Project_cGVHD

#Чтение данных

AI_Tcells <- read_csv(
  "../../raw_data/AI_Tcells_для ЕА - Sheet1.csv",
  locale = locale(decimal_mark = ","),  # указываем, что десятичный разделитель - запятая
  show_col_types = FALSE
)

glimpse(AI_Tcells)

## Rows: 37,884
## Columns: 5
## $ ID         <dbl> 50, 69, 58, 2, 52, 42, 44, 1, 31, 49, 34, 33, 8, 6, 46, 27,…
## $ Time_OS    <dbl> 663, 503, 257, 434, 792, 363, 391, 786, 469, 447, 473, 559,…
## $ cGVHD_time <dbl> NA, 203, NA, 134, NA, NA, NA, NA, NA, 186, NA, NA, 203, 165…
## $ Names      <chr> "+180_ПЕР.КРОВЬ/4_TFH", "+180_ПЕР.КРОВЬ/4_TFH", "+180_ПЕР.К…
## $ Abs_Value  <dbl> 127.34533, 99.38984, 91.87249, 77.06436, 76.47210, 72.00345…

sum(is.na(AI_Tcells$Abs_Value))

## [1] 0

#Редактирование данных

AI_Tcells_data <- AI_Tcells %>%
  mutate(Analysis_day = str_extract(Names, "^[^_]+")) %>% # Извлекаем часть до первого "_" 
  mutate(Сell_population = str_extract(Names, "(?<=\\/).*")) %>% # Извлекаем все после "/"
  select(ID, Analysis_day, Сell_population, everything()) %>% # Перемещаем извлеченные данные в начало
  separate_rows(Analysis_day, sep = ",") %>% # Создаем новые строки, если несколько значений разделены запятыми
  mutate(Analysis_day = str_trim(Analysis_day))


AI_Tcells_data <- AI_Tcells_data %>%
  mutate(cGVHD_present = ifelse(is.na(AI_Tcells_data$cGVHD_time), 0, 1))

AI_Tcells_data <- AI_Tcells_data %>%
  mutate(cGVHD_present = factor(cGVHD_present, levels = c(0, 1), labels = c("No", "Yes")))

AI_Tcells_data <- AI_Tcells_data %>%
  mutate(across(c(Analysis_day, Сell_population), ~ factor(.)))

glimpse(AI_Tcells_data)

## Rows: 37,884
## Columns: 8
## $ ID              <dbl> 50, 69, 58, 2, 52, 42, 44, 1, 31, 49, 34, 33, 8, 6, 46…
## $ Analysis_day    <fct> +180, +180, +180, +180, +180, +180, +180, +180, +180, …
## $ Сell_population <fct> 4_TFH, 4_TFH, 4_TFH, 4_TFH, 4_TFH, 4_TFH, 4_TFH, 4_TFH…
## $ Time_OS         <dbl> 663, 503, 257, 434, 792, 363, 391, 786, 469, 447, 473,…
## $ cGVHD_time      <dbl> NA, 203, NA, 134, NA, NA, NA, NA, NA, 186, NA, NA, 203…
## $ Names           <chr> "+180_ПЕР.КРОВЬ/4_TFH", "+180_ПЕР.КРОВЬ/4_TFH", "+180_…
## $ Abs_Value       <dbl> 127.34533, 99.38984, 91.87249, 77.06436, 76.47210, 72.…
## $ cGVHD_present   <fct> No, Yes, No, Yes, No, No, No, No, No, Yes, No, No, Yes…

AI_Tcells_filtered <- AI_Tcells_data %>%
  mutate(
    Analysis_time = ifelse(
      str_detect(Analysis_day, "^ДЕНЬ\\sХРРТПХ\\s\\+180$"), cGVHD_time + 180,
      ifelse(
        str_detect(Analysis_day, "^ДЕНЬ\\sХРРТПХ\\s\\+90$"), cGVHD_time + 90,
        ifelse(
          str_detect(Analysis_day, "^ДЕНЬ\\sХРРТПХ\\s\\+60$"), cGVHD_time + 60,
          ifelse(
            str_detect(Analysis_day, "^ДЕНЬ\\sХРРТПХ\\s\\+30$"), cGVHD_time + 30,
            ifelse(
              str_detect(Analysis_day, "^ДЕНЬ\\sХРРТПХ$"), cGVHD_time,
              ifelse(
                str_detect(Analysis_day, "^\\+180$"), 180,
                ifelse(
                  str_detect(Analysis_day, "^\\+90$"), 90,
                  ifelse(
                    str_detect(Analysis_day, "^\\+60$"), 60,
                    ifelse(
                      str_detect(Analysis_day, "^\\+30$"), 30,
                      ifelse(
                        str_detect(Analysis_day, "^\\+365$"), 365, NA_real_
                      )))))))))))

 AI_Tcells_filtered <- AI_Tcells_filtered  %>%
  filter(Analysis_day != "+30" & Analysis_day != "+60")
 
  AI_Tcells_filtered <- AI_Tcells_filtered %>%
  filter(!(Analysis_time == 180 & !is.na(cGVHD_time) & cGVHD_time < 180))
                   
AI_Tcells_filtered <- AI_Tcells_filtered %>%
  select(ID, Time_OS, cGVHD_present, cGVHD_time, Analysis_day, Analysis_time, Сell_population, Abs_Value)

AI_Tcells_filtered <- AI_Tcells_filtered %>%
  arrange(ID, Analysis_time)

AI_Tcells_filtered <- AI_Tcells_filtered %>%
  mutate(across(c(Time_OS, cGVHD_time, Analysis_time), ~ factor(.)))

glimpse(AI_Tcells_filtered)

## Rows: 34,440
## Columns: 8
## $ ID              <dbl> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, …
## $ Time_OS         <fct> 786, 786, 786, 786, 786, 786, 786, 786, 786, 786, 786,…
## $ cGVHD_present   <fct> No, No, No, No, No, No, No, No, No, No, No, No, No, No…
## $ cGVHD_time      <fct> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
## $ Analysis_day    <fct> +90, +90, +90, +90, +90, +90, +90, +90, +90, +90, +90,…
## $ Analysis_time   <fct> 90, 90, 90, 90, 90, 90, 90, 90, 90, 90, 90, 90, 90, 90…
## $ Сell_population <fct> 4_TFH, 4_TH1, 4_TH17, 4_Th17TO1, 4_TH2, 4_TH22, 4+ (IM…
## $ Abs_Value       <dbl> 45.32738173, 7.89113186, 14.20660985, 3.33781372, 7.56…

#Описательные статистики

statistics <- list(
  
          `_Количество субъектов` = ~length(.x) %>% as.character(),
          `_Количество (есть данные)` = ~sum(!is.na(.x)) %>% as.character(),
          `_Нет данных` = ~sum(is.na(.x)) %>% as.character(),
          `_Ср. знач.` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", mean(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
          `_Станд. отклон.` = ~ifelse(sum(!is.na(.x)) < 3, "Н/П*", sd(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
          `_95% ДИ для среднего` = ~{
    n <- sum(!is.na(.x))
    ifelse(n < 3, "Н/П*", 
           paste0(round(mean(.x, na.rm = TRUE) - 1.96 * sd(.x, na.rm = TRUE) / sqrt(n), 2), " - ", round(mean(.x, na.rm = TRUE) + 1.96 * sd(.x, na.rm = TRUE) / sqrt(n), 2))
    )
  },
          `_мин. - макс.` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", paste0(min(.x, na.rm = TRUE) %>% round(2), " - ", max(.x, na.rm = TRUE) %>% round(2))),
          `_Медиана` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", median(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
          `_Q1 - Q3` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", paste0(quantile(.x, 0.25, na.rm = TRUE) %>% round(2), " - ", quantile(.x, 0.75, na.rm = TRUE) %>% round(2)))
    )




#AI_Tcells_filtered %>%
 # select(`Analysis_day`, `Сell_population`, `cGVHD_present`, Abs_Value) %>%
  #group_by(`Analysis_day`, `Сell_population`, `cGVHD_present`) %>%
  #summarize(across(Abs_Value, statistics)) %>% # Применяем список statistics к Abs_Value
  #pivot_longer(cols = -c(`Analysis_day`, `Сell_population`, `cGVHD_present`)) %>%
  #separate(name, into = c("Variable", "Statistics"), sep = "__") %>%
  #pivot_wider(names_from = c(cGVHD_present, Statistics), values_from = value) %>%
  #arrange(Analysis_day, Сell_population) %>%
  #flextable() %>%
  #theme_box() %>%
  #align(align = "center", part = "all") %>%
  #merge_v(c("Analysis_day", "Сell_population"))



# Создаём функцию для t-теста
t_test_wrapper <- function(data, var) {
  # Проверяем достаточно ли данных в каждой группе
  n_yes <- sum(!is.na(data$Abs_Value[data$cGVHD_present == "Yes"]))
  n_no <- sum(!is.na(data$Abs_Value[data$cGVHD_present == "No"]))
  
  if(n_yes < 3 || n_no < 3) {
    return("Н/П*")
  }
  
  # Выполняем t-тест
  test_result <- try(
    t.test(Abs_Value ~ cGVHD_present, data = data)$p.value,
    silent = TRUE
  )
  
  if(inherits(test_result, "try-error")) {
    return("Ошибка")
  }
  
  return(as.character(round(test_result, 4)))
}

# Сначала соберем все p-values в отдельный датафрейм
p_values_df <- AI_Tcells_filtered %>%
  group_by(Analysis_day, Сell_population) %>%
  summarise(
    p_value = t_test_wrapper(cur_data(), Abs_Value),
    .groups = "drop"
  )

## Warning: There was 1 warning in `summarise()`.
## ℹ In argument: `p_value = t_test_wrapper(cur_data(), Abs_Value)`.
## ℹ In group 1: `Analysis_day = +180` and `Сell_population = 4_TFH`.
## Caused by warning:
## ! `cur_data()` was deprecated in dplyr 1.1.0.
## ℹ Please use `pick()` instead.

# Создаем вектор для хранения скорректированных p-values
p_values_df <- p_values_df %>%
  mutate(
    adj_p_value = p_value  # Сначала копируем исходные p-values
  )

# Находим индексы числовых p-values
numeric_indices <- !p_values_df$p_value %in% c("Н/П*", "Ошибка")

if(sum(numeric_indices) > 0) {
  # Конвертируем в числовой формат только валидные p-values
  numeric_p_values <- as.numeric(p_values_df$p_value[numeric_indices])
  
  # Применяем коррекцию только к числовым значениям
  adj_p_values <- p.adjust(numeric_p_values, method = "BH")
  
  # Обновляем только числовые значения в столбце adj_p_value
  p_values_df$adj_p_value[numeric_indices] <- as.character(round(adj_p_values, 4))
}

# Основной код для создания таблицы
result <- AI_Tcells_filtered %>%
  select(`Analysis_day`, `Сell_population`, `cGVHD_present`, Abs_Value) %>%
  group_by(`Analysis_day`, `Сell_population`, `cGVHD_present`) %>%
  summarize(across(Abs_Value, statistics), .groups = "drop") %>%
  pivot_longer(cols = -c(`Analysis_day`, `Сell_population`, `cGVHD_present`)) %>%
  separate(name, into = c("Variable", "Statistics"), sep = "__") %>%
  pivot_wider(names_from = c(cGVHD_present, Statistics), values_from = value) %>%
  # Присоединяем p-values
  left_join(p_values_df, by = c("Analysis_day", "Сell_population")) %>%
    rename(
    "t-test, p-value" = p_value,
    "t-test, adj p-value (BH)" = adj_p_value
  ) %>%
  # Создаём финальную таблицу
  arrange(Analysis_day, Сell_population) %>%
  flextable() %>%
  theme_box() %>%
  align(align = "center", part = "all") %>%
  merge_v(c("Analysis_day", "Сell_population"))

