT+`             NA         NA      NA       NA
## `8+PD-1-TIGIT-`             NA         NA      NA       NA
## `8+PD-1-TIGIT+`             NA         NA      NA       NA
## `8+TIGIT+`                  NA         NA      NA       NA
## `8EMTM+226+`                NA         NA      NA       NA
## `8EMTM+39+`                 NA         NA      NA       NA
## `8EMTM+DR+`                 NA         NA      NA       NA
## `8EMTM+PD-1+`               NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT+`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT+`         NA         NA      NA       NA
## `8EMTM+TIGIT+`              NA         NA      NA       NA
## `8NV+226+`                  NA         NA      NA       NA
## `8NV+39+`                   NA         NA      NA       NA
## `8NV+DR+`                   NA         NA      NA       NA
## `8NV+PD-1+`                 NA         NA      NA       NA
## `8NV+PD-1+TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1+TIGIT+`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT+`           NA         NA      NA       NA
## `8NV+TIGIT+`                NA         NA      NA       NA
## `8TREG`                     NA         NA      NA       NA
## `8ЕМ`                       NA         NA      NA       NA
## `8СМ+226+`                  NA         NA      NA       NA
## `8СМ+39+`                   NA         NA      NA       NA
## `8СМ+DR+`                   NA         NA      NA       NA
## `8СМ+PD-1+`                 NA         NA      NA       NA
## `8СМ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8СМ+TIGIT+`                NA         NA      NA       NA
## `8ТЕ+226+`                  NA         NA      NA       NA
## `8ТЕ+39+`                   NA         NA      NA       NA
## `8ТЕ+DR+`                   NA         NA      NA       NA
## `8ТЕ+PD-1+`                 NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8ТЕ+TIGIT+`                NA         NA      NA       NA
## `8ТМ`                       NA         NA      NA       NA
## TREG_CM                     NA         NA      NA       NA
## TREG_EMTM                   NA         NA      NA       NA
## TREG_NV                     NA         NA      NA       NA
## TREG_TE                     NA         NA      NA       NA
## `TREG+226+`                 NA         NA      NA       NA
## `TREG+226+TIGIT-`           NA         NA      NA       NA
## `TREG+226+TIGIT+`           NA         NA      NA       NA
## `TREG+226-TIGIT-`           NA         NA      NA       NA
## `TREG+226-TIGIT+`           NA         NA      NA       NA
## `TREG+39+`                  NA         NA      NA       NA
## `TREG+DR+`                  NA         NA      NA       NA
## `TREG+PD-1+`                NA         NA      NA       NA
## `TREG+TIGIT+`               NA         NA      NA       NA
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 9.1068e+01  on 66  degrees of freedom
## Residual deviance: 3.8883e-10  on  0  degrees of freedom
## AIC: 134
## 
## Number of Fisher Scoring iterations: 25
model_90_filter_2 <- glm(cGVHD_present ~ `4+ (IM STAT)` + `4NV(СТАР2)` + `4NV` + `4NV_TH17` + `4NV_Th17TO1` + `4NV_TH2` + `4NV+226+` + `4NV+PD-1-TIGIT-` + `4NV+TIGIT+` + `4ЕМ_TH1` + `4ЕМ_TH17` + `4ЕМ_Th17TO1` + `4СМ` + `4СМ_TH22` + `4ТЕ+PD-1+TIGIT-` + `8+ (IM STAT)` + `8+` + `8+DR+` + `8+PD-1+` + `8+PD-1+TIGIT+` + `8+TIGIT+` + `8EMTM` + `8EMTM+226+` + `8EMTM+39+` + `8EMTM+DR+` + `8EMTM+PD-1+` +  `8EMTM+PD-1+TIGIT-` + `8EMTM+PD-1+TIGIT+` + `8EMTM+PD-1-TIGIT+` + `8EMTM+TIGIT+` + `8NV` + `8TREG` + `8ТЕ(СТАР2)` + `8ТЕ+226+` + `8ТЕ+DR+` + `8ТЕ+PD-1+` + `8ТЕ+PD-1+TIGIT+` + `8ТМ`, data = data_90, family = binomial)                          
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
model_90_filter_2 <- glm(cGVHD_present ~ `4NV_TH17` + `4NV_TH2` + `4NV+226+` + `4NV+PD-1-TIGIT-` + `4ЕМ_TH17` + `4ЕМ_Th17TO1` + `8+DR+` + `8+PD-1+` + `8+PD-1+TIGIT+` + `8EMTM+39+` + `8EMTM+DR+` + `8EMTM+PD-1+` +  `8EMTM+PD-1+TIGIT-` + `8EMTM+TIGIT+` + `8NV` + `8TREG` + `8ТЕ+DR+` +   `8ТЕ+PD-1+TIGIT+`, data = data_90, family = binomial) 
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
summary(model_90_filter_2)
## 
## Call:
## glm(formula = cGVHD_present ~ `4NV_TH17` + `4NV_TH2` + `4NV+226+` + 
##     `4NV+PD-1-TIGIT-` + `4ЕМ_TH17` + `4ЕМ_Th17TO1` + `8+DR+` + 
##     `8+PD-1+` + `8+PD-1+TIGIT+` + `8EMTM+39+` + `8EMTM+DR+` + 
##     `8EMTM+PD-1+` + `8EMTM+PD-1+TIGIT-` + `8EMTM+TIGIT+` + `8NV` + 
##     `8TREG` + `8ТЕ+DR+` + `8ТЕ+PD-1+TIGIT+`, family = binomial, 
##     data = data_90)
## 
## Coefficients:
##                       Estimate Std. Error z value Pr(>|z|)  
## (Intercept)          -0.562595   0.674208  -0.834   0.4040  
## `4NV_TH17`            0.600160   0.797564   0.752   0.4518  
## `4NV_TH2`             0.191467   0.193999   0.987   0.3237  
## `4NV+226+`           -0.162948   0.213486  -0.763   0.4453  
## `4NV+PD-1-TIGIT-`     0.155361   0.181271   0.857   0.3914  
## `4ЕМ_TH17`          -11.998866   9.866320  -1.216   0.2239  
## `4ЕМ_Th17TO1`        -5.845051   3.428431  -1.705   0.0882 .
## `8+DR+`              -0.436723   0.224706  -1.944   0.0520 .
## `8+PD-1+`             0.007366   0.019088   0.386   0.6996  
## `8+PD-1+TIGIT+`       0.794734   0.444771   1.787   0.0740 .
## `8EMTM+39+`          -0.059645   0.050367  -1.184   0.2363  
## `8EMTM+DR+`           0.486709   0.233585   2.084   0.0372 *
## `8EMTM+PD-1+`        -0.979300   0.513995  -1.905   0.0567 .
## `8EMTM+PD-1+TIGIT-`   0.988064   0.584346   1.691   0.0909 .
## `8EMTM+TIGIT+`        0.096118   0.087828   1.094   0.2738  
## `8NV`                 0.010953   0.052602   0.208   0.8351  
## `8TREG`              -0.011642   0.008210  -1.418   0.1562  
## `8ТЕ+DR+`             0.440618   0.228786   1.926   0.0541 .
## `8ТЕ+PD-1+TIGIT+`    -0.798576   0.445109  -1.794   0.0728 .
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 91.068  on 66  degrees of freedom
## Residual deviance: 58.630  on 48  degrees of freedom
## AIC: 96.63
## 
## Number of Fisher Scoring iterations: 7