# Выводим таблицу
result

Analysis_day	Сell_population	Variable	No_Количество субъектов	No_Количество (есть данные)	No_Нет данных	No_Ср. знач.	No_Станд. отклон.	No_95% ДИ для среднего	No_мин. - макс.	No_Медиана	No_Q1 - Q3	Yes_Количество субъектов	Yes_Количество (есть данные)	Yes_Нет данных	Yes_Ср. знач.	Yes_Станд. отклон.	Yes_95% ДИ для среднего	Yes_мин. - макс.	Yes_Медиана	Yes_Q1 - Q3	t-test, p-value	t-test, adj p-value (BH)
+180	4_TFH	Abs_Value	28	28	0	45.23	28.19	34.79 - 55.67	8.17 - 127.35	40.6	22.45 - 65.56	14	14	0	37.18	27.83	22.6 - 51.76	2.96 - 99.39	35.05	15.51 - 48.27	0.3868	0.6866
	4_TH1	Abs_Value	28	28	0	30.97	28.29	20.5 - 41.45	7.26 - 139.21	21.63	12.61 - 40.09	14	14	0	25.29	17.73	16 - 34.58	2.75 - 63.56	21.81	11.79 - 31.97	0.4314	0.7016
	4_TH17	Abs_Value	28	28	0	16.23	10.05	12.51 - 19.95	2.89 - 50.55	15.11	10.46 - 18.16	14	14	0	21.45	18.56	11.73 - 31.17	4.26 - 64.57	14.3	7.63 - 31.94	0.3393	0.6781
	4_Th17TO1	Abs_Value	28	28	0	4.72	3.18	3.54 - 5.89	1.1 - 13.48	3.96	2.45 - 5.84	14	14	0	5.4	4.28	3.15 - 7.64	0.37 - 14.28	4.01	2.13 - 8.88	0.6048	0.7822
	4_TH2	Abs_Value	28	28	0	19.81	14.65	14.38 - 25.23	3.06 - 52.15	14.55	7.62 - 30.35	14	14	0	25.44	33.42	7.93 - 42.94	4.36 - 132.22	13.3	8.77 - 24.71	0.5558	0.7482
	4_TH22	Abs_Value	28	28	0	5.43	4.37	3.82 - 7.05	0.11 - 17.53	4.44	2.27 - 6.29	14	14	0	7.12	7.42	3.23 - 11.01	0.6 - 23.07	2.51	1.43 - 12.46	0.4431	0.7032
	4+	Abs_Value	28	28	0	86.07	70.15	60.08 - 112.05	5.3 - 282.24	67.56	40.39 - 98.89	14	14	0	127.74	115.12	67.43 - 188.04	30.9 - 465.64	81.58	54.97 - 183.63	0.2295	0.6781
	4+ (IM STAT)	Abs_Value	28	28	0	76.11	63.83	52.47 - 99.75	4.58 - 261.9	59.63	31.36 - 88.74	14	14	0	111.92	111.9	53.3 - 170.54	31.06 - 463.87	67.8	49.95 - 149.55	0.282	0.6781
	4+226+	Abs_Value	28	28	0	240.03	119.69	195.69 - 284.36	82.61 - 581.74	237.99	154.89 - 305.8	14	14	0	253.52	138.82	180.79 - 326.24	59.38 - 494.52	233.24	142.9 - 349.53	0.759	0.884
	4+39+	Abs_Value	28	28	0	58.56	45.04	41.88 - 75.24	1.62 - 164.84	44.35	28.99 - 83.56	14	14	0	70.14	50.91	43.47 - 96.81	0.38 - 146.53	83.04	21.52 - 108.28	0.4776	0.7185
	4+DR+	Abs_Value	28	28	0	118.21	78.19	89.25 - 147.17	18.11 - 386.46	103.52	62.43 - 147.72	14	14	0	88.68	61.64	56.39 - 120.97	2.7 - 196.42	90.06	39.97 - 120.04	0.1915	0.6781
	4+PD-1-TIGIT-	Abs_Value	28	28	0	88.95	59.1	67.06 - 110.84	12.4 - 216.52	71.92	38.42 - 131.56	14	14	0	124.6	89.68	77.62 - 171.58	21.15 - 336.65	103.12	48.41 - 181.86	0.1936	0.6781
	4+PD-1-TIGIT+	Abs_Value	28	28	0	8.59	6.57	6.16 - 11.02	0.33 - 26.88	7.44	3.72 - 12.65	14	14	0	12.15	11.99	5.87 - 18.44	1.08 - 42.09	7.08	3.75 - 14.78	0.3144	0.6781
	4+PD-1+	Abs_Value	28	28	0	163.55	100.44	126.35 - 200.75	60.8 - 544	146.17	92.9 - 204.31	14	14	0	137.32	78.18	96.36 - 178.27	19.13 - 251.25	137.45	85.35 - 188.75	0.3595	0.6829
	4+PD-1+TIGIT-	Abs_Value	28	28	0	82.11	47.24	64.61 - 99.61	24.66 - 231.24	70.6	42.83 - 113.14	14	14	0	69.48	41.05	47.97 - 90.98	11.98 - 141.31	71.58	41.53 - 92.15	0.379	0.6866
	4+PD-1+TIGIT+	Abs_Value	28	28	0	81.44	60.21	59.14 - 103.75	23.47 - 312.76	70.14	36.23 - 104.1	14	14	0	67.84	41.86	45.91 - 89.77	6.97 - 118.9	74.09	34.46 - 107.46	0.3997	0.6866
	4+TIGIT+	Abs_Value	28	28	0	90.03	62.5	66.88 - 113.18	27.22 - 316.38	78.85	39.78 - 118.18	14	14	0	80	50.5	53.54 - 106.45	8.05 - 142.11	83.98	37.28 - 128.03	0.5796	0.7625
	4NV	Abs_Value	28	28	0	47.92	50.96	29.04 - 66.79	1.38 - 219.79	32.76	17.69 - 57.58	14	14	0	68.98	57.36	38.93 - 99.03	8.01 - 221.84	63.72	22.76 - 100.68	0.2563	0.6781
	4NV(СТАР2)	Abs_Value	28	28	0	41.99	45.17	25.26 - 58.72	1.11 - 184.63	28.89	15.07 - 54.98	14	14	0	64.13	53.04	36.35 - 91.92	7.33 - 199	55.39	24.35 - 92.65	0.1941	0.6781
	4NV_TH1	Abs_Value	28	28	0	2.34	3.55	1.02 - 3.65	0.01 - 18.64	1.69	0.55 - 2.22	14	14	0	5.4	7.87	1.28 - 9.52	0.26 - 31.18	3.5	0.99 - 5.44	0.1848	0.6781
	4NV_TH17	Abs_Value	28	28	0	1.43	1.4	0.91 - 1.95	0.17 - 5.2	0.84	0.43 - 2.12	14	14	0	1.76	1.66	0.89 - 2.63	0.15 - 6.65	1.37	0.68 - 2.26	0.5269	0.739
	4NV_Th17TO1	Abs_Value	28	28	0	0.16	0.19	0.09 - 0.23	0 - 0.76	0.09	0.04 - 0.17	14	14	0	0.44	0.69	0.08 - 0.8	0.03 - 2.7	0.2	0.1 - 0.46	0.1581	0.6781
	4NV_TH2	Abs_Value	28	28	0	10	10.71	6.03 - 13.97	0.32 - 42.08	5.32	1.9 - 16.43	14	14	0	6.01	4.03	3.9 - 8.12	0.9 - 15.34	4.93	3.44 - 7.26	0.0898	0.6781
	4NV_TH22	Abs_Value	28	28	0	0.12	0.13	0.07 - 0.17	0 - 0.47	0.05	0.03 - 0.19	14	14	0	0.2	0.22	0.08 - 0.31	0 - 0.85	0.16	0.05 - 0.24	0.2363	0.6781
	4NV+226+	Abs_Value	28	28	0	34.27	40.56	19.24 - 49.29	1.04 - 182.46	25.68	11.13 - 43.23	14	14	0	55.97	47.49	31.1 - 80.85	6.77 - 176.27	47.59	19.76 - 79.5	0.1569	0.6781
	4NV+39+	Abs_Value	28	28	0	1.13	1.41	0.61 - 1.66	0.01 - 6.53	0.59	0.27 - 1.45	14	14	0	2.25	2.81	0.78 - 3.72	0.05 - 10.36	1.6	0.35 - 2.53	0.1805	0.6781
	4NV+DR+	Abs_Value	28	28	0	3.59	4.26	2.02 - 5.17	0.18 - 18.97	2.07	0.83 - 4.89	14	14	0	3.51	3.73	1.56 - 5.47	0.16 - 12.36	1.95	1.19 - 4.3	0.9487	0.9711
	4NV+PD-1-TIGIT-	Abs_Value	28	28	0	37.82	41.89	22.3 - 53.33	0.89 - 162.97	26.57	10.46 - 51.5	14	14	0	57.92	49.73	31.87 - 83.97	6.57 - 183.96	52.16	20.83 - 83.48	0.207	0.6781
	4NV+PD-1-TIGIT+	Abs_Value	28	28	0	1.06	1.51	0.5 - 1.62	0.07 - 5.24	0.41	0.13 - 1.22	14	14	0	1.77	2.27	0.58 - 2.96	0.08 - 8.38	0.69	0.41 - 2.19	0.3061	0.6781
	4NV+PD-1+TIGIT-	Abs_Value	28	28	0	2.19	2.63	1.22 - 3.16	0.07 - 10.74	1.21	0.51 - 2.14	14	14	0	2.94	3.29	1.22 - 4.67	0.26 - 11.91	1.3	0.73 - 4.66	0.4625	0.7142
	4NV+PD-1+TIGIT+	Abs_Value	28	28	0	0.92	1.16	0.49 - 1.35	0.07 - 6.02	0.64	0.15 - 1.11	14	14	0	1.5	1.45	0.74 - 2.26	0.06 - 4.55	1.06	0.43 - 1.72	0.2059	0.6781
	4NV+PD1+	Abs_Value	28	28	0	3.11	3.54	1.8 - 4.42	0.15 - 16.77	2.1	0.94 - 3.82	14	14	0	4.44	4.28	2.2 - 6.69	0.49 - 15.18	2.53	1.15 - 6.58	0.3243	0.6781
	4NV+TIGIT+	Abs_Value	28	28	0	1.98	2.4	1.09 - 2.87	0.15 - 10.91	1.18	0.46 - 2.38	14	14	0	3.27	3.41	1.48 - 5.06	0.14 - 12.48	1.97	1.02 - 4.53	0.221	0.6781
	4ЕМ	Abs_Value	28	28	0	27.44	62.36	4.35 - 50.54	0.05 - 337.94	15.05	5.39 - 24.18	14	14	0	8.4	8.82	3.77 - 13.02	0.17 - 25.86	5.24	1.79 - 9.96	0.1238	0.6781
	4ЕМ_TH1	Abs_Value	28	28	0	10.52	21.21	2.67 - 18.38	0 - 112.94	4.34	1.5 - 10.68	14	14	0	3.18	4.44	0.85 - 5.5	0.03 - 12.98	1.11	0.26 - 3.35	0.0886	0.6781
	4ЕМ_TH17	Abs_Value	28	28	0	0.03	0.05	0.01 - 0.05	0 - 0.18	0.01	0 - 0.03	14	14	0	0.07	0.16	-0.01 - 0.15	0 - 0.59	0.01	0 - 0.04	0.3904	0.6866
	4ЕМ_Th17TO1	Abs_Value	28	28	0	0.51	0.93	0.16 - 0.86	0 - 4.85	0.2	0.07 - 0.57	14	14	0	0.19	0.22	0.08 - 0.31	0 - 0.66	0.13	0.03 - 0.23	0.0996	0.6781
	4ЕМ_TH2	Abs_Value	28	28	0	1.79	4.75	0.03 - 3.55	0 - 24.46	0.2	0.02 - 1.83	14	14	0	0.32	0.59	0.01 - 0.62	0.01 - 2.2	0.08	0.04 - 0.28	0.1176	0.6781
	4ЕМ_TH22	Abs_Value	28	28	0	0.01	0.02	0 - 0.02	0 - 0.11	0	0 - 0.01	14	14	0	0.01	0.01	0 - 0.01	0 - 0.05	0	0 - 0	0.4551	0.7131
	4ЕМ+226+	Abs_Value	28	28	0	131.59	96.96	95.68 - 167.5	29.52 - 477.35	86.56	66.35 - 180.01	14	14	0	105.55	69.84	68.96 - 142.13	22.39 - 224.92	90.27	45.45 - 150.7	0.3264	0.6781
	4ЕМ+39+	Abs_Value	28	28	0	36.82	35.18	23.79 - 49.85	0.88 - 146.09	23.82	17.36 - 48.28	14	14	0	39.21	29.01	24.01 - 54.41	0.25 - 83.93	40.64	10.33 - 58.8	0.8168	0.9094
	4ЕМ+DR+	Abs_Value	28	28	0	80.97	68.49	55.6 - 106.34	10.12 - 341.19	52.11	40.32 - 119.37	14	14	0	51.14	37.29	31.61 - 70.68	2.19 - 150.75	51.7	25.99 - 61.76	0.0754	0.6781
	4ЕМ+PD1-TIGIT-	Abs_Value	28	28	0	26.19	17.91	19.56 - 32.83	2 - 69.84	21.04	12.78 - 37.04	14	14	0	28.45	24.11	15.82 - 41.08	2.07 - 74.3	23.78	8.55 - 37.9	0.76	0.884
	4ЕМ+PD1-TIGIT+	Abs_Value	28	28	0	3.33	2.73	2.32 - 4.34	0.08 - 9.42	2.47	1.26 - 5.09	14	14	0	4.11	3.66	2.19 - 6.03	0.19 - 11.47	2.6	1.05 - 6.71	0.4911	0.7192
	4ЕМ+PD1+	Abs_Value	28	28	0	109.28	90.94	75.59 - 142.96	26.74 - 465.38	74.09	54.15 - 143.28	14	14	0	78.12	49.93	51.96 - 104.27	15.86 - 159.29	77.61	40.3 - 96.23	0.16	0.6781
	4ЕМ+PD1+TIGIT-	Abs_Value	28	28	0	56.89	40.09	42.04 - 71.73	12.43 - 175.98	44.68	27.37 - 76.23	14	14	0	40.42	25.27	27.18 - 53.65	7.04 - 85.23	38.63	20.38 - 56.75	0.113	0.6781
	4ЕМ+PD1+TIGIT+	Abs_Value	28	28	0	52.39	54.96	32.03 - 72.75	13.52 - 289.4	39.84	18.79 - 77.5	14	14	0	37.7	27.66	23.21 - 52.19	4.8 - 89.86	29.72	15.62 - 55.48	0.2561	0.6781
	4ЕМ+TIGIT+	Abs_Value	28	28	0	55.72	55.87	35.03 - 76.42	14.57 - 292.02	40.91	19.91 - 84.16	14	14	0	41.81	29.93	26.13 - 57.49	6.19 - 95.58	35.76	16.71 - 61.83	0.2999	0.6781
	4ЕМTM	Abs_Value	28	28	0	138.8	99.73	101.86 - 175.74	30.94 - 480.41	105.39	68.28 - 188.97	14	14	0	110.67	71.84	73.04 - 148.31	23.66 - 228.74	94.42	48.98 - 159.67	0.303	0.6781
	4СМ	Abs_Value	28	28	0	61.75	37.84	47.73 - 75.77	13.26 - 146.46	52.11	30.84 - 91.37	14	14	0	76.5	55.02	47.68 - 105.32	10.54 - 214.21	63.18	36.55 - 115.1	0.378	0.6866
	4СМ(СТАР2)	Abs_Value	28	28	0	47.2	26.48	37.4 - 57.01	7.82 - 107.45	43.92	23.6 - 62.8	14	14	0	58.39	51.76	31.28 - 85.51	8.04 - 200.31	44.16	28.4 - 63.93	0.4575	0.7142
	4СМ_TH1	Abs_Value	28	28	0	1.47	1.67	0.85 - 2.09	0.07 - 7.15	0.97	0.45 - 1.42	14	14	0	3.57	5.03	0.93 - 6.2	0.3 - 20.04	2.01	0.94 - 4	0.1503	0.6781
	4СМ_TH17	Abs_Value	28	28	0	7.3	4.88	5.49 - 9.1	1.27 - 20.38	6.35	3.64 - 9.25	14	14	0	9.16	7.08	5.46 - 12.87	2.38 - 28.22	8.46	3.19 - 12.75	0.3861	0.6866
	4СМ_Th17TO1	Abs_Value	28	28	0	0.49	0.49	0.31 - 0.67	0.04 - 2.29	0.34	0.2 - 0.55	14	14	0	0.96	1.18	0.34 - 1.58	0.04 - 4.47	0.57	0.24 - 0.97	0.1713	0.6781
	4СМ_TH2	Abs_Value	28	28	0	4.52	3.7	3.15 - 5.89	0.45 - 18.22	3.69	1.93 - 6.35	14	14	0	7.16	7.96	2.99 - 11.33	1.8 - 29.39	3.6	2.62 - 5.96	0.2551	0.6781
	4СМ_TH22	Abs_Value	28	28	0	0.64	0.59	0.43 - 0.86	0.02 - 2.89	0.47	0.28 - 0.88	14	14	0	1.13	1.03	0.59 - 1.67	0.08 - 3.27	0.91	0.44 - 1.5	0.1197	0.6781
	4СМ+226+	Abs_Value	28	28	0	43.71	25.43	34.29 - 53.13	7.56 - 105.79	39.19	22.71 - 57.23	14	14	0	54.63	48.32	29.32 - 79.94	7.28 - 188.86	41.68	27.29 - 61.77	0.4392	0.7016
	4СМ+39+	Abs_Value	28	28	0	13.31	11.75	8.96 - 17.66	0.11 - 41.64	9	5.26 - 21.33	14	14	0	20.63	22.13	9.04 - 32.22	0.05 - 75.65	13.68	6.29 - 27.45	0.2629	0.6781
	4СМ+DR+	Abs_Value	28	28	0	14.05	12.11	9.56 - 18.53	1.83 - 40.68	7.66	5.74 - 22.38	14	14	0	15.17	18.57	5.44 - 24.9	0.29 - 56.48	5.82	3.97 - 19.91	0.8402	0.9146
	4СМ+PD1-TIGIT-	Abs_Value	28	28	0	15.05	9.37	11.58 - 18.52	2.82 - 32.52	13.06	6.32 - 25.05	14	14	0	22.08	26.2	8.35 - 35.8	3.91 - 99.16	13.5	6.88 - 21.33	0.3464	0.6781
	4СМ+PD1-TIGIT+	Abs_Value	28	28	0	2.23	2.09	1.45 - 3	0.09 - 7.53	1.54	0.52 - 2.95	14	14	0	3.38	4.01	1.28 - 5.49	0.15 - 15.02	1.9	1.02 - 4.37	0.3251	0.6781
	4СМ+PD1+	Abs_Value	28	28	0	29.92	18.68	23 - 36.84	3.4 - 75.06	26.33	17.08 - 40.87	14	14	0	32.93	28.96	17.76 - 48.1	1.74 - 94.4	23.08	14.69 - 43.5	0.7278	0.8715
	4СМ+PD1+TIGIT-	Abs_Value	28	28	0	11.7	7.17	9.05 - 14.36	2.06 - 26.13	9.96	6.8 - 14.44	14	14	0	12.4	10.65	6.83 - 17.98	1.38 - 31.91	8.2	4.81 - 16.08	0.8267	0.9094
	4СМ+PD1+TIGIT+	Abs_Value	28	28	0	18.22	14.61	12.81 - 23.63	1.34 - 62.79	15.67	8.1 - 21.06	14	14	0	20.53	19.49	10.32 - 30.73	0.36 - 62.83	14.99	8.23 - 26.26	0.6996	0.8548
4СМ+TIGIT+	Abs_Value	28	28	0	20.45	16.09	14.48 - 26.41	1.79 - 69.48	16.63	10.12 - 28.13	14	14	0	23.91	22.07	12.35 - 35.47	0.54 - 73.37	18.51	9.93 - 31.86	0.6073	0.7822
4ТM_TH1	Abs_Value	28	28	0	12.31	11.97	7.87 - 16.74	1.94 - 55.53	9.77	3.97 - 14.73	14	14	0	6.96	3.66	5.04 - 8.88	1.3 - 14.41	7.44	4.52 - 8.95	0.0368	0.6781
4ТM_TH17	Abs_Value	28	28	0	6.86	4.9	5.04 - 8.67	0.9 - 22.86	5.87	3.72 - 8.31	14	14	0	9.69	12.24	3.28 - 16.1	0.94 - 44.13	5.29	2.16 - 8.55	0.4184	0.6976
4ТM_Th17TO1	Abs_Value	28	28	0	3.12	2.5	2.19 - 4.05	0.79 - 10.52	2.39	1.52 - 3.62	14	14	0	3.02	2.9	1.5 - 4.54	0.28 - 10.5	2.48	1.05 - 3.28	0.9136	0.956
4ТM_TH2	Abs_Value	28	28	0	2.51	1.95	1.79 - 3.24	0.6 - 8.26	1.85	1.07 - 3.5	14	14	0	9.55	22.23	-2.1 - 21.19	0.3 - 85.75	2.62	1.3 - 5.59	0.2583	0.6781
4ТM_TH22	Abs_Value	28	28	0	4.15	3.93	2.7 - 5.61	0.09 - 16.55	2.84	1.63 - 5.23	14	14	0	5.06	5.9	1.97 - 8.15	0.44 - 17.35	1.66	0.69 - 8.22	0.6107	0.7845
4ТREG	Abs_Value	28	28	0	2.75	3.7	1.38 - 4.12	0.02 - 16	1.38	0.9 - 2.78	14	14	0	4.35	5.5	1.47 - 7.23	0.12 - 14.85	1.4	0.74 - 7.52	0.3382	0.6781
4ТREG(СТАР2)	Abs_Value	28	28	0	90.87	75.13	63.04 - 118.69	6.1 - 296.08	68.88	41.46 - 106.71	14	14	0	130.77	113.81	71.16 - 190.39	33.78 - 462.62	81.71	57.83 - 189.89	0.2492	0.6781
4ТREG_TH1	Abs_Value	28	28	0	0.26	0.26	0.16 - 0.35	0 - 1.28	0.2	0.08 - 0.3	14	14	0	0.34	0.47	0.09 - 0.58	0.06 - 1.9	0.21	0.1 - 0.32	0.5511	0.7482
4ТREG_TH17	Abs_Value	28	28	0	3.91	3.31	2.69 - 5.14	0.31 - 12.56	2.76	1.86 - 4.74	14	14	0	6.68	8.57	2.19 - 11.16	1.2 - 33.26	3.34	1.93 - 7.31	0.2627	0.6781
4ТREG_Th17TO1	Abs_Value	28	28	0	0.13	0.31	0.02 - 0.25	0 - 1.66	0.06	0.03 - 0.13	14	14	0	0.13	0.18	0.04 - 0.23	0.02 - 0.63	0.05	0.03 - 0.18	0.9919	0.9959
4ТREG_TH2	Abs_Value	28	28	0	2.09	1.71	1.46 - 2.73	0.18 - 7.26	1.67	0.77 - 3.26	14	14	0	3.65	4.38	1.36 - 5.95	0.49 - 17.5	2.38	1.13 - 4.78	0.2189	0.6781
4ТREG_TH22	Abs_Value	28	28	0	3.11	3.04	1.99 - 4.24	0.3 - 12.42	2.39	1.25 - 3.74	14	14	0	3.93	5.42	1.09 - 6.77	0.35 - 21.16	1.78	1.02 - 4.67	0.6063	0.7822
4ТЕ	Abs_Value	28	28	0	6.72	8.07	3.74 - 9.71	0.05 - 26.78	3.24	1.24 - 9.35	14	14	0	13.5	18.66	3.72 - 23.27	0.19 - 58.83	4.9	1.72 - 12.7	0.213	0.6781
4ТЕ(СТАР2)	Abs_Value	28	28	0	31.02	19.78	23.69 - 38.34	8.86 - 75.37	26.45	13.85 - 44.23	14	14	0	39.2	30.52	23.21 - 55.19	3.55 - 106.79	41.45	13.83 - 56.32	0.3736	0.6866
4ТЕ_TH1	Abs_Value	28	28	0	2.42	3.41	1.15 - 3.68	0 - 13.95	0.63	0.27 - 3.19	14	14	0	3.48	5.58	0.55 - 6.4	0.01 - 16.37	1.35	0.21 - 2.73	0.5225	0.7387
4ТЕ_TH17	Abs_Value	28	28	0	0.01	0.01	0 - 0.01	0 - 0.05	0	0 - 0.01	14	14	0	0.07	0.24	-0.05 - 0.2	0 - 0.91	0	0 - 0.01	0.3494	0.6781
4ТЕ_Th17TO1	Abs_Value	28	28	0	0.09	0.13	0.04 - 0.14	0 - 0.51	0.02	0 - 0.14	14	14	0	0.34	0.77	-0.07 - 0.74	0 - 2.9	0.04	0 - 0.19	0.2571	0.6781
4ТЕ_TH2	Abs_Value	28	28	0	0.46	0.69	0.2 - 0.71	0 - 2.26	0.06	0.01 - 0.58	14	14	0	0.59	1.53	-0.21 - 1.39	0 - 5.84	0.14	0.03 - 0.29	0.7584	0.884
4ТЕ_TH22	Abs_Value	28	28	0	0.01	0.02	0 - 0.02	0 - 0.09	0	0 - 0.01	14	14	0	0.01	0.01	0 - 0.02	0 - 0.05	0.01	0 - 0.02	0.7002	0.8548
4ТЕ+226+	Abs_Value	28	28	0	28.62	18.94	21.61 - 35.64	5.39 - 69.68	23.92	13.41 - 41.25	14	14	0	35.9	28.65	20.89 - 50.9	3.23 - 101.25	34.74	13.45 - 52.71	0.4001	0.6866
4ТЕ+39+	Abs_Value	28	28	0	6.91	6.93	4.34 - 9.47	0.19 - 30.14	5.03	1.49 - 9.56	14	14	0	7.6	7.97	3.42 - 11.77	0.03 - 29.54	6.06	1.39 - 11.47	0.7852	0.8997
4ТЕ+DR+	Abs_Value	28	28	0	19.05	16.74	12.85 - 25.25	2.33 - 69.31	15.63	8.38 - 20.29	14	14	0	18.69	18.7	8.89 - 28.49	0.08 - 60.5	14.65	6.75 - 20.78	0.9522	0.9711
4ТЕ+PD-1-TIGIT-	Abs_Value	28	28	0	9.06	6.86	6.52 - 11.6	0.69 - 29.76	7.41	3.88 - 12.42	14	14	0	15.11	13.39	8.09 - 22.13	1.05 - 47.45	10.59	5.29 - 23.72	0.1309	0.6781
4ТЕ+PD-1-TIGIT+	Abs_Value	28	28	0	1.87	1.73	1.22 - 2.51	0.07 - 8.02	1.4	0.7 - 2.21	14	14	0	2.7	2.9	1.18 - 4.22	0.13 - 9.27	0.93	0.55 - 4.17	0.335	0.6781
4ТЕ+PD-1+	Abs_Value	28	28	0	20.09	15.55	14.33 - 25.85	4.6 - 58.48	15.83	8.96 - 25.92	14	14	0	21.39	19.12	11.37 - 31.4	0.77 - 67.28	18.59	6.5 - 26.82	0.8281	0.9094
4ТЕ+PD-1+TIGIT-	Abs_Value	28	28	0	11.17	10.71	7.2 - 15.14	1.41 - 39.92	6.31	4.63 - 12.94	14	14	0	13.62	14.7	5.92 - 21.32	0.44 - 55.01	9.37	4.15 - 16.57	0.5853	0.7646
4ТЕ+PD-1+TIGIT+	Abs_Value	28	28	0	8.92	6.9	6.37 - 11.48	1.92 - 25.95	6.34	4.22 - 11.45	14	14	0	7.77	7.08	4.06 - 11.47	0.33 - 22.79	5.5	1.8 - 12.24	0.6192	0.7904
4ТЕ+TIGIT+	Abs_Value	28	28	0	10.79	7.88	7.87 - 13.71	2.51 - 30.84	8.43	5.19 - 14.18	14	14	0	10.47	9.63	5.42 - 15.51	0.46 - 32.06	7.69	2.46 - 15.9	0.9148	0.956
4ТМ	Abs_Value	28	28	0	109.01	67.42	84.03 - 133.98	32.08 - 253.34	82.13	53.03 - 141.37	14	14	0	93.26	64.47	59.48 - 127.03	14.63 - 197.92	80.46	41.2 - 144.82	0.4687	0.718
8+	Abs_Value	28	28	0	622.09	563.47	413.38 - 830.81	31.86 - 2078.56	508.16	107.88 - 982.15	14	14	0	371.07	337.5	194.28 - 547.86	2.77 - 942.86	259.72	57.26 - 608.29	0.0799	0.6781
8+ (IM STAT)	Abs_Value	28	28	0	806.12	725.48	537.4 - 1074.84	40.65 - 2479.37	632.98	234.59 - 1142.94	14	14	0	472.41	437.65	243.15 - 701.67	3.11 - 1413.27	383.59	88.25 - 709.03	0.0718	0.6781
8+226+	Abs_Value	28	28	0	1002.67	905.76	667.17 - 1338.17	109.2 - 3905.17	724.17	336.58 - 1226.89	14	14	0	628.39	516.74	357.7 - 899.07	16.08 - 1833.29	558.95	189.54 - 973.48	0.0967	0.6781
8+39+	Abs_Value	28	28	0	179.05	399.93	30.91 - 327.19	2.21 - 2089.83	65.06	28.88 - 134.15	14	14	0	108.54	95.6	58.46 - 158.62	0.53 - 266.18	81.42	23.84 - 181.37	0.3833	0.6866
8+DR+	Abs_Value	28	28	0	821.88	776.49	534.26 - 1109.5	36.66 - 3420.38	664.31	204.99 - 1135.08	14	14	0	465.82	437.17	236.81 - 694.82	3.7 - 1528.67	351.66	136.04 - 604.53	0.065	0.6781
8+PD-1-TIGIT-	Abs_Value	28	28	0	325.57	336.9	200.78 - 450.36	22.38 - 1345.43	230.47	60.24 - 415.57	14	14	0	229.44	191.28	129.24 - 329.64	10.99 - 612.35	201.15	90.92 - 361.15	0.2462	0.6781
8+PD-1-TIGIT+	Abs_Value	28	28	0	361.91	450.75	194.95 - 528.87	9.64 - 1906.78	198.53	112.67 - 338.93	14	14	0	163.73	156.05	81.98 - 245.47	0.61 - 587.72	112.8	63.09 - 234.43	0.0436	0.6781
8+PD-1+	Abs_Value	28	28	0	411.44	357.34	279.08 - 543.8	50.77 - 1157.32	242.05	152.08 - 581.29	14	14	0	297.17	333.76	122.34 - 472.01	5.1 - 1050.36	159.01	59.23 - 468.65	0.3159	0.6781
8+PD-1+TIGIT-	Abs_Value	28	28	0	92.8	86.8	60.64 - 124.95	3.08 - 350.2	71.08	33.32 - 120.94	14	14	0	101.97	140.21	28.52 - 175.41	3.19 - 429.98	40.54	9.22 - 155.68	0.8251	0.9094
8+PD-1+TIGIT+	Abs_Value	28	28	0	318.65	299.61	207.67 - 429.62	46.78 - 1020.62	184.97	102.83 - 432.2	14	14	0	195.21	199.07	90.93 - 299.49	1.91 - 620.38	112.82	50.02 - 325.98	0.1207	0.6781
8+TIGIT+	Abs_Value	28	28	0	680.56	684.87	426.88 - 934.23	83.69 - 2694.32	445.34	208.98 - 860.66	14	14	0	358.94	319.1	191.78 - 526.09	2.52 - 917.19	249.08	109.73 - 599.54	0.0445	0.6781
8EMTM	Abs_Value	28	28	0	297.12	413.32	144.02 - 450.21	7.83 - 1882.93	118.32	33.55 - 468.12	14	14	0	108.26	114.49	48.29 - 168.24	1.35 - 336.64	47.26	26.7 - 176.25	0.0309	0.6781
8EMTM+226+	Abs_Value	28	28	0	262.72	393.38	117.01 - 408.43	7.18 - 1881.01	107.78	30.67 - 330.96	14	14	0	90.82	94.44	41.36 - 140.29	1.28 - 270.09	37.28	21.54 - 160.05	0.0358	0.6781
8EMTM+39+	Abs_Value	28	28	0	75.18	204.28	-0.48 - 150.85	0.15 - 979.7	13.33	3.81 - 46.74	14	14	0	32.61	38.02	12.69 - 52.52	0.1 - 115.58	11.44	5.54 - 57.22	0.2946	0.6781
8EMTM+DR+	Abs_Value	28	28	0	253.32	362.91	118.89 - 387.74	3.36 - 1678.23	111.52	23.45 - 398.7	14	14	0	89.85	96.75	39.17 - 140.53	0.6 - 266.01	40.98	18.71 - 127.09	0.0325	0.6781
8EMTM+PD-1-TIGIT-	Abs_Value	28	28	0	78.51	128.66	30.85 - 126.16	0.77 - 396.55	20.79	3.43 - 68.29	14	14	0	20.46	23.19	8.31 - 32.61	0.57 - 81.18	14.3	5.74 - 21.89	0.0277	0.6781
8EMTM+PD-1-TIGIT+	Abs_Value	28	28	0	80.36	173.57	16.07 - 144.65	0.65 - 878.14	26.76	4.11 - 51.64	14	14	0	19.34	28.41	4.46 - 34.22	0.06 - 105.56	7.53	4.44 - 20.2	0.08	0.6781
8EMTM+PD-1+	Abs_Value	28	28	0	138.25	190.06	67.85 - 208.65	2.76 - 628.57	55.93	23.94 - 121.89	14	14	0	68.46	80.08	26.51 - 110.41	0.72 - 222.51	27.74	13.79 - 80.99	0.103	0.6781
8EMTM+PD-1+TIGIT-	Abs_Value	28	28	0	29.59	41.13	14.36 - 44.83	0.58 - 176.22	11.82	4 - 44.68	14	14	0	20.55	29.3	5.2 - 35.9	0.5 - 91.63	6.05	2.11 - 25.21	0.4182	0.6976
8EMTM+PD-1+TIGIT+	Abs_Value	28	28	0	108.66	159.34	49.64 - 167.68	2.05 - 544.23	35.07	19.33 - 100.5	14	14	0	47.91	56.83	18.14 - 77.68	0.22 - 167.49	21.69	11.54 - 52.86	0.0797	0.6781
8EMTM+TIGIT+	Abs_Value	28	28	0	189.02	302.12	77.12 - 300.93	4.08 - 1330.49	66.41	23.7 - 205.97	14	14	0	67.25	82.58	23.99 - 110.51	0.28 - 273.06	29.94	16.68 - 82.47	0.0547	0.6781
8NV	Abs_Value	28	28	0	21.59	23.9	12.74 - 30.45	1.08 - 117.97	16.42	9.44 - 22.67	14	14	0	24.99	15.76	16.73 - 33.24	2.58 - 62.15	23.87	17.89 - 30.86	0.5859	0.7646
8NV(СТАР2)	Abs_Value	28	28	0	25.71	29.33	14.85 - 36.58	1.52 - 104.32	16.23	9.59 - 25.92	14	14	0	23.68	15.83	15.39 - 31.98	2.85 - 55.29	23.65	12.38 - 28.58	0.7728	0.8946
8NV+226+	Abs_Value	28	28	0	22.4	26.13	12.72 - 32.08	1.4 - 96.72	14.48	9.13 - 23.05	14	14	0	21.49	15.19	13.53 - 29.45	2.73 - 54.93	21.56	10.55 - 25.09	0.8881	0.9417