#Heat map

# Создание корреляционной матрицы
correlation_matrix <- cor(data_90_num, method = "spearman")

# Иерархическая кластеризация
cor_hclust <- hclust(dist((1-correlation_matrix)), method = "complete")

# Создание тепловой карты 
pheatmap(
  correlation_matrix,
  cluster_rows = cor_hclust,
  cluster_cols = cor_hclust,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица",
  annotation_col = NULL,
  annotation_row = NULL,
  fontsize = 10
)

##кластеры

# Функция для расчета SSE
wss <- function(k) {
  km <- kmeans(data_90_num, centers = k, nstart = 25)
  return(km$tot.withinss)
}

# Расчет SSE для k от 1 до 10
k.values <- 1:10
SSE <- sapply(k.values, wss)

# Построение графика
plot(k.values, SSE, type = "b", xlab = "Число кластеров", ylab = "Сумма квадратов ошибок (SSE)", 
     main = "Метод локтя")
lines(k.values, SSE, col = "red")

library(cluster)

silhouette_scores <- sapply(2:10, function(k) {
  km <- kmeans(data_90_num, centers = k, nstart = 25)
  sil <- silhouette(km$cluster, dist(data_90_num))
  mean(sil[, 3])
})

# Построение графика
plot(2:10, silhouette_scores, type = "b", xlab = "Число кластеров", ylab = "Средний силуэтный коэффициент", 
     main = "Критерий силуэта")
lines(2:10, silhouette_scores, col = "red")

#Деление на 10 кластеров + отдельные матрицы

clusters <- cutree(cor_hclust, k = 10)

table(clusters)
## clusters
##  1  2  3  4  5  6  7  8  9 10 
## 29 27 14 13  9  9 38  9  6 10
cluster_1_vars <- names(which(clusters == 1))
cluster_2_vars <- names(which(clusters == 2))
cluster_3_vars <- names(which(clusters == 3))
cluster_4_vars <- names(which(clusters == 4))
cluster_5_vars <- names(which(clusters == 5))
cluster_6_vars <- names(which(clusters == 6))
cluster_7_vars <- names(which(clusters == 7))
cluster_8_vars <- names(which(clusters == 8))
cluster_9_vars <- names(which(clusters == 9))
cluster_10_vars <- names(which(clusters == 10))
cluster_1_matrix <- correlation_matrix[cluster_1_vars, cluster_1_vars]

pheatmap(
  cluster_1_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для первого кластера"
)

cluster_2_matrix <- correlation_matrix[cluster_2_vars, cluster_2_vars]

pheatmap(
  cluster_2_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для второго кластера"
)

cluster_3_matrix <- correlation_matrix[cluster_3_vars, cluster_3_vars]

pheatmap(
  cluster_3_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для третьего кластера"
)

cluster_4_matrix <- correlation_matrix[cluster_4_vars, cluster_4_vars]

pheatmap(
  cluster_4_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для четвертого кластера"
)

cluster_5_matrix <- correlation_matrix[cluster_5_vars, cluster_5_vars]

pheatmap(
  cluster_5_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для пятого кластера"
)

cluster_6_matrix <- correlation_matrix[cluster_6_vars, cluster_6_vars]

pheatmap(
  cluster_6_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для шестого кластера"
)

cluster_7_matrix <- correlation_matrix[cluster_7_vars, cluster_7_vars]

pheatmap(
  cluster_7_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для седьмого кластера"
)

cluster_8_matrix <- correlation_matrix[cluster_8_vars, cluster_8_vars]

pheatmap(
  cluster_8_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для восьмого кластера"
)

cluster_9_matrix <- correlation_matrix[cluster_9_vars, cluster_9_vars]

pheatmap(
  cluster_9_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для девятого кластера"
)

cluster_10_matrix <- correlation_matrix[cluster_10_vars, cluster_10_vars]

pheatmap(
  cluster_10_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для десятого кластера"
)

#Деление на 5 кластеров + корреляционные матрицы

clusters_2 <- cutree(cor_hclust, k = 5)

table(clusters_2)
## clusters_2
##  1  2  3  4  5 
## 52 27 23 24 38
cluster_1 <- names(which(clusters_2 == 1))
cluster_2 <- names(which(clusters_2 == 2))
cluster_3 <- names(which(clusters_2 == 3))
cluster_4 <- names(which(clusters_2 == 4))
cluster_5 <- names(which(clusters_2 == 5))
cluster_matrix_1 <- correlation_matrix[cluster_1, cluster_1]

pheatmap(
  cluster_matrix_1,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для первого кластера"
)

cluster_matrix_2 <- correlation_matrix[cluster_2, cluster_2]

pheatmap(
  cluster_matrix_2,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для второго кластера"
)

cluster_matrix_3 <- correlation_matrix[cluster_3, cluster_3]

pheatmap(
  cluster_matrix_3,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для третьего кластера"
)

cluster_matrix_4 <- correlation_matrix[cluster_4, cluster_4]

pheatmap(
  cluster_matrix_4,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для четвертого кластера"
)

cluster_matrix_5 <- correlation_matrix[cluster_5, cluster_5]

pheatmap(
  cluster_matrix_5,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для пятого кластера"
)

Модель по результатам heat map (отобранные предикторы), 90 день

model_90_filter_finish <- glm(cGVHD_present ~ `4СМ_TH1` + `4_TH22`+ `TREG+PD-1+` + `4ЕМ_TH17` + `4ЕМ+39+` + `4ТREG_TH1` + `8ТЕ` + `4NV_TH2` + `TREG+226-TIGIT-` + `8NV+DR+` + `4NV+PD-1+TIGIT-` + `8EMTM+39+` + `8СМ+TIGIT+`, data = data_90, family = binomial) 