8NV+39+	Abs_Value	28	28	0	1.56	2.33	0.7 - 2.42	0.02 - 11.42	0.78	0.25 - 1.66	14	14	0	2.11	2.34	0.89 - 3.34	0.07 - 8.56	1.34	0.31 - 3.21	0.4782	0.7185
8NV+DR+	Abs_Value	28	28	0	6.17	10.12	2.42 - 9.91	0.12 - 49.7	2.7	1.26 - 4.71	14	14	0	3.34	2.64	1.96 - 4.72	0.26 - 7.84	2.29	1.05 - 5.31	0.1755	0.6781
8NV+PD-1-TIGIT-	Abs_Value	28	28	0	17.04	23.81	8.22 - 25.86	0.93 - 101.41	10.66	4.93 - 15.8	14	14	0	18.89	13.6	11.76 - 26.01	1.46 - 46.07	18.38	8.18 - 23.33	0.7507	0.884
8NV+PD-1-TIGIT+	Abs_Value	28	28	0	2.24	2.68	1.25 - 3.23	0.03 - 11.3	1.55	0.34 - 3.23	14	14	0	1.51	1.78	0.58 - 2.44	0.04 - 6.46	0.76	0.46 - 1.73	0.3	0.6781
8NV+PD-1+	Abs_Value	28	28	0	6.43	15.22	0.79 - 12.07	0.07 - 81.13	1.76	0.97 - 6.11	14	14	0	3.28	2.88	1.78 - 4.79	0.21 - 8.57	2.47	0.8 - 5.02	0.2988	0.6781
8NV+PD-1+TIGIT-	Abs_Value	28	28	0	2.57	6.54	0.15 - 5	0 - 33.28	0.59	0.23 - 1.48	14	14	0	1.62	2.37	0.38 - 2.86	0.03 - 8.09	0.6	0.17 - 1.4	0.4967	0.7192
8NV+PD-1+TIGIT+	Abs_Value	28	28	0	3.86	9.06	0.5 - 7.21	0.07 - 47.85	1.05	0.52 - 3.46	14	14	0	1.66	1.33	0.97 - 2.36	0.12 - 3.69	1.47	0.5 - 2.93	0.2197	0.6781
8NV+TIGIT+	Abs_Value	28	28	0	6.1	10.28	2.29 - 9.91	0.3 - 51.41	2.39	1.28 - 5.55	14	14	0	3.17	2.45	1.89 - 4.46	0.16 - 9.39	2.43	1.43 - 4.38	0.1633	0.6781
8TREG	Abs_Value	28	28	0	679.26	594.1	459.2 - 899.32	31.9 - 1960.13	525.99	129.72 - 1051.71	14	14	0	382.04	350.32	198.53 - 565.55	2.7 - 946.35	277.39	59.9 - 604.13	0.0489	0.6781
8ЕМ	Abs_Value	28	28	0	291.16	561.39	83.22 - 499.11	1.35 - 2912.66	125.79	31.89 - 295.25	14	14	0	90.19	129.54	22.33 - 158.05	0.67 - 462.87	36.63	12.78 - 100.3	0.0811	0.6781
8СМ	Abs_Value	28	28	0	11.52	12.63	6.84 - 16.2	0.38 - 54.12	7.33	2.43 - 14.43	14	14	0	9.54	9.95	4.33 - 14.75	0.18 - 31.81	6.55	1.76 - 14.02	0.5836	0.7646
8СМ(СТАР2)	Abs_Value	28	28	0	12.03	22.84	3.57 - 20.49	0.51 - 115.04	4.3	1.89 - 8.54	14	14	0	6.81	9.89	1.63 - 11.99	0.11 - 35.91	2.44	0.66 - 6.83	0.3087	0.6781
8СМ+226+	Abs_Value	28	28	0	10.52	21.31	2.63 - 18.42	0.44 - 108.09	3.47	1.75 - 5.99	14	14	0	5.24	7.02	1.56 - 8.91	0.11 - 25.41	2.05	0.61 - 5.89	0.2419	0.6781
8СМ+39+	Abs_Value	28	28	0	2.85	4.64	1.13 - 4.57	0.01 - 20.23	1.11	0.43 - 3.12	14	14	0	3.3	5.33	0.51 - 6.1	0.01 - 18.76	0.64	0.22 - 4.13	0.7908	0.9
8СМ+DR+	Abs_Value	28	28	0	9.66	17.15	3.31 - 16.02	0.24 - 80.54	2.92	1.56 - 6.47	14	14	0	5.39	9.41	0.46 - 10.32	0.03 - 34.59	1.62	0.36 - 4.96	0.3035	0.6781
8СМ+PD-1-TIGIT-	Abs_Value	28	28	0	3	6.6	0.55 - 5.44	0.05 - 32.39	0.87	0.29 - 1.87	14	14	0	1.37	2.12	0.26 - 2.48	0.07 - 8.16	0.49	0.27 - 1.5	0.2416	0.6781
8СМ+PD-1-TIGIT+	Abs_Value	28	28	0	1.91	3.44	0.64 - 3.18	0.04 - 14.86	0.7	0.37 - 1.31	14	14	0	1.23	1.53	0.43 - 2.04	0 - 4.15	0.36	0.1 - 2.61	0.3841	0.6866
8СМ+PD-1+	Abs_Value	28	28	0	7.12	14.26	1.84 - 12.4	0.05 - 71.03	2.34	0.96 - 4.64	14	14	0	4.21	8.1	-0.03 - 8.46	0.05 - 30.23	1.56	0.36 - 2.97	0.4047	0.6902
8СМ+PD-1+TIGIT-	Abs_Value	28	28	0	1.78	6.19	-0.52 - 4.07	0 - 33.01	0.26	0.16 - 0.61	14	14	0	0.61	1.47	-0.16 - 1.38	0 - 5.66	0.15	0.08 - 0.32	0.3502	0.6781
8СМ+PD-1+TIGIT+	Abs_Value	28	28	0	5.34	8.9	2.05 - 8.64	0.05 - 38.02	2.19	0.73 - 4.38	14	14	0	3.6	6.72	0.08 - 7.12	0.01 - 24.57	1.36	0.23 - 2.52	0.4838	0.7191
8СМ+TIGIT+	Abs_Value	28	28	0	7.25	11.51	2.99 - 11.52	0.4 - 49.64	2.65	1.25 - 5.84	14	14	0	4.84	7.96	0.67 - 9.01	0.01 - 28.72	1.75	0.32 - 5.24	0.4319	0.7016
8ТЕ	Abs_Value	28	28	0	559.44	510.22	370.45 - 748.43	21.49 - 1984.18	386.13	153.78 - 765.25	14	14	0	420.95	394.25	214.43 - 627.47	7.02 - 1388.56	342.96	112.41 - 593	0.3393	0.6781
8ТЕ(СТАР2)	Abs_Value	28	28	0	760.76	651.04	519.61 - 1001.91	85.43 - 2454.12	597.34	233.36 - 973.93	14	14	0	549.84	485.59	295.48 - 804.21	7.28 - 1753.87	466.62	147.37 - 857.41	0.2465	0.6781
8ТЕ+226+	Abs_Value	28	28	0	704.58	620.82	474.63 - 934.54	70.48 - 2224.98	536.59	198.58 - 886.97	14	14	0	509.43	457.91	269.56 - 749.3	7.03 - 1680.66	433.53	143.45 - 734.61	0.2577	0.6781
8ТЕ+39+	Abs_Value	28	28	0	99.09	204.61	23.3 - 174.88	1.13 - 1085.66	36.16	19.58 - 97.46	14	14	0	69.82	56.96	39.98 - 99.66	0.35 - 156.59	66.19	19.81 - 122.1	0.4859	0.7192
8ТЕ+DR+	Abs_Value	28	28	0	550.8	518.65	358.69 - 742.91	32.15 - 1885.95	371.81	169.71 - 755.01	14	14	0	366.48	382.45	166.14 - 566.82	2.71 - 1408.92	283.06	108.34 - 403.66	0.2018	0.6781
8ТЕ+PD-1-TIGIT-	Abs_Value	28	28	0	226.53	232.94	140.25 - 312.82	8.85 - 977.38	164.89	42.74 - 353.97	14	14	0	188.06	174.91	96.44 - 279.69	3.37 - 546.54	169.72	26.6 - 300.93	0.5531	0.7482
8ТЕ+PD-1-TIGIT+	Abs_Value	28	28	0	277.01	322.66	157.5 - 396.53	7.28 - 1118.76	123.53	75.39 - 287.87	14	14	0	141.13	133.62	71.14 - 211.13	0.49 - 476.45	94.63	53.31 - 192.7	0.0618	0.6781
8ТЕ+PD-1+	Abs_Value	28	28	0	257.22	242.24	167.49 - 346.94	17.31 - 1012.86	154.35	86.77 - 439.93	14	14	0	220.64	278.8	74.6 - 366.68	3.41 - 959.6	108.29	34.51 - 279.19	0.6797	0.8445
8ТЕ+PD-1+TIGIT-	Abs_Value	28	28	0	58.57	57.31	37.35 - 79.8	1.78 - 217.83	39.31	22.3 - 67.46	14	14	0	79.23	118.31	17.25 - 141.2	1.91 - 388.34	30.42	5.88 - 75.42	0.5453	0.7482
8ТЕ+PD-1+TIGIT+	Abs_Value	28	28	0	198.64	200.93	124.21 - 273.07	15.53 - 830.14	115.53	61.29 - 258.57	14	14	0	141.41	163.22	55.91 - 226.92	1.5 - 571.26	74.7	27.15 - 208.77	0.33	0.6781
8ТЕ+TIGIT+	Abs_Value	28	28	0	475.65	478.92	298.26 - 653.05	60.35 - 1948.91	252.29	153.4 - 603.44	14	14	0	282.55	260.54	146.07 - 419.03	1.99 - 818.99	211.43	85.61 - 488.13	0.0987	0.6781
8ТМ	Abs_Value	28	28	0	103.51	167.34	41.52 - 165.49	2.77 - 712.4	34.28	16.32 - 98.29	14	14	0	49.25	78.03	8.38 - 90.13	0.73 - 307.9	27.39	15.88 - 50.35	0.1599	0.6781
TREG_CM	Abs_Value	28	28	0	2.14	2.4	1.25 - 3.03	0.05 - 9.79	1.38	0.49 - 2.36	14	14	0	2.57	3.89	0.53 - 4.61	0.08 - 14.95	1.28	0.6 - 1.82	0.7069	0.8566
TREG_EMTM	Abs_Value	28	28	0	17.07	15.93	11.16 - 22.97	1.71 - 79.04	11.8	7.19 - 20.87	14	14	0	23.74	23.55	11.4 - 36.07	3.25 - 71.51	13.29	6.66 - 30.27	0.3508	0.6781
TREG_NV	Abs_Value	28	28	0	2.24	2.91	1.16 - 3.32	0.02 - 11.22	1.29	0.44 - 2.39	14	14	0	2.21	2.61	0.85 - 3.58	0.49 - 10.39	1.26	0.64 - 2.63	0.9759	0.9879
TREG_TE	Abs_Value	28	28	0	4.46	4.48	2.8 - 6.12	0.29 - 19.01	3.7	2.1 - 5.47	14	14	0	4.99	5.47	2.13 - 7.85	0.54 - 18.3	3.13	1.41 - 6.1	0.7545	0.884
TREG+226-TIGIT-	Abs_Value	28	28	0	1.91	2.28	1.07 - 2.76	0.06 - 11.41	1.39	0.6 - 2.11	14	14	0	1.4	1.22	0.76 - 2.05	0.31 - 4.01	1.07	0.42 - 1.65	0.3556	0.6781
TREG+226-TIGIT+	Abs_Value	28	28	0	6.74	8.02	3.76 - 9.71	0.18 - 38.6	5.2	2.3 - 7.67	14	14	0	7.97	7.25	4.17 - 11.76	1.07 - 20.55	4.6	2.36 - 11.54	0.6201	0.7904
TREG+226+	Abs_Value	28	28	0	17.57	14.26	12.28 - 22.85	2.11 - 72.09	13.14	8.74 - 23.1	14	14	0	24.28	23.94	11.73 - 36.82	3.56 - 75.66	15.56	8.02 - 25.79	0.3469	0.6781
TREG+226+TIGIT-	Abs_Value	28	28	0	2.66	2.05	1.9 - 3.43	0.72 - 9.99	2.19	1.3 - 3.23	14	14	0	2.42	1.96	1.39 - 3.45	0.39 - 6.34	1.77	0.79 - 3.59	0.7059	0.8566
TREG+226+TIGIT+	Abs_Value	28	28	0	14.9	12.92	10.12 - 19.69	1.18 - 66.55	11.55	7.27 - 20.12	14	14	0	21.86	22.38	10.14 - 33.58	3.17 - 69.85	14.16	5.8 - 24.61	0.296	0.6781
TREG+39+	Abs_Value	28	28	0	19.34	18.14	12.62 - 26.06	1.99 - 77.53	14.73	6.89 - 25.57	14	14	0	23.53	22.77	11.6 - 35.46	1.37 - 84.95	16.15	8.12 - 28.06	0.5548	0.7482
TREG+DR+	Abs_Value	28	28	0	18.53	15.12	12.93 - 24.13	1.78 - 70.63	14.35	9.08 - 24.63	14	14	0	24.48	24.67	11.56 - 37.41	2.12 - 76.07	14.29	6.38 - 26.68	0.4181	0.6976
TREG+PD-1+	Abs_Value	28	28	0	10.89	9.84	7.24 - 14.53	0.6 - 38.32	7.38	4.29 - 14.03	14	14	0	14.55	15.86	6.24 - 22.86	1.03 - 49.25	7.67	3.58 - 21.24	0.4391	0.7016
TREG+TIGIT+	Abs_Value	28	28	0	21.64	17.99	14.97 - 28.3	1.42 - 73.15	18.37	9.26 - 25.7	14	14	0	29.83	29.43	14.41 - 45.25	4.64 - 90.4	17.4	7.87 - 35.58	0.3518	0.6781
+365	4_TFH	Abs_Value	13	13	0	65.34	37.16	45.14 - 85.54	5.63 - 132.09	55.23	38.65 - 82.38	13	13	0	47.29	18.76	37.09 - 57.49	9.47 - 72.66	48.7	31.58 - 58.4	0.1356	0.6781
	4_TH1	Abs_Value	13	13	0	64.63	39.03	43.42 - 85.85	9.91 - 143.83	54.59	38.59 - 83.06	13	13	0	51.88	51.35	23.97 - 79.8	4.31 - 161.95	30.9	24.11 - 47.41	0.4833	0.7191
	4_TH17	Abs_Value	13	13	0	22.1	10.62	16.32 - 27.87	7.99 - 40.27	20.97	11.82 - 31.4	13	13	0	34.53	29.41	18.54 - 50.52	8.97 - 109.23	27.65	10.99 - 43.52	0.1721	0.6781
	4_Th17TO1	Abs_Value	13	13	0	13.04	11.55	6.76 - 19.32	2.42 - 39.63	7.87	5.63 - 16.31	13	13	0	12.94	11.49	6.69 - 19.19	0.78 - 39.95	11.04	5.89 - 12.47	0.9829	0.9889
	4_TH2	Abs_Value	13	13	0	16.53	8.19	12.08 - 20.98	6.89 - 32.23	12.56	10.25 - 22.2	13	13	0	30.97	23.54	18.18 - 43.77	2.45 - 80.42	22.23	14.68 - 46.11	0.0543	0.6781
	4_TH22	Abs_Value	13	13	0	9.21	7.41	5.18 - 13.24	0.85 - 24.41	7.54	3.3 - 10.42	13	13	0	12.98	13.47	5.66 - 20.3	2.27 - 43.52	6.25	4.4 - 15.95	0.3877	0.6866
	4+	Abs_Value	13	13	0	159.05	136.59	84.8 - 233.3	52.48 - 526.69	107.32	91.29 - 157.54	13	13	0	172.82	136.8	98.46 - 247.19	20.84 - 561.4	130.33	87.45 - 197.84	0.7994	0.9
	4+ (IM STAT)	Abs_Value	13	13	0	137.87	118.1	73.67 - 202.07	31.83 - 437.37	99.83	69.48 - 153.93	13	13	0	148.86	129.99	78.19 - 219.52	34.32 - 535.83	107.92	75.74 - 188.69	0.8235	0.9094
	4+226+	Abs_Value	13	13	0	434.09	215.97	316.69 - 551.5	148.12 - 908.92	418.16	322.85 - 569.2	13	13	0	367.91	194.37	262.25 - 473.57	151.09 - 689.45	315.14	175.04 - 503.96	0.4197	0.6976
	4+39+	Abs_Value	13	13	0	72.82	50.19	45.54 - 100.1	1.86 - 157.32	60.9	38.64 - 114.42	13	13	0	74.42	74.23	34.07 - 114.77	3 - 294.7	60.08	35.85 - 82.73	0.9493	0.9711
	4+DR+	Abs_Value	13	13	0	203.14	165.82	113 - 293.28	35.88 - 695.8	161.93	120.52 - 239.44	13	13	0	133.82	113.21	72.28 - 195.36	37.87 - 433.17	95.63	55.05 - 152.03	0.2268	0.6781
	4+PD-1-TIGIT-	Abs_Value	13	13	0	165.45	107.03	107.26 - 223.63	21.66 - 409.4	156.17	91.71 - 213.7	13	13	0	185.55	122.99	118.69 - 252.41	24.56 - 339.45	150.3	79.8 - 326.94	0.6607	0.8271
	4+PD-1-TIGIT+	Abs_Value	13	13	0	16.44	17.32	7.02 - 25.86	2.68 - 63.64	9.45	6.4 - 17.7	13	13	0	17.39	13.74	9.92 - 24.87	2.16 - 46.7	16.77	5.77 - 21.51	0.8777	0.9388
	4+PD-1+	Abs_Value	13	13	0	272.3	172.15	178.72 - 365.88	68.05 - 718.28	212.65	175.68 - 364.54	13	13	0	196.05	112.02	135.15 - 256.95	83.25 - 411.97	154.89	113.41 - 227.46	0.1953	0.6781
	4+PD-1+TIGIT-	Abs_Value	13	13	0	146.17	77.12	104.24 - 188.09	32.8 - 282.13	132.55	92.16 - 201.04	13	13	0	107.58	67.37	70.96 - 144.21	46.73 - 237.8	79.56	56.16 - 133.4	0.1872	0.6781
	4+PD-1+TIGIT+	Abs_Value	13	13	0	126.13	107.17	67.88 - 184.39	35.25 - 436.15	83.52	68.11 - 152.21	13	13	0	88.47	54.2	59 - 117.93	30.53 - 233.4	75.33	55.61 - 113.02	0.2732	0.6781
	4+TIGIT+	Abs_Value	13	13	0	142.57	121.53	76.51 - 208.64	43.18 - 499.79	99.63	74.52 - 168.55	13	13	0	105.86	60.23	73.12 - 138.6	32.86 - 256.89	101.96	75.38 - 140.76	0.3424	0.6781
	4NV	Abs_Value	13	13	0	83.4	55.4	53.28 - 113.51	2.54 - 194.07	71.69	45.79 - 109.06	13	13	0	94.65	79.18	51.61 - 137.69	7.74 - 219.7	69.52	34.57 - 167.25	0.6788	0.8445
	4NV(СТАР2)	Abs_Value	13	13	0	71.79	48.37	45.5 - 98.08	1.85 - 171.15	63.56	33.81 - 105.47	13	13	0	89.8	80.11	46.25 - 133.35	7.32 - 237.87	56.13	28.32 - 149.96	0.4959	0.7192
	4NV_TH1	Abs_Value	13	13	0	4.35	3.03	2.7 - 6	0.17 - 12.15	4.03	2.45 - 5.59	13	13	0	7.88	9.31	2.82 - 12.95	0.56 - 30	3.45	0.75 - 7.62	0.2135	0.6781
	4NV_TH17	Abs_Value	13	13	0	2.16	1.44	1.38 - 2.95	0.4 - 5.09	2.02	1.3 - 2.34	13	13	0	2.65	2.59	1.24 - 4.06	0.16 - 8.85	1.59	1.21 - 2.92	0.5581	0.7482
	4NV_Th17TO1	Abs_Value	13	13	0	0.47	0.36	0.27 - 0.66	0.01 - 1.3	0.48	0.14 - 0.58	13	13	0	0.71	0.62	0.37 - 1.05	0.05 - 2.08	0.44	0.35 - 1.02	0.2427	0.6781
	4NV_TH2	Abs_Value	13	13	0	5.6	4.78	3 - 8.2	0.5 - 15.38	3.94	2.56 - 7.64	13	13	0	6.66	4.7	4.1 - 9.22	0.21 - 13.51	6.09	2.92 - 10.3	0.573	0.7599
	4NV_TH22	Abs_Value	13	13	0	0.19	0.18	0.09 - 0.29	0.02 - 0.61	0.1	0.07 - 0.35	13	13	0	0.21	0.21	0.1 - 0.33	0 - 0.63	0.12	0.06 - 0.3	0.7948	0.9
	4NV+226+	Abs_Value	13	13	0	63.84	42.61	40.67 - 87	1.8 - 148.33	61.02	31.32 - 92.36	13	13	0	77.25	69.95	39.23 - 115.28	6.18 - 203.08	46.99	23.72 - 137.98	0.5615	0.7507
	4NV+39+	Abs_Value	13	13	0	0.99	0.73	0.6 - 1.39	0.01 - 2.47	0.98	0.33 - 1.51	13	13	0	2.6	2.83	1.06 - 4.13	0.09 - 9.72	1.74	0.51 - 2.99	0.0686	0.6781
	4NV+DR+	Abs_Value	13	13	0	4.45	4.54	1.98 - 6.91	0.32 - 17.75	2.89	1.89 - 6	13	13	0	6.1	4.37	3.72 - 8.47	0.24 - 15.82	4.32	4.05 - 7.56	0.3547	0.6781
	4NV+PD-1-TIGIT-	Abs_Value	13	13	0	64.15	44.02	40.22 - 88.08	1.55 - 158.4	59.59	23.79 - 90.38	13	13	0	82.01	75.65	40.89 - 123.14	3.6 - 218.79	46.91	24.7 - 143.53	0.4708	0.718
	4NV+PD-1-TIGIT+	Abs_Value	13	13	0	1.17	0.8	0.73 - 1.6	0.12 - 2.96	1.03	0.73 - 1.25	13	13	0	2.87	4.3	0.53 - 5.21	0.12 - 15.6	1.05	0.52 - 2.65	0.1853	0.6781
	4NV+PD-1+TIGIT-	Abs_Value	13	13	0	4.79	6.39	1.31 - 8.27	0.06 - 24.15	3.42	0.79 - 6.07	13	13	0	2.71	1.97	1.64 - 3.78	0.5 - 6.2	1.72	1.22 - 4.6	0.2805	0.6781
	4NV+PD-1+TIGIT+	Abs_Value	13	13	0	1.68	1.31	0.97 - 2.39	0.07 - 4.48	1.38	0.81 - 2.15	13	13	0	2.21	2.39	0.91 - 3.51	0.17 - 8.03	1.35	0.46 - 2.5	0.4905	0.7192
	4NV+PD1+	Abs_Value	13	13	0	6.47	7.25	2.53 - 10.41	0.15 - 27.06	4.9	1.31 - 9.5	13	13	0	4.92	3.56	2.98 - 6.86	0.76 - 12.63	4.21	2.41 - 7	0.4985	0.7192
	4NV+TIGIT+	Abs_Value	13	13	0	2.85	1.84	1.85 - 3.85	0.19 - 5.28	2.47	1.65 - 4.98	13	13	0	5.08	5.67	1.99 - 8.16	0.51 - 18.1	2.26	1.08 - 7.52	0.198	0.6781
	4ЕМ	Abs_Value	13	13	0	83.51	154.98	-0.73 - 167.76	1.65 - 581.05	33.56	14.28 - 75.09	13	13	0	17.36	26.78	2.81 - 31.92	1.9 - 101.46	8.09	3.96 - 16.47	0.1538	0.6781
	4ЕМ_TH1	Abs_Value	13	13	0	23.16	22.92	10.7 - 35.61	0.28 - 69.88	15.02	3.71 - 37.18	13	13	0	7.54	14.11	-0.13 - 15.21	0.01 - 52.73	3.07	1.65 - 6.09	0.0493	0.6781
	4ЕМ_TH17	Abs_Value	13	13	0	0.03	0.03	0.01 - 0.05	0 - 0.09	0.02	0 - 0.05	13	13	0	0.03	0.06	0 - 0.06	0 - 0.21	0.01	0 - 0.02	0.923	0.9601
	4ЕМ_Th17TO1	Abs_Value	13	13	0	1.88	2.85	0.33 - 3.43	0 - 8.02	0.32	0.14 - 1.18	13	13	0	0.24	0.32	0.07 - 0.42	0 - 1.11	0.14	0.05 - 0.22	0.0621	0.6781
	4ЕМ_TH2	Abs_Value	13	13	0	0.39	0.4	0.17 - 0.61	0.03 - 1.27	0.2	0.1 - 0.69	13	13	0	0.34	0.6	0.01 - 0.67	0.01 - 2.26	0.12	0.08 - 0.23	0.8195	0.9094
	4ЕМ_TH22	Abs_Value	13	13	0	0	0	0 - 0	0 - 0.01	0	0 - 0	13	13	0	0.01	0.04	-0.01 - 0.04	0 - 0.16	0	0 - 0	0.4002	0.6866
	4ЕМ+226+	Abs_Value	13	13	0	241.9	173.33	147.68 - 336.12	62.6 - 660.98	192.43	126 - 371.99	13	13	0	156.43	96.58	103.93 - 208.93	36.18 - 318.08	115.17	96.39 - 232.48	0.1371	0.6781
	4ЕМ+39+	Abs_Value	13	13	0	51.04	39.02	29.83 - 72.26	0.65 - 127.55	40.86	19.93 - 76.25	13	13	0	41.88	36.21	22.2 - 61.56	2.04 - 139.13	41.5	18.65 - 51.06	0.5408	0.7475
	4ЕМ+DR+	Abs_Value	13	13	0	143.14	130.26	72.33 - 213.95	24.28 - 526.3	98.4	72.9 - 188.23	13	13	0	73.97	53.76	44.75 - 103.19	14.83 - 210.31	58.06	41.44 - 85.21	0.0958	0.6781
	4ЕМ+PD1-TIGIT-	Abs_Value	13	13	0	59.16	70.32	20.93 - 97.39	6.26 - 270.35	39.84	11.7 - 71.22	13	13	0	44.32	43.87	20.47 - 68.16	8.74 - 154.67	34.94	10.44 - 48.14	0.5257	0.739
	4ЕМ+PD1-TIGIT+	Abs_Value	13	13	0	7.95	12.5	1.15 - 14.75	0.32 - 45.6	2.72	1.4 - 8.4	13	13	0	6.49	8.26	2 - 10.98	0.59 - 31.87	4.02	2.89 - 6.55	0.728	0.8715
	4ЕМ+PD1+	Abs_Value	13	13	0	180.81	135.5	107.15 - 254.46	43.74 - 548.64	137.64	103.09 - 195.8	13	13	0	115.38	69.07	77.83 - 152.93	26.83 - 264.13	96.95	75.64 - 122.6	0.1385	0.6781
	4ЕМ+PD1+TIGIT-	Abs_Value	13	13	0	99.02	55.6	68.8 - 129.24	23.17 - 193.88	90.04	75.08 - 118.97	13	13	0	67.82	46.16	42.73 - 92.91	19.11 - 155.38	55.65	36.28 - 64.22	0.1331	0.6781
	4ЕМ+PD1+TIGIT+	Abs_Value	13	13	0	81.79	88.52	33.66 - 129.91	20.57 - 354.76	58.89	33.68 - 100.01	13	13	0	47.56	30.46	31 - 64.12	7.72 - 133.76	45.49	34.65 - 52.2	0.2075	0.6781
	4ЕМ+TIGIT+	Abs_Value	13	13	0	89.74	99.99	35.38 - 144.1	22.59 - 400.36	65.3	34 - 104.03	13	13	0	54.05	33.34	35.92 - 72.17	8.33 - 140.74	49.17	43.44 - 55.09	0.2414	0.6781
	4ЕМTM	Abs_Value	13	13	0	247.92	174.89	152.85 - 342.99	72.79 - 665.46	195.97	127.24 - 388.28	13	13	0	166.18	102.77	110.32 - 222.05	37.63 - 337	124.63	100.11 - 239.49	0.1623	0.6781
	4СМ	Abs_Value	13	13	0	82.66	50.33	55.3 - 110.01	18.35 - 207.67	82.63	42.12 - 89.44	13	13	0	103.94	71.91	64.85 - 143.03	15.91 - 260.46	97.48	45.2 - 151.85	0.3917	0.6866
	4СМ(СТАР2)	Abs_Value	13	13	0	65.89	37.99	45.24 - 86.54	15.11 - 150.25	71.44	33.76 - 85.67	13	13	0	78.17	54.08	48.77 - 107.57	21.2 - 184.54	63.26	33.85 - 106.54	0.5101	0.7296
	4СМ_TH1	Abs_Value	13	13	0	3.04	2.68	1.59 - 4.5	0.6 - 9.36	2.39	1.29 - 3.47	13	13	0	6.69	8.01	2.34 - 11.05	0.38 - 30.36	4.94	1.58 - 9.1	0.1408	0.6781
	4СМ_TH17	Abs_Value	13	13	0	8.34	3.64	6.36 - 10.32	3.64 - 15.46	8.09	5.18 - 10.54	13	13	0	12.96	11.28	6.83 - 19.1	1.95 - 34.36	9.47	3.78 - 16.8	0.1806	0.6781
	4СМ_Th17TO1	Abs_Value	13	13	0	1.34	1.07	0.76 - 1.92	0.21 - 3.08	1.16	0.56 - 1.82	13	13	0	2.43	2.17	1.25 - 3.61	0.19 - 8.34	2.34	1 - 2.67	0.1227	0.6781
	4СМ_TH2	Abs_Value	13	13	0	4.14	2.3	2.89 - 5.4	1.33 - 7.78	3.88	2.09 - 6.68	13	13	0	11.09	12.08	4.52 - 17.65	1.16 - 45.88	8.49	1.29 - 12.84	0.0628	0.6781
	4СМ_TH22	Abs_Value	13	13	0	1.19	1.56	0.34 - 2.04	0.11 - 5.84	0.58	0.35 - 1.17	13	13	0	2.43	3.58	0.48 - 4.38	0.06 - 13.33	0.87	0.72 - 3.09	0.2681	0.6781
	4СМ+226+	Abs_Value	13	13	0	63.24	36.6	43.34 - 83.13	14.8 - 144.2	68.05	31.79 - 79.68	13	13	0	74.53	51.68	46.43 - 102.62	19.64 - 178.97	60.07	32.98 - 98.97	0.5272	0.739
	4СМ+39+	Abs_Value	13	13	0	14.91	11.7	8.55 - 21.26	0.06 - 40.39	12.19	7.06 - 23.23	13	13	0	21.13	30.82	4.37 - 37.88	0.51 - 118.64	13.06	6.43 - 21.8	0.5064	0.7264
	4СМ+DR+	Abs_Value	13	13	0	14.01	13.93	6.44 - 21.58	3.76 - 45.11	7.05	5.05 - 14.82	13	13	0	20.3	19.59	9.65 - 30.95	3.93 - 64.82	10.94	7.81 - 24.58	0.3556	0.6781
	4СМ+PD1-TIGIT-	Abs_Value	13	13	0	20.25	14.14	12.57 - 27.94	4.29 - 55.03	18.98	7.57 - 25.24	13	13	0	27.33	20.43	16.22 - 38.43	2.11 - 68.44	22.11	12.3 - 37.2	0.3161	0.6781
	4СМ+PD1-TIGIT+	Abs_Value	13	13	0	3.66	4.04	1.46 - 5.86	0.36 - 15.7	2.8	1.36 - 3.88	13	13	0	4.74	3.84	2.65 - 6.82	0.21 - 13.54	4.14	1.62 - 6.43	0.4918	0.7192
	4СМ+PD1+	Abs_Value	13	13	0	41.98	30.47	25.41 - 58.54	9.99 - 123.91	42.49	20.33 - 50.99	13	13	0	46.1	35.48	26.81 - 65.39	3.36 - 122.72	37.27	22.3 - 73.22	0.7533	0.884
	4СМ+PD1+TIGIT-	Abs_Value	13	13	0	16.12	9.75	10.82 - 21.42	3.23 - 31.56	17.02	6.71 - 24.01	13	13	0	17.93	14.88	9.84 - 26.02	1.56 - 55.65	13.15	8.49 - 25.36	0.7172	0.867
	4СМ+PD1+TIGIT+	Abs_Value	13	13	0	25.86	22.41	13.68 - 38.04	5.36 - 92.35	26.08	10.22 - 29.56	13	13	0	28.18	21.56	16.45 - 39.9	1.8 - 67.07	20.7	16.4 - 42.34	0.7908	0.9
4СМ+TIGIT+	Abs_Value	13	13	0	29.52	23.78	16.6 - 42.45	6.2 - 97.93	28.45	12.82 - 35.43	13	13	0	32.91	24.07	19.83 - 46	4.81 - 74.86	22.06	20.58 - 48.77	0.7209	0.8691
4ТM_TH1	Abs_Value	13	13	0	23.31	14.47	15.45 - 31.18	3.7 - 54.39	19.8	12 - 27.68	13	13	0	17.67	22.34	5.53 - 29.81	0.31 - 88.8	12.46	6.04 - 17.61	0.4532	0.7124
4ТM_TH17	Abs_Value	13	13	0	10.76	7.93	6.45 - 15.07	1.32 - 26.41	6.78	5.51 - 14.52	13	13	0	17.44	20.5	6.3 - 28.58	2.44 - 68.85	11.71	5.53 - 16.7	0.2899	0.6781
4ТM_Th17TO1	Abs_Value	13	13	0	8.52	7.97	4.19 - 12.86	1.35 - 28.42	5.41	3.78 - 9.57	13	13	0	8.54	9.73	3.25 - 13.83	0.13 - 35.59	6.45	2.87 - 9.11	0.9959	0.9959
4ТM_TH2	Abs_Value	13	13	0	5.43	6.04	2.14 - 8.71	0.67 - 19.04	2.96	1.96 - 4.7	13	13	0	9.45	10.03	4 - 14.91	0.77 - 33.45	3.13	1.44 - 15.46	0.2299	0.6781
4ТM_TH22	Abs_Value	13	13	0	7.06	6.43	3.56 - 10.56	0.34 - 22.69	6.47	2.19 - 8.34	13	13	0	9.1	10.7	3.28 - 14.91	1.11 - 38.35	4.1	2.72 - 13.99	0.563	0.7507
4ТREG	Abs_Value	13	13	0	2.67	3.56	0.73 - 4.6	0.18 - 14.06	1.89	0.91 - 2.05	13	13	0	3.25	3.83	1.17 - 5.33	0.49 - 13.02	1.36	1.12 - 3.25	0.6927	0.8514
4ТREG(СТАР2)	Abs_Value	13	13	0	166.74	142.02	89.54 - 243.94	52.54 - 539.05	122.66	94.71 - 157.59	13	13	0	176.73	132	104.98 - 248.49	45.87 - 554.23	125.25	100.3 - 206.41	0.8542	0.9205
4ТREG_TH1	Abs_Value	13	13	0	0.34	0.18	0.25 - 0.44	0.12 - 0.68	0.26	0.23 - 0.45	13	13	0	0.36	0.37	0.16 - 0.56	0.09 - 1.26	0.19	0.14 - 0.39	0.8509	0.9201
4ТREG_TH17	Abs_Value	13	13	0	4.58	3.04	2.93 - 6.24	1.23 - 13.43	4.22	2.99 - 5.13	13	13	0	6.46	4.28	4.13 - 8.79	2.62 - 15.15	4.65	3.37 - 7.8	0.2109	0.6781
4ТREG_Th17TO1	Abs_Value	13	13	0	0.1	0.09	0.05 - 0.14	0.02 - 0.3	0.06	0.03 - 0.16	13	13	0	0.15	0.14	0.07 - 0.22	0 - 0.38	0.06	0.05 - 0.23	0.2956	0.6781