summary(model_90_filter_finish)
## 
## Call:
## glm(formula = cGVHD_present ~ `4СМ_TH1` + `4_TH22` + `TREG+PD-1+` + 
##     `4ЕМ_TH17` + `4ЕМ+39+` + `4ТREG_TH1` + `8ТЕ` + `4NV_TH2` + 
##     `TREG+226-TIGIT-` + `8NV+DR+` + `4NV+PD-1+TIGIT-` + `8EMTM+39+` + 
##     `8СМ+TIGIT+`, family = binomial, data = data_90)
## 
## Coefficients:
##                     Estimate Std. Error z value Pr(>|z|)  
## (Intercept)        -0.700678   0.653080  -1.073   0.2833  
## `4СМ_TH1`           0.200270   0.213659   0.937   0.3486  
## `4_TH22`            0.199067   0.117592   1.693   0.0905 .
## `TREG+PD-1+`        0.085986   0.069854   1.231   0.2183  
## `4ЕМ_TH17`        -10.781745  11.975131  -0.900   0.3679  
## `4ЕМ+39+`          -0.039620   0.024450  -1.620   0.1051  
## `4ТREG_TH1`         1.861241   1.718133   1.083   0.2787  
## `8ТЕ`              -0.002228   0.001679  -1.327   0.1845  
## `4NV_TH2`           0.400092   0.175911   2.274   0.0229 *
## `TREG+226-TIGIT-`  -0.890614   0.608079  -1.465   0.1430  
## `8NV+DR+`          -0.327920   0.166921  -1.965   0.0495 *
## `4NV+PD-1+TIGIT-`  -0.251259   0.410354  -0.612   0.5403  
## `8EMTM+39+`         0.026298   0.012307   2.137   0.0326 *
## `8СМ+TIGIT+`        0.025814   0.066322   0.389   0.6971  
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 91.068  on 66  degrees of freedom
## Residual deviance: 64.971  on 53  degrees of freedom
## AIC: 92.971
## 
## Number of Fisher Scoring iterations: 7

##Корреляции в model_90_filter_finish

data_90_num_model <- data_90 %>%
  select(`4СМ_TH1`, `4_TH22`,`TREG+PD-1+`, `4ЕМ_TH17`, `4ЕМ+39+`, `4ТREG_TH1`, `8ТЕ`, `4NV_TH2`, `TREG+226-TIGIT-`, `8NV+DR+`, `4NV+PD-1+TIGIT-`, `8EMTM+39+`, `8СМ+TIGIT+`) 


data_90_num_model_cor <- cor(data_90_num_model)

corrplot(data_90_num_model_cor, method = "circle", type = "upper", tl.col = "black", tl.cex = 0.7)

corrplot(data_90_num_model_cor, method = 'number')

##Диагностика model_90_filter_finish 90 день

Проверка формы зависимости логита от \(X\) на линейность:

df_check <- model_90_filter_finish %>% broom::augment() %>% 
  dplyr::select(-starts_with("."), .fitted) %>% 
  dplyr::select(where(is.numeric)) %>% 
  pivot_longer(-.fitted) %>% 
  rename(logit = .fitted)
  
ggplot() +
  geom_point(aes(x = value, y = logit), df_check) +
  geom_smooth(aes(x = value, y = logit), df_check, color = "red", se = FALSE) +
  facet_wrap(~ name, scales = "free") +
  theme_bw()
## `geom_smooth()` using method = 'loess' and formula = 'y ~ x'

Мультиколлинеарность:

car::vif(model_90_filter_finish)
##         `4СМ_TH1`          `4_TH22`      `TREG+PD-1+`        `4ЕМ_TH17` 
##          2.465438          1.849622          1.444725          1.581198 
##         `4ЕМ+39+`       `4ТREG_TH1`             `8ТЕ`         `4NV_TH2` 
##          2.088637          1.915383          2.578817          2.311035 
## `TREG+226-TIGIT-`         `8NV+DR+` `4NV+PD-1+TIGIT-`       `8EMTM+39+` 
##          2.353237          2.167347          1.463771          2.204821 
##      `8СМ+TIGIT+` 
##          1.736319

Выбросы

resid_panel(model_90_filter_finish, plots = c("lev", "cookd"))
## Warning in helper_plotly_label(model): в результате преобразования созданы NA
## Warning in helper_plotly_label(model): в результате преобразования созданы NA

Модель по результатам heat map (отобранные предикторы), 180 день

model_180_filter_finish <- glm(cGVHD_present ~ `4СМ_TH1` + `4_TH22`+ `TREG+PD-1+` + `4ЕМ_TH17` + `4ЕМ+39+` + `4ТREG_TH1` + `8ТЕ` + `4NV_TH2` + `4NV_Th17TO1` + `8NV+DR+` + `4NV+PD-1+TIGIT-` + `8EMTM+39+` + `8СМ+TIGIT+`, data = data_180, family = binomial) 


summary(model_180_filter_finish)
## 
## Call:
## glm(formula = cGVHD_present ~ `4СМ_TH1` + `4_TH22` + `TREG+PD-1+` + 
##     `4ЕМ_TH17` + `4ЕМ+39+` + `4ТREG_TH1` + `8ТЕ` + `4NV_TH2` + 
##     `4NV_Th17TO1` + `8NV+DR+` + `4NV+PD-1+TIGIT-` + `8EMTM+39+` + 
##     `8СМ+TIGIT+`, family = binomial, data = data_180)
## 
## Coefficients:
##                     Estimate Std. Error z value Pr(>|z|)
## (Intercept)       -1.1419914  1.0702854  -1.067    0.286
## `4СМ_TH1`          0.4745997  0.3242301   1.464    0.143
## `4_TH22`           0.1368453  0.1165034   1.175    0.240
## `TREG+PD-1+`       0.0362640  0.0585317   0.620    0.536
## `4ЕМ_TH17`         2.5650151  5.8451669   0.439    0.661
## `4ЕМ+39+`          0.0020392  0.0207330   0.098    0.922
## `4ТREG_TH1`       -2.6278044  4.0082651  -0.656    0.512
## `8ТЕ`             -0.0008452  0.0016178  -0.522    0.601
## `4NV_TH2`         -0.1621211  0.1268905  -1.278    0.201
## `4NV_Th17TO1`      0.5616999  2.7822101   0.202    0.840
## `8NV+DR+`         -0.1235626  0.1251563  -0.987    0.324
## `4NV+PD-1+TIGIT-`  0.0462197  0.1847806   0.250    0.802
## `8EMTM+39+`       -0.0036416  0.0074200  -0.491    0.624
## `8СМ+TIGIT+`       0.0725012  0.0858565   0.844    0.398
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 53.467  on 41  degrees of freedom
## Residual deviance: 37.070  on 28  degrees of freedom
## AIC: 65.07
## 
## Number of Fisher Scoring iterations: 6
df_check <- model_180_filter_finish %>% broom::augment() %>% 
  dplyr::select(-starts_with("."), .fitted) %>% 
  dplyr::select(where(is.numeric)) %>% 
  pivot_longer(-.fitted) %>% 
  rename(logit = .fitted)
  
ggplot() +
  geom_point(aes(x = value, y = logit), df_check) +
  geom_smooth(aes(x = value, y = logit), df_check, color = "red", se = FALSE) +
  facet_wrap(~ name, scales = "free") +
  theme_bw()
## `geom_smooth()` using method = 'loess' and formula = 'y ~ x'

#Множественный регрессионный анализ, поправка на множественное сравнение, Forrest plot и Vulcano plot