4ТREG_TH2	Abs_Value	13	13	0	2.41	1.05	1.84 - 2.99	1.11 - 4.61	2.24	1.58 - 3.13	13	13	0	2.79	1.48	1.99 - 3.59	1.05 - 6.08	3.1	1.6 - 3.72	0.462	0.7142
4ТREG_TH22	Abs_Value	13	13	0	6.66	9.3	1.6 - 11.71	0.91 - 36.5	4.71	1.83 - 7.21	13	13	0	5.61	4.82	2.98 - 8.23	1.59 - 16.79	3.95	3.02 - 5.3	0.7225	0.8691
4ТЕ	Abs_Value	13	13	0	25.68	28.83	10.01 - 41.35	0.7 - 97.53	14.36	5.41 - 36.71	13	13	0	21.25	36.25	1.54 - 40.95	0.66 - 114.7	6.81	1.17 - 15.4	0.7331	0.8733
4ТЕ(СТАР2)	Abs_Value	13	13	0	69.3	56.53	38.57 - 100.03	21.6 - 217.76	46.95	33.64 - 77.25	13	13	0	64.29	62.48	30.33 - 98.26	11.38 - 207.55	49.68	22.31 - 72.87	0.8323	0.91
4ТЕ_TH1	Abs_Value	13	13	0	6.79	6.41	3.31 - 10.27	0.05 - 20.2	3.66	1.66 - 10.59	13	13	0	7.37	15.9	-1.27 - 16.01	0.01 - 52.19	0.58	0.33 - 3.53	0.9044	0.9546
4ТЕ_TH17	Abs_Value	13	13	0	0.01	0.01	0 - 0.01	0 - 0.04	0	0 - 0.01	13	13	0	0.01	0.01	0 - 0.01	0 - 0.01	0.01	0 - 0.01	0.4966	0.7192
4ТЕ_Th17TO1	Abs_Value	13	13	0	0.19	0.26	0.05 - 0.33	0 - 0.76	0.05	0.02 - 0.21	13	13	0	0.13	0.23	0 - 0.25	0 - 0.78	0.02	0 - 0.15	0.5389	0.7475
4ТЕ_TH2	Abs_Value	13	13	0	0.2	0.24	0.07 - 0.33	0.01 - 0.83	0.11	0.04 - 0.35	13	13	0	0.44	0.72	0.05 - 0.82	0 - 2.33	0.16	0.03 - 0.27	0.2834	0.6781
4ТЕ_TH22	Abs_Value	13	13	0	0.01	0.01	0 - 0.02	0 - 0.05	0	0 - 0.02	13	13	0	0	0.01	0 - 0.01	0 - 0.02	0	0 - 0	0.2025	0.6781
4ТЕ+226+	Abs_Value	13	13	0	65.9	56.15	35.37 - 96.42	17.35 - 215.7	42.5	29.7 - 75.76	13	13	0	59.23	61.82	25.62 - 92.84	10.21 - 202.6	44.9	16.88 - 66.16	0.776	0.8962
4ТЕ+39+	Abs_Value	13	13	0	5.97	3.71	3.96 - 7.99	0.43 - 11.93	5.87	3.68 - 7.92	13	13	0	8.84	10.79	2.97 - 14.7	0.21 - 33.74	4.21	2.04 - 10.76	0.3801	0.6866
4ТЕ+DR+	Abs_Value	13	13	0	42.24	43.71	18.48 - 66	5.42 - 168.72	28.9	15.47 - 52.93	13	13	0	33.35	48.35	7.07 - 59.63	3.27 - 156.97	11.63	6.03 - 29.26	0.6274	0.7976
4ТЕ+PD-1-TIGIT-	Abs_Value	13	13	0	21.71	21.28	10.14 - 33.28	4.28 - 78.19	11.57	8.36 - 33.76	13	13	0	31.59	38.22	10.81 - 52.37	1.94 - 132.13	15.24	6.25 - 29.36	0.4258	0.7016
4ТЕ+PD-1-TIGIT+	Abs_Value	13	13	0	3.64	4.06	1.43 - 5.85	0.48 - 16.23	2.38	1.68 - 3.48	13	13	0	3.28	3.04	1.63 - 4.94	0.35 - 11.49	2.91	0.97 - 3.98	0.802	0.9009
4ТЕ+PD-1+	Abs_Value	13	13	0	43.94	41.38	21.45 - 66.44	5.49 - 162.5	35.01	19.7 - 60.4	13	13	0	29.42	25.64	15.48 - 43.36	4.99 - 90	15.98	11.62 - 37.85	0.2949	0.6781
4ТЕ+PD-1+TIGIT-	Abs_Value	13	13	0	26.62	24.8	13.14 - 40.11	2.04 - 86.28	19.27	8.78 - 45.33	13	13	0	19.02	19.62	8.35 - 29.69	1.62 - 67.21	10.7	5.15 - 25.97	0.395	0.6866
4ТЕ+PD-1+TIGIT+	Abs_Value	13	13	0	17.32	19.33	6.81 - 27.83	3.45 - 76.22	13.34	5.89 - 15.88	13	13	0	10.4	7.98	6.06 - 14.74	2.91 - 25.6	9.16	3.58 - 14.14	0.2503	0.6781
4ТЕ+TIGIT+	Abs_Value	13	13	0	20.96	23.17	8.36 - 33.56	6.37 - 92.45	14.32	7.06 - 18.99	13	13	0	13.68	10.38	8.04 - 19.33	3.26 - 34.28	10.04	4.92 - 17.05	0.3162	0.6781
4ТМ	Abs_Value	13	13	0	165.75	92.33	115.55 - 215.94	55.5 - 339.62	164.24	81.42 - 247.66	13	13	0	141.19	99.78	86.95 - 195.42	36.46 - 328.01	100.61	81.37 - 204.29	0.521	0.7387
8+	Abs_Value	13	13	0	973.01	747.72	566.54 - 1379.47	57.71 - 2452.07	696.99	568.49 - 1161.65	13	13	0	546.63	640.27	198.58 - 894.69	80.74 - 2238.8	261.13	202.41 - 598.49	0.1318	0.6781
8+ (IM STAT)	Abs_Value	13	13	0	1085.12	786.37	657.64 - 1512.59	70.67 - 2683.52	803.31	580.14 - 1328.08	13	13	0	682.26	755.81	271.4 - 1093.12	101.71 - 2673.64	370.08	238.86 - 856.27	0.1955	0.6781
8+226+	Abs_Value	13	13	0	1425.23	900.19	935.88 - 1914.58	104.01 - 3338.48	1387.98	879.96 - 1695.87	13	13	0	897.07	877.53	420.04 - 1374.1	239.21 - 3240.63	640.91	367.77 - 988.26	0.1429	0.6781
8+39+	Abs_Value	13	13	0	149.18	125.68	80.86 - 217.5	6.69 - 401.66	156.01	25.68 - 185.72	13	13	0	124.59	156.16	39.7 - 209.48	3.22 - 554.73	73.44	39.08 - 132.9	0.6625	0.8273
8+DR+	Abs_Value	13	13	0	974.76	581.03	658.91 - 1290.61	77.9 - 2000.24	936.64	510.81 - 1096.91	13	13	0	655.65	764.95	239.82 - 1071.49	43.35 - 2729.41	426.73	213.57 - 575.13	0.2435	0.6781
8+PD-1-TIGIT-	Abs_Value	13	13	0	507.33	502.02	234.43 - 780.23	38.12 - 1570.48	378.56	162 - 611.39	13	13	0	333.33	368.67	132.92 - 533.73	70.59 - 1371.15	188.7	106.63 - 341.99	0.3247	0.6781
8+PD-1-TIGIT+	Abs_Value	13	13	0	417.34	339.24	232.92 - 601.75	74.35 - 1183.71	385.59	155.15 - 548.77	13	13	0	350.04	412.25	125.94 - 574.14	10.16 - 1209.08	151.69	95.73 - 384	0.6537	0.8226
8+PD-1+	Abs_Value	13	13	0	558.18	542.33	263.36 - 852.99	49.89 - 2097	491.09	237.65 - 612.58	13	13	0	305.61	194.81	199.71 - 411.51	93.13 - 731.94	253.18	149.01 - 438.12	0.1348	0.6781
8+PD-1+TIGIT-	Abs_Value	13	13	0	185.76	205.22	74.2 - 297.32	9.05 - 678.2	96.85	71.47 - 262.8	13	13	0	96.17	103.78	39.75 - 152.58	10.94 - 364.07	60.93	36.55 - 101.92	0.1774	0.6781
8+PD-1+TIGIT+	Abs_Value	13	13	0	372.41	395.78	157.27 - 587.56	40.84 - 1584.15	337.51	134.58 - 412.25	13	13	0	209.44	130.02	138.76 - 280.12	47.09 - 434.48	141.45	123.92 - 304.44	0.1794	0.6781
8+TIGIT+	Abs_Value	13	13	0	789.75	541.86	495.19 - 1084.31	115.8 - 2034.4	738.06	518.85 - 986.73	13	13	0	559.48	510.03	282.22 - 836.74	57.24 - 1576.95	372.8	202.83 - 818.49	0.2756	0.6781
8EMTM	Abs_Value	13	13	0	347.92	377.57	142.67 - 553.16	47.77 - 1398.17	228.63	102.82 - 403.3	13	13	0	121.21	97.04	68.46 - 173.96	13.51 - 335.18	95.26	39.69 - 172.92	0.0553	0.6781
8EMTM+226+	Abs_Value	13	13	0	337.02	376.23	132.5 - 541.54	28.26 - 1379.5	194.8	96.04 - 400.41	13	13	0	103.51	83.81	57.95 - 149.07	9.76 - 283.7	83.19	35.2 - 160.55	0.0476	0.6781
8EMTM+39+	Abs_Value	13	13	0	48.82	39.13	27.55 - 70.09	0.18 - 109.55	59.12	5.97 - 71.91	13	13	0	21.96	19.26	11.49 - 32.43	0.97 - 52.65	22.44	4.66 - 39.32	0.0398	0.6781
8EMTM+DR+	Abs_Value	13	13	0	255.33	238.84	125.5 - 385.16	34.54 - 830.52	168.04	77.85 - 362.11	13	13	0	95.55	84.09	49.84 - 141.26	9.62 - 298.35	72.75	36.73 - 130.68	0.0381	0.6781
8EMTM+PD-1-TIGIT-	Abs_Value	13	13	0	139.91	302.81	-24.7 - 304.51	4.45 - 1106.11	38.89	21.54 - 55.16	13	13	0	31.53	32.99	13.6 - 49.47	3.23 - 96.46	18.1	11.17 - 41.75	0.2232	0.6781
8EMTM+PD-1-TIGIT+	Abs_Value	13	13	0	74.21	86.1	27.4 - 121.01	7.63 - 242.77	24.48	12.4 - 102.51	13	13	0	27.79	34.5	9.04 - 46.55	0.5 - 119.96	8.44	5.38 - 32.25	0.0904	0.6781
8EMTM+PD-1+	Abs_Value	13	13	0	133.8	119.06	69.08 - 198.52	26.27 - 466.71	113.35	50.13 - 177.14	13	13	0	61.88	40.26	40 - 83.77	9.78 - 119.51	46.3	25.86 - 100.57	0.0572	0.6781
8EMTM+PD-1+TIGIT-	Abs_Value	13	13	0	48.19	71.54	9.31 - 87.08	4.29 - 268.37	24.49	11.08 - 37.34	13	13	0	16.93	15.96	8.25 - 25.6	4.23 - 56.1	10.28	5.44 - 19.35	0.1477	0.6781
8EMTM+PD-1+TIGIT+	Abs_Value	13	13	0	85.61	60.36	52.8 - 118.42	18.92 - 198.34	51.77	42.13 - 115.72	13	13	0	44.95	33.54	26.72 - 63.19	5.55 - 107.53	34.48	20.57 - 61.05	0.0473	0.6781
8EMTM+TIGIT+	Abs_Value	13	13	0	159.81	106.94	101.68 - 217.95	28.09 - 300.85	188.17	51.37 - 267.22	13	13	0	72.75	63.36	38.31 - 107.19	6.05 - 220.12	65.96	25.68 - 91.65	0.0203	0.6781
8NV	Abs_Value	13	13	0	45.79	28.32	30.4 - 61.18	8.16 - 95.21	33.84	25.59 - 65.7	13	13	0	58.65	50.58	31.15 - 86.14	4.62 - 189.4	63.06	19.96 - 75.23	0.4339	0.7016
8NV(СТАР2)	Abs_Value	13	13	0	33.1	22.31	20.97 - 45.23	3.18 - 72.59	32.88	19.17 - 37.83	13	13	0	67.91	68.16	30.86 - 104.96	4.23 - 232.76	53.18	17.68 - 97.88	0.1012	0.6781
8NV+226+	Abs_Value	13	13	0	27.93	18.66	17.79 - 38.07	3.13 - 63.08	28.59	13.02 - 32.37	13	13	0	57.09	62.6	23.06 - 91.12	3.16 - 230.07	42.18	16.37 - 86.19	0.1296	0.6781
8NV+39+	Abs_Value	13	13	0	1.43	1.01	0.88 - 1.97	0.03 - 3.49	1.2	0.63 - 2.01	13	13	0	6.03	8.56	1.38 - 10.68	0.15 - 30.4	1.66	0.7 - 8.3	0.0776	0.6781
8NV+DR+	Abs_Value	13	13	0	2.85	1.73	1.91 - 3.79	0.61 - 5.76	3.32	1.55 - 3.99	13	13	0	12.46	20.78	1.17 - 23.76	0.52 - 79.65	6.78	2.29 - 11.12	0.122	0.6781
8NV+PD-1-TIGIT-	Abs_Value	13	13	0	26.32	19.51	15.71 - 36.93	1.66 - 66.52	23.52	13.57 - 31.19	13	13	0	46.66	61.95	12.99 - 80.34	1.58 - 223.18	27.39	5.68 - 64.64	0.2772	0.6781
8NV+PD-1-TIGIT+	Abs_Value	13	13	0	2.68	3.16	0.96 - 4.41	0.41 - 11.42	1.59	0.81 - 2.43	13	13	0	13.29	33.02	-4.65 - 31.24	0.08 - 122.5	4.44	0.7 - 7.9	0.2708	0.6781
8NV+PD-1+	Abs_Value	13	13	0	4.1	4	1.92 - 6.27	0.06 - 14.35	3.65	1.11 - 5.19	13	13	0	7.95	6.45	4.45 - 11.46	0.97 - 19.52	7.03	1.76 - 13.46	0.0818	0.6781
8NV+PD-1+TIGIT-	Abs_Value	13	13	0	1.92	2.63	0.49 - 3.35	0 - 9.29	1.1	0.26 - 2.14	13	13	0	2.55	4.08	0.33 - 4.76	0.01 - 12.11	0.95	0.33 - 1.92	0.6453	0.8141
8NV+PD-1+TIGIT+	Abs_Value	13	13	0	2.18	1.69	1.26 - 3.1	0.06 - 5.06	2.04	0.57 - 3.18	13	13	0	5.41	5.98	2.16 - 8.66	0.22 - 17.65	2.61	0.96 - 7.01	0.0823	0.6781
8NV+TIGIT+	Abs_Value	13	13	0	4.86	3.3	3.07 - 6.66	0.78 - 11.87	4.46	2.67 - 5.87	13	13	0	18.7	37.34	-1.59 - 39	0.34 - 140.04	7	2.51 - 15.5	0.2075	0.6781
8TREG	Abs_Value	13	13	0	965.31	737.01	564.66 - 1365.95	59.02 - 2419.83	706.42	583.47 - 1219.41	13	13	0	556.75	632.79	212.76 - 900.74	76.34 - 2160.15	285.5	205.13 - 632.61	0.1428	0.6781
8ЕМ	Abs_Value	13	13	0	311.07	295.94	150.2 - 471.94	24.53 - 949.3	173.01	112.84 - 509.36	13	13	0	94.72	105.65	37.29 - 152.15	9.71 - 355.83	43.06	20.95 - 153.4	0.0254	0.6781
8СМ	Abs_Value	13	13	0	15.13	15.6	6.65 - 23.61	1.96 - 50.29	7.37	6.27 - 22.09	13	13	0	30.87	44.13	6.88 - 54.86	1.67 - 142.48	10.98	7.36 - 18.61	0.2441	0.6781
8СМ(СТАР2)	Abs_Value	13	13	0	11.88	13.94	4.3 - 19.46	1.34 - 46.77	7.23	3.84 - 11.07	13	13	0	16.92	18.98	6.6 - 27.24	0.7 - 60.65	7.86	4.01 - 18.59	0.4483	0.7069
8СМ+226+	Abs_Value	13	13	0	10.47	12.38	3.74 - 17.2	1.34 - 39.93	6.41	3.65 - 8.63	13	13	0	12.1	13.57	4.72 - 19.47	0.67 - 48.69	5.72	3.42 - 14.13	0.7518	0.884
8СМ+39+	Abs_Value	13	13	0	3.33	5.24	0.48 - 6.18	0.01 - 19.68	1.82	0.38 - 2.84	13	13	0	6.07	12.52	-0.73 - 12.88	0.09 - 46.33	1.96	0.45 - 3.22	0.4763	0.7185
8СМ+DR+	Abs_Value	13	13	0	8.74	11.98	2.23 - 15.25	0.88 - 44.36	4.53	2.55 - 7.74	13	13	0	13.2	16.24	4.37 - 22.02	0.31 - 51.36	5.17	2.6 - 14.49	0.4346	0.7016
8СМ+PD-1-TIGIT-	Abs_Value	13	13	0	2.9	5.41	-0.04 - 5.84	0.16 - 20.49	1.44	0.48 - 2.54	13	13	0	1.96	1.61	1.08 - 2.84	0.4 - 5.04	1.23	0.74 - 3.13	0.5569	0.7482
8СМ+PD-1-TIGIT+	Abs_Value	13	13	0	2.07	2.82	0.54 - 3.6	0.33 - 11.01	1.15	0.76 - 2.16	13	13	0	2.86	3.64	0.88 - 4.84	0.03 - 10.87	1.04	0.69 - 2.58	0.5424	0.7475
8СМ+PD-1+	Abs_Value	13	13	0	6.91	11.09	0.87 - 12.94	0.1 - 42.6	3.62	2.28 - 6.34	13	13	0	12.1	14.82	4.04 - 20.16	0.27 - 50.7	4.48	3.17 - 15.62	0.3226	0.6781
8СМ+PD-1+TIGIT-	Abs_Value	13	13	0	0.93	1.19	0.28 - 1.57	0.01 - 3.85	0.47	0.36 - 0.73	13	13	0	0.97	1.09	0.38 - 1.57	0.02 - 3.03	0.37	0.36 - 1.87	0.9152	0.956
8СМ+PD-1+TIGIT+	Abs_Value	13	13	0	5.98	10.14	0.47 - 11.49	0.09 - 38.76	3.15	1.56 - 5.57	13	13	0	11.13	14.46	3.27 - 18.98	0.21 - 48.83	4.1	2.81 - 13.11	0.305	0.6781
8СМ+TIGIT+	Abs_Value	13	13	0	8.05	10.57	2.31 - 13.8	0.84 - 40.38	4.83	1.89 - 7.96	13	13	0	13.99	17.4	4.53 - 23.44	0.24 - 54.85	6.27	3.21 - 14.15	0.3057	0.6781
8ТЕ	Abs_Value	13	13	0	869.23	644.32	518.97 - 1219.49	48.7 - 2173	678.5	416.74 - 1057.9	13	13	0	606.45	793.52	175.08 - 1037.81	134.4 - 2935.15	219.33	198.73 - 688.04	0.3636	0.6856
8ТЕ(СТАР2)	Abs_Value	13	13	0	1088.37	788.89	659.52 - 1517.21	93.35 - 2737.76	862.07	555.03 - 1157.21	13	13	0	781.56	896.57	294.18 - 1268.94	166.03 - 3213.82	433.23	252.42 - 870.46	0.3637	0.6856
8ТЕ+226+	Abs_Value	13	13	0	1049.05	777.66	626.31 - 1471.8	61.08 - 2644.03	809.38	490.38 - 1109.6	13	13	0	723.53	873.45	248.72 - 1198.35	102.22 - 3154.74	330.69	241 - 755.51	0.3257	0.6781
8ТЕ+39+	Abs_Value	13	13	0	95.14	95.05	43.47 - 146.81	6 - 323.26	59.84	17.3 - 125.59	13	13	0	89.92	138.94	14.4 - 165.45	0.86 - 469.2	34.47	19.83 - 82.62	0.912	0.956
8ТЕ+DR+	Abs_Value	13	13	0	708.11	502.81	434.78 - 981.44	41.33 - 1775.21	735.53	301.99 - 890.82	13	13	0	533.66	738.23	132.35 - 934.97	21.59 - 2669.82	281.95	170.74 - 471.59	0.489	0.7192
8ТЕ+PD-1-TIGIT-	Abs_Value	13	13	0	337.96	331	158.02 - 517.9	15.42 - 1169.4	281.68	96.42 - 398.93	13	13	0	252.89	368.08	52.79 - 452.98	20.48 - 1323.33	90.82	75.37 - 235.12	0.5414	0.7475
8ТЕ+PD-1-TIGIT+	Abs_Value	13	13	0	336.82	282.52	183.24 - 490.4	55.35 - 990.18	230.35	129.05 - 524.75	13	13	0	305.71	393.99	91.53 - 519.88	9.5 - 1190.46	115.13	84.56 - 360.57	0.8192	0.9094
8ТЕ+PD-1+	Abs_Value	13	13	0	413.59	484.86	150.01 - 677.16	22.59 - 1901.19	292.97	194.23 - 413.6	13	13	0	222.97	188.23	120.64 - 325.29	35.09 - 700.03	158.31	79.05 - 286.81	0.2055	0.6781
8ТЕ+PD-1+TIGIT-	Abs_Value	13	13	0	134.91	151.57	52.51 - 217.3	3.74 - 471.95	77.76	39.32 - 156.96	13	13	0	75.64	97.57	22.6 - 128.69	5.67 - 353.82	34.83	20.61 - 91.8	0.2494	0.6781
8ТЕ+PD-1+TIGIT+	Abs_Value	13	13	0	278.68	365.98	79.73 - 477.63	17.97 - 1429.23	170.79	92.76 - 256.65	13	13	0	147.32	116.29	84.1 - 210.54	29.42 - 357.6	97.13	47.51 - 213.88	0.2372	0.6781
8ТЕ+TIGIT+	Abs_Value	13	13	0	615.5	501.71	342.77 - 888.24	73.32 - 1866.88	534.52	260.99 - 702.42	13	13	0	453.03	479.73	192.25 - 713.81	50.85 - 1536.67	255.67	138.62 - 699.97	0.4071	0.6902
8ТМ	Abs_Value	13	13	0	91.97	114.04	29.98 - 153.97	8.37 - 434.09	50.69	27.35 - 101.77	13	13	0	40.32	29.2	24.44 - 56.19	7.07 - 92.45	41.07	15.16 - 59.97	0.1366	0.6781
TREG_CM	Abs_Value	13	13	0	2.42	1.84	1.42 - 3.42	0.14 - 6.15	2.01	1.33 - 2.54	13	13	0	2.71	1.9	1.68 - 3.74	0.28 - 6.58	2.28	1.11 - 3.81	0.6901	0.8514
TREG_EMTM	Abs_Value	13	13	0	24.38	24.24	11.2 - 37.55	5.53 - 99.28	18.31	13.69 - 22.04	13	13	0	25.58	19.9	14.76 - 36.39	7.98 - 69.64	17.52	13.91 - 21.39	0.8914	0.9432
TREG_NV	Abs_Value	13	13	0	3.55	3.84	1.47 - 5.64	0.06 - 14.23	1.97	0.89 - 5.29	13	13	0	2.64	2.1	1.5 - 3.79	0.25 - 6.8	2.13	1.02 - 3.33	0.4631	0.7142
TREG_TE	Abs_Value	13	13	0	4.21	2.25	2.99 - 5.43	1.56 - 7.78	4.02	2.5 - 6.18	13	13	0	5.64	5.48	2.66 - 8.62	0.86 - 21.61	4.58	2.18 - 5.65	0.3977	0.6866
TREG+226-TIGIT-	Abs_Value	13	13	0	2.65	2.38	1.36 - 3.94	0.1 - 8.35	1.52	0.93 - 3.87	13	13	0	2.11	1.55	1.26 - 2.95	0.36 - 6.14	1.57	1.19 - 2.92	0.4981	0.7192
TREG+226-TIGIT+	Abs_Value	13	13	0	8.55	9.6	3.33 - 13.77	1.64 - 38.5	6.04	5.1 - 8.12	13	13	0	9.68	9.67	4.43 - 14.94	2.48 - 38.88	6.4	4.11 - 10.14	0.7663	0.8892
TREG+226+	Abs_Value	13	13	0	23.33	17.35	13.9 - 32.76	5.38 - 73.34	18.84	18.45 - 20.72	13	13	0	24.82	15.9	16.17 - 33.46	11.37 - 58.24	16.66	14.9 - 27.08	0.8218	0.9094
TREG+226+TIGIT-	Abs_Value	13	13	0	3.58	1.73	2.64 - 4.51	0.75 - 6.7	3.71	2.55 - 4.11	13	13	0	3.56	2.26	2.33 - 4.79	0.51 - 7.21	3.12	1.9 - 5.7	0.9829	0.9889
TREG+226+TIGIT+	Abs_Value	13	13	0	19.75	16.29	10.9 - 28.61	4.63 - 66.64	15.88	12.83 - 17.82	13	13	0	21.26	15.02	13.09 - 29.43	9.07 - 53.05	13.69	11.28 - 24.82	0.8088	0.9044
TREG+39+	Abs_Value	13	13	0	25.41	26.51	11 - 39.82	2.29 - 106.13	19.11	14.33 - 23.39	13	13	0	23.29	14.76	15.27 - 31.32	3.34 - 61.46	21.21	14.48 - 30.08	0.8044	0.9015
TREG+DR+	Abs_Value	13	13	0	22.98	20.31	11.94 - 34.02	5.52 - 82.63	17.99	13.55 - 21.67	13	13	0	26.36	22.63	14.06 - 38.66	9.15 - 87.97	19.48	11.7 - 26.27	0.6923	0.8514
TREG+PD-1+	Abs_Value	13	13	0	17.32	19.33	6.81 - 27.83	3.42 - 77.43	12.22	7.39 - 18.37	13	13	0	16.03	11.14	9.98 - 22.09	4.48 - 48.13	13.81	11.21 - 15.23	0.8377	0.9139
TREG+TIGIT+	Abs_Value	13	13	0	28.3	25.29	14.56 - 42.05	6.62 - 105.14	21.63	19.46 - 22.95	13	13	0	30.94	23.05	18.41 - 43.47	11.55 - 89.91	21.94	17.8 - 37.88	0.7833	0.8997
+90	4_TFH	Abs_Value	39	39	0	16.33	13.43	12.11 - 20.55	0 - 61.09	13.26	8.06 - 22.35	28	28	0	14.42	12.25	9.88 - 18.96	1.1 - 45.51	10.81	4.76 - 18.65	0.5483	0.7482
	4_TH1	Abs_Value	39	39	0	35.1	96.74	4.74 - 65.47	0.16 - 608.2	10.47	5.84 - 24.35	28	28	0	17.24	24.14	8.3 - 26.19	0.03 - 113.81	9.26	4.29 - 17.68	0.2747	0.6781
	4_TH17	Abs_Value	39	39	0	13.84	8.71	11.11 - 16.57	0.02 - 34.84	12.75	6.74 - 18.73	28	28	0	13.49	9.77	9.87 - 17.11	0.86 - 40.22	11.94	6.64 - 20.16	0.8803	0.9395
	4_Th17TO1	Abs_Value	39	39	0	3.39	3.17	2.4 - 4.39	0.03 - 17.49	2.3	1.43 - 4.6	28	28	0	3.75	4.89	1.93 - 5.56	0.05 - 18.77	2.09	0.78 - 3.94	0.7375	0.8764
	4_TH2	Abs_Value	39	39	0	13.04	22.22	6.06 - 20.01	0.02 - 143.45	8.78	5.17 - 13.6	28	28	0	13.67	9.99	9.97 - 17.37	0.58 - 37.81	10.16	6.22 - 19.3	0.8754	0.9383
	4_TH22	Abs_Value	39	39	0	3.91	3.18	2.91 - 4.91	0 - 13.92	3.12	1.51 - 5.85	28	28	0	4.25	3.86	2.82 - 5.68	0.02 - 14.86	3.06	1.61 - 5.72	0.7032	0.8564
	4+	Abs_Value	39	39	0	70.84	76.56	46.81 - 94.87	0.01 - 430.92	59.43	20.66 - 92.9	28	28	0	83.71	46.4	66.52 - 100.89	1.65 - 194.52	81.98	48.2 - 121.66	0.3964	0.6866
	4+ (IM STAT)	Abs_Value	39	39	0	65.93	72.58	43.14 - 88.71	0 - 397.77	47.44	19.37 - 82.94	28	28	0	74.78	44.66	58.24 - 91.32	2.77 - 186.76	77.26	37.17 - 96.8	0.5398	0.7475
	4+226+	Abs_Value	39	39	0	155.71	179.73	99.3 - 212.12	0.31 - 1046.46	128.08	68.58 - 160.33	28	28	0	132.45	73.4	105.26 - 159.64	16.89 - 269.89	131.07	76.06 - 166.98	0.4698	0.718
	4+39+	Abs_Value	39	39	0	39.48	31.48	29.6 - 49.36	0.07 - 135.08	37.22	19.19 - 54.81	28	28	0	40.21	33.36	27.86 - 52.57	0.49 - 110.79	34.79	9.36 - 63.23	0.9278	0.963
	4+DR+	Abs_Value	39	39	0	102.8	170.68	49.23 - 156.37	0.05 - 960.16	65.32	31.43 - 87.28	28	28	0	64.77	56.51	43.84 - 85.71	4.16 - 250.67	51.29	24.28 - 82.42	0.2011	0.6781
	4+PD-1-TIGIT-	Abs_Value	39	39	0	48.64	34	37.97 - 59.31	0.03 - 131.28	34.59	25.53 - 75.58	28	28	0	55.29	44.79	38.69 - 71.88	6.67 - 166.24	41.71	22.29 - 76.75	0.5119	0.73
	4+PD-1-TIGIT+	Abs_Value	39	39	0	8.16	24.25	0.55 - 15.77	0 - 154.31	3.78	1.76 - 6.59	28	28	0	4.87	3.39	3.61 - 6.12	0.25 - 12.65	3.76	2.29 - 7.19	0.4071	0.6902
	4+PD-1+	Abs_Value	39	39	0	108.13	148.15	61.64 - 154.63	0.33 - 789.05	77.82	46.08 - 97.71	28	28	0	82.56	62.59	59.37 - 105.74	7.01 - 256.14	70.45	36.32 - 110.92	0.3389	0.6781
	4+PD-1+TIGIT-	Abs_Value	39	39	0	55.79	53.07	39.14 - 72.45	0.28 - 262.81	35.44	26.29 - 61.74	28	28	0	47.04	40.36	32.09 - 61.98	3.7 - 176.04	35.9	21.62 - 63.3	0.4459	0.7054
	4+PD-1+TIGIT+	Abs_Value	39	39	0	52.34	100.95	20.66 - 84.03	0.05 - 526.23	28.49	18 - 44.4	28	28	0	35.52	29.85	24.47 - 46.58	3.31 - 119.05	23.88	15.59 - 49.99	0.3309	0.6781
	4+TIGIT+	Abs_Value	39	39	0	60.51	121.07	22.51 - 98.51	0.05 - 680.54	31.37	20.51 - 50.09	28	28	0	40.39	31.42	28.75 - 52.03	4.89 - 130.02	28.02	20.05 - 55.79	0.3264	0.6781
	4NV	Abs_Value	39	39	0	17.03	15.12	12.28 - 21.78	0 - 55.9	12.73	6.44 - 21.38	28	28	0	28.77	26.38	19 - 38.55	3.15 - 110.75	18.27	8.39 - 39.7	0.0404	0.6781
	4NV(СТАР2)	Abs_Value	39	39	0	15.95	15.14	11.2 - 20.7	0 - 54	10.42	6.42 - 18.05	28	28	0	26.63	24.08	17.71 - 35.55	4.36 - 99.11	18.69	7.91 - 35.34	0.0444	0.6781
	4NV_TH1	Abs_Value	39	39	0	1.27	1.37	0.84 - 1.7	0 - 6.02	0.92	0.31 - 1.7	28	28	0	1.99	2.02	1.24 - 2.74	0.01 - 7.62	1.39	0.42 - 2.94	0.1094	0.6781
	4NV_TH17	Abs_Value	39	39	0	0.59	0.58	0.41 - 0.77	0 - 2.9	0.41	0.18 - 0.81	28	28	0	0.92	0.76	0.64 - 1.2	0.12 - 3.24	0.68	0.45 - 1.19	0.0582	0.6781
	4NV_Th17TO1	Abs_Value	39	39	0	0.11	0.12	0.08 - 0.15	0 - 0.43	0.07	0.02 - 0.17	28	28	0	0.21	0.25	0.12 - 0.3	0.01 - 1.08	0.12	0.04 - 0.24	0.0737	0.6781
	4NV_TH2	Abs_Value	39	39	0	1.99	2.41	1.23 - 2.74	0 - 11.34	1.09	0.62 - 2.33	28	28	0	4.1	4.56	2.41 - 5.79	0.14 - 20.02	2.86	1.01 - 5.49	0.0312	0.6781
	4NV_TH22	Abs_Value	39	39	0	0.05	0.08	0.03 - 0.08	0 - 0.32	0.02	0.01 - 0.06	28	28	0	0.09	0.12	0.05 - 0.14	0 - 0.55	0.04	0.01 - 0.15	0.1106	0.6781
	4NV+226+	Abs_Value	39	39	0	13.74	13.09	9.63 - 17.84	0 - 43.3	9.21	6.11 - 15.8	28	28	0	23.13	21.19	15.28 - 30.98	3.48 - 85.04	16.11	7.06 - 29.98	0.044	0.6781
	4NV+39+	Abs_Value	39	39	0	0.7	0.89	0.42 - 0.98	0 - 3.98	0.4	0.1 - 0.87	28	28	0	0.98	0.98	0.61 - 1.34	0.01 - 4.69	0.75	0.48 - 1.13	0.2396	0.6781
	4NV+DR+	Abs_Value	39	39	0	1.96	3.25	0.94 - 2.98	0 - 17.28	0.83	0.41 - 1.75	28	28	0	1.75	1.95	1.03 - 2.47	0.25 - 10.14	1.16	0.7 - 1.82	0.7485	0.884
	4NV+PD-1-TIGIT-	Abs_Value	39	39	0	14.19	14.36	9.69 - 18.7	0 - 47.46	9.27	4.44 - 17.37	28	28	0	24.61	23.7	15.84 - 33.39	2.32 - 98.02	16.98	6.11 - 33.64	0.0448	0.6781
	4NV+PD-1-TIGIT+	Abs_Value	39	39	0	0.46	0.79	0.22 - 0.71	0 - 4.58	0.26	0.11 - 0.41	28	28	0	0.61	0.55	0.4 - 0.81	0.07 - 2.14	0.44	0.25 - 0.7	0.3928	0.6866