# Копируем данные для переименования
data_90_copy <- data_90

# Функция для безопасных имен переменных
make_safe_names <- function(names) {
  # Заменяем недопустимые символы на '_'
  safe_names <- make.names(names, unique = TRUE)
  return(safe_names)
}

# Функция для выполнения регрессии и коррекции p-значений
perform_multiple_regression <- function(data) {
  # Находим числовые колонки, исключая целевую
  numeric_cols <- names(data)[sapply(data, is.numeric) & names(data) != "cGVHD_present"]
  
  # Создаем копию данных с безопасными именами
  data_safe <- data
  names(data_safe) <- make_safe_names(names(data))
  
  # Обновляем список числовых колонок с безопасными именами
  numeric_cols_safe <- make_safe_names(numeric_cols)
  
  # Список для хранения результатов
  regression_results <- list()
  
  # Цикл по всем числовым переменным
  for (i in seq_along(numeric_cols_safe)) {
    col <- numeric_cols_safe[i]
    original_col <- numeric_cols[i]
    
    formula <- as.formula(paste("cGVHD_present ~", col))
    model <- glm(formula, data = data_safe, family = binomial())
    
    # Извлечение результатов
    tidy_model <- tidy(model, conf.int = TRUE)
    tidy_model$original_variable <- original_col
    regression_results[[original_col]] <- tidy_model
  }
  
  # Коррекция p-значений методом Бенджамини-Хохберга
  p_values <- sapply(regression_results, function(x) x$p.value[2])
  adjusted_p_values <- p.adjust(p_values, method = "BH")
  
  # Обновление результатов скорректированными p-значениями
  for (i in seq_along(regression_results)) {
    regression_results[[names(regression_results)[i]]]$p.adj <- adjusted_p_values[i]
  }
  
  return(regression_results)
}

# Выполнение регрессионного анализа
results <- perform_multiple_regression(data_90_copy)
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
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## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
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## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
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## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
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## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
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## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
# Подготовка данных для Forest Plot
forest_data <- do.call(rbind, lapply(names(results), function(col) {
  res <- results[[col]]
  data.frame(
    variable = col,
    estimate = res$estimate[2],
    conf.low = res$conf.low[2],
    conf.high = res$conf.high[2],
    p.adj = res$p.adj[2]
  )
}))

# Forest Plot
forest_plot_1 <- ggplot(forest_data, aes(y = reorder(variable, estimate), x = estimate)) +
  geom_point(size = 3) +
  geom_errorbarh(aes(xmin = conf.low, xmax = conf.high), height = 0.2) +
  geom_vline(xintercept = 0, linetype = "dashed") +
  theme_minimal() +
  labs(title = "Forest Plot of Regression Coefficients", 
       x = "Coefficient Estimate", 
       y = "Variables") +
  theme(axis.text.x = element_blank()) + #убрали текст с вертикальной оси после coord_flip()
   scale_x_continuous(limits = c(-75, 25)) +
    coord_flip()

forest_plot_2 <- ggplot(forest_data, aes(y = reorder(variable, estimate), x = estimate, color = p.adj < 0.05)) +
  geom_point(size = 2) +
  geom_errorbarh(aes(xmin = conf.low, xmax = conf.high), height = 0.1) +
  geom_vline(xintercept = 0, linetype = "dashed") +
  theme_minimal() +
  labs(title = "Forest Plot of Regression Coefficients (p-adjust)", 
       x = "Coefficient Estimate", 
       y = "Variables") +
  theme(axis.text.x = element_blank()) +
  scale_x_continuous(limits = c(-75, 50)) +
  coord_flip() +
  scale_color_manual(values = c("TRUE" = "red", "FALSE" = "black"))


# Volcano Plot 
volcano_plot_1 <- ggplot(forest_data, aes(x = estimate, y = -log10(p.adj))) +
  geom_point(aes(color = p.adj < 0.05)) +
  geom_text_repel(aes(label = variable),
                  box.padding = 0.5,
                  max.overlaps = Inf,
                  size = 2,
                  segment.size = 0.2,
                   segment.linetype = "solid",
                   segment.alpha = 0.5) + # Управляем толщиной линий
    scale_color_manual(values = c("TRUE" = "red", "FALSE" = "black")) +
  theme_minimal() +
  labs(title = "Volcano Plot",
       x = "Coefficient Estimate",
       y = "-log10(Adjusted p-value)") +
  scale_x_continuous(limits = c(-20, 8)) +
   scale_y_continuous(limits = c(0, 0.18))

# Вывод результатов
print(forest_data)
##                            variable      estimate      conf.low     conf.high
## 4_TFH                         4_TFH -1.192789e-02  -0.053208193  2.624051e-02
## 4_TH1                         4_TH1 -6.601313e-03  -0.029766044  3.009291e-03
## 4_TH17                       4_TH17 -4.308347e-03  -0.059739379  4.966030e-02
## 4_Th17TO1                 4_Th17TO1  2.286947e-02  -0.104923124  1.506918e-01
## 4_TH2                         4_TH2  1.955833e-03  -0.030201781  3.313621e-02
## 4_TH22                       4_TH22  2.880987e-02  -0.114728565  1.723961e-01
## 4+ (IM STAT)           4+ (IM STAT)  2.306123e-03  -0.005734818  1.087413e-02
## 4+                               4+  3.052174e-03  -0.004529199  1.154683e-02
## 4+226+                       4+226+ -1.272667e-03  -0.006287738  2.261703e-03
## 4+39+                         4+39+  7.264395e-04  -0.014854194  1.610321e-02
## 4+DR+                         4+DR+ -3.213373e-03  -0.011929145  1.353236e-03
## 4+PD-1+                     4+PD-1+ -2.169453e-03  -0.009020198  2.232934e-03
## 4+PD-1+TIGIT-         4+PD-1+TIGIT- -4.085288e-03  -0.016292979  6.297043e-03
## 4+PD-1+TIGIT+         4+PD-1+TIGIT+ -3.446140e-03  -0.016352915  3.378383e-03
## 4+PD-1-TIGIT-         4+PD-1-TIGIT-  4.482373e-03  -0.008223370  1.747532e-02
## 4+PD-1-TIGIT+         4+PD-1-TIGIT+ -1.456310e-02  -0.114348491  1.672480e-02
## 4+TIGIT+                   4+TIGIT+ -3.040573e-03  -0.014932729  2.816980e-03
## 4NV(СТАР2)               4NV(СТАР2)  2.946307e-02   0.003157308  6.032737e-02
## 4NV                             4NV  2.931199e-02   0.004010783  5.954912e-02
## 4NV_TH1                     4NV_TH1  2.607140e-01  -0.034348791  5.983811e-01
## 4NV_TH17                   4NV_TH17  7.844828e-01   0.020829753  1.691711e+00
## 4NV_Th17TO1             4NV_Th17TO1  2.933089e+00   0.121140037  6.421601e+00
## 4NV_TH2                     4NV_TH2  2.024009e-01   0.038313652  4.147739e-01
## 4NV_TH22                   4NV_TH22  4.699992e+00  -0.533238620  1.102395e+01
## 4NV+226+                   4NV+226+  3.406572e-02   0.003808529  6.984789e-02
## 4NV+39+                     4NV+39+  3.264935e-01  -0.201775887  9.173007e-01
## 4NV+DR+                     4NV+DR+ -2.811586e-02  -0.242749162  1.519534e-01
## 4NV+PD1+                   4NV+PD1+  6.997821e-02  -0.311046372  4.508367e-01
## 4NV+PD-1+TIGIT-     4NV+PD-1+TIGIT-  6.282884e-02  -0.448499366  5.643206e-01
## 4NV+PD-1+TIGIT+     4NV+PD-1+TIGIT+  2.583120e-01  -0.785509150  1.337379e+00
## 4NV+PD-1-TIGIT-     4NV+PD-1-TIGIT-  3.059930e-02   0.003400347  6.257681e-02
## 4NV+PD-1-TIGIT+     4NV+PD-1-TIGIT+  2.939970e-01  -0.419933981  1.122351e+00
## 4NV+TIGIT+               4NV+TIGIT+  2.120261e-01  -0.293119036  7.530865e-01
## 4ЕМ                             4ЕМ -9.706025e-03  -0.044487015  1.930841e-03
## 4ЕМ_TH1                     4ЕМ_TH1 -4.551469e-02  -0.160400164  4.438920e-03
## 4ЕМ_TH17                   4ЕМ_TH17 -1.135250e+01 -33.830606874 -7.104417e-01
## 4ЕМ_Th17TO1             4ЕМ_Th17TO1 -5.644614e+00 -11.867157882 -1.471248e+00
## 4ЕМ_TH2                     4ЕМ_TH2 -2.109105e-01  -1.011913703  3.109271e-02
## 4ЕМ_TH22                   4ЕМ_TH22 -1.026784e+01 -41.521216241  1.044726e+01
## 4ЕМ+226+                   4ЕМ+226+ -3.986835e-03  -0.013845678  2.204190e-03
## 4ЕМ+39+                     4ЕМ+39+ -6.625632e-03  -0.034215574  1.989209e-02
## 4ЕМ+DR+                     4ЕМ+DR+ -5.474407e-03  -0.019228845  1.944977e-03
## 4ЕМ+PD1+                   4ЕМ+PD1+ -3.824117e-03  -0.014656994  2.990452e-03
## 4ЕМ+PD1+TIGIT-       4ЕМ+PD1+TIGIT- -6.301864e-03  -0.024186629  8.952337e-03
## 4ЕМ+PD1+TIGIT+       4ЕМ+PD1+TIGIT+ -6.607567e-03  -0.029574105  4.371054e-03
## 4ЕМ+PD1-TIGIT-       4ЕМ+PD1-TIGIT- -1.566218e-02  -0.050425049  1.453703e-02
## 4ЕМ+PD1-TIGIT+       4ЕМ+PD1-TIGIT+ -6.474996e-02  -0.350919775  3.146187e-02
## 4ЕМ+TIGIT+               4ЕМ+TIGIT+ -6.276076e-03  -0.028181875  3.810628e-03
## 4ЕМTM                         4ЕМTM -3.829029e-03  -0.013268465  2.213791e-03
## 4СМ(СТАР2)               4СМ(СТАР2)  6.453075e-03  -0.016663598  3.062525e-02
## 4СМ                             4СМ  1.691211e-02  -0.004638123  4.056495e-02
## 4СМ_TH1                     4СМ_TH1  2.942211e-03  -0.260373957  2.465506e-01
## 4СМ_TH17                   4СМ_TH17  7.781370e-02  -0.025064358  1.880996e-01
## 4СМ_Th17TO1             4СМ_Th17TO1  4.089293e-01  -0.361590570  1.280204e+00
## 4СМ_TH2                     4СМ_TH2  1.645319e-01   0.015139493  3.403715e-01
## 4СМ_TH22                   4СМ_TH22  6.297697e-01  -0.064865270  1.424744e+00
## 4СМ+226+                   4СМ+226+  7.529372e-03  -0.017057480  3.342749e-02
## 4СМ+39+                     4СМ+39+  1.703792e-02  -0.028542819  6.416434e-02
## 4СМ+DR+                     4СМ+DR+ -8.241032e-03  -0.048732330  2.137218e-02
## 4СМ+PD1+                   4СМ+PD1+  1.684060e-03  -0.029116091  3.146615e-02
## 4СМ+PD1+TIGIT-       4СМ+PD1+TIGIT-  7.812635e-03  -0.075864739  9.073960e-02
## 4СМ+PD1+TIGIT+       4СМ+PD1+TIGIT+  1.298687e-03  -0.041652816  4.169538e-02
## 4СМ+PD1-TIGIT-       4СМ+PD1-TIGIT-  3.707706e-02  -0.022283090  1.008015e-01
## 4СМ+PD1-TIGIT+       4СМ+PD1-TIGIT+ -8.665034e-03  -0.333056389  2.823657e-01
## 4СМ+TIGIT+               4СМ+TIGIT+  9.266205e-04  -0.038311784  3.761018e-02
## 4ТM_TH1                     4ТM_TH1 -9.890246e-03  -0.045154865  1.803704e-02
## 4ТM_TH17                   4ТM_TH17 -8.974865e-02  -0.205328221  1.018344e-02
## 4ТM_Th17TO1             4ТM_Th17TO1  6.128490e-02  -0.120536423  2.541365e-01
## 4ТM_TH2                     4ТM_TH2  3.326909e-02  -0.098463743  1.743657e-01
## 4ТM_TH22                   4ТM_TH22 -5.450642e-03  -0.180917563  1.638927e-01
## 4ТREG(СТАР2)           4ТREG(СТАР2)  2.992617e-03  -0.004600390  1.140269e-02
## 4ТREG                         4ТREG  9.974799e-02  -0.047338058  4.299644e-01
## 4ТREG_TH1                 4ТREG_TH1  3.594778e-01  -1.730241399  2.429116e+00
## 4ТREG_TH17               4ТREG_TH17  7.377884e-02  -0.088605508  2.474507e-01
## 4ТREG_Th17TO1         4ТREG_Th17TO1  2.194209e+00  -2.110730531  6.882077e+00
## 