	4NV+PD-1+TIGIT-	Abs_Value	39	39	0	0.87	1.14	0.51 - 1.23	0 - 4.56	0.35	0.23 - 0.96	28	28	0	0.93	0.76	0.65 - 1.21	0.1 - 3.04	0.72	0.34 - 1.24	0.7927	0.9
	4NV+PD-1+TIGIT+	Abs_Value	39	39	0	0.42	0.56	0.25 - 0.6	0 - 2.84	0.19	0.08 - 0.57	28	28	0	0.48	0.35	0.35 - 0.61	0.05 - 1.27	0.4	0.23 - 0.62	0.5964	0.7763
	4NV+PD1+	Abs_Value	39	39	0	1.29	1.54	0.81 - 1.77	0 - 6.69	0.63	0.33 - 1.84	28	28	0	1.41	0.95	1.06 - 1.76	0.25 - 3.76	1.16	0.64 - 1.95	0.6939	0.8514
	4NV+TIGIT+	Abs_Value	39	39	0	0.88	1.11	0.54 - 1.23	0 - 5.34	0.5	0.24 - 1.04	28	28	0	1.08	0.76	0.8 - 1.37	0.19 - 3.42	0.91	0.5 - 1.39	0.3839	0.6866
	4ЕМ	Abs_Value	39	39	0	29.18	89.5	1.09 - 57.27	0.01 - 428.8	3.42	0.63 - 16.48	28	28	0	7.64	17.2	1.27 - 14.01	0 - 67.92	0.8	0.19 - 3.72	0.1502	0.6781
	4ЕМ_TH1	Abs_Value	39	39	0	11.29	43.51	-2.37 - 24.94	0 - 267.92	1.06	0.16 - 3.75	28	28	0	1.94	5.86	-0.23 - 4.11	0 - 30.53	0.2	0.03 - 0.92	0.1925	0.6781
	4ЕМ_TH17	Abs_Value	39	39	0	0.07	0.19	0.01 - 0.13	0 - 0.9	0.01	0 - 0.03	28	28	0	0.01	0.03	0 - 0.02	0 - 0.15	0	0 - 0.01	0.0572	0.6781
	4ЕМ_Th17TO1	Abs_Value	39	39	0	0.29	0.88	0.01 - 0.56	0 - 5.46	0.04	0.01 - 0.32	28	28	0	0.04	0.08	0.01 - 0.07	0 - 0.41	0.01	0 - 0.04	0.0894	0.6781
	4ЕМ_TH2	Abs_Value	39	39	0	3.8	21.09	-2.81 - 10.42	0 - 131.99	0.08	0.02 - 0.43	28	28	0	0.3	0.62	0.07 - 0.53	0 - 2.67	0.03	0.01 - 0.2	0.3066	0.6781
	4ЕМ_TH22	Abs_Value	39	39	0	0.01	0.03	0 - 0.02	0 - 0.15	0	0 - 0	28	28	0	0.01	0.01	0 - 0.01	0 - 0.05	0	0 - 0	0.3268	0.6781
	4ЕМ+226+	Abs_Value	39	39	0	85.97	111.51	50.98 - 120.97	0.28 - 553.6	60.55	31.84 - 87.48	28	28	0	61.27	45.72	44.34 - 78.21	2.92 - 184.9	61.09	24.67 - 85.82	0.2184	0.6781
	4ЕМ+39+	Abs_Value	39	39	0	23.58	18.88	17.65 - 29.5	0.07 - 70.57	22.61	9.99 - 38	28	28	0	21.36	18.22	14.61 - 28.11	0.36 - 65.22	19.28	3.74 - 34.53	0.6308	0.7999
	4ЕМ+DR+	Abs_Value	39	39	0	64.34	103.15	31.97 - 96.71	0.05 - 497.18	41.66	22.69 - 54.93	28	28	0	39.41	37.3	25.59 - 53.22	1.61 - 158.94	31.55	12.09 - 55.55	0.1711	0.6781
	4ЕМ+PD1-TIGIT-	Abs_Value	39	39	0	17.15	17.92	11.53 - 22.78	0.02 - 72.04	10.23	5.61 - 20.32	28	28	0	13.15	14.56	7.75 - 18.54	0.12 - 53.88	6.67	4.26 - 15.63	0.3174	0.6781
	4ЕМ+PD1-TIGIT+	Abs_Value	39	39	0	3.48	10.15	0.29 - 6.66	0 - 64.16	1.27	0.67 - 2.64	28	28	0	1.74	1.51	1.18 - 2.3	0.03 - 5.22	1.22	0.61 - 2.92	0.2989	0.6781
	4ЕМ+PD1+	Abs_Value	39	39	0	68.62	97.13	38.13 - 99.1	0.31 - 488.16	42.29	29.92 - 67.94	28	28	0	49.55	43.2	33.55 - 65.55	2.85 - 169.81	41.27	18.21 - 65.64	0.2824	0.6781
	4ЕМ+PD1+TIGIT-	Abs_Value	39	39	0	36.22	35.42	25.1 - 47.33	0.26 - 163.47	25.02	16.2 - 42.8	28	28	0	29.95	28.72	19.32 - 40.59	1.55 - 118.87	21.16	10.76 - 39.53	0.4278	0.7016
	4ЕМ+PD1+TIGIT+	Abs_Value	39	39	0	32.4	66.32	11.58 - 53.22	0.05 - 343.46	16.95	9.28 - 23.66	28	28	0	19.6	19.73	12.29 - 26.9	1.3 - 92.73	14.3	6.25 - 25.74	0.2611	0.6781
	4ЕМ+TIGIT+	Abs_Value	39	39	0	35.88	73.29	12.88 - 58.88	0.05 - 349.01	18.54	10.11 - 26.96	28	28	0	21.34	20.59	13.71 - 28.97	1.44 - 97.96	18.46	6.9 - 26.92	0.2457	0.6781
	4ЕМTM	Abs_Value	39	39	0	89.25	112.7	53.88 - 124.62	0.33 - 560.51	61.41	33.6 - 92.27	28	28	0	64.44	48.25	46.57 - 82.31	3.5 - 201.17	63.48	25.56 - 91.84	0.225	0.6781
	4СМ	Abs_Value	39	39	0	31.42	22.37	24.4 - 38.44	0 - 119.97	27.94	16.69 - 46.26	28	28	0	40.08	23.5	31.38 - 48.79	5.35 - 88.59	43.11	17.54 - 53.18	0.1344	0.6781
	4СМ(СТАР2)	Abs_Value	39	39	0	30.02	22.79	22.87 - 37.17	0 - 133.51	26.43	16.63 - 38.84	28	28	0	32.97	19.84	25.62 - 40.32	1.94 - 67.99	34.65	16.28 - 44.77	0.5747	0.7601
	4СМ_TH1	Abs_Value	39	39	0	1.56	2.53	0.76 - 2.35	0 - 15.41	1.1	0.34 - 1.69	28	28	0	1.57	1.47	1.03 - 2.12	0 - 4.36	0.9	0.36 - 2.7	0.9785	0.9885
	4СМ_TH17	Abs_Value	39	39	0	5.03	3.89	3.81 - 6.25	0 - 15.87	4.24	1.91 - 7.32	28	28	0	6.77	5.73	4.65 - 8.89	0.22 - 20.07	4.4	2 - 10.07	0.17	0.6781
	4СМ_Th17TO1	Abs_Value	39	39	0	0.38	0.57	0.21 - 0.56	0 - 3.07	0.24	0.06 - 0.41	28	28	0	0.55	0.73	0.28 - 0.82	0.03 - 3.05	0.25	0.12 - 0.65	0.3224	0.6781
	4СМ_TH2	Abs_Value	39	39	0	3.18	2.55	2.38 - 3.98	0 - 11.68	2.61	1.48 - 4.55	28	28	0	5.02	4.33	3.42 - 6.63	0.29 - 18.6	4.09	1.54 - 8.19	0.0505	0.6781
	4СМ_TH22	Abs_Value	39	39	0	0.53	0.65	0.33 - 0.74	0 - 3.29	0.32	0.1 - 0.69	28	28	0	0.85	0.79	0.56 - 1.14	0.01 - 2.75	0.79	0.19 - 1.1	0.0902	0.6781
	4СМ+226+	Abs_Value	39	39	0	27.75	21.33	21.06 - 34.45	0 - 125.07	23.75	15.53 - 36.02	28	28	0	30.78	18.69	23.86 - 37.71	1.86 - 63.84	32.53	15.09 - 40.76	0.5396	0.7475
	4СМ+39+	Abs_Value	39	39	0	10.35	10.02	7.2 - 13.49	0 - 49.38	9.36	1.53 - 13.97	28	28	0	12.32	11.87	7.92 - 16.71	0.01 - 39.63	9.41	1.22 - 17.71	0.479	0.7185
	4СМ+DR+	Abs_Value	39	39	0	14.08	20.69	7.59 - 20.58	0 - 127.35	9.85	5.25 - 13.14	28	28	0	11.9	10.78	7.91 - 15.89	0.25 - 41.83	8.12	3.91 - 16.05	0.5771	0.7612
	4СМ+PD1-TIGIT-	Abs_Value	39	39	0	9.47	6.39	7.46 - 11.47	0 - 23.26	7.52	5.37 - 13.64	28	28	0	11.96	10.31	8.14 - 15.78	0.12 - 41.2	8.6	4.25 - 18.41	0.264	0.6781
	4СМ+PD1-TIGIT+	Abs_Value	39	39	0	1.44	2.08	0.78 - 2.09	0 - 12.64	0.77	0.45 - 2.01	28	28	0	1.41	1.22	0.96 - 1.86	0.01 - 4.72	1.1	0.6 - 1.79	0.9483	0.9711
	4СМ+PD1+	Abs_Value	39	39	0	19.12	18.7	13.25 - 24.99	0 - 111.86	16.09	9.77 - 23.86	28	28	0	19.6	14.8	14.12 - 25.08	0.46 - 61.96	17.76	10.26 - 23.57	0.9061	0.9546
	4СМ+PD1+TIGIT-	Abs_Value	39	39	0	8.47	5.96	6.6 - 10.34	0 - 23.93	7.21	4.23 - 13.21	28	28	0	8.74	6.04	6.5 - 10.98	0.31 - 24.42	8.55	5.14 - 11.06	0.855	0.9205
	4СМ+PD1+TIGIT+	Abs_Value	39	39	0	10.65	14.71	6.04 - 15.27	0 - 90.89	7.63	3.58 - 11.64	28	28	0	10.86	9.95	7.18 - 14.55	0.15 - 37.55	8.88	5.08 - 12.27	0.9441	0.9711
4СМ+TIGIT+	Abs_Value	39	39	0	12.09	16.62	6.87 - 17.31	0 - 103.53	9	4.03 - 13.68	28	28	0	12.28	10.32	8.45 - 16.1	0.27 - 38.44	10.69	5.63 - 14.57	0.9553	0.9711
4ТM_TH1	Abs_Value	39	39	0	12.66	19.35	6.58 - 18.73	0.14 - 107.61	5.15	2.95 - 13.84	28	28	0	9.75	16.05	3.8 - 15.69	0.01 - 69.74	3.11	1.28 - 9.12	0.5047	0.7261
4ТM_TH17	Abs_Value	39	39	0	7.59	5.69	5.8 - 9.37	0.02 - 20.47	5.91	3.82 - 10.49	28	28	0	5.4	4.24	3.83 - 6.97	0.07 - 17.72	4.87	2.86 - 7.51	0.0761	0.6781
4ТM_Th17TO1	Abs_Value	39	39	0	2.19	1.71	1.65 - 2.72	0.03 - 6.88	1.88	0.98 - 3.01	28	28	0	2.64	3.74	1.26 - 4.02	0 - 13.42	1.26	0.4 - 2.99	0.5522	0.7482
4ТM_TH2	Abs_Value	39	39	0	3.2	3.01	2.26 - 4.15	0.02 - 13.03	2.17	1.45 - 3.93	28	28	0	3.69	4.82	1.91 - 5.48	0.07 - 25.5	2.9	0.95 - 4.16	0.6371	0.8058
4ТM_TH22	Abs_Value	39	39	0	3.03	2.8	2.15 - 3.91	0 - 11.23	1.9	1.07 - 4.73	28	28	0	2.99	3.07	1.85 - 4.12	0 - 11.35	2.21	0.77 - 4.02	0.9515	0.9711
4ТREG	Abs_Value	39	39	0	1.24	1.42	0.79 - 1.69	0 - 5.79	0.69	0.23 - 1.75	28	28	0	2.41	6.03	0.18 - 4.64	0.03 - 32.72	1.27	0.48 - 2.01	0.3225	0.6781
4ТREG(СТАР2)	Abs_Value	39	39	0	73	75.81	49.2 - 96.79	0.01 - 424.27	59.76	24.03 - 94.33	28	28	0	85.58	47.59	67.95 - 103.2	1.89 - 193.24	83.08	45.45 - 117.11	0.4082	0.6902
4ТREG_TH1	Abs_Value	39	39	0	0.2	0.24	0.12 - 0.28	0 - 0.92	0.14	0.03 - 0.2	28	28	0	0.22	0.24	0.13 - 0.31	0 - 1	0.15	0.07 - 0.3	0.7316	0.8733
4ТREG_TH17	Abs_Value	39	39	0	2.82	2.61	2 - 3.64	0.01 - 11.98	1.98	0.91 - 4.27	28	28	0	3.49	3.54	2.17 - 4.8	0.06 - 15.96	2.59	1.19 - 4.07	0.4005	0.6866
4ТREG_Th17TO1	Abs_Value	39	39	0	0.07	0.1	0.04 - 0.1	0 - 0.44	0.04	0.01 - 0.08	28	28	0	0.1	0.14	0.05 - 0.15	0 - 0.47	0.04	0.02 - 0.1	0.3475	0.6781
4ТREG_TH2	Abs_Value	39	39	0	1.54	1.37	1.11 - 1.97	0 - 5.88	1.46	0.53 - 2.34	28	28	0	2.23	2.84	1.18 - 3.28	0.22 - 14.5	1.3	0.74 - 3.06	0.2427	0.6781
4ТREG_TH22	Abs_Value	39	39	0	1.69	2.05	1.05 - 2.33	0.01 - 11.04	1.01	0.55 - 2.04	28	28	0	1.82	1.85	1.14 - 2.51	0 - 8.31	1.47	0.4 - 2.49	0.7863	0.8997
4ТЕ	Abs_Value	39	39	0	11.59	46.78	-3.09 - 26.27	0.01 - 293.46	0.64	0.2 - 5.63	28	28	0	2.37	3.82	0.96 - 3.78	0.03 - 14.73	0.88	0.24 - 2.04	0.2278	0.6781
4ТЕ(СТАР2)	Abs_Value	39	39	0	27.59	51.5	11.43 - 43.76	0.03 - 310.52	13.13	6.43 - 23.4	28	28	0	17.96	16.22	11.95 - 23.97	1.53 - 73.6	12.4	8.11 - 26.72	0.279	0.6781
4ТЕ_TH1	Abs_Value	39	39	0	5.91	29.66	-3.4 - 15.22	0 - 185.79	0.13	0.02 - 1.02	28	28	0	0.47	1.02	0.09 - 0.85	0 - 4.5	0.14	0.01 - 0.33	0.2599	0.6781
4ТЕ_TH17	Abs_Value	39	39	0	0.01	0.03	0 - 0.02	0 - 0.17	0	0 - 0	28	28	0	0.01	0.02	0 - 0.01	0 - 0.07	0	0 - 0	0.4728	0.718
4ТЕ_Th17TO1	Abs_Value	39	39	0	0.13	0.65	-0.08 - 0.33	0 - 4.08	0.01	0 - 0.03	28	28	0	0.01	0.02	0 - 0.02	0 - 0.07	0	0 - 0.01	0.2706	0.6781
4ТЕ_TH2	Abs_Value	39	39	0	0.42	1.36	-0.01 - 0.84	0 - 6.25	0.01	0 - 0.12	28	28	0	0.08	0.13	0.04 - 0.13	0 - 0.51	0.02	0 - 0.12	0.1315	0.6781
4ТЕ_TH22	Abs_Value	39	39	0	0.01	0.01	0 - 0.01	0 - 0.06	0	0 - 0.01	28	28	0	0	0.01	0 - 0.01	0 - 0.05	0	0 - 0	0.4354	0.7016
4ТЕ+226+	Abs_Value	39	39	0	26.34	51.15	10.28 - 42.39	0.03 - 307.76	11.03	6.12 - 22.51	28	28	0	16.66	15.37	10.97 - 22.35	1.33 - 71.49	11.51	7.18 - 22.78	0.271	0.6781
4ТЕ+39+	Abs_Value	39	39	0	4.33	3.99	3.08 - 5.59	0 - 17.63	3.24	0.79 - 6.09	28	28	0	5.45	6.64	2.99 - 7.91	0.05 - 29.5	3.18	1.51 - 6.83	0.4309	0.7016
4ТЕ+DR+	Abs_Value	39	39	0	20.75	45.95	6.33 - 35.17	0 - 273.14	8.21	4.06 - 17.59	28	28	0	11.62	15.22	5.98 - 17.26	0.27 - 71.42	7.25	3.38 - 11.19	0.2534	0.6781
4ТЕ+PD-1-TIGIT-	Abs_Value	39	39	0	7.42	9.57	4.42 - 10.42	0 - 48.37	3.79	2.16 - 8.9	28	28	0	5.1	4.7	3.36 - 6.84	0.27 - 20.57	4.19	2.35 - 5.99	0.1945	0.6781
4ТЕ+PD-1-TIGIT+	Abs_Value	39	39	0	2.5	10.09	-0.67 - 5.67	0 - 63.72	0.68	0.29 - 1.27	28	28	0	1.05	0.99	0.68 - 1.42	0.02 - 4.29	0.78	0.36 - 1.29	0.3773	0.6866
4ТЕ+PD-1+	Abs_Value	39	39	0	17.67	35.09	6.66 - 28.68	0.02 - 198.43	7.84	3.82 - 16	28	28	0	11.81	14.43	6.47 - 17.16	0.53 - 65.87	7.14	3.15 - 12.28	0.3527	0.6781
4ТЕ+PD-1+TIGIT-	Abs_Value	39	39	0	9.85	14.26	5.38 - 14.33	0.02 - 68.31	3.85	2.12 - 11.01	28	28	0	7.28	9.7	3.69 - 10.88	0.31 - 45.47	3.94	1.99 - 7.31	0.3832	0.6866
4ТЕ+PD-1+TIGIT+	Abs_Value	39	39	0	7.82	22.22	0.84 - 14.79	0 - 130.12	2.71	1.56 - 4.95	28	28	0	4.53	5.52	2.49 - 6.58	0.23 - 21.97	2.11	1.41 - 5.09	0.3806	0.6866
4ТЕ+TIGIT+	Abs_Value	39	39	0	10.32	31.7	0.37 - 20.27	0 - 193.84	3.7	2.22 - 6.07	28	28	0	5.58	6.07	3.33 - 7.83	0.34 - 22.91	3.11	2.07 - 5.82	0.3679	0.6866
4ТМ	Abs_Value	39	39	0	68.73	44.83	54.66 - 82.8	0.29 - 206.37	59.16	36.36 - 89.43	28	28	0	60.2	43.52	44.08 - 76.32	2.7 - 156.95	59.02	21.18 - 93.81	0.4377	0.7016
8+	Abs_Value	39	39	0	338.23	532.81	171.01 - 505.45	3.6 - 2131.88	94.25	33.79 - 338.12	28	28	0	163.88	420.4	8.16 - 319.59	0.65 - 2174.4	32.02	7.98 - 107.38	0.1397	0.6781
8+ (IM STAT)	Abs_Value	39	39	0	367.88	552.6	194.44 - 541.31	3.93 - 2176.1	99.73	39.92 - 499.23	28	28	0	190.71	457.37	21.29 - 360.12	0.71 - 2351.17	40.68	13.82 - 116.25	0.1569	0.6781
8+226+	Abs_Value	39	39	0	470.53	618.71	276.35 - 664.71	19.73 - 2309.79	182.21	83.91 - 662.23	28	28	0	254.15	484.55	74.67 - 433.63	7.76 - 2484.23	93.15	40.59 - 227.28	0.1136	0.6781
8+39+	Abs_Value	39	39	0	50.88	78.12	26.36 - 75.39	0.09 - 418.95	23.41	8.89 - 61.49	28	28	0	47.44	107.14	7.75 - 87.13	0.2 - 562.33	12.38	3.76 - 49.88	0.8858	0.9413
8+DR+	Abs_Value	39	39	0	367.32	527.47	201.78 - 532.87	4.94 - 2168.46	142.83	62.61 - 414.98	28	28	0	216.12	474.09	40.51 - 391.73	2.26 - 2431.19	63.22	19.15 - 162.93	0.2241	0.6781
8+PD-1-TIGIT-	Abs_Value	39	39	0	135.49	198.3	73.25 - 197.72	5.63 - 815.7	39.97	17.51 - 139.58	28	28	0	76.66	134.27	26.93 - 126.39	1.36 - 704.51	40.59	10.93 - 84.58	0.1526	0.6781
8+PD-1-TIGIT+	Abs_Value	39	39	0	144.2	244.69	67.4 - 221	1.37 - 1271.22	31.04	10.46 - 209.95	28	28	0	65.97	141.78	13.46 - 118.49	1 - 719.74	15.57	7.8 - 62.55	0.1044	0.6781
8+PD-1+	Abs_Value	39	39	0	217.19	328.31	114.15 - 320.23	7.78 - 1736.81	95	38.06 - 229.28	28	28	0	133.94	258.59	38.15 - 229.72	1.8 - 1201.16	35.47	16.3 - 80.32	0.2504	0.6781
8+PD-1+TIGIT-	Abs_Value	39	39	0	71.54	104.23	38.83 - 104.25	1.45 - 448.19	26.52	4.16 - 106.41	28	28	0	41.87	87.52	9.45 - 74.29	0.7 - 428.96	12.39	3.78 - 32.22	0.2113	0.6781
8+PD-1+TIGIT+	Abs_Value	39	39	0	145.65	238.86	70.69 - 220.62	5.05 - 1288.62	68.95	21.04 - 122.68	28	28	0	92.07	178.77	25.85 - 158.28	0.99 - 772.2	19.64	11.2 - 49.28	0.2976	0.6781
8+TIGIT+	Abs_Value	39	39	0	289.85	431.67	154.37 - 425.33	6.42 - 1840.75	94.56	43.22 - 313.01	28	28	0	158.04	314.31	41.62 - 274.46	1.99 - 1491.94	43.96	19.14 - 109.1	0.1529	0.6781
8EMTM	Abs_Value	39	39	0	77.74	115.56	41.47 - 114	2.95 - 582.56	29.11	9.7 - 91.47	28	28	0	70.04	204.35	-5.65 - 145.73	0.4 - 1077.88	11.45	3.34 - 45.52	0.8582	0.9219
8EMTM+226+	Abs_Value	39	39	0	72.96	112.94	37.51 - 108.41	2.29 - 577.84	28.32	7.48 - 83.22	28	28	0	64.24	192.62	-7.11 - 135.59	0.36 - 1020.79	10.3	2.38 - 43.16	0.8312	0.91
8EMTM+39+	Abs_Value	39	39	0	14.47	23.42	7.12 - 21.82	0.04 - 99.93	4.62	1.73 - 15.46	28	28	0	15.07	51.88	-4.14 - 34.29	0.03 - 277.35	1.72	0.75 - 9.77	0.9544	0.9711
8EMTM+DR+	Abs_Value	39	39	0	64.68	100.49	33.15 - 96.22	1.79 - 474.38	25.43	8.16 - 71.87	28	28	0	62.31	194.49	-9.73 - 134.35	0.28 - 1026.67	6.98	1.25 - 30.94	0.9532	0.9711
8EMTM+PD-1-TIGIT-	Abs_Value	39	39	0	16.56	28.57	7.59 - 25.52	0.1 - 131.33	4.96	1.16 - 19.06	28	28	0	14.71	44.65	-1.83 - 31.25	0.1 - 237.98	2.42	0.29 - 9.52	0.8481	0.9196
8EMTM+PD-1-TIGIT+	Abs_Value	39	39	0	18.89	47.24	4.06 - 33.71	0.12 - 275.2	4.85	0.88 - 12.82	28	28	0	12.87	39.42	-1.74 - 27.47	0.04 - 206	0.93	0.23 - 7.56	0.5727	0.7599
8EMTM+PD-1+	Abs_Value	39	39	0	42.29	57.22	24.33 - 60.25	2.21 - 240.61	17.22	6.99 - 48.08	28	28	0	42.46	121.77	-2.64 - 87.57	0.27 - 633.9	6.11	1.59 - 25.15	0.9945	0.9959
8EMTM+PD-1+TIGIT-	Abs_Value	39	39	0	13	16.61	7.78 - 18.21	0.2 - 74.77	5.86	1.15 - 19.09	28	28	0	13.87	44.21	-2.5 - 30.25	0.08 - 235.25	2.36	0.47 - 7.78	0.9209	0.9599
8EMTM+PD-1+TIGIT+	Abs_Value	39	39	0	29.3	44.1	15.46 - 43.14	0.71 - 188.94	11.73	3.71 - 27.49	28	28	0	28.59	79.29	-0.78 - 57.96	0.12 - 398.65	3.64	1.15 - 13.56	0.9662	0.9801
8EMTM+TIGIT+	Abs_Value	39	39	0	48.18	86.13	21.15 - 75.22	0.83 - 464.14	17.79	5.39 - 42.69	28	28	0	41.46	118.34	-2.38 - 85.29	0.16 - 604.65	4.85	1.71 - 21.19	0.799	0.9
8NV	Abs_Value	39	39	0	7.64	9.28	4.73 - 10.56	0.02 - 46.45	5.08	1.98 - 8.98	28	28	0	11.62	11.65	7.31 - 15.94	0.67 - 55.43	7.91	5.17 - 17.08	0.1405	0.6781
8NV(СТАР2)	Abs_Value	39	39	0	9.6	11.35	6.04 - 13.16	0.03 - 49.35	5.19	2.26 - 10.73	28	28	0	11.25	10.66	7.3 - 15.19	1.05 - 48.26	6.76	4.77 - 14.25	0.5468	0.7482
8NV+226+	Abs_Value	39	39	0	8.68	10.74	5.31 - 12.05	0.03 - 49.26	4.68	1.99 - 10.06	28	28	0	9.91	9.3	6.47 - 13.36	0.95 - 40.2	5.96	4.28 - 12.51	0.6174	0.7904
8NV+39+	Abs_Value	39	39	0	0.6	0.97	0.29 - 0.9	0 - 5.17	0.3	0.06 - 0.64	28	28	0	0.67	0.81	0.36 - 0.97	0.01 - 3.73	0.44	0.13 - 0.8	0.7558	0.884
8NV+DR+	Abs_Value	39	39	0	2.56	4.43	1.17 - 3.96	0.01 - 16.54	0.66	0.3 - 1.9	28	28	0	1.37	2.02	0.62 - 2.12	0.03 - 9.92	0.6	0.44 - 1.22	0.1426	0.6781
8NV+PD-1-TIGIT-	Abs_Value	39	39	0	7.04	9.42	4.09 - 10	0 - 43.98	3.81	1.03 - 8.78	28	28	0	9.61	10.56	5.7 - 13.52	0.23 - 47.12	5.74	3.06 - 12.31	0.3088	0.6781
8NV+PD-1-TIGIT+	Abs_Value	39	39	0	1.11	1.92	0.51 - 1.72	0 - 9.21	0.49	0.22 - 0.85	28	28	0	0.73	0.83	0.42 - 1.03	0.05 - 3.77	0.46	0.23 - 0.72	0.2655	0.6781
8NV+PD-1+	Abs_Value	39	39	0	1.45	2.12	0.78 - 2.11	0.02 - 10	0.52	0.2 - 1.5	28	28	0	0.91	1.11	0.5 - 1.32	0.05 - 3.96	0.44	0.23 - 1.06	0.1836	0.6781
8NV+PD-1+TIGIT-	Abs_Value	39	39	0	0.5	0.92	0.21 - 0.79	0 - 4.91	0.15	0.03 - 0.5	28	28	0	0.31	0.36	0.18 - 0.45	0 - 1.26	0.2	0.08 - 0.4	0.2527	0.6781
8NV+PD-1+TIGIT+	Abs_Value	39	39	0	0.95	1.35	0.52 - 1.37	0.01 - 5.16	0.39	0.15 - 1.12	28	28	0	0.6	0.89	0.27 - 0.92	0.04 - 3.31	0.25	0.17 - 0.38	0.2056	0.6781
8NV+TIGIT+	Abs_Value	39	39	0	2.06	3.05	1.1 - 3.02	0.01 - 12.72	0.88	0.45 - 2.26	28	28	0	1.32	1.63	0.72 - 1.93	0.11 - 6.55	0.64	0.46 - 1.05	0.2063	0.6781
8TREG	Abs_Value	39	39	0	334.51	529.5	168.33 - 500.7	3.32 - 2109.36	93.76	33.11 - 326.8	28	28	0	166.61	430.63	7.1 - 326.11	0.67 - 2227.15	31.77	8.02 - 102.77	0.158	0.6781
8ЕМ	Abs_Value	39	39	0	79.03	128.38	38.73 - 119.32	0.46 - 668.2	28.95	7.36 - 99.94	28	28	0	67.68	206.05	-8.64 - 144	0.11 - 1084.06	7.04	1.01 - 34.8	0.7979	0.9
8СМ	Abs_Value	39	39	0	2.88	6.14	0.95 - 4.81	0.01 - 37.25	0.94	0.56 - 2.43	28	28	0	5.32	12.63	0.64 - 9.99	0.08 - 67.57	2.36	0.34 - 5.01	0.351	0.6781
8СМ(СТАР2)	Abs_Value	39	39	0	6	19.68	-0.18 - 12.17	0.02 - 118.92	1.16	0.72 - 3.09	28	28	0	3.83	5.57	1.77 - 5.9	0.02 - 19.92	1.88	0.27 - 4.27	0.5181	0.7367
8СМ+226+	Abs_Value	39	39	0	5.61	19.33	-0.46 - 11.67	0.02 - 118.25	1.08	0.6 - 2.93	28	28	0	3.33	4.75	1.57 - 5.09	0.02 - 16.84	1.68	0.22 - 3.34	0.483	0.7191
8СМ+39+	Abs_Value	39	39	0	0.93	1.62	0.43 - 1.44	0 - 9.34	0.47	0.18 - 0.76	28	28	0	1.27	1.93	0.55 - 1.98	0 - 6.95	0.2	0.07 - 1.77	0.4626	0.7142
8СМ+DR+	Abs_Value	39	39	0	5.16	17.97	-0.48 - 10.8	0.01 - 107.27	0.96	0.51 - 2.09	28	28	0	2.81	5.22	0.87 - 4.74	0.01 - 19.49	0.69	0.13 - 1.93	0.4428	0.7032
8СМ+PD-1-TIGIT-	Abs_Value	39	39	0	1.23	2.88	0.32 - 2.13	0 - 15.65	0.25	0.11 - 0.88	28	28	0	1.12	1.58	0.54 - 1.71	0 - 5.79	0.49	0.11 - 1.24	0.8486	0.9196
8СМ+PD-1-TIGIT+	Abs_Value	39	39	0	2.1	9.31	-0.83 - 5.02	0 - 58.16	0.2	0.1 - 0.58	28	28	0	0.69	1.18	0.25 - 1.12	0 - 5.17	0.2	0.05 - 0.61	0.3555	0.6781
8СМ+PD-1+	Abs_Value	39	39	0	2.67	7.9	0.2 - 5.15	0.02 - 45.11	0.74	0.28 - 1.51	28	28	0	2.03	3.93	0.57 - 3.48	0.01 - 15.63	0.52	0.1 - 1.43	0.6598	0.8271
8СМ+PD-1+TIGIT-	Abs_Value	39	39	0	0.68	1.95	0.07 - 1.29	0 - 9.81	0.15	0.03 - 0.35	28	28	0	0.49	1	0.12 - 0.86	0.01 - 4.45	0.11	0.04 - 0.38	0.6059	0.7822
8СМ+PD-1+TIGIT+	Abs_Value	39	39	0	1.99	6.19	0.05 - 3.94	0.01 - 37.26	0.62	0.21 - 1.18	28	28	0	1.53	2.99	0.43 - 2.64	0 - 11.18	0.39	0.06 - 1.08	0.6889	0.8514
8СМ+TIGIT+	Abs_Value	39	39	0	4.09	15.41	-0.75 - 8.93	0.01 - 95.42	0.8	0.34 - 1.64	28	28	0	2.22	3.86	0.79 - 3.65	0 - 12.71	0.7	0.13 - 2.13	0.4714	0.718
8ТЕ	Abs_Value	39	39	0	340.55	488.28	187.3 - 493.79	4.38 - 1891.65	72.89	27.04 - 523.74	28	28	0	135.07	228.34	50.49 - 219.65	0.46 - 1033.99	42.13	12.61 - 131.19	0.0251	0.6781
8ТЕ(СТАР2)	Abs_Value	39	39	0	399.82	532.76	232.61 - 567.03	7.72 - 2117.62	121.61	53.59 - 623.55	28	28	0	190.71	317.08	73.26 - 308.16	2.04 - 1520.64	74.98	26.84 - 165.62	0.0492	0.6781
8ТЕ+226+	Abs_Value	39	39	0	380.04	511.32	219.56 - 540.51	6.99 - 1998.95	102.32	50.26 - 599.53	28	28	0	176.1	299.7	65.09 - 287.11	1.84 - 1441.91	61.81	24.47 - 147.36	0.0447	0.6781
8ТЕ+39+	Abs_Value	39	39	0	34.3	57.18	16.35 - 52.25	0.05 - 321.3	13.22	3.65 - 43.95	28	28	0	30.36	56.92	9.27 - 51.44	0.07 - 278.04	7.6	2.95 - 34.51	0.781	0.8997
8ТЕ+DR+	Abs_Value	39	39	0	291.49	426.01	157.79 - 425.2	2.61 - 1916.64	93.22	40.64 - 361.39	28	28	0	149.34	282.01	44.88 - 253.8	1.18 - 1379.51	39.48	15.08 - 122	0.1054	0.6781
8ТЕ+PD-1-TIGIT-	Abs_Value	39	39	0	109.69	170.26	56.25 - 163.13	2.07 - 692.88	26.6	9.18 - 117.4	28	28	0	50.89	89.3	17.81 - 83.97	0.56 - 459.76	20.6	5.05 - 62.44	0.0716	0.6781
8ТЕ+PD-1-TIGIT+	Abs_Value	39	39	0	121.05	193.14	60.43 - 181.66	0.99 - 921.44	24.4	8.44 - 190.13	28	28	0	51.55	101.85	13.82 - 89.27	0.45 - 504.62	14.1	4.74 - 55.63	0.0612	0.6781
8ТЕ+PD-1+	Abs_Value	39	39	0	169.08	280.68	80.99 - 257.17	3.69 - 1526.37	67.37	26.03 - 170.51	28	28	0	88.27	149.38	32.94 - 143.6	1.03 - 556.25	29.97	12.58 - 69.83	0.1331	0.6781
8ТЕ+PD-1+TIGIT-	Abs_Value	39	39	0	56.8	90.76	28.31 - 85.28	0.82 - 403.46	18.56	2.45 - 72.41	28	28	0	27.18	48.92	9.06 - 45.3	0.47 - 190.87	7.59	2.07 - 25.75	0.0906	0.6781
8ТЕ+PD-1+TIGIT+	Abs_Value	39	39	0	112.28	201.35	49.09 - 175.48	2.85 - 1122.91	47.52	13.89 - 97.11	28	28	0	61.09	106.19	21.76 - 100.43	0.56 - 365.38	14.54	8.69 - 41.59	0.1827	0.6781
8ТЕ+TIGIT+	Abs_Value	39	39	0	233.33	346.67	124.53 - 342.13	3.84 - 1498.44	77.37	26.2 - 269.88	28	28	0	112.64	198.57	39.09 - 186.19	1.01 - 870	29.7	14.87 - 94.69	0.0765	0.6781
8ТМ	Abs_Value	39	39	0	20.92	28	12.13 - 29.7	0.43 - 149.26	12.18	4.59 - 22.53	28	28	0	20.26	37.21	6.47 - 34.04	0.34 - 179.51	5.25	1.36 - 17.61	0.9375	0.9711
TREG_CM	Abs_Value	39	39	0	0.81	0.88	0.54 - 1.09	0 - 4.33	0.5	0.26 - 1.08	28	28	0	1.48	2.72	0.47 - 2.49	0.02 - 14.66	0.92	0.32 - 1.56	0.2223	0.6781
TREG_EMTM	Abs_Value	39	39	0	8.82	8.27	6.22 - 11.41	0.05 - 40.11	7.21	2.95 - 12.43	28	28	0	11.9	17.5	5.42 - 18.38	0.05 - 93.26	6.51	3.01 - 13.22	0.3923	0.6866
TREG_NV	Abs_Value	39	39	0	0.93	0.89	0.65 - 1.21	0 - 3.03	0.71	0.21 - 1.47	28	28	0	1.21	0.82	0.91 - 1.52	0.01 - 3.4	1.13	0.63 - 1.75	0.1786	0.6781
TREG_TE	Abs_Value	39	39	0	2.37	1.78	1.81 - 2.93	0 - 6.11	2.06	1.15 - 3.5	28	28	0	3.04	2.65	2.06 - 4.02	0.19 - 8.97	2.17	0.97 - 4.09	0.2505	0.6781
TREG+226-TIGIT-	Abs_Value	39	39	0	0.85	0.78	0.61 - 1.1	0 - 2.66	0.63	0.17 - 1.39	28	28	0	0.88	0.74	0.61 - 1.15	0.04 - 3.18	0.69	0.34 - 1.18	0.8825	0.9398
TREG+226-TIGIT+	Abs_Value	39	39	0	3.39	3.18	2.39 - 4.39	0.01 - 13.35	2.67	0.95 - 4.88	28	28	0	4.62	7.57	1.82 - 7.43	0.22 - 40.78	2.82	1.46 - 4.13	0.4216	0.6984
TREG+226+	Abs_Value	39	39	0	8.82	7.4	6.49 - 11.14	0.04 - 38.28	9.02	3.48 - 11.72	28	28	0	12.15	14.13	6.92 - 17.38	0.85 - 72.45	7.91	3.79 - 14.59	0.2615	0.6781
TREG+226+TIGIT-	Abs_Value	39	39	0	1.36	1.22	0.98 - 1.75	0.01 - 4.82	0.92	0.52 - 1.82	28	28	0	1.67	1.7	1.04 - 2.3	0.06 - 7.96	1.15	0.6 - 1.92	0.413	0.6959
TREG+226+TIGIT+	Abs_Value	39	39	0	7.46	6.55	5.4 - 9.51	0.02 - 33.46	6.06	2.41 - 10.44	28	28	0	10.48	13.51	5.47 - 15.48	0.25 - 70.7	6.52	3.05 - 13.06	0.2811	0.6781
TREG+39+	Abs_Value	39	39	0	9.7	9.56	6.7 - 12.7	0.03 - 45.27	6.69	3.41 - 11.8	28	28	0	13.81	20.79	6.11 - 21.52	0.18 - 111.4	8.3	3.67 - 15.91	0.336	0.6781
TREG+DR+	Abs_Value	39	39	0	9.7	8.49	7.03 - 12.36	0.02 - 39.81	8.49	3.47 - 13.01	28	28	0	13.29	19.64	6.01 - 20.56	0.59 - 105.25	8.1	3.56 - 14.05	0.3701	0.6866
TREG+PD-1+	Abs_Value	39	39	0	4.45	3.85	3.25 - 5.66	0.04 - 18.35	3.67	1.4 - 6.2	28	28	0	7.17	13.16	2.29 - 12.04	0.13 - 69.61	3.88	1.6 - 7.43	0.2978	0.6781
TREG+TIGIT+	Abs_Value	39	39	0	10.84	9.27	7.93 - 13.75	0.03 - 42.48	10.53	3.55 - 14.81	28	28	0	15.1	20.74	7.42 - 22.78	0.47 - 111.49	9.01	5.36 - 17.63	0.3169	0.6781
ДЕНЬ ХРРТПХ	4_TFH	Abs_Value										25	25	0	46.78	39.66	31.24 - 62.33	3.66 - 168.34	34.25	19.83 - 64.77	Н/П*	Н/П*
	4_TH1	Abs_Value										25	25	0	28.17	17.06	21.49 - 34.86	2.66 - 65.39	29.97	13.25 - 43.17	Н/П*	Н/П*
	4_TH17	Abs_Value										25	25	0	23.29	13.52	17.99 - 28.59	6.68 - 64.57	22.22	12.65 - 29.78	Н/П*	Н/П*
	4_Th17TO1	Abs_Value										25	25	0	6.06	5.4	3.95 - 8.18	0.56 - 23.85	3.82	2.86 - 8.1	Н/П*	Н/П*
	4_TH2	Abs_Value										25	25	0	24.18	26.58	13.76 - 34.6	3.39 - 132.22	18.42	6.59 - 29.27	Н/П*	Н/П*
	4_TH22	Abs_Value										25	25	0	9.62	7.61	6.64 - 12.61	0.26 - 32.21	8.69	4.42 - 13.49	Н/П*	Н/П*
	4+	Abs_Value										25	25	0	123.28	57.09	100.9 - 145.65	16.38 - 237.04	115.81	79.15 - 170.15	Н/П*	Н/П*
	4+ (IM STAT)	Abs_Value										25	25	0	97.67	44.6	80.19 - 115.15	13.95 - 188.96	87.06	67.78 - 126.32	Н/П*	Н/П*
	4+226+	Abs_Value										25	25	0	284.34	122.79	236.2 - 332.47	44.53 - 608.12	278.03	201.64 - 345.8	Н/П*	Н/П*
	4+39+	Abs_Value										25	25	0	85.6	65.58	59.89 - 111.31	1.02 - 286.69	76.43	53.19 - 108.3	Н/П*	Н/П*
	4+DR+	Abs_Value										25	25	0	133.94	87.87	99.5 - 168.39	24.34 - 400.84	100.49	65.24 - 183.02	Н/П*	Н/П*
	4+PD-1-TIGIT-	Abs_Value										25	25	0	109.61	70.62	81.92 - 137.29	11.55 - 243.96	96.09	49.56 - 150.68	Н/П*	Н/П*
	4+PD-1-TIGIT+	Abs_Value										25	25	0	11.95	10.29	7.91 - 15.98	0.92 - 41.1	7.95	3.98 - 17.77	Н/П*	Н/П*
	4+PD-1+	Abs_Value										25	25	0	182.38	99.2	143.5 - 221.27	33.38 - 484.17	145.59	109.23 - 237.38	Н/П*	Н/П*
	4+PD-1+TIGIT-	Abs_Value										25	25	0	100.64	63.31	75.83 - 125.46	20.2 - 286.07	76.64	62.96 - 141.45	Н/П*	Н/П*
	4+PD-1+TIGIT+	Abs_Value										25	25	0	81.74	43.96	64.51 - 98.97	13.19 - 198.1	79.59	47.71 - 110.6	Н/П*	Н/П*
	4+TIGIT+	Abs_Value										25	25	0	93.69	50.24	73.99 - 113.38	14.67 - 216.64	95.41	52.98 - 120.07	Н/П*	Н/П*
	4NV	Abs_Value										25	25	0	59.45	55.09	37.86 - 81.05	4.48 - 237.61	41.58	22.62 - 88.96	Н/П*	Н/П*
	4NV(СТАР2)	Abs_Value										25	25	0	53.26	52.95	32.5 - 74.02	3.89 - 222.55	32.64	13.42 - 88.36	Н/П*	Н/П*
	4NV_TH1	Abs_Value										25	25	0	3.11	2.72	2.05 - 4.18	0.07 - 9.51	2.24	0.8 - 4.69	Н/П*	Н/П*
	4NV_TH17	Abs_Value										25	25	0	1.55	1.46	0.98 - 2.12	0.21 - 7.19	1.07	0.67 - 2.07	Н/П*	Н/П*
	4NV_Th17TO1	Abs_Value										25	25	0	0.29	0.27	0.19 - 0.4	0.01 - 0.98	0.18	0.08 - 0.47	Н/П*	Н/П*
	4NV_TH2	Abs_Value										25	25	0	5.15	4.7	3.31 - 7	0.31 - 17.87	4.14	1.2 - 7.06	Н/П*	Н/П*
	4NV_TH22	Abs_Value										25	25	0	0.33	0.63	0.09 - 0.58	0 - 2.8	0.14	0.02 - 0.23	Н/П*	Н/П*
	4NV+226+	Abs_Value										25	25	0	47.3	50.15	27.64 - 66.96	3.83 - 221.43	31.18	10.03 - 73.8	Н/П*	Н/П*
	4NV+39+	Abs_Value										25	25	0	1.82	2.11	0.99 - 2.64	0.01 - 8.35	1.27	0.52 - 2.01	Н/П*	Н/П*
	4NV+DR+	Abs_Value										25	25	0	5.64	9.28	2 - 9.27	0.3 - 37.06	1.76	0.72 - 4.8	Н/П*	Н/П*
	4NV+PD-1-TIGIT-	Abs_Value										25	25	0	47.97	50.69	28.1 - 67.84	2.87 - 213.68	29.51	11.05 - 80.14	Н/П*	Н/П*
	4NV+PD-1-TIGIT+	Abs_Value										25	25	0	1.28	1.33	0.76 - 1.8	0.07 - 4.54	0.82	0.23 - 1.88	Н/П*	Н/П*
	4NV+PD-1+TIGIT-	Abs_Value										25	25	0	2.66	2.35	1.74 - 3.58	0.06 - 8.51	2.16	0.7 - 4.62	Н/П*	Н/П*
	4NV+PD-1+TIGIT+	Abs_Value										25	25	0	1.34	1.3	0.83 - 1.85	0 - 4.85	0.89	0.43 - 1.66	Н/П*	Н/П*
	4NV+PD1+	Abs_Value										25	25	0	4	3.45	2.65 - 5.36	0.09 - 13.36	3.04	1.59 - 6.34	Н/П*	Н/П*
	4NV+TIGIT+	Abs_Value										25	25	0	2.63	2.37	1.7 - 3.56	0.25 - 9.38	1.69	0.89 - 4	Н/П*	Н/П*
	4ЕМ	Abs_Value										25	25	0	15.22	19.1	7.73 - 22.71	0.09 - 72.83	9.43	2.27 - 17.96	Н/П*	Н/П*
	4ЕМ_TH1	Abs_Value										25	25	0	3.81	5.49	1.66 - 5.96	0.02 - 22.18	0.97	0.49 - 5.17	Н/П*	Н/П*
	4ЕМ_TH17	Abs_Value										25	25	0	0.06	0.13	0.01 - 0.11	0 - 0.59	0.01	0 - 0.04	Н/П*	Н/П*
	4ЕМ_Th17TO1	Abs_Value										25	25	0	0.12	0.18	0.05 - 0.19	0 - 0.62	0.04	0.01 - 0.13	Н/П*	Н/П*
	4ЕМ_TH2	Abs_Value										25	25	0	0.61	1.02	0.21 - 1.01	0 - 4.75	0.14	0.04 - 0.82	Н/П*	Н/П*
	4ЕМ_TH22	Abs_Value										25	25	0	0.01	0.03	0 - 0.02	0 - 0.13	0	0 - 0.01	Н/П*	Н/П*
	4ЕМ+226+	Abs_Value										25	25	0	132.71	80.8	101.04 - 164.39	14.74 - 377.13	111.79	84.69 - 160.46	Н/П*	Н/П*
	4ЕМ+39+	Abs_Value										25	25	0	50	45.87	32.01 - 67.98	0.71 - 224.9	45.43	20.01 - 70.49	Н/П*	Н/П*
	4ЕМ+DR+	Abs_Value										25	25	0	78.78	58.01	56.04 - 101.52	10.43 - 286.47	68.2	44.3 - 88.66	Н/П*	Н/П*
	4ЕМ+PD1-TIGIT-	Abs_Value										25	25	0	25.76	20.32	17.79 - 33.73	2.51 - 88.41	27.57	7.35 - 35.72	Н/П*	Н/П*
	4ЕМ+PD1-TIGIT+	Abs_Value										25	25	0	4.14	5.03	2.17 - 6.11	0.34 - 23.64	2.5	1.05 - 4.75	Н/П*	Н/П*
	4ЕМ+PD1+	Abs_Value										25	25	0	108.73	71.45	80.73 - 136.74	13.21 - 337.48	97.98	58.91 - 132.51	Н/П*	Н/П*
	4ЕМ+PD1+TIGIT-	Abs_Value										25	25	0	63.06	44.82	45.49 - 80.63	7.96 - 196.34	51.81	33.43 - 77.66	Н/П*	Н/П*
	4ЕМ+PD1+TIGIT+	Abs_Value										25	25	0	45.67	32.49	32.94 - 58.41	5.26 - 141.13	35.6	20.06 - 64.51	Н/П*	Н/П*
	4ЕМ+TIGIT+	Abs_Value										25	25	0	49.81	35.48	35.9 - 63.72	5.74 - 149.98	39.47	21.38 - 64.84	Н/П*	Н/П*
	4ЕМTM	Abs_Value										25	25	0	138.63	83	106.1 - 171.17	16.21 - 387.82	118.34	88.22 - 172.43	Н/П*	Н/П*
	4СМ	Abs_Value										25	25	0	78.18	48	59.37 - 97	11.92 - 198.01	73.12	43.13 - 103.34	Н/П*	Н/П*
	4СМ(СТАР2)	Abs_Value										25	25	0	59.67	36.54	45.35 - 73.99	2.49 - 132.74	61.2	36.49 - 76.35	Н/П*	Н/П*
	4СМ_TH1	Abs_Value										25	25	0	3.24	2.9	2.1 - 4.38	0.16 - 10.97	2.47	1.01 - 4.11	Н/П*	Н/П*
	4СМ_TH17	Abs_Value										25	25	0	9.24	5.27	7.18 - 11.31	1.77 - 19.65	9.32	4.72 - 13.61	Н/П*	Н/П*
	4СМ_Th17TO1	Abs_Value										25	25	0	0.99	1.06	0.58 - 1.41	0.07 - 4.84	0.7	0.25 - 1.41	Н/П*	Н/П*
	4СМ_TH2	Abs_Value										25	25	0	6.96	7.36	4.07 - 9.84	0.79 - 29.39	4.68	2.11 - 7.6	Н/П*	Н/П*
	4СМ_TH22	Abs_Value										25	25	0	1.65	1.92	0.9 - 2.4	0.03 - 7.43	1.02	0.52 - 1.23	Н/П*	Н/П*
	4СМ+226+	Abs_Value										25	25	0	56.59	34.4	43.1 - 70.07	2.12 - 125.18	57.79	33.85 - 71.78	Н/П*	Н/П*
	4СМ+39+	Abs_Value										25	25	0	18.81	15.5	12.73 - 24.89	0.07 - 49.53	15.95	3.9 - 35.62	Н/П*	Н/П*
	4СМ+DR+	Abs_Value										25	25	0	18.62	15.78	12.43 - 24.8	0.13 - 54.42	13.43	6.54 - 28.21	Н/П*	Н/П*
	4СМ+PD1-TIGIT-	Abs_Value										25	25	0	19.47	16.23	13.11 - 25.83	0.75 - 58.09	16.18	6.62 - 29.33	Н/П*	Н/П*
	4СМ+PD1-TIGIT+	Abs_Value										25	25	0	2.82	2.62	1.8 - 3.85	0.03 - 8.27	1.65	0.74 - 5.23	Н/П*	Н/П*
	4СМ+PD1+	Abs_Value										25	25	0	37.38	23.64	28.11 - 46.65	0.25 - 85.43	34.06	18.31 - 51.53	Н/П*	Н/П*
	4СМ+PD1+TIGIT-	Abs_Value										25	25	0	16.56	12.88	11.51 - 21.61	0.11 - 53.01	11.48	8.77 - 21.87	Н/П*	Н/П*
	4СМ+PD1+TIGIT+	Abs_Value										25	25	0	20.82	12.6	15.88 - 25.76	0.14 - 43.85	22.44	8.69 - 29.97	Н/П*	Н/П*
4СМ+TIGIT+	Abs_Value										25	25	0	23.64	13.8	18.23 - 29.05	0.29 - 46.52	26.56	10.49 - 34.71	Н/П*	Н/П*
4ТM_TH1	Abs_Value										25	25	0	13.08	9.46	9.38 - 16.79	1.35 - 30.38	9.27	4.69 - 20.15	Н/П*	Н/П*
4ТM_TH17	Abs_Value										25	25	0	11.34	10.3	7.3 - 15.38	1.71 - 44.13	7.67	5.11 - 11.72	Н/П*	Н/П*
4ТM_Th17TO1	Abs_Value										25	25	0	3.97	4.14	2.34 - 5.59	0.27 - 18.81	2.41	1.67 - 4.26	Н/П*	Н/П*
4ТM_TH2	Abs_Value										25	25	0	9.21	17.57	2.33 - 16.1	0.45 - 85.75	4.09	2.14 - 8.69	Н/П*	Н/П*
4ТM_TH22	Abs_Value										25	25	0	6.69	6.49	4.14 - 9.23	0.16 - 30.35	4.96	2.64 - 8.68	Н/П*	Н/П*
4ТREG	Abs_Value										25	25	0	4.55	4.75	2.69 - 6.42	0.17 - 15.12	2.33	1.41 - 5.5	Н/П*	Н/П*
4ТREG(СТАР2)	Abs_Value										25	25	0	124.67	57.17	102.25 - 147.08	17.21 - 253.28	119.85	81.78 - 149.18	Н/П*	Н/П*
4ТREG_TH1	Abs_Value										25	25	0	0.31	0.21	0.22 - 0.39	0 - 0.83	0.23	0.17 - 0.41	Н/П*	Н/П*
4ТREG_TH17	Abs_Value										25	25	0	6.35	6.5	3.8 - 8.9	0.56 - 33.26	4.59	2.68 - 6.76	Н/П*	Н/П*
4ТREG_Th17TO1	Abs_Value										25	25	0	0.11	0.12	0.07 - 0.16	0 - 0.41	0.06	0.02 - 0.16	Н/П*	Н/П*
4ТREG_TH2	Abs_Value										25	25	0	3.47	3.49	2.11 - 4.84	0.25 - 17.5	2.55	1.61 - 3.8	Н/П*	Н/П*
4ТREG_TH22	Abs_Value										25	25	0	5.76	6.51	3.2 - 8.31	0.28 - 27.55	3.6	1.78 - 7.3	Н/П*	Н/П*
4ТЕ	Abs_Value										25	25	0	11.9	17.25	5.14 - 18.66	0.09 - 58.86	4.5	0.69 - 12.45	Н/П*	Н/П*
4ТЕ(СТАР2)	Abs_Value										25	25	0	50.4	40.13	34.67 - 66.13	7.25 - 172.13	43.71	18.43 - 63.13	Н/П*	Н/П*
4ТЕ_TH1	Abs_Value										25	25	0	2.02	3.2	0.76 - 3.27	0.01 - 10.1	0.52	0.13 - 1.84	Н/П*	Н/П*
4ТЕ_TH17	Abs_Value										25	25	0	0.02	0.04	0.01 - 0.04	0 - 0.16	0	0 - 0.03	Н/П*	Н/П*
4ТЕ_Th17TO1	Abs_Value										25	25	0	0.08	0.16	0.02 - 0.15	0 - 0.61	0.01	0 - 0.06	Н/П*	Н/П*
4ТЕ_TH2	Abs_Value										25	25	0	0.73	1.98	-0.04 - 1.51	0 - 9.46	0.07	0.01 - 0.35	Н/П*	Н/П*
4ТЕ_TH22	Abs_Value										25	25	0	0.01	0.01	0 - 0.01	0 - 0.07	0	0 - 0.01	Н/П*	Н/П*
4ТЕ+226+	Abs_Value										25	25	0	46.05	37.07	31.52 - 60.59	4.81 - 157.81	34.32	16.83 - 55.87	Н/П*	Н/П*
4ТЕ+39+	Abs_Value										25	25	0	14.6	20.15	6.7 - 22.5	0.22 - 95.56	9.76	2.35 - 17.25	Н/П*	Н/П*
4ТЕ+DR+	Abs_Value										25	25	0	30.46	30.03	18.69 - 42.23	1.44 - 116.89	20.47	8.45 - 44.76	Н/П*	Н/П*
4ТЕ+PD-1-TIGIT-	Abs_Value										25	25	0	15.13	14.11	9.6 - 20.66	2.1 - 56.74	10.33	5.61 - 18.87	Н/П*	Н/П*
4ТЕ+PD-1-TIGIT+	Abs_Value										25	25	0	3.58	4.89	1.66 - 5.49	0.12 - 23.61	2.14	0.94 - 3.94	Н/П*	Н/П*
4ТЕ+PD-1+	Abs_Value										25	25	0	31.69	27.12	21.06 - 42.32	3.94 - 91.79	23.98	10.09 - 46.99	Н/П*	Н/П*
4ТЕ+PD-1+TIGIT-	Abs_Value										25	25	0	18.29	16.74	11.73 - 24.85	1.07 - 61.87	9.57	5.85 - 25.01	Н/П*	Н/П*
4ТЕ+PD-1+TIGIT+	Abs_Value										25	25	0	13.4	13.04	8.29 - 18.51	1.84 - 53.98	7.5	4.05 - 19.89	Н/П*	Н/П*
4ТЕ+TIGIT+	Abs_Value										25	25	0	16.98	17.1	10.27 - 23.68	2.16 - 77.59	9.52	5.84 - 22.91	Н/П*	Н/П*
4ТМ	Abs_Value										25	25	0	126.88	66	101 - 152.75	21.41 - 291.47	116.87	85.67 - 147	Н/П*	Н/П*
8+	Abs_Value										25	25	0	498.65	380.89	349.34 - 647.96	1.92 - 1531.11	465.29	212.98 - 655.91	Н/П*	Н/П*
8+ (IM STAT)	Abs_Value										25	25	0	631.78	466.48	448.92 - 814.64	2.46 - 1698.96	591.33	265.98 - 867.29	Н/П*	Н/П*
8+226+	Abs_Value										25	25	0	814.06	535.69	604.07 - 1024.05	19.37 - 1852.8	729.4	398.53 - 1197.61	Н/П*	Н/П*
8+39+	Abs_Value										25	25	0	129.07	99.17	90.2 - 167.95	0.32 - 376.08	118.53	39.62 - 192.09	Н/П*	Н/П*
8+DR+	Abs_Value										25	25	0	651.17	434.05	481.02 - 821.32	13.26 - 1528.67	612.95	326.33 - 927.99	Н/П*	Н/П*
8+PD-1-TIGIT-	Abs_Value										25	25	0	248.99	224.98	160.79 - 337.18	3.06 - 946.44	216.46	92.27 - 271.42	Н/П*	Н/П*
8+PD-1-TIGIT+	Abs_Value										25	25	0	245.52	230.44	155.18 - 335.85	2.47 - 1005.42	192.22	72.97 - 331.8	Н/П*	Н/П*
8+PD-1+	Abs_Value										25	25	0	407.97	320.62	282.28 - 533.65	15.39 - 1058.56	284.89	148.47 - 599.28	Н/П*	Н/П*
8+PD-1+TIGIT-	Abs_Value										25	25	0	134.3	139	79.81 - 188.79	1.56 - 459.85	88.41	25.85 - 205.09	Н/П*	Н/П*
8+PD-1+TIGIT+	Abs_Value										25	25	0	273.67	208.59	191.9 - 355.44	10.91 - 761.58	216.27	111.37 - 411.76	Н/П*	Н/П*
8+TIGIT+	Abs_Value										25	25	0	519.19	361.77	377.37 - 661	13.76 - 1510.56	440.22	286.58 - 740.07	Н/П*	Н/П*
8EMTM	Abs_Value										25	25	0	153.27	133.38	100.98 - 205.56	1.17 - 410.17	107.03	55.31 - 248.39	Н/П*	Н/П*
8EMTM+226+	Abs_Value										25	25	0	131.1	115.53	85.81 - 176.39	0.94 - 359.16	91.21	32.65 - 222.03	Н/П*	Н/П*
8EMTM+39+	Abs_Value										25	25	0	33.29	37.04	18.77 - 47.81	0.19 - 141.21	23.35	3.51 - 49.02	Н/П*	Н/П*
8EMTM+DR+	Abs_Value										25	25	0	127.59	109.66	84.6 - 170.57	0.88 - 335.96	89.9	51 - 214.35	Н/П*	Н/П*
8EMTM+PD-1-TIGIT-	Abs_Value										25	25	0	30.74	38.35	15.71 - 45.78	0.1 - 179.93	19.92	7.51 - 44.09	Н/П*	Н/П*
8EMTM+PD-1-TIGIT+	Abs_Value										25	25	0	30.4	37.31	15.78 - 45.03	0.16 - 117.39	12.39	6.97 - 47.2	Н/П*	Н/П*
8EMTM+PD-1+	Abs_Value										25	25	0	92.12	83.1	59.55 - 124.7	0.9 - 285.03	57.46	30.15 - 154.36	Н/П*	Н/П*
8EMTM+PD-1+TIGIT-	Abs_Value										25	25	0	29.46	31.22	17.22 - 41.71	0.17 - 100.3	16.91	4.9 - 39.89	Н/П*	Н/П*
8EMTM+PD-1+TIGIT+	Abs_Value										25	25	0	62.66	60.31	39.02 - 86.3	0.73 - 237.56	42.98	13.9 - 97.09	Н/П*	Н/П*
8EMTM+TIGIT+	Abs_Value										25	25	0	93.06	89.71	57.89 - 128.23	0.9 - 307.05	57.53	21.15 - 129.95	Н/П*	Н/П*
8NV	Abs_Value										25	25	0	33.21	33.93	19.91 - 46.51	0.67 - 133.23	21.08	13.74 - 46.67	Н/П*	Н/П*
8NV(СТАР2)	Abs_Value										25	25	0	27.96	36.41	13.69 - 42.24	1.05 - 179.03	16.26	10.73 - 29.41	Н/П*	Н/П*
8NV+226+	Abs_Value										25	25	0	24.54	34.6	10.98 - 38.11	0.95 - 177.03	15.01	8.92 - 27.06	Н/П*	Н/П*
8NV+39+	Abs_Value										25	25	0	1.92	1.63	1.28 - 2.56	0.01 - 5.99	1.53	0.58 - 2.96	Н/П*	Н/П*
8NV+DR+	Abs_Value										25	25	0	6.24	10.17	2.25 - 10.23	0.38 - 48.85	2.94	1.04 - 5.9	Н/П*	Н/П*
8NV+PD-1-TIGIT-	Abs_Value										25	25	0	19.4	34.27	5.97 - 32.83	0.23 - 174.66	11.05	4.45 - 20.75	Н/П*	Н/П*
8NV+PD-1-TIGIT+	Abs_Value										25	25	0	3.48	8.65	0.09 - 6.87	0 - 42.43	0.86	0.41 - 2.46	Н/П*	Н/П*
8NV+PD-1+	Abs_Value										25	25	0	5.08	7.31	2.22 - 7.95	0.23 - 28.31	2.74	0.51 - 4.76	Н/П*	Н/П*
8NV+PD-1+TIGIT-	Abs_Value										25	25	0	1.03	1.39	0.49 - 1.58	0.01 - 5.9	0.61	0.2 - 1.38	Н/П*	Н/П*
8NV+PD-1+TIGIT+	Abs_Value										25	25	0	4.05	6.73	1.41 - 6.69	0.21 - 27.87	1.99	0.42 - 3.22	Н/П*	Н/П*
8NV+TIGIT+	Abs_Value										25	25	0	7.53	14.75	1.75 - 13.31	0.34 - 70.3	3.4	1.15 - 5.16	Н/П*	Н/П*
8TREG	Abs_Value										25	25	0	493.78	393.53	339.52 - 648.05	1.91 - 1599.38	417.54	205.29 - 666.09	Н/П*	Н/П*
8ЕМ	Abs_Value										25	25	0	140.54	128.18	90.3 - 190.79	0.54 - 545.89	110.91	33.4 - 214.98	Н/П*	Н/П*
8СМ	Abs_Value										25	25	0	17.95	24.9	8.19 - 27.71	0.11 - 105.04	8.58	2.52 - 17.67	Н/П*	Н/П*
8СМ(СТАР2)	Abs_Value										25	25	0	13.52	19.22	5.98 - 21.05	0.09 - 72.63	6.1	0.61 - 16.26	Н/П*	Н/П*
8СМ+226+	Abs_Value										25	25	0	10.31	13.06	5.2 - 15.43	0.09 - 45.56	5.66	0.57 - 14.18	Н/П*	Н/П*
8СМ+39+	Abs_Value										25	25	0	3.82	5.9	1.5 - 6.13	0.02 - 27.07	1.25	0.22 - 5.33	Н/П*	Н/П*
8СМ+DR+	Abs_Value										25	25	0	11.17	17.18	4.43 - 17.9	0.04 - 66.63	3.76	0.49 - 13.92	Н/П*	Н/П*
8СМ+PD-1-TIGIT-	Abs_Value										25	25	0	2.36	4.33	0.66 - 4.06	0.01 - 19.15	1.08	0.24 - 1.78	Н/П*	Н/П*
8СМ+PD-1-TIGIT+	Abs_Value										25	25	0	3.03	5.92	0.71 - 5.35	0.01 - 20.43	0.68	0.14 - 1.28	Н/П*	Н/П*
8СМ+PD-1+	Abs_Value										25	25	0	8.13	12.1	3.39 - 12.87	0.04 - 47.52	2.83	0.56 - 10.63	Н/П*	Н/П*
8СМ+PD-1+TIGIT-	Abs_Value										25	25	0	0.87	1.26	0.37 - 1.36	0.01 - 4.51	0.39	0.09 - 0.98	Н/П*	Н/П*
8СМ+PD-1+TIGIT+	Abs_Value										25	25	0	7.26	11.71	2.67 - 11.85	0.03 - 47.06	2.6	0.47 - 9.47	Н/П*	Н/П*
8СМ+TIGIT+	Abs_Value										25	25	0	10.29	16.53	3.81 - 16.77	0.05 - 67.49	3.33	0.5 - 11.66	Н/П*	Н/П*
8ТЕ	Abs_Value										25	25	0	526.75	392.68	372.82 - 680.68	6.82 - 1431.59	493.67	225.49 - 711.59	Н/П*	Н/П*
8ТЕ(СТАР2)	Abs_Value										25	25	0	704.23	474.15	518.36 - 890.1	9.74 - 1753.87	671.37	292.51 - 1022.83	Н/П*	Н/П*
8ТЕ+226+	Abs_Value										25	25	0	645.4	455.86	466.71 - 824.1	9.12 - 1680.66	581.45	261.89 - 979.95	Н/П*	Н/П*
8ТЕ+39+	Abs_Value										25	25	0	88.98	65.87	63.16 - 114.8	0.09 - 223.92	77.45	22.4 - 137.03	Н/П*	Н/П*
8ТЕ+DR+	Abs_Value										25	25	0	504.45	358.36	363.97 - 644.93	5.03 - 1408.92	489.78	214.85 - 707.77	Н/П*	Н/П*
8ТЕ+PD-1-TIGIT-	Abs_Value										25	25	0	195.18	190	120.7 - 269.66	2.48 - 718.37	161.26	68.44 - 228.42	Н/П*	Н/П*
8ТЕ+PD-1-TIGIT+	Abs_Value										25	25	0	207.54	191.78	132.36 - 282.71	1.65 - 830	165.2	64.29 - 316.92	Н/П*	Н/П*
8ТЕ+PD-1+	Abs_Value										25	25	0	301.51	262.45	198.63 - 404.39	5.61 - 959.6	209.97	111.48 - 427.65	Н/П*	Н/П*
8ТЕ+PD-1+TIGIT-	Abs_Value										25	25	0	103.07	115.9	57.64 - 148.5	1.36 - 388.34	52.08	15.99 - 159.29	Н/П*	Н/П*
8ТЕ+PD-1+TIGIT+	Abs_Value										25	25	0	198.44	163.25	134.45 - 262.44	3.52 - 571.26	139.35	75.68 - 315.01	Н/П*	Н/П*
8ТЕ+TIGIT+	Abs_Value										25	25	0	405.98	282.45	295.26 - 516.7	5.17 - 1145.01	322.14	207.82 - 585.29	Н/П*	Н/П*
8ТМ	Abs_Value										25	25	0	60	52.55	39.4 - 80.6	1.16 - 174.35	46.8	15.99 - 80.83	Н/П*	Н/П*
TREG_CM	Abs_Value										25	25	0	2.85	3.16	1.61 - 4.09	0.08 - 14.1	1.69	0.82 - 5.02	Н/П*	Н/П*
TREG_EMTM	Abs_Value										25	25	0	26.47	20.09	18.6 - 34.35	1.78 - 71.51	18.06	12.84 - 38.69	Н/П*	Н/П*
TREG_NV	Abs_Value										25	25	0	2.08	1.86	1.35 - 2.81	0 - 5.4	1.27	0.52 - 3.17	Н/П*	Н/П*
TREG_TE	Abs_Value										25	25	0	7.28	6.07	4.9 - 9.67	0.53 - 26.44	6.27	2.86 - 10.36	Н/П*	Н/П*
TREG+226-TIGIT-	Abs_Value										25	25	0	1.62	1.28	1.12 - 2.12	0.12 - 4.76	1.5	0.65 - 2.33	Н/П*	Н/П*
TREG+226-TIGIT+	Abs_Value										25	25	0	9.08	7.58	6.11 - 12.05	0.46 - 26.78	7.51	3.39 - 12.27	Н/П*	Н/П*
TREG+226+	Abs_Value										25	25	0	28.24	19.1	20.76 - 35.73	2.27 - 67.09	23.95	14.49 - 38.08	Н/П*	Н/П*
TREG+226+TIGIT-	Abs_Value										25	25	0	3.15	1.96	2.38 - 3.92	0.49 - 6.55	3.21	1.26 - 4.58	Н/П*	Н/П*
TREG+226+TIGIT+	Abs_Value										25	25	0	25.1	17.57	18.21 - 31.98	1.77 - 60.99	20.4	12.88 - 33.39	Н/П*	Н/П*
TREG+39+	Abs_Value										25	25	0	28.72	19.78	20.97 - 36.48	1.42 - 83.91	24.01	17.28 - 37.7	Н/П*	Н/П*
TREG+DR+	Abs_Value										25	25	0	30.1	21.09	21.84 - 38.37	2.28 - 75.55	26.18	14.64 - 46.59	Н/П*	Н/П*
TREG+PD-1+	Abs_Value										25	25	0	17.15	13.87	11.71 - 22.58	0.47 - 49.25	13.78	6.67 - 21.27	Н/П*	Н/П*
TREG+TIGIT+	Abs_Value										25	25	0	34.18	23.64	24.91 - 43.45	2.24 - 85.67	28.53	17.3 - 48.19	Н/П*	Н/П*
ДЕНЬ ХРРТПХ +180	4_TFH	Abs_Value										8	8	0	58.53	30.95	37.08 - 79.97	4.33 - 100.17	64.6	47.58 - 74.95	Н/П*	Н/П*
	4_TH1	Abs_Value										8	8	0	52.88	45.82	21.12 - 84.63	5.76 - 139.51	36.23	26.33 - 62.23	Н/П*	Н/П*
	4_TH17	Abs_Value										8	8	0	38.59	34.42	14.74 - 62.45	2.67 - 109.23	29.75	15.91 - 48.75	Н/П*	Н/П*
	4_Th17TO1	Abs_Value										8	8	0	13.55	11.87	5.32 - 21.78	0.52 - 39.95	11.73	8.79 - 14.84	Н/П*	Н/П*
	4_TH2	Abs_Value										8	8	0	27.12	24.59	10.08 - 44.16	3.71 - 80.42	17.94	14.69 - 28.01	Н/П*	Н/П*
	4_TH22	Abs_Value										8	8	0	16.82	15.81	5.86 - 27.77	0.47 - 43.52	13.74	4.49 - 23.15	Н/П*	Н/П*
	4+	Abs_Value										8	8	0	205.27	137.06	110.3 - 300.25	27.34 - 489.56	190.56	125.9 - 246.2	Н/П*	Н/П*
	4+ (IM STAT)	Abs_Value										8	8	0	174.71	118.7	92.46 - 256.97	21.35 - 418.46	161.61	105.77 - 208.22	Н/П*	Н/П*
	4+226+	Abs_Value										8	8	0	432.98	214.56	284.3 - 581.66	58.67 - 689.45	488.08	298.46 - 546.5	Н/П*	Н/П*