4ТREG_TH2                 4ТREG_TH2  1.697747e-01  -0.074402815  4.920320e-01
## 4ТREG_TH22               4ТREG_TH22  3.438166e-02  -0.226874367  2.932528e-01
## 4ТЕ(СТАР2)               4ТЕ(СТАР2) -8.666494e-03  -0.035327664  5.813436e-03
## 4ТЕ                             4ТЕ -6.458256e-02  -0.179692196  1.563777e-03
## 4ТЕ_TH1                     4ТЕ_TH1 -2.360022e-01  -0.703718076 -1.551099e-02
## 4ТЕ_TH17                   4ТЕ_TH17 -7.299372e+00 -38.649479175  1.256012e+01
## 4ТЕ_Th17TO1             4ТЕ_Th17TO1 -1.774795e+01 -47.695632249 -2.146875e+00
## 4ТЕ_TH2                     4ТЕ_TH2 -9.320401e-01  -4.039935135  1.086067e-01
## 4ТЕ_TH22                   4ТЕ_TH22 -1.744097e+01 -69.999146488  2.468971e+01
## 4ТЕ+226+                   4ТЕ+226+ -9.094341e-03  -0.037043399  5.750676e-03
## 4ТЕ+39+                     4ТЕ+39+  4.119643e-02  -0.052867455  1.435782e-01
## 4ТЕ+DR+                     4ТЕ+DR+ -1.088313e-02  -0.044530700  5.989214e-03
## 4ТЕ+PD-1+                 4ТЕ+PD-1+ -9.216858e-03  -0.040543357  9.699847e-03
## 4ТЕ+PD-1+TIGIT-     4ТЕ+PD-1+TIGIT- -1.818962e-02  -0.069199553  2.217053e-02
## 4ТЕ+PD-1+TIGIT+     4ТЕ+PD-1+TIGIT+ -1.476146e-02  -0.082082005  1.697998e-02
## 4ТЕ+PD-1-TIGIT-     4ТЕ+PD-1-TIGIT- -4.504298e-02  -0.136808132  2.288264e-02
## 4ТЕ+PD-1-TIGIT+     4ТЕ+PD-1-TIGIT+ -4.235761e-02            NA  3.792714e-02
## 4ТЕ+TIGIT+               4ТЕ+TIGIT+ -1.177285e-02  -0.072042248  1.181967e-02
## 4ТМ                             4ТМ -4.554485e-03  -0.016581118  6.621550e-03
## 8+ (IM STAT)           8+ (IM STAT) -8.047779e-04  -0.002256401  2.481918e-04
## 8+                               8+ -8.944099e-04  -0.002496242  2.313553e-04
## 8+226+                       8+226+ -8.073626e-04  -0.002101420  1.552208e-04
## 8+39+                         8+39+ -4.310858e-04  -0.006878449  5.114558e-03
## 8+DR+                         8+DR+ -6.945413e-04  -0.002101746  3.503550e-04
## 8+PD-1+                     8+PD-1+ -1.101171e-03  -0.003517477  6.643026e-04
## 8+PD-1+TIGIT-         8+PD-1+TIGIT- -3.644808e-03  -0.010843644  1.763569e-03
## 8+PD-1+TIGIT+         8+PD-1+TIGIT+ -1.363957e-03  -0.004677822  1.068784e-03
## 8+PD-1-TIGIT-         8+PD-1-TIGIT- -2.301747e-03  -0.006480818  7.790071e-04
## 8+PD-1-TIGIT+         8+PD-1-TIGIT+ -2.512063e-03  -0.006777948  3.856124e-04
## 8+TIGIT+                   8+TIGIT+ -1.065960e-03  -0.003003019  3.387724e-04
## 8EMTM                         8EMTM -3.231769e-04  -0.004234766  2.900799e-03
## 8EMTM+226+               8EMTM+226+ -4.047680e-04  -0.004571004  2.966600e-03
## 8EMTM+39+                 8EMTM+39+  4.300058e-04  -0.015196125  1.477788e-02
## 8EMTM+DR+                 8EMTM+DR+ -1.139179e-04  -0.004205662  3.433143e-03
## 8EMTM+PD-1+             8EMTM+PD-1+  2.177711e-05  -0.006481992  5.891883e-03
## 8EMTM+PD-1+TIGIT- 8EMTM+PD-1+TIGIT-  9.189195e-04  -0.017978415  1.883762e-02
## 8EMTM+PD-1+TIGIT+ 8EMTM+PD-1+TIGIT+ -1.950759e-04  -0.009559274  8.179936e-03
## 8EMTM+PD-1-TIGIT- 8EMTM+PD-1-TIGIT- -1.496974e-03  -0.018576070  1.258540e-02
## 8EMTM+PD-1-TIGIT+ 8EMTM+PD-1-TIGIT+ -3.489338e-03  -0.020174930  8.028849e-03
## 8EMTM+TIGIT+           8EMTM+TIGIT+ -7.032457e-04  -0.006781974  4.290054e-03
## 8NV(СТАР2)               8NV(СТАР2)  1.361576e-02  -0.031288953  5.944562e-02
## 8NV                             8NV  3.849184e-02  -0.009713654  9.576209e-02
## 8NV+226+                   8NV+226+  1.213997e-02  -0.037077835  6.187507e-02
## 8NV+39+                     8NV+39+  8.379380e-02  -0.483143494  6.490125e-01
## 8NV+DR+                     8NV+DR+ -1.120911e-01  -0.334406160  3.887328e-02
## 8NV+PD-1+                 8NV+PD-1+ -2.042232e-01  -0.606927612  9.675565e-02
## 8NV+PD-1+TIGIT-     8NV+PD-1+TIGIT- -4.352068e-01  -1.520287462  2.999592e-01
## 8NV+PD-1+TIGIT+     8NV+PD-1+TIGIT+ -2.866860e-01  -0.850054256  1.536046e-01
## 8NV+PD-1-TIGIT-     8NV+PD-1-TIGIT-  2.646975e-02  -0.023067033  8.053411e-02
## 8NV+PD-1-TIGIT+     8NV+PD-1-TIGIT+ -1.908475e-01  -0.677642461  1.470535e-01
## 8NV+TIGIT+               8NV+TIGIT+ -1.334034e-01  -0.416613832  7.339542e-02
## 8TREG                         8TREG -8.475997e-04  -0.002415032  2.632552e-04
## 8ЕМ                             8ЕМ -4.441537e-04  -0.004279948  2.626299e-03
## 8СМ(СТАР2)               8СМ(СТАР2) -1.105947e-02  -0.073664981  2.308438e-02
## 8СМ                             8СМ  3.062386e-02  -0.024549124  1.195902e-01
## 8СМ+226+                   8СМ+226+ -1.280425e-02  -0.085594550  2.278949e-02
## 8СМ+39+                     8СМ+39+  1.087545e-01  -0.174149816  4.149762e-01
## 8СМ+DR+                     8СМ+DR+ -1.523045e-02  -0.090736043  2.286988e-02
## 8СМ+PD-1+                 8СМ+PD-1+ -1.668810e-02  -0.124634528  6.114210e-02
## 8СМ+PD-1+TIGIT-     8СМ+PD-1+TIGIT- -7.915222e-02  -0.508316957  2.312430e-01
## 8СМ+PD-1+TIGIT+     8СМ+PD-1+TIGIT+ -1.939491e-02  -0.161747057  8.132773e-02
## 8СМ+PD-1-TIGIT-     8СМ+PD-1-TIGIT- -1.876911e-02  -0.264661639  1.902866e-01
## 8СМ+PD-1-TIGIT+     8СМ+PD-1-TIGIT+ -4.969508e-02  -0.394095492  3.928102e-02
## 8СМ+TIGIT+               8СМ+TIGIT+ -1.699291e-02  -0.116894240  2.816586e-02
## 8ТЕ(СТАР2)               8ТЕ(СТАР2) -1.228451e-03  -0.002890620  7.762858e-06
## 8ТЕ                             8ТЕ -1.642412e-03  -0.003730554 -1.551474e-04
## 8ТЕ+226+                   8ТЕ+226+ -1.318327e-03  -0.003085873 -1.576719e-05
## 8ТЕ+39+                     8ТЕ+39+ -1.280958e-03  -0.011644917  7.485492e-03
## 8ТЕ+DR+                     8ТЕ+DR+ -1.256611e-03  -0.003283363  2.311296e-04
## 8ТЕ+PD-1+                 8ТЕ+PD-1+ -2.052920e-03  -0.005812765  4.932080e-04
## 8ТЕ+PD-1+TIGIT-     8ТЕ+PD-1+TIGIT- -6.626415e-03  -0.017358858  9.545961e-04
## 8ТЕ+PD-1+TIGIT+     8ТЕ+PD-1+TIGIT+ -2.475322e-03  -0.007600324  9.657084e-04
## 8ТЕ+PD-1-TIGIT-     8ТЕ+PD-1-TIGIT- -3.624402e-03  -0.009212732  3.529961e-04
## 8ТЕ+PD-1-TIGIT+     8ТЕ+PD-1-TIGIT+ -3.607313e-03  -0.008909730  1.300236e-04
## 8ТЕ+TIGIT+               8ТЕ+TIGIT+ -1.769967e-03  -0.004468783  1.750598e-04
## 8ТМ                             8ТМ -6.597081e-04  -0.017889012  1.495558e-02
## TREG_CM                     TREG_CM  2.699803e-01  -0.060875348  8.322506e-01
## TREG_EMTM                 TREG_EMTM  1.963620e-02  -0.019606176  7.123463e-02
## TREG_NV                     TREG_NV  3.893276e-01  -0.176951123  9.853837e-01
## TREG_TE                     TREG_TE  1.417832e-01  -0.081908776  3.780830e-01
## TREG+226+                 TREG+226+  3.105693e-02  -0.016258837  9.091851e-02
## TREG+226+TIGIT-     TREG+226+TIGIT-  1.520811e-01  -0.190878573  5.207239e-01
## TREG+226+TIGIT+     TREG+226+TIGIT+  3.270098e-02  -0.018358487  1.002788e-01
## TREG+226-TIGIT-     TREG+226-TIGIT-  4.902853e-02  -0.609246111  6.974801e-01
## TREG+226-TIGIT+     TREG+226-TIGIT+  4.460158e-02  -0.049181155  1.734679e-01
## TREG+39+                   TREG+39+  1.934120e-02  -0.014326261  6.597026e-02
## TREG+DR+                   TREG+DR+  1.926575e-02  -0.016732736  6.872729e-02
## TREG+PD-1+               TREG+PD-1+  4.150195e-02  -0.019923457  1.440264e-01
## TREG+TIGIT+             TREG+TIGIT+  2.059914e-02  -0.013561723  6.793911e-02
##                       p.adj
## 4_TFH             0.7746926
## 4_TH1             0.7527201
## 4_TH17            0.9627693
## 4_Th17TO1         0.8772403
## 4_TH2             0.9627693
## 4_TH22            0.8626506
## 4+ (IM STAT)      0.7746926
## 4+                0.7508243
## 4+226+            0.7746926
## 4+39+             0.9741645
## 4+DR+             0.7508243
## 4+PD-1+           0.7508243
## 4+PD-1+TIGIT-     0.7527201
## 4+PD-1+TIGIT+     0.7508243
## 4+PD-1-TIGIT-     0.7746173
## 4+PD-1-TIGIT+     0.7746926
## 4+TIGIT+          0.7508243
## 4NV(СТАР2)        0.7508243
## 4NV               0.7508243
## 4NV_TH1           0.7508243
## 4NV_TH17          0.7508243
## 4NV_Th17TO1       0.7508243
## 4NV_TH2           0.7508243
## 4NV_TH22          0.7508243
## 4NV+226+          0.7508243
## 4NV+39+           0.7508243
## 4NV+DR+           0.9141400
## 4NV+PD1+          0.8772403
## 4NV+PD-1+TIGIT-   0.9262301
## 4NV+PD-1+TIGIT+   0.8015183
## 4NV+PD-1-TIGIT-   0.7508243
## 4NV+PD-1-TIGIT+   0.7508243
## 4NV+TIGIT+        0.7508243
## 4ЕМ               0.7508243
## 4ЕМ_TH1           0.7508243
## 4ЕМ_TH17          0.7508243
## 4ЕМ_Th17TO1       0.7508243
## 4ЕМ_TH2           0.7746926
## 4ЕМ_TH22          0.7508243
## 4ЕМ+226+          0.7508243
## 4ЕМ+39+           0.8033715
## 4ЕМ+DR+           0.7508243
## 4ЕМ+PD1+          0.7508243
## 4ЕМ+PD1+TIGIT-    0.7508243
## 4ЕМ+PD1+TIGIT+    0.7508243
## 4ЕМ+PD1-TIGIT-    0.7508243
## 4ЕМ+PD1-TIGIT+    0.7746926
## 4ЕМ+TIGIT+        0.7508243
## 4ЕМTM             0.7508243
## 4СМ(СТАР2)        0.7814361
## 4СМ               0.7508243
## 4СМ_TH1           0.9858508
## 4СМ_TH17          0.7508243
## 4СМ_Th17TO1       0.7508243
## 4СМ_TH2           0.7508243
## 4СМ_TH22          0.7508243
## 4СМ+226+          0.7746926
## 4СМ+39+           0.7527201
## 4СМ+DR+           0.8015183
## 4СМ+PD1+          0.9736931
## 4СМ+PD1+TIGIT-    0.9569874
## 4СМ+PD1+TIGIT+    0.9741645
## 4СМ+PD1-TIGIT-    0.7508243
## 4СМ+PD1-TIGIT+    0.9741645
## 4СМ+TIGIT+        0.9741645
## 4ТM_TH1           0.7746926
## 4ТM_TH17          0.7508243
## 4ТM_Th17TO1       0.7746926
## 4ТM_TH2           0.8015183
## 4ТM_TH22          0.9741645
## 4ТREG(СТАР2)      0.7508243
## 4ТREG             0.7508243
## 4ТREG_TH1         0.8842108
## 4ТREG_TH17        0.7508243
## 4ТREG_Th17TO1     0.7508243
## 4ТREG_TH2         0.7508243
## 4ТREG_TH22        0.9144398
## 4ТЕ(СТАР2)        0.7508243
## 4ТЕ               0.7508243
## 4ТЕ_TH1           0.7508243
## 4ТЕ_TH17          0.7746926
## 4ТЕ_Th17TO1       0.7508243
## 4ТЕ_TH2           0.7508243
## 4ТЕ_TH22          0.7508243
## 4ТЕ+226+          0.7508243
## 4ТЕ+39+           0.7508243
## 4ТЕ+DR+           0.7508243
## 4ТЕ+PD-1+         0.7508243
## 4ТЕ+PD-1+TIGIT-   0.7508243
## 4ТЕ+PD-1+TIGIT+   0.7727447
## 4ТЕ+PD-1-TIGIT-   0.7508243
## 4ТЕ+PD-1-TIGIT+   0.7746926
## 4ТЕ+TIGIT+        0.7746926
## 4ТМ               0.7508243
## 8+ (IM STAT)      0.7508243
## 8+                0.7508243
## 8+226+            0.7508243
## 8+39+             0.9627693
## 8+DR+             0.7508243
## 8+PD-1+           0.7508243
## 8+PD-1+TIGIT-     0.7508243
## 8+PD-1+TIGIT+     0.7508243
## 8+PD-1-TIGIT-     0.7508243
## 8+PD-1-TIGIT+     0.7508243
## 8+TIGIT+          0.7508243
## 8EMTM             0.9531593
## 8EMTM+226+        0.9335033
## 8EMTM+39+         0.9741645
## 8EMTM+DR+         0.9741645
## 8EMTM+PD-1+       0.9937872
## 8EMTM+PD-1+TIGIT- 0.9736931
## 8EMTM+PD-1+TIGIT+ 0.9741645
## 8EMTM+PD-1-TIGIT- 0.9501433
## 8EMTM+PD-1-TIGIT+ 0.7814361
## 8EMTM+TIGIT+      0.9144398
## 8NV(СТАР2)        0.7746926
## 8NV               0.7508243
## 8NV+226+          0.8015183
## 8NV+39+           0.9141400
## 8NV+DR+           0.7508243
## 8NV+PD-1+         0.7508243
## 8NV+PD-1+TIGIT-   0.7508243
## 8NV+PD-1+TIGIT+   0.7508243
## 8NV+PD-1-TIGIT-   0.7508243
## 8NV+PD-1-TIGIT+   0.7508243
## 8NV+TIGIT+        0.7508243
## 8TREG             0.7508243
## 8ЕМ               0.9144398
## 8СМ(СТАР2)        0.7814361
## 8СМ               0.7508243
## 8СМ+226+          0.7746926
## 8СМ+39+           0.7508243
## 8СМ+DR+           0.7746926
## 8СМ+PD-1+         0.8626506
## 8СМ+PD-1+TIGIT-   0.8116272
## 8СМ+PD-1+TIGIT+   0.8772403
## 8СМ+PD-1-TIGIT-   0.9584098
## 8СМ+PD-1-TIGIT+   0.7746926
## 8СМ+TIGIT+        0.7746926
## 8ТЕ(СТАР2)        0.7508243
## 8ТЕ               0.7508243
## 8ТЕ+226+          0.7508243
## 8ТЕ+39+           0.9144398
## 8ТЕ+DR+           0.7508243
## 8ТЕ+PD-1+         0.7508243
## 8ТЕ+PD-1+TIGIT-   0.7508243
## 8ТЕ+PD-1+TIGIT+   0.7508243
## 8ТЕ+PD-1-TIGIT-   0.7508243
## 8ТЕ+PD-1-TIGIT+   0.7508243
## 8ТЕ+TIGIT+        0.7508243
## 8ТМ               0.9741645
## TREG_CM           0.7508243
## TREG_EMTM         0.7508243
## TREG_NV           0.7508243
## TREG_TE           0.7508243
## TREG+226+         0.7508243
## TREG+226+TIGIT-   0.7508243
## TREG+226+TIGIT+   0.7508243
## TREG+226-TIGIT-   0.9627693
## TREG+226-TIGIT+   0.7508243
## TREG+39+          0.7508243
## TREG+DR+          0.7508243
## TREG+PD-1+        0.7508243
## TREG+TIGIT+       0.7508243
forest_plot_1
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_errorbarh()`).