	4+39+	Abs_Value										8	8	0	114.8	142.15	16.29 - 213.3	6.16 - 379.73	55.9	20.16 - 143.57	Н/П*	Н/П*
	4+DR+	Abs_Value										8	8	0	197.76	167.54	81.66 - 313.86	6.74 - 444.36	163.5	72.37 - 295.08	Н/П*	Н/П*
	4+PD-1-TIGIT-	Abs_Value										8	8	0	206.19	112.04	128.55 - 283.83	31.34 - 339.45	224.31	130.99 - 288.22	Н/П*	Н/П*
	4+PD-1-TIGIT+	Abs_Value										8	8	0	16.48	11.95	8.21 - 24.76	2.07 - 40.26	17.21	7.4 - 20.31	Н/П*	Н/П*
	4+PD-1+	Abs_Value										8	8	0	238.14	155.46	130.41 - 345.87	26.44 - 477.88	228.22	126.89 - 358.38	Н/П*	Н/П*
	4+PD-1+TIGIT-	Abs_Value										8	8	0	148.9	112.95	70.63 - 227.18	15.97 - 335.51	125.94	65.84 - 232.62	Н/П*	Н/П*
	4+PD-1+TIGIT+	Abs_Value										8	8	0	89.24	47.33	56.44 - 122.03	10.47 - 142.37	104.53	57.68 - 125.2	Н/П*	Н/П*
	4+TIGIT+	Abs_Value										8	8	0	105.72	51.47	70.05 - 141.39	12.54 - 150.32	124.1	89.31 - 142.76	Н/П*	Н/П*
	4NV	Abs_Value										8	8	0	93.17	65.58	47.73 - 138.61	19.14 - 205.24	71.98	45.66 - 143.14	Н/П*	Н/П*
	4NV(СТАР2)	Abs_Value										8	8	0	87.06	67.44	40.32 - 133.8	15.78 - 204.98	75.64	29.46 - 122.75	Н/П*	Н/П*
	4NV_TH1	Abs_Value										8	8	0	6.12	5.65	2.21 - 10.04	0.75 - 18.23	5.36	2.44 - 7.52	Н/П*	Н/П*
	4NV_TH17	Abs_Value										8	8	0	1.8	0.86	1.21 - 2.4	0.5 - 2.92	1.57	1.29 - 2.59	Н/П*	Н/П*
	4NV_Th17TO1	Abs_Value										8	8	0	0.61	0.34	0.38 - 0.85	0.09 - 1.14	0.55	0.43 - 0.78	Н/П*	Н/П*
	4NV_TH2	Abs_Value										8	8	0	4.96	3.85	2.29 - 7.63	1.43 - 13.51	4.14	2.61 - 5.87	Н/П*	Н/П*
	4NV_TH22	Abs_Value										8	8	0	0.14	0.2	0 - 0.28	0 - 0.63	0.08	0.03 - 0.13	Н/П*	Н/П*
	4NV+226+	Abs_Value										8	8	0	76.75	65.59	31.3 - 122.2	15.45 - 203.08	56.76	25.71 - 109.58	Н/П*	Н/П*
	4NV+39+	Abs_Value										8	8	0	2.28	3.15	0.09 - 4.46	0.09 - 9.72	1.37	0.51 - 2.32	Н/П*	Н/П*
	4NV+DR+	Abs_Value										8	8	0	6.77	4.31	3.78 - 9.76	0.2 - 11.36	7.33	3.62 - 10.86	Н/П*	Н/П*
	4NV+PD-1-TIGIT-	Abs_Value										8	8	0	79.19	64.15	34.73 - 123.64	14.59 - 193.32	66.91	27.72 - 106.01	Н/П*	Н/П*
	4NV+PD-1-TIGIT+	Abs_Value										8	8	0	1.66	1.64	0.52 - 2.8	0.35 - 5.35	1.06	0.8 - 1.67	Н/П*	Н/П*
	4NV+PD-1+TIGIT-	Abs_Value										8	8	0	4.6	5.7	0.65 - 8.55	0.4 - 17.59	3.03	1.04 - 5.15	Н/П*	Н/П*
	4NV+PD-1+TIGIT+	Abs_Value										8	8	0	1.62	1.45	0.62 - 2.62	0.17 - 4.37	1.73	0.25 - 2.24	Н/П*	Н/П*
	4NV+PD1+	Abs_Value										8	8	0	6.21	6.46	1.74 - 10.69	0.59 - 19.7	4.91	1.24 - 8.58	Н/П*	Н/П*
	4NV+TIGIT+	Abs_Value										8	8	0	3.28	2.72	1.39 - 5.16	0.62 - 7.58	2.76	1.01 - 4.46	Н/П*	Н/П*
	4ЕМ	Abs_Value										8	8	0	22.52	34.85	-1.63 - 46.68	1.83 - 101.46	7.62	3.66 - 18.69	Н/П*	Н/П*
	4ЕМ_TH1	Abs_Value										8	8	0	10.41	17.96	-2.04 - 22.85	0.23 - 52.73	2.65	1.26 - 8.81	Н/П*	Н/П*
	4ЕМ_TH17	Abs_Value										8	8	0	0.02	0.03	-0.01 - 0.04	0 - 0.1	0.01	0 - 0.01	Н/П*	Н/П*
	4ЕМ_Th17TO1	Abs_Value										8	8	0	0.1	0.07	0.05 - 0.15	0 - 0.2	0.1	0.05 - 0.15	Н/П*	Н/П*
	4ЕМ_TH2	Abs_Value										8	8	0	0.47	0.76	-0.05 - 1	0.02 - 2.26	0.13	0.07 - 0.5	Н/П*	Н/П*
	4ЕМ_TH22	Abs_Value										8	8	0	0	0	0 - 0	0 - 0.01	0	0 - 0	Н/П*	Н/П*
	4ЕМ+226+	Abs_Value										8	8	0	213.97	149.24	110.55 - 317.39	23.82 - 444.2	247.06	80.19 - 304.9	Н/П*	Н/П*
	4ЕМ+39+	Abs_Value										8	8	0	77.91	110.06	1.65 - 154.18	3.69 - 325.68	35.53	8.19 - 86.25	Н/П*	Н/П*
	4ЕМ+DR+	Abs_Value										8	8	0	129.31	120.6	45.74 - 212.88	5.04 - 373.34	118.88	40.25 - 160.95	Н/П*	Н/П*
	4ЕМ+PD1-TIGIT-	Abs_Value										8	8	0	61.31	55.08	23.14 - 99.47	6.25 - 154.67	56.62	9.86 - 91.88	Н/П*	Н/П*
	4ЕМ+PD1-TIGIT+	Abs_Value										8	8	0	7.01	10.31	-0.13 - 14.16	0.61 - 31.87	3.91	1.77 - 6.35	Н/П*	Н/П*
	4ЕМ+PD1+	Abs_Value										8	8	0	153.48	114.77	73.95 - 233.01	17.49 - 364.92	160.65	71.44 - 203.18	Н/П*	Н/П*
	4ЕМ+PD1+TIGIT-	Abs_Value										8	8	0	103.85	87.77	43.03 - 164.67	10.35 - 266.71	97.4	31.99 - 150	Н/П*	Н/П*
	4ЕМ+PD1+TIGIT+	Abs_Value										8	8	0	49.63	30.49	28.5 - 70.76	7.14 - 98.21	54.21	36.04 - 63.49	Н/П*	Н/П*
	4ЕМ+TIGIT+	Abs_Value										8	8	0	56.64	34.43	32.79 - 80.5	7.75 - 100.36	61.16	38.96 - 78.79	Н/П*	Н/П*
	4ЕМTM	Abs_Value										8	8	0	221.8	153.13	115.69 - 327.92	24.35 - 452.24	261.67	83.92 - 313.95	Н/П*	Н/П*
	4СМ	Abs_Value										8	8	0	105.82	85.55	46.53 - 165.1	13.53 - 260.46	90.77	53.74 - 132.89	Н/П*	Н/П*
	4СМ(СТАР2)	Abs_Value										8	8	0	83.32	59.93	41.78 - 124.85	10.93 - 184.54	67.98	49.57 - 116.93	Н/П*	Н/П*
	4СМ_TH1	Abs_Value										8	8	0	5.01	3.72	2.43 - 7.59	0.38 - 10.83	5.21	2.47 - 6.57	Н/П*	Н/П*
	4СМ_TH17	Abs_Value										8	8	0	12.73	11.95	4.45 - 21.01	1.07 - 34.36	8.51	5.91 - 15.66	Н/П*	Н/П*
	4СМ_Th17TO1	Abs_Value										8	8	0	2.1	1.47	1.08 - 3.11	0.06 - 4.39	1.89	1.23 - 3.02	Н/П*	Н/П*
	4СМ_TH2	Abs_Value										8	8	0	10.33	14.82	0.06 - 20.6	1.12 - 45.88	5.88	2.99 - 7.9	Н/П*	Н/П*
	4СМ_TH22	Abs_Value										8	8	0	2.49	4.52	-0.65 - 5.62	0.17 - 13.33	0.55	0.33 - 1.69	Н/П*	Н/П*
	4СМ+226+	Abs_Value										8	8	0	79.57	57.71	39.58 - 119.56	10.84 - 178.97	64.6	47.28 - 109.65	Н/П*	Н/П*
	4СМ+39+	Abs_Value										8	8	0	24.52	39.26	-2.68 - 51.73	0.7 - 118.64	10.4	3.23 - 23.72	Н/П*	Н/П*
	4СМ+DR+	Abs_Value										8	8	0	25.78	24.1	9.08 - 42.48	0.72 - 64.82	18.55	9.27 - 36.47	Н/П*	Н/П*
	4СМ+PD1-TIGIT-	Abs_Value										8	8	0	28.9	21.97	13.68 - 44.13	6.03 - 68.44	20.78	14.22 - 39.45	Н/П*	Н/П*
	4СМ+PD1-TIGIT+	Abs_Value										8	8	0	4.4	3.18	2.2 - 6.6	0.45 - 8.85	4.32	1.57 - 6.77	Н/П*	Н/П*
	4СМ+PD1+	Abs_Value										8	8	0	50.01	39.97	22.31 - 77.71	3.36 - 122.72	44.08	25.57 - 73.81	Н/П*	Н/П*
	4СМ+PD1+TIGIT-	Abs_Value										8	8	0	22.23	17.51	10.09 - 34.36	1.56 - 55.65	21.54	11.54 - 29.87	Н/П*	Н/П*
	4СМ+PD1+TIGIT+	Abs_Value										8	8	0	27.78	23.32	11.62 - 43.95	1.8 - 67.07	20.45	14.02 - 44.31	Н/П*	Н/П*
4СМ+TIGIT+	Abs_Value										8	8	0	32.18	26.02	14.15 - 50.22	2.3 - 74.86	22.93	17.51 - 51.35	Н/П*	Н/П*
4ТM_TH1	Abs_Value										8	8	0	19.51	19.98	5.67 - 33.35	0.88 - 65.78	14.44	10.42 - 21.14	Н/П*	Н/П*
4ТM_TH17	Abs_Value										8	8	0	22.44	25.21	4.97 - 39.91	0.98 - 68.85	13.68	5.06 - 27.62	Н/П*	Н/П*
4ТM_Th17TO1	Abs_Value										8	8	0	9.76	11.07	2.09 - 17.43	0.18 - 35.59	6.91	5.21 - 9.69	Н/П*	Н/П*
4ТM_TH2	Abs_Value										8	8	0	8.68	11.09	0.99 - 16.37	0.78 - 33.45	4.33	1.8 - 9.67	Н/П*	Н/П*
4ТM_TH22	Abs_Value										8	8	0	12.51	12.63	3.75 - 21.26	0.22 - 38.35	9.62	3.27 - 17.13	Н/П*	Н/П*
4ТREG	Abs_Value										8	8	0	3.38	3.33	1.08 - 5.69	0.52 - 9.96	2.06	1.18 - 4.33	Н/П*	Н/П*
4ТREG(СТАР2)	Abs_Value										8	8	0	204.35	131.83	112.99 - 295.7	27.24 - 474.51	195.64	124.48 - 241.62	Н/П*	Н/П*
4ТREG_TH1	Abs_Value										8	8	0	0.35	0.25	0.17 - 0.52	0.1 - 0.82	0.29	0.14 - 0.44	Н/П*	Н/П*
4ТREG_TH17	Abs_Value										8	8	0	7.31	5.37	3.59 - 11.03	1.01 - 15.15	5.27	3.34 - 12.25	Н/П*	Н/П*
4ТREG_Th17TO1	Abs_Value										8	8	0	0.14	0.13	0.05 - 0.22	0.03 - 0.33	0.06	0.04 - 0.24	Н/П*	Н/П*
4ТREG_TH2	Abs_Value										8	8	0	2.82	1.72	1.62 - 4.01	1.04 - 6.08	2.8	1.28 - 3.61	Н/П*	Н/П*
4ТREG_TH22	Abs_Value										8	8	0	7.11	5.87	3.04 - 11.17	0.61 - 16.79	5.23	3.58 - 9.37	Н/П*	Н/П*
4ТЕ	Abs_Value										8	8	0	20.66	39.04	-6.39 - 47.71	0.47 - 114.7	3.04	0.82 - 20.35	Н/П*	Н/П*
4ТЕ(СТАР2)	Abs_Value										8	8	0	66.94	63.13	23.19 - 110.68	8.27 - 207.55	60.47	23.6 - 74.9	Н/П*	Н/П*
4ТЕ_TH1	Abs_Value										8	8	0	7.58	18.08	-4.94 - 20.11	0.15 - 52.19	0.8	0.3 - 2.5	Н/П*	Н/П*
4ТЕ_TH17	Abs_Value										8	8	0	0.01	0.01	0 - 0.01	0 - 0.01	0	0 - 0.01	Н/П*	Н/П*
4ТЕ_Th17TO1	Abs_Value										8	8	0	0.04	0.05	0 - 0.07	0 - 0.15	0.02	0 - 0.04	Н/П*	Н/П*
4ТЕ_TH2	Abs_Value										8	8	0	0.56	0.89	-0.06 - 1.18	0 - 2.33	0.11	0.01 - 0.64	Н/П*	Н/П*
4ТЕ_TH22	Abs_Value										8	8	0	0	0	0 - 0	0 - 0.01	0	0 - 0	Н/П*	Н/П*
4ТЕ+226+	Abs_Value										8	8	0	61.16	62.06	18.15 - 104.16	8.06 - 202.6	51.87	19 - 66.98	Н/П*	Н/П*
4ТЕ+39+	Abs_Value										8	8	0	9.82	12.1	1.43 - 18.2	0.46 - 33.74	3.66	1.87 - 13.89	Н/П*	Н/П*
4ТЕ+DR+	Abs_Value										8	8	0	35.56	50.84	0.32 - 70.79	0.75 - 156.97	25	4.98 - 31.35	Н/П*	Н/П*
4ТЕ+PD-1-TIGIT-	Abs_Value										8	8	0	35.93	43.64	5.7 - 66.17	4.15 - 132.13	20.84	7.97 - 38.36	Н/П*	Н/П*
4ТЕ+PD-1-TIGIT+	Abs_Value										8	8	0	3.27	1.93	1.93 - 4.61	0.39 - 6.11	3.42	2.52 - 4.23	Н/П*	Н/П*
4ТЕ+PD-1+	Abs_Value										8	8	0	27.73	21.67	12.72 - 42.75	3.73 - 69.3	23.92	12.48 - 38.56	Н/П*	Н/П*
4ТЕ+PD-1+TIGIT-	Abs_Value										8	8	0	17.95	16.1	6.79 - 29.11	2.56 - 50.24	15.05	5 - 25.28	Н/П*	Н/П*
4ТЕ+PD-1+TIGIT+	Abs_Value										8	8	0	9.78	7.1	4.86 - 14.7	1.17 - 20.13	9.12	4.04 - 13.67	Н/П*	Н/П*
4ТЕ+TIGIT+	Abs_Value										8	8	0	13.05	8.5	7.16 - 18.94	1.56 - 25.17	12.54	7.22 - 18.44	Н/П*	Н/П*
4ТМ	Abs_Value										8	8	0	197.18	140.24	100 - 294.36	17.69 - 412.31	221.7	76.18 - 269.6	Н/П*	Н/П*
8+	Abs_Value										8	8	0	523.34	519.66	163.23 - 883.44	59.76 - 1524.17	277.21	193.35 - 719.8	Н/П*	Н/П*
8+ (IM STAT)	Abs_Value										8	8	0	644.48	596.98	230.79 - 1058.16	79.31 - 1806.25	379.1	320.21 - 790.62	Н/П*	Н/П*
8+226+	Abs_Value										8	8	0	874.92	701.97	388.48 - 1361.36	127.09 - 2191.35	644.85	432.11 - 1059.39	Н/П*	Н/П*
8+39+	Abs_Value										8	8	0	133.28	177.9	10 - 256.55	6.21 - 554.73	90.88	36.72 - 131.09	Н/П*	Н/П*
8+DR+	Abs_Value										8	8	0	623.87	537.07	251.69 - 996.04	31.3 - 1792.18	448.68	399.48 - 668.98	Н/П*	Н/П*
8+PD-1-TIGIT-	Abs_Value										8	8	0	308.48	285.61	110.56 - 506.39	49.48 - 800.45	220.15	94.66 - 424.06	Н/П*	Н/П*
8+PD-1-TIGIT+	Abs_Value										8	8	0	327.41	389.55	57.47 - 597.36	7.25 - 1202.9	218.74	86.19 - 402.2	Н/П*	Н/П*
8+PD-1+	Abs_Value										8	8	0	361.17	212.11	214.18 - 508.16	75.83 - 699.18	393.45	178.08 - 489.96	Н/П*	Н/П*
8+PD-1+TIGIT-	Abs_Value										8	8	0	83.59	67.58	36.76 - 130.42	21.48 - 241.24	67	48.28 - 87.75	Н/П*	Н/П*
8+PD-1+TIGIT+	Abs_Value										8	8	0	277.58	166.02	162.53 - 392.63	29.43 - 457.94	313.32	127.01 - 423.77	Н/П*	Н/П*
8+TIGIT+	Abs_Value										8	8	0	604.99	480.7	271.89 - 938.1	36.68 - 1567.95	426.9	346.35 - 842.55	Н/П*	Н/П*
8EMTM	Abs_Value										8	8	0	157.47	116.33	76.86 - 238.09	20.06 - 335.18	141.63	55.89 - 238.23	Н/П*	Н/П*
8EMTM+226+	Abs_Value										8	8	0	134.77	98.65	66.41 - 203.14	17.63 - 283.7	122.32	48.9 - 208.61	Н/П*	Н/П*
8EMTM+39+	Abs_Value										8	8	0	23.39	19.6	9.81 - 36.97	0.97 - 52.74	23.57	4.09 - 39.48	Н/П*	Н/П*
8EMTM+DR+	Abs_Value										8	8	0	125.15	96.78	58.09 - 192.22	8.01 - 298.35	118.77	46.34 - 167.33	Н/П*	Н/П*
8EMTM+PD-1-TIGIT-	Abs_Value										8	8	0	40.68	37.73	14.54 - 66.83	4.5 - 95.71	29.93	7.39 - 69.84	Н/П*	Н/П*
8EMTM+PD-1-TIGIT+	Abs_Value										8	8	0	34.07	42.71	4.47 - 63.67	0.84 - 119.96	17.86	3.85 - 44.74	Н/П*	Н/П*
8EMTM+PD-1+	Abs_Value										8	8	0	82.72	49.41	48.48 - 116.96	14.72 - 164.57	91.68	42.91 - 105.3	Н/П*	Н/П*
8EMTM+PD-1+TIGIT-	Abs_Value										8	8	0	20.07	12.58	11.35 - 28.78	7.32 - 39.52	16.06	11.7 - 24.89	Н/П*	Н/П*
8EMTM+PD-1+TIGIT+	Abs_Value										8	8	0	62.65	40.44	34.63 - 90.68	7.4 - 125.68	67.48	30.29 - 84.25	Н/П*	Н/П*
8EMTM+TIGIT+	Abs_Value										8	8	0	96.72	74.19	45.31 - 148.14	8.24 - 220.12	86.84	34.65 - 150.96	Н/П*	Н/П*
8NV	Abs_Value										8	8	0	58.05	57.22	18.41 - 97.7	8.51 - 189.4	38.1	29.77 - 65.86	Н/П*	Н/П*
8NV(СТАР2)	Abs_Value										8	8	0	62.09	73.13	11.41 - 112.77	4.23 - 232.76	49.11	19.27 - 60.6	Н/П*	Н/П*
8NV+226+	Abs_Value										8	8	0	55.11	73.03	4.5 - 105.72	3.16 - 230.07	39.17	16.6 - 50.78	Н/П*	Н/П*
8NV+39+	Abs_Value										8	8	0	4.26	5.01	0.79 - 7.73	0.15 - 12.88	2.24	0.88 - 5.74	Н/П*	Н/П*
8NV+DR+	Abs_Value										8	8	0	7.12	4.48	4.01 - 10.22	0.28 - 14.07	7.08	5.08 - 9.53	Н/П*	Н/П*
8NV+PD-1-TIGIT-	Abs_Value										8	8	0	50.51	73.06	-0.12 - 101.14	1.58 - 223.18	31.16	6.06 - 46.52	Н/П*	Н/П*
8NV+PD-1-TIGIT+	Abs_Value										8	8	0	2.95	3.36	0.62 - 5.28	0.22 - 10.07	1.38	0.69 - 4.48	Н/П*	Н/П*
8NV+PD-1+	Abs_Value										8	8	0	8.63	6.89	3.86 - 13.41	0.97 - 19.85	5.91	4.14 - 14.06	Н/П*	Н/П*
8NV+PD-1+TIGIT-	Abs_Value										8	8	0	4.43	5.63	0.52 - 8.33	0.01 - 14.25	1.89	0.41 - 6.52	Н/П*	Н/П*
8NV+PD-1+TIGIT+	Abs_Value										8	8	0	4.21	3.64	1.69 - 6.73	0.67 - 11.23	3.44	1.25 - 5.95	Н/П*	Н/П*
8NV+TIGIT+	Abs_Value										8	8	0	7.16	5.53	3.32 - 10.99	0.89 - 17.04	6.64	2.49 - 9.86	Н/П*	Н/П*
8TREG	Abs_Value										8	8	0	545.21	535.4	174.2 - 916.22	63.17 - 1610.29	285.52	252.25 - 701.11	Н/П*	Н/П*
8ЕМ	Abs_Value										8	8	0	126.1	115.45	46.1 - 206.11	11.85 - 355.83	107.95	44.1 - 171.12	Н/П*	Н/П*
8СМ	Abs_Value										8	8	0	25.41	36.82	-0.1 - 50.93	1.27 - 101.48	8.12	4.79 - 25.98	Н/П*	Н/П*
8СМ(СТАР2)	Abs_Value										8	8	0	17.73	22.04	2.46 - 33.01	1.08 - 60.65	7.6	2.54 - 24.44	Н/П*	Н/П*
8СМ+226+	Abs_Value										8	8	0	12.44	16.05	1.32 - 23.56	0.99 - 48.69	6.15	2.15 - 15.5	Н/П*	Н/П*
8СМ+39+	Abs_Value										8	8	0	7.04	15.93	-4 - 18.07	0.16 - 46.33	1.44	0.35 - 3.16	Н/П*	Н/П*
8СМ+DR+	Abs_Value										8	8	0	14.92	19.56	1.36 - 28.47	0.37 - 51.36	5.17	2.11 - 20.71	Н/П*	Н/П*
8СМ+PD-1-TIGIT-	Abs_Value										8	8	0	1.63	1.3	0.73 - 2.53	0.27 - 3.93	1.31	0.61 - 2.23	Н/П*	Н/П*
8СМ+PD-1-TIGIT+	Abs_Value										8	8	0	2.56	3.87	-0.12 - 5.24	0.1 - 10.87	0.92	0.41 - 2.29	Н/П*	Н/П*
8СМ+PD-1+	Abs_Value										8	8	0	13.54	17.72	1.26 - 25.82	0.32 - 50.7	5.37	1.99 - 18.71	Н/П*	Н/П*
8СМ+PD-1+TIGIT-	Abs_Value										8	8	0	0.83	0.89	0.21 - 1.45	0.07 - 2.5	0.39	0.3 - 1.15	Н/П*	Н/П*
8СМ+PD-1+TIGIT+	Abs_Value										8	8	0	12.71	17.22	0.78 - 24.64	0.25 - 48.83	4.73	1.69 - 16.73	Н/П*	Н/П*
8СМ+TIGIT+	Abs_Value										8	8	0	15.27	20.33	1.19 - 29.36	0.38 - 54.85	5.65	1.91 - 20.23	Н/П*	Н/П*
8ТЕ	Abs_Value										8	8	0	526.81	519.95	166.5 - 887.11	93.48 - 1482.15	311.25	217.77 - 578.75	Н/П*	Н/П*
8ТЕ(СТАР2)	Abs_Value										8	8	0	758.43	674.09	291.31 - 1225.55	102.52 - 2054.76	434.61	392.31 - 1019.77	Н/П*	Н/П*
8ТЕ+226+	Abs_Value										8	8	0	671.96	634.86	232.03 - 1111.89	99.94 - 1884.09	365.53	285.22 - 895.47	Н/П*	Н/П*
8ТЕ+39+	Abs_Value										8	8	0	98.34	153.1	-7.75 - 204.43	3.31 - 469.2	52.07	22.93 - 83.65	Н/П*	Н/П*
8ТЕ+DR+	Abs_Value										8	8	0	476.4	443.49	169.08 - 783.72	22.67 - 1449.4	347.41	254.15 - 533.69	Н/П*	Н/П*
8ТЕ+PD-1-TIGIT-	Abs_Value										8	8	0	215.55	257.1	37.39 - 393.71	27.26 - 700.86	96.41	53.34 - 261.11	Н/П*	Н/П*
8ТЕ+PD-1-TIGIT+	Abs_Value										8	8	0	287.16	348.87	45.41 - 528.92	6.1 - 1067.1	161.64	80.81 - 375.23	Н/П*	Н/П*
8ТЕ+PD-1+	Abs_Value										8	8	0	255.71	174.09	135.07 - 376.35	56.75 - 510.33	280.27	73.87 - 389.33	Н/П*	Н/П*
8ТЕ+PD-1+TIGIT-	Abs_Value										8	8	0	58.3	58.42	17.81 - 98.78	9.24 - 196.26	45.46	31.28 - 55.95	Н/П*	Н/П*
8ТЕ+PD-1+TIGIT+	Abs_Value										8	8	0	197.42	137.47	102.15 - 292.68	20.98 - 357.6	223.55	55.71 - 318.96	Н/П*	Н/П*
8ТЕ+TIGIT+	Abs_Value										8	8	0	484.58	411.65	199.32 - 769.84	27.07 - 1300.32	334.3	235.14 - 721.94	Н/П*	Н/П*
8ТМ	Abs_Value										8	8	0	60.95	59.05	20.03 - 101.87	5.98 - 184.39	45.83	15.25 - 85.13	Н/П*	Н/П*
TREG_CM	Abs_Value										8	8	0	3.13	2.18	1.62 - 4.64	0.39 - 6.58	3.11	1.67 - 4.65	Н/П*	Н/П*
TREG_EMTM	Abs_Value										8	8	0	29.53	23.85	13 - 46.06	6.83 - 69.64	18.05	12.58 - 49.74	Н/П*	Н/П*
TREG_NV	Abs_Value										8	8	0	3.25	2.28	1.67 - 4.83	0.25 - 6.33	3.11	1.52 - 5.23	Н/П*	Н/П*
TREG_TE	Abs_Value										8	8	0	7.23	7.34	2.15 - 12.32	0.92 - 21.61	4.92	1.87 - 9.42	Н/П*	Н/П*
TREG+226-TIGIT-	Abs_Value										8	8	0	3.02	2.09	1.58 - 4.47	0.34 - 6.14	2.75	1.39 - 4.23	Н/П*	Н/П*
TREG+226-TIGIT+	Abs_Value										8	8	0	11.51	12.13	3.1 - 19.91	1.18 - 38.88	8.41	4.02 - 13.26	Н/П*	Н/П*
TREG+226+	Abs_Value										8	8	0	28.74	20.29	14.68 - 42.8	7.4 - 58.24	20.17	14.48 - 43.06	Н/П*	Н/П*
TREG+226+TIGIT-	Abs_Value										8	8	0	4.69	2.41	3.02 - 6.36	0.65 - 7.21	5.74	2.69 - 6.14	Н/П*	Н/П*
TREG+226+TIGIT+	Abs_Value										8	8	0	24.05	18.56	11.2 - 36.91	6.75 - 51.84	16.08	10.13 - 36.09	Н/П*	Н/П*
TREG+39+	Abs_Value										8	8	0	26.13	18.4	13.38 - 38.88	6.67 - 62.29	24.03	11.41 - 33.36	Н/П*	Н/П*
TREG+DR+	Abs_Value										8	8	0	30.35	28.97	10.28 - 50.42	4.17 - 87.97	17.23	11.06 - 44.75	Н/П*	Н/П*
TREG+PD-1+	Abs_Value										8	8	0	18.73	16.12	7.57 - 29.9	4.48 - 54.08	14.55	9.46 - 19.64	Н/П*	Н/П*
TREG+TIGIT+	Abs_Value										8	8	0	35.56	28.98	15.48 - 55.65	7.94 - 89.91	23.42	15.76 - 51.2	Н/П*	Н/П*
ДЕНЬ ХРРТПХ +30	4_TFH	Abs_Value										15	15	0	41.42	35.22	23.59 - 59.25	1.88 - 144.19	34.77	19.59 - 48.2	Н/П*	Н/П*
	4_TH1	Abs_Value										15	15	0	18.7	11.35	12.96 - 24.44	0.66 - 34.4	17.15	9.34 - 28.6	Н/П*	Н/П*
	4_TH17	Abs_Value										15	15	0	27.05	22.76	15.53 - 38.57	3.09 - 89.01	29.2	9.12 - 34.98	Н/П*	Н/П*
	4_Th17TO1	Abs_Value										15	15	0	5.5	5	2.97 - 8.03	0.12 - 17.42	3.34	2.54 - 6.4	Н/П*	Н/П*
	4_TH2	Abs_Value										15	15	0	32.35	34.88	14.7 - 50	2.05 - 117.68	19.15	12.1 - 29.88	Н/П*	Н/П*
	4_TH22	Abs_Value										15	15	0	10.2	8.13	6.09 - 14.32	0.28 - 25.4	8.22	4.08 - 16.88	Н/П*	Н/П*
	4+	Abs_Value										15	15	0	113.45	77.06	74.45 - 152.44	12.27 - 279.76	115.34	52.55 - 137.07	Н/П*	Н/П*
	4+ (IM STAT)	Abs_Value										15	15	0	83.06	47.94	58.8 - 107.32	4.93 - 174.05	94.04	49.17 - 113.02	Н/П*	Н/П*
	4+226+	Abs_Value										15	15	0	258.58	149.29	183.03 - 334.13	16.9 - 520.8	261.93	133.57 - 367.46	Н/П*	Н/П*
	4+39+	Abs_Value										15	15	0	60.66	49.31	35.7 - 85.61	7.34 - 160.47	51.07	18.09 - 98.84	Н/П*	Н/П*
	4+DR+	Abs_Value										15	15	0	84.97	62.79	53.19 - 116.74	9.79 - 265.5	83.23	48.31 - 108.22	Н/П*	Н/П*
	4+PD-1-TIGIT-	Abs_Value										15	15	0	126.96	82.73	85.1 - 168.83	5.65 - 256.76	136.66	45.58 - 192.53	Н/П*	Н/П*
	4+PD-1-TIGIT+	Abs_Value										15	15	0	9.1	6.8	5.66 - 12.55	0.42 - 23.61	6.58	4.12 - 14.19	Н/П*	Н/П*
	4+PD-1+	Abs_Value										15	15	0	141.17	92.6	94.31 - 188.03	11.98 - 315.97	130.18	76.11 - 198.25	Н/П*	Н/П*
	4+PD-1+TIGIT-	Abs_Value										15	15	0	75.02	49.16	50.14 - 99.89	7.35 - 183.9	75.16	37.11 - 95.98	Н/П*	Н/П*
	4+PD-1+TIGIT+	Abs_Value										15	15	0	66.15	46.61	42.57 - 89.74	4.63 - 152.42	45.69	36.49 - 103.46	Н/П*	Н/П*
	4+TIGIT+	Abs_Value										15	15	0	75.26	51.98	48.95 - 101.56	5.05 - 169.73	56.34	40.61 - 112.97	Н/П*	Н/П*
	4NV	Abs_Value										15	15	0	68.83	57.06	39.95 - 97.71	4.02 - 183.37	52.65	22.6 - 99.81	Н/П*	Н/П*
	4NV(СТАР2)	Abs_Value										15	15	0	61.97	55.34	33.97 - 89.98	3.41 - 181.45	44.3	19.68 - 93.27	Н/П*	Н/П*
	4NV_TH1	Abs_Value										15	15	0	3.96	3.53	2.18 - 5.75	0.17 - 10.34	2.83	0.67 - 6.5	Н/П*	Н/П*
	4NV_TH17	Abs_Value										15	15	0	2.14	1.92	1.17 - 3.11	0.28 - 6.27	1.46	0.75 - 2.59	Н/П*	Н/П*
	4NV_Th17TO1	Abs_Value										15	15	0	0.38	0.41	0.17 - 0.59	0.01 - 1.64	0.31	0.08 - 0.53	Н/П*	Н/П*
	4NV_TH2	Abs_Value										15	15	0	7.94	7.05	4.37 - 11.51	0.44 - 23.62	5.43	1.83 - 14.44	Н/П*	Н/П*
	4NV_TH22	Abs_Value										15	15	0	0.12	0.14	0.05 - 0.19	0 - 0.49	0.09	0.02 - 0.14	Н/П*	Н/П*
	4NV+226+	Abs_Value										15	15	0	55.53	50.79	29.83 - 81.23	3.06 - 175.11	39.74	17.39 - 84.16	Н/П*	Н/П*
	4NV+39+	Abs_Value										15	15	0	1.75	2.76	0.35 - 3.14	0.01 - 11.3	1.08	0.37 - 1.7	Н/П*	Н/П*
	4NV+DR+	Abs_Value										15	15	0	3.23	3.9	1.26 - 5.2	0.15 - 13.12	1.81	1.05 - 2.84	Н/П*	Н/П*
	4NV+PD-1-TIGIT-	Abs_Value										15	15	0	58.02	53.13	31.13 - 84.9	2.88 - 176.14	41.17	17.05 - 88.71	Н/П*	Н/П*
	4NV+PD-1-TIGIT+	Abs_Value										15	15	0	1.07	1.18	0.47 - 1.66	0.08 - 4.15	0.68	0.23 - 1.59	Н/П*	Н/П*
	4NV+PD-1+TIGIT-	Abs_Value										15	15	0	2.03	2.76	0.64 - 3.43	0.09 - 11.35	1.28	0.72 - 2.04	Н/П*	Н/П*
	4NV+PD-1+TIGIT+	Abs_Value										15	15	0	0.86	0.73	0.49 - 1.22	0.08 - 2.32	0.66	0.43 - 1.16	Н/П*	Н/П*
	4NV+PD1+	Abs_Value										15	15	0	2.89	3.29	1.22 - 4.56	0.17 - 13.68	1.81	1.35 - 3.46	Н/П*	Н/П*
	4NV+TIGIT+	Abs_Value										15	15	0	1.92	1.87	0.98 - 2.87	0.16 - 6.48	1.36	0.74 - 2.73	Н/П*	Н/П*
	4ЕМ	Abs_Value										15	15	0	8.01	9.16	3.37 - 12.65	0.03 - 29.57	3.27	2.21 - 14.05	Н/П*	Н/П*
	4ЕМ_TH1	Abs_Value										15	15	0	1.58	1.93	0.6 - 2.55	0.01 - 6.46	1.04	0.52 - 1.68	Н/П*	Н/П*