forest_plot_2
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_errorbarh()`).

volcano_plot_1

# Volcano Plot 
volcano_plot_2 <- ggplot(forest_data, aes(x = estimate, y = -log10(p.adj))) +
  # Добавляем прозрачность точкам через alpha
  geom_point(aes(color = p.adj < 0.05), alpha = 0.5) +
  # Добавляем условие для отображения подписей
  geom_text_repel(data = subset(forest_data, estimate < -5 | estimate > 1),
                  aes(label = variable),
                  box.padding = 0.5,
                  max.overlaps = Inf,
                  size = 4,
                  segment.size = 0.2,
                  segment.linetype = "solid",
                  segment.alpha = 0.5) +
  scale_color_manual(values = c("TRUE" = "red", "FALSE" = "black")) +
  theme_minimal() +
  labs(title = "Volcano Plot",
       x = "Coefficient Estimate",
       y = "-log10(Adjusted p-value)") +
  scale_x_continuous(limits = c(-20, 8)) +
  scale_y_continuous(limits = c(0, 0.18))

volcano_plot_2

volcano_plot_3 <- ggplot(forest_data, aes(x = estimate, y = -log10(p.adj))) +
  # Добавляем логику для трех цветов на основе estimate
  geom_point(aes(color = case_when(
    estimate < -5 ~ "below_threshold",
    estimate > 1 ~ "above_threshold",
    TRUE ~ "within_threshold"
  )),
  size = 3,  
  alpha = 0.7) + 
  
  # Добавляем подписи для выбросов
  geom_text_repel(data = subset(forest_data, estimate < -5 | estimate > 1),
                  aes(label = variable),
                  box.padding = 0.5,
                  max.overlaps = Inf,
                  size = 4,
                  segment.size = 0.2,
                  segment.linetype = "solid",
                  segment.alpha = 0.5) +
  
  # Применяем цветовую палитру 
  scale_color_manual(
    values = c(
      "below_threshold" = "#304289",  # Синий для точек ниже -5
      "above_threshold" = "#893056",  # Красный для точек выше 1
      "within_threshold" = "#898889"  # Серый для точек между порогами
    ),
    guide = "none"  # Убираем легенду
  ) +
  
  theme_minimal() +
  labs(title = "Volcano Plot",
       x = "Coefficient Estimate",
       y = "-log10(Adjusted p-value)") +
  scale_x_continuous(limits = c(-20, 8)) +
  scale_y_continuous(limits = c(0, 0.18))

volcano_plot_3