	4ЕМ_TH17	Abs_Value										15	15	0	0.14	0.47	-0.1 - 0.38	0 - 1.83	0	0 - 0.03	Н/П*	Н/П*
	4ЕМ_Th17TO1	Abs_Value										15	15	0	0.09	0.13	0.02 - 0.16	0 - 0.54	0.06	0.01 - 0.09	Н/П*	Н/П*
	4ЕМ_TH2	Abs_Value										15	15	0	1.2	3.96	-0.8 - 3.2	0.01 - 15.48	0.08	0.04 - 0.29	Н/П*	Н/П*
	4ЕМ_TH22	Abs_Value										15	15	0	0	0.01	0 - 0.01	0 - 0.02	0	0 - 0	Н/П*	Н/П*
	4ЕМ+226+	Abs_Value										15	15	0	117.34	79.32	77.19 - 157.48	6.84 - 253.96	92.56	50.54 - 178.57	Н/П*	Н/П*
	4ЕМ+39+	Abs_Value										15	15	0	37.54	33.1	20.79 - 54.29	4.45 - 111.55	28.6	11.75 - 57.97	Н/П*	Н/П*
	4ЕМ+DR+	Abs_Value										15	15	0	57.12	45.75	33.97 - 80.27	4.57 - 188.94	47.84	28.28 - 73.33	Н/П*	Н/П*
	4ЕМ+PD1-TIGIT-	Abs_Value										15	15	0	32.35	27.25	18.56 - 46.13	0.6 - 91.12	36.85	8.89 - 47.51	Н/П*	Н/П*
	4ЕМ+PD1-TIGIT+	Abs_Value										15	15	0	3.44	2.85	2 - 4.88	0.08 - 9.64	2.2	1.27 - 5.62	Н/П*	Н/П*
	4ЕМ+PD1+	Abs_Value										15	15	0	87.7	57.65	58.53 - 116.87	6.41 - 195.8	79.37	42.57 - 133.07	Н/П*	Н/П*
	4ЕМ+PD1+TIGIT-	Abs_Value										15	15	0	48.54	31.01	32.84 - 64.23	4.01 - 115.09	45.93	23.82 - 71.85	Н/П*	Н/П*
	4ЕМ+PD1+TIGIT+	Abs_Value										15	15	0	39.16	28.54	24.72 - 53.61	2.39 - 80.71	28.76	15.72 - 70.77	Н/П*	Н/П*
	4ЕМ+TIGIT+	Abs_Value										15	15	0	42.6	30.6	27.12 - 58.09	2.47 - 88.33	29.75	17.11 - 74.95	Н/П*	Н/П*
	4ЕМTM	Abs_Value										15	15	0	123.49	83.06	81.45 - 165.52	7.08 - 263.87	97.56	55.67 - 186.59	Н/П*	Н/П*
	4СМ	Abs_Value										15	15	0	72.69	52.49	46.12 - 99.25	6.84 - 182.94	64.37	31.44 - 103.84	Н/П*	Н/П*
	4СМ(СТАР2)	Abs_Value										15	15	0	59.44	43.19	37.59 - 81.3	3.79 - 156.19	53.43	30.31 - 83.44	Н/П*	Н/П*
	4СМ_TH1	Abs_Value										15	15	0	2.57	2.12	1.5 - 3.64	0.18 - 6.72	2.27	0.7 - 3.4	Н/П*	Н/П*
	4СМ_TH17	Abs_Value										15	15	0	10.25	7.2	6.61 - 13.89	1.53 - 20.35	10.12	3.42 - 16.88	Н/П*	Н/П*
	4СМ_Th17TO1	Abs_Value										15	15	0	1.09	1.3	0.44 - 1.75	0.04 - 4.95	0.57	0.5 - 1.03	Н/П*	Н/П*
	4СМ_TH2	Abs_Value										15	15	0	7.94	10.63	2.56 - 13.32	0.53 - 43.16	5.73	1.69 - 8.08	Н/П*	Н/П*
	4СМ_TH22	Abs_Value										15	15	0	1.21	1.35	0.52 - 1.89	0.09 - 5.05	0.66	0.21 - 1.6	Н/П*	Н/П*
	4СМ+226+	Abs_Value										15	15	0	56.63	41.5	35.63 - 77.64	3.54 - 150.99	51.16	28.19 - 79.37	Н/П*	Н/П*
	4СМ+39+	Abs_Value										15	15	0	16.23	16.63	7.81 - 24.65	0.32 - 63.2	15.74	4.09 - 21.21	Н/П*	Н/П*
	4СМ+DR+	Abs_Value										15	15	0	11.87	9.36	7.13 - 16.61	0.74 - 30.47	11.86	4.41 - 16.27	Н/П*	Н/П*
	4СМ+PD1-TIGIT-	Abs_Value										15	15	0	23.04	16.45	14.71 - 31.36	0.98 - 52.58	23.91	7.34 - 33.86	Н/П*	Н/П*
	4СМ+PD1-TIGIT+	Abs_Value										15	15	0	2.64	2.07	1.59 - 3.69	0.1 - 6.56	2.19	0.98 - 3.81	Н/П*	Н/П*
	4СМ+PD1+	Abs_Value										15	15	0	33.77	29.24	18.97 - 48.57	2.28 - 112.1	25.79	15.5 - 40.13	Н/П*	Н/П*
	4СМ+PD1+TIGIT-	Abs_Value										15	15	0	14.41	12.54	8.06 - 20.76	1.16 - 43.45	10.48	6.3 - 19.55	Н/П*	Н/П*
	4СМ+PD1+TIGIT+	Abs_Value										15	15	0	19.36	17.82	10.34 - 28.38	1.13 - 68.65	14.97	9.62 - 21.95	Н/П*	Н/П*
4СМ+TIGIT+	Abs_Value										15	15	0	22	19.34	12.21 - 31.79	1.33 - 75.21	16.36	13.43 - 24.87	Н/П*	Н/П*
4ТM_TH1	Abs_Value										15	15	0	6.89	5.17	4.28 - 9.51	0.2 - 15.48	5.33	3.2 - 10.96	Н/П*	Н/П*
4ТM_TH17	Abs_Value										15	15	0	13.31	15.17	5.64 - 20.99	0.71 - 55.73	10.63	3.85 - 13.15	Н/П*	Н/П*
4ТM_Th17TO1	Abs_Value										15	15	0	3.4	3.05	1.85 - 4.94	0.05 - 9.26	2.18	1.5 - 4.78	Н/П*	Н/П*
4ТM_TH2	Abs_Value										15	15	0	13.23	22.12	2.04 - 24.43	0.25 - 77.73	3.24	1.25 - 10.52	Н/П*	Н/П*
4ТM_TH22	Abs_Value										15	15	0	7.99	7.02	4.43 - 11.54	0.09 - 23.06	5.64	2.71 - 13.79	Н/П*	Н/П*
4ТREG	Abs_Value										15	15	0	4.6	4.45	2.35 - 6.85	0.4 - 16.67	3.82	1.9 - 5.07	Н/П*	Н/П*
4ТREG(СТАР2)	Abs_Value										15	15	0	115.61	78.89	75.68 - 155.53	12.1 - 286.85	117.64	52.03 - 141.84	Н/П*	Н/П*
4ТREG_TH1	Abs_Value										15	15	0	0.29	0.22	0.17 - 0.4	0.01 - 0.75	0.25	0.11 - 0.48	Н/П*	Н/П*
4ТREG_TH17	Abs_Value										15	15	0	7.04	7.91	3.04 - 11.05	0.53 - 24.8	3.6	2.5 - 6.65	Н/П*	Н/П*
4ТREG_Th17TO1	Abs_Value										15	15	0	0.1	0.11	0.05 - 0.15	0 - 0.34	0.06	0.02 - 0.16	Н/П*	Н/П*
4ТREG_TH2	Abs_Value										15	15	0	4.32	5.41	1.59 - 7.06	0.18 - 18.49	2.52	1.77 - 3.33	Н/П*	Н/П*
4ТREG_TH22	Abs_Value										15	15	0	6.24	5.63	3.39 - 9.09	0.48 - 19.57	5	1.79 - 7.33	Н/П*	Н/П*
4ТЕ	Abs_Value										15	15	0	5.88	8.77	1.44 - 10.32	0.02 - 33.66	3.33	0.28 - 7.82	Н/П*	Н/П*
4ТЕ(СТАР2)	Abs_Value										15	15	0	31.57	20.83	21.03 - 42.11	3.14 - 68.2	27.41	20.69 - 43.27	Н/П*	Н/П*
4ТЕ_TH1	Abs_Value										15	15	0	1.51	2.07	0.47 - 2.56	0.01 - 6.53	0.37	0.06 - 2.29	Н/П*	Н/П*
4ТЕ_TH17	Abs_Value										15	15	0	0.01	0.03	0 - 0.02	0 - 0.1	0	0 - 0.01	Н/П*	Н/П*
4ТЕ_Th17TO1	Abs_Value										15	15	0	0.05	0.08	0.01 - 0.1	0 - 0.26	0.01	0 - 0.08	Н/П*	Н/П*
4ТЕ_TH2	Abs_Value										15	15	0	0.14	0.18	0.05 - 0.23	0 - 0.61	0.07	0 - 0.23	Н/П*	Н/П*
4ТЕ_TH22	Abs_Value										15	15	0	0.01	0.02	0 - 0.02	0 - 0.06	0	0 - 0.01	Н/П*	Н/П*
4ТЕ+226+	Abs_Value										15	15	0	28.47	18.77	18.97 - 37.97	2.9 - 61.52	24.82	18.55 - 41	Н/П*	Н/П*
4ТЕ+39+	Abs_Value										15	15	0	5.25	3.92	3.26 - 7.23	0.69 - 13.77	4.75	1.81 - 7.46	Н/П*	Н/П*
4ТЕ+DR+	Abs_Value										15	15	0	12.88	9.8	7.92 - 17.84	0.58 - 35.94	11.91	4.58 - 18.14	Н/П*	Н/П*
4ТЕ+PD-1-TIGIT-	Abs_Value										15	15	0	12.52	10.11	7.4 - 17.63	0.87 - 37.08	10.68	7.43 - 14.06	Н/П*	Н/П*
4ТЕ+PD-1-TIGIT+	Abs_Value										15	15	0	1.89	1.74	1.01 - 2.77	0.07 - 7.04	1.41	0.78 - 2.42	Н/П*	Н/П*
4ТЕ+PD-1+	Abs_Value										15	15	0	17.17	12.94	10.62 - 23.72	1.5 - 42.91	15.16	8.07 - 20.76	Н/П*	Н/П*
4ТЕ+PD-1+TIGIT-	Abs_Value										15	15	0	10.15	8.57	5.81 - 14.49	0.74 - 31.83	7.39	4 - 15.3	Н/П*	Н/П*
4ТЕ+PD-1+TIGIT+	Abs_Value										15	15	0	7.01	5.67	4.14 - 9.88	0.76 - 22.71	6.36	4.24 - 7.37	Н/П*	Н/П*
4ТЕ+TIGIT+	Abs_Value										15	15	0	8.9	7.28	5.22 - 12.59	0.88 - 29.75	7.6	5.02 - 10.38	Н/П*	Н/П*
4ТМ	Abs_Value										15	15	0	110.74	77.46	71.54 - 149.94	5 - 226.12	88.73	45.16 - 173.91	Н/П*	Н/П*
8+	Abs_Value										15	15	0	454.96	301.52	302.37 - 607.55	23.55 - 922.88	549.84	163.75 - 673.27	Н/П*	Н/П*
8+ (IM STAT)	Abs_Value										15	15	0	585.72	390.28	388.21 - 783.23	24.94 - 1331.74	688.88	220.35 - 851.78	Н/П*	Н/П*
8+226+	Abs_Value										15	15	0	735.7	486.29	489.6 - 981.79	38.86 - 1789.01	825.43	303.22 - 983.5	Н/П*	Н/П*
8+39+	Abs_Value										15	15	0	114.39	114.56	56.41 - 172.36	16.66 - 357.72	41.29	24.39 - 183.7	Н/П*	Н/П*
8+DR+	Abs_Value										15	15	0	575.11	408.95	368.15 - 782.06	42.24 - 1466.62	593.7	229.91 - 684.66	Н/П*	Н/П*
8+PD-1-TIGIT-	Abs_Value										15	15	0	251.97	184.25	158.73 - 345.21	11.27 - 622.7	261.4	86.93 - 385.69	Н/П*	Н/П*
8+PD-1-TIGIT+	Abs_Value										15	15	0	242.39	172.19	155.25 - 329.53	8.34 - 526.18	205.45	92.47 - 382.59	Н/П*	Н/П*
8+PD-1+	Abs_Value										15	15	0	354.74	310.4	197.66 - 511.83	17.27 - 1087.66	309.38	134.94 - 539.92	Н/П*	Н/П*
8+PD-1+TIGIT-	Abs_Value										15	15	0	123.02	146.03	49.11 - 196.92	2.82 - 534.79	60.17	29.02 - 171.1	Н/П*	Н/П*
8+PD-1+TIGIT+	Abs_Value										15	15	0	231.73	193.18	133.96 - 329.49	14.46 - 610.79	129.1	105.33 - 354.03	Н/П*	Н/П*
8+TIGIT+	Abs_Value										15	15	0	474.11	307.19	318.66 - 629.57	37.05 - 948.67	494.17	217.71 - 739.83	Н/П*	Н/П*
8EMTM	Abs_Value										15	15	0	129.44	92.83	82.46 - 176.42	1.08 - 323.39	126.6	59.22 - 174.2	Н/П*	Н/П*
8EMTM+226+	Abs_Value										15	15	0	102.37	66.2	68.87 - 135.87	0.93 - 235.61	114.55	49.95 - 145.93	Н/П*	Н/П*
8EMTM+39+	Abs_Value										15	15	0	27.9	31.46	11.98 - 43.82	0.67 - 104.21	14.41	5.84 - 41.03	Н/П*	Н/П*
8EMTM+DR+	Abs_Value										15	15	0	104.25	73.16	67.22 - 141.27	0.9 - 274.76	100.99	55.05 - 136.05	Н/П*	Н/П*
8EMTM+PD-1-TIGIT-	Abs_Value										15	15	0	23.96	15.74	15.99 - 31.93	0.14 - 48.43	28.99	10.71 - 32.49	Н/П*	Н/П*
8EMTM+PD-1-TIGIT+	Abs_Value										15	15	0	27.07	30.9	11.43 - 42.71	0.05 - 97	13.96	6.64 - 40.15	Н/П*	Н/П*
8EMTM+PD-1+	Abs_Value										15	15	0	78.41	59.13	48.49 - 108.34	0.88 - 195.42	71.52	43.76 - 92.46	Н/П*	Н/П*
8EMTM+PD-1+TIGIT-	Abs_Value										15	15	0	23.48	20.37	13.17 - 33.79	0.31 - 69.43	19.83	6.65 - 34.68	Н/П*	Н/П*
8EMTM+PD-1+TIGIT+	Abs_Value										15	15	0	54.93	47.52	30.88 - 78.98	0.58 - 163.69	42.61	29.39 - 68.04	Н/П*	Н/П*
8EMTM+TIGIT+	Abs_Value										15	15	0	82	74.15	44.47 - 119.53	0.63 - 226.09	54.58	32.91 - 131.91	Н/П*	Н/П*
8NV	Abs_Value										15	15	0	32.09	27.63	18.11 - 46.08	4.86 - 82.24	20.92	9.56 - 48.01	Н/П*	Н/П*
8NV(СТАР2)	Abs_Value										15	15	0	34.3	28.76	19.74 - 48.85	2.72 - 93.55	24.99	6.57 - 58.3	Н/П*	Н/П*
8NV+226+	Abs_Value										15	15	0	29.83	25.73	16.8 - 42.85	2.36 - 87.03	24.46	5.45 - 49.76	Н/П*	Н/П*
8NV+39+	Abs_Value										15	15	0	3.41	4.89	0.93 - 5.88	0 - 17.8	1.14	0.37 - 4.4	Н/П*	Н/П*
8NV+DR+	Abs_Value										15	15	0	5.06	6	2.02 - 8.09	0.27 - 21.82	2.96	1.32 - 5.7	Н/П*	Н/П*
8NV+PD-1-TIGIT-	Abs_Value										15	15	0	27.14	26.38	13.79 - 40.49	0.86 - 90.53	19.82	5.58 - 46.88	Н/П*	Н/П*
8NV+PD-1-TIGIT+	Abs_Value										15	15	0	2.26	2.32	1.08 - 3.43	0.19 - 8.04	1.63	0.54 - 3.45	Н/П*	Н/П*
8NV+PD-1+	Abs_Value										15	15	0	4.9	7.29	1.21 - 8.59	0.09 - 25.44	1.31	0.74 - 5.67	Н/П*	Н/П*
8NV+PD-1+TIGIT-	Abs_Value										15	15	0	1.18	1.9	0.22 - 2.14	0.01 - 6.86	0.32	0.09 - 1.31	Н/П*	Н/П*
8NV+PD-1+TIGIT+	Abs_Value										15	15	0	3.71	5.8	0.78 - 6.65	0.08 - 21.78	1.01	0.62 - 4.05	Н/П*	Н/П*
8NV+TIGIT+	Abs_Value										15	15	0	5.97	6.65	2.61 - 9.34	0.35 - 25.67	3.22	1.54 - 8.12	Н/П*	Н/П*
8TREG	Abs_Value										15	15	0	445.89	292.69	297.77 - 594.01	20.46 - 892.2	544.62	162.87 - 665.11	Н/П*	Н/П*
8ЕМ	Abs_Value										15	15	0	92.33	61.79	61.06 - 123.6	0.5 - 229.56	93.55	43.05 - 128.36	Н/П*	Н/П*
8СМ	Abs_Value										15	15	0	21.45	27.26	7.65 - 35.24	0.61 - 77.79	8.32	4.62 - 24.69	Н/П*	Н/П*
8СМ(СТАР2)	Abs_Value										15	15	0	18.25	24.46	5.87 - 30.62	0.4 - 85.81	7.24	2.61 - 25.28	Н/П*	Н/П*
8СМ+226+	Abs_Value										15	15	0	12.81	17.04	4.18 - 21.43	0.36 - 60.98	6.43	2.05 - 15.28	Н/П*	Н/П*
8СМ+39+	Abs_Value										15	15	0	6.38	10.39	1.12 - 11.64	0.12 - 32.91	1.15	0.4 - 6.79	Н/П*	Н/П*
8СМ+DR+	Abs_Value										15	15	0	14.68	19.65	4.74 - 24.63	0.17 - 63.4	4.51	2.17 - 22.39	Н/П*	Н/П*
8СМ+PD-1-TIGIT-	Abs_Value										15	15	0	2.85	3.95	0.85 - 4.85	0.03 - 15.83	1.77	0.64 - 2.93	Н/П*	Н/П*
8СМ+PD-1-TIGIT+	Abs_Value										15	15	0	3.4	4.78	0.99 - 5.82	0.07 - 18.1	1.05	0.32 - 5.38	Н/П*	Н/П*
8СМ+PD-1+	Abs_Value										15	15	0	11.99	16.71	3.53 - 20.45	0.15 - 51.89	4	1.51 - 15.08	Н/П*	Н/П*
8СМ+PD-1+TIGIT-	Abs_Value										15	15	0	1.24	1.7	0.38 - 2.1	0.02 - 6.29	0.57	0.13 - 1.91	Н/П*	Н/П*
8СМ+PD-1+TIGIT+	Abs_Value										15	15	0	10.75	15.28	3.02 - 18.49	0.12 - 48.73	2.14	1.38 - 13.8	Н/П*	Н/П*
8СМ+TIGIT+	Abs_Value										15	15	0	14.16	19.6	4.24 - 24.08	0.2 - 66.83	4.86	2.03 - 20.16	Н/П*	Н/П*
8ТЕ	Abs_Value										15	15	0	481.07	361.97	297.88 - 664.25	6.43 - 1353.64	461.4	190.67 - 655.26	Н/П*	Н/П*
8ТЕ(СТАР2)	Abs_Value										15	15	0	664.73	461.52	431.16 - 898.29	56.16 - 1732.27	718.48	241.65 - 862.68	Н/П*	Н/П*
8ТЕ+226+	Abs_Value										15	15	0	588.82	441.14	365.57 - 812.07	33.24 - 1657.11	649.69	210.33 - 738.66	Н/П*	Н/П*
8ТЕ+39+	Abs_Value										15	15	0	76.43	77.61	37.16 - 115.71	12.62 - 275.32	36.22	15.97 - 128.88	Н/П*	Н/П*
8ТЕ+DR+	Abs_Value										15	15	0	450.51	368.94	263.8 - 637.22	39.8 - 1367.91	434.18	172.47 - 533.54	Н/П*	Н/П*
8ТЕ+PD-1-TIGIT-	Abs_Value										15	15	0	197.21	165.31	113.55 - 280.86	7.02 - 566.21	180.62	47.02 - 306.88	Н/П*	Н/П*
8ТЕ+PD-1-TIGIT+	Abs_Value										15	15	0	208.78	145.39	135.2 - 282.36	7.47 - 439.67	188.42	79.03 - 308.92	Н/П*	Н/П*
8ТЕ+PD-1+	Abs_Value										15	15	0	258.74	270.88	121.66 - 395.82	15.97 - 1004.7	215.94	72.21 - 321.98	Н/П*	Н/П*
8ТЕ+PD-1+TIGIT-	Abs_Value										15	15	0	97.06	132.41	30.05 - 164.06	2.47 - 498.86	43.16	15.49 - 123.69	Н/П*	Н/П*
8ТЕ+PD-1+TIGIT+	Abs_Value										15	15	0	161.68	155.73	82.87 - 240.5	13.5 - 505.84	83.47	58.05 - 198.7	Н/П*	Н/П*
8ТЕ+TIGIT+	Abs_Value										15	15	0	370.46	242.29	247.85 - 493.08	30.75 - 687.19	449	158.04 - 566.74	Н/П*	Н/П*
8ТМ	Abs_Value										15	15	0	59.34	51.96	33.04 - 85.64	1.32 - 166.73	42.86	21.57 - 82.19	Н/П*	Н/П*
TREG_CM	Abs_Value										15	15	0	2.08	1.6	1.27 - 2.89	0.16 - 5.88	1.61	0.95 - 3.23	Н/П*	Н/П*
TREG_EMTM	Abs_Value										15	15	0	29.34	25.6	16.39 - 42.3	1.8 - 84.82	25.51	11.82 - 34.09	Н/П*	Н/П*
TREG_NV	Abs_Value										15	15	0	1.88	1.65	1.04 - 2.71	0.08 - 4.93	1.29	0.54 - 3.14	Н/П*	Н/П*
TREG_TE	Abs_Value										15	15	0	4.65	3.51	2.87 - 6.42	0.61 - 11.35	3.75	2.05 - 5.65	Н/П*	Н/П*
TREG+226-TIGIT-	Abs_Value										15	15	0	1.81	1.59	1 - 2.62	0.1 - 5.34	1.12	1.01 - 2.25	Н/П*	Н/П*
TREG+226-TIGIT+	Abs_Value										15	15	0	7.69	6.68	4.31 - 11.07	0.59 - 26.4	5.69	3.99 - 11.05	Н/П*	Н/П*
TREG+226+	Abs_Value										15	15	0	28.52	23.47	16.64 - 40.4	2.17 - 75.68	24.5	13.63 - 29.7	Н/П*	Н/П*
TREG+226+TIGIT-	Abs_Value										15	15	0	2.89	1.74	2.01 - 3.77	0.17 - 7.07	3.06	1.71 - 3.51	Н/П*	Н/П*
TREG+226+TIGIT+	Abs_Value										15	15	0	25.63	22.38	14.3 - 36.96	2 - 69.16	21.31	10.97 - 26.56	Н/П*	Н/П*
TREG+39+	Abs_Value										15	15	0	25.07	18.82	15.55 - 34.6	2.7 - 79.85	18.08	15.1 - 30.32	Н/П*	Н/П*
TREG+DR+	Abs_Value										15	15	0	29.17	24.94	16.55 - 41.79	2.49 - 88.09	23.93	13.72 - 33.11	Н/П*	Н/П*
TREG+PD-1+	Abs_Value										15	15	0	18.76	20.3	8.49 - 29.03	1.91 - 63.74	7.76	5.51 - 20.16	Н/П*	Н/П*
TREG+TIGIT+	Abs_Value										15	15	0	33.32	27.8	19.25 - 47.39	2.59 - 95.01	29.17	14.94 - 37.72	Н/П*	Н/П*
ДЕНЬ ХРРТПХ +60	4_TFH	Abs_Value										11	11	0	28.68	15.62	19.45 - 37.91	3.33 - 54.11	28.46	19.56 - 37.1	Н/П*	Н/П*
	4_TH1	Abs_Value										11	11	0	35.88	30.33	17.95 - 53.81	4.85 - 102.42	24.35	17.37 - 50.66	Н/П*	Н/П*
	4_TH17	Abs_Value										11	11	0	16.99	8.94	11.71 - 22.27	5.06 - 31.95	14.47	11.07 - 22.14	Н/П*	Н/П*
	4_Th17TO1	Abs_Value										11	11	0	5.93	3.78	3.7 - 8.16	0.57 - 14.51	5.47	3.56 - 8.08	Н/П*	Н/П*
	4_TH2	Abs_Value										11	11	0	23.51	26.51	7.84 - 39.18	3.06 - 91.26	12.68	8.27 - 24.48	Н/П*	Н/П*
	4_TH22	Abs_Value										11	11	0	7.43	7.7	2.87 - 11.98	0.89 - 23.85	4.44	1.81 - 8.44	Н/П*	Н/П*
	4+	Abs_Value										11	11	0	143.45	110.14	78.36 - 208.54	18.83 - 343.47	103.46	76.62 - 181.02	Н/П*	Н/П*
	4+ (IM STAT)	Abs_Value										11	11	0	107.12	91.74	52.91 - 161.34	9 - 338.01	96.04	49.64 - 120.74	Н/П*	Н/П*
	4+226+	Abs_Value										11	11	0	295.97	201.02	177.18 - 414.77	52.17 - 682.45	246.62	161.27 - 388.47	Н/П*	Н/П*
	4+39+	Abs_Value										11	11	0	56.6	45.2	29.89 - 83.31	4.61 - 145.64	66.4	16.69 - 76.04	Н/П*	Н/П*
	4+DR+	Abs_Value										11	11	0	88.9	67.23	49.17 - 128.63	8.23 - 193.07	71.11	34.8 - 139.33	Н/П*	Н/П*
	4+PD-1-TIGIT-	Abs_Value										11	11	0	169.02	167.56	70 - 268.04	14.91 - 537.94	125.88	45.31 - 244.85	Н/П*	Н/П*
	4+PD-1-TIGIT+	Abs_Value										11	11	0	10.29	9.13	4.89 - 15.68	0.63 - 31.44	8.82	3.66 - 14.76	Н/П*	Н/П*
	4+PD-1+	Abs_Value										11	11	0	138.29	71.58	95.99 - 180.59	31.78 - 262.8	132.83	96.83 - 170.43	Н/П*	Н/П*
	4+PD-1+TIGIT-	Abs_Value										11	11	0	83.27	52.91	52.01 - 114.54	23.07 - 198.47	79.56	45.64 - 98.1	Н/П*	Н/П*
	4+PD-1+TIGIT+	Abs_Value										11	11	0	55.01	24.32	40.64 - 69.39	8.71 - 95.48	53.46	45.38 - 69.83	Н/П*	Н/П*
	4+TIGIT+	Abs_Value										11	11	0	65.3	30.88	47.05 - 83.55	9.38 - 126.92	64.95	55 - 74.97	Н/П*	Н/П*
	4NV	Abs_Value										11	11	0	94	128.87	17.84 - 170.15	6.21 - 420.64	45.02	11.53 - 100.8	Н/П*	Н/П*
	4NV(СТАР2)	Abs_Value										11	11	0	97.76	149.09	9.65 - 185.86	1.3 - 510.77	49.15	8.92 - 96.81	Н/П*	Н/П*
	4NV_TH1	Abs_Value										11	11	0	6.91	9.37	1.37 - 12.44	0.25 - 29.1	3.44	0.76 - 7.04	Н/П*	Н/П*
	4NV_TH17	Abs_Value										11	11	0	1.98	1.99	0.8 - 3.16	0.16 - 6.19	1.44	0.51 - 2.58	Н/П*	Н/П*
	4NV_Th17TO1	Abs_Value										11	11	0	0.69	0.68	0.28 - 1.09	0 - 1.82	0.46	0.1 - 1.17	Н/П*	Н/П*
	4NV_TH2	Abs_Value										11	11	0	8.76	13.32	0.89 - 16.63	0.21 - 40.56	2.29	1.3 - 7.28	Н/П*	Н/П*
	4NV_TH22	Abs_Value										11	11	0	0.15	0.19	0.04 - 0.27	0 - 0.62	0.06	0.03 - 0.18	Н/П*	Н/П*
	4NV+226+	Abs_Value										11	11	0	87.24	146.03	0.94 - 173.54	1.18 - 502.6	42.25	7.16 - 82.61	Н/П*	Н/П*
	4NV+39+	Abs_Value										11	11	0	1.66	1.79	0.6 - 2.72	0.02 - 4.32	0.51	0.12 - 3.09	Н/П*	Н/П*
	4NV+DR+	Abs_Value										11	11	0	2.91	2.8	1.25 - 4.56	0.06 - 7.64	3.2	0.27 - 4.87	Н/П*	Н/П*
	4NV+PD-1-TIGIT-	Abs_Value										11	11	0	91.34	140.61	8.25 - 174.44	1.08 - 481.6	45.15	7.96 - 89.58	Н/П*	Н/П*
	4NV+PD-1-TIGIT+	Abs_Value										11	11	0	2.58	3.72	0.37 - 4.78	0 - 11.49	1.13	0.18 - 2.86	Н/П*	Н/П*
	4NV+PD-1+TIGIT-	Abs_Value										11	11	0	2.39	3.59	0.27 - 4.51	0.15 - 12.43	1.02	0.42 - 2.62	Н/П*	Н/П*
	4NV+PD-1+TIGIT+	Abs_Value										11	11	0	1.45	1.57	0.52 - 2.37	0.03 - 5.24	1.15	0.28 - 2.18	Н/П*	Н/П*
	4NV+PD1+	Abs_Value										11	11	0	3.84	5.01	0.88 - 6.8	0.21 - 17.68	2.86	0.75 - 4.59	Н/П*	Н/П*
	4NV+TIGIT+	Abs_Value										11	11	0	4.02	5.04	1.05 - 7	0.03 - 16.74	2.98	0.44 - 4.8	Н/П*	Н/П*
	4ЕМ	Abs_Value										11	11	0	23.6	38.73	0.72 - 46.49	0.38 - 135.76	6.94	4.53 - 24.3	Н/П*	Н/П*
	4ЕМ_TH1	Abs_Value										11	11	0	8.99	12.65	1.52 - 16.47	0.08 - 41.51	3.69	0.85 - 12.85	Н/П*	Н/П*
	4ЕМ_TH17	Abs_Value										11	11	0	0.02	0.03	0 - 0.04	0 - 0.11	0.01	0 - 0.04	Н/П*	Н/П*
	4ЕМ_Th17TO1	Abs_Value										11	11	0	0.18	0.21	0.05 - 0.3	0.01 - 0.61	0.05	0.03 - 0.32	Н/П*	Н/П*
	4ЕМ_TH2	Abs_Value										11	11	0	1.32	3.66	-0.85 - 3.48	0.01 - 12.33	0.23	0.1 - 0.35	Н/П*	Н/П*
	4ЕМ_TH22	Abs_Value										11	11	0	0	0	0 - 0.01	0 - 0.01	0	0 - 0.01	Н/П*	Н/П*
	4ЕМ+226+	Abs_Value										11	11	0	112.6	58.93	77.78 - 147.43	36.25 - 233.28	115.17	67.72 - 144.4	Н/П*	Н/П*
	4ЕМ+39+	Abs_Value										11	11	0	33.27	23.41	19.43 - 47.11	3.55 - 66.1	32.47	14.72 - 53.53	Н/П*	Н/П*
	4ЕМ+DR+	Abs_Value										11	11	0	59.19	49.1	30.17 - 88.21	7.54 - 169.88	45.31	22.39 - 86.64	Н/П*	Н/П*
	4ЕМ+PD1-TIGIT-	Abs_Value										11	11	0	29.45	24.24	15.13 - 43.78	5.75 - 67.06	17.26	11.39 - 49.37	Н/П*	Н/П*
	4ЕМ+PD1-TIGIT+	Abs_Value										11	11	0	2.69	1.88	1.58 - 3.8	0.32 - 5.74	3.05	0.98 - 4.2	Н/П*	Н/П*
	4ЕМ+PD1+	Abs_Value										11	11	0	84.6	55	52.1 - 117.11	28.52 - 229.28	75.61	50.19 - 100.5	Н/П*	Н/П*
	4ЕМ+PD1+TIGIT-	Abs_Value										11	11	0	54.13	44.26	27.97 - 80.29	21.05 - 175.37	43.85	24.53 - 62.18	Н/П*	Н/П*
	4ЕМ+PD1+TIGIT+	Abs_Value										11	11	0	30.47	13.79	22.32 - 38.62	7.43 - 53.91	31.76	23.22 - 34.75	Н/П*	Н/П*
	4ЕМ+TIGIT+	Abs_Value										11	11	0	33.16	13.77	25.02 - 41.29	7.96 - 54.23	35.86	25.41 - 39.15	Н/П*	Н/П*
	4ЕМTM	Abs_Value										11	11	0	116.74	58.8	81.99 - 151.5	39.04 - 235.35	118.96	70.64 - 149.95	Н/П*	Н/П*
	4СМ	Abs_Value										11	11	0	82.27	64.92	43.9 - 120.63	6.36 - 204.91	96.73	26.33 - 114.43	Н/П*	Н/П*
	4СМ(СТАР2)	Abs_Value										11	11	0	65.12	54.23	33.07 - 97.16	5.4 - 150.09	69.58	12.28 - 95.96	Н/П*	Н/П*
	4СМ_TH1	Abs_Value										11	11	0	4.48	6.89	0.4 - 8.55	0.17 - 24.29	2.37	1.2 - 3.37	Н/П*	Н/П*
	4СМ_TH17	Abs_Value										11	11	0	7.88	6.56	4 - 11.76	1.54 - 20.3	4.17	2.85 - 12.14	Н/П*	Н/П*
	4СМ_Th17TO1	Abs_Value										11	11	0	1.69	1.82	0.61 - 2.76	0.01 - 5.86	1	0.51 - 2.18	Н/П*	Н/П*
	4СМ_TH2	Abs_Value										11	11	0	8.01	11.02	1.5 - 14.52	0.84 - 37.81	2.11	1.93 - 9.41	Н/П*	Н/П*
	4СМ_TH22	Abs_Value										11	11	0	1.64	2.41	0.22 - 3.07	0.02 - 7.61	0.49	0.24 - 2.1	Н/П*	Н/П*
	4СМ+226+	Abs_Value										11	11	0	61.44	51.86	30.79 - 92.08	4.91 - 144.32	63.53	11.59 - 91.57	Н/П*	Н/П*
	4СМ+39+	Abs_Value										11	11	0	15.09	17.6	4.69 - 25.49	0.26 - 50.51	6.36	0.91 - 24.68	Н/П*	Н/П*
	4СМ+DR+	Abs_Value										11	11	0	11.87	11.99	4.78 - 18.96	0.3 - 29.76	4.52	3.34 - 23.4	Н/П*	Н/П*
	4СМ+PD1-TIGIT-	Abs_Value										11	11	0	30.48	28.97	13.36 - 47.6	2.17 - 79.64	31.41	4.29 - 50.23	Н/П*	Н/П*
	4СМ+PD1-TIGIT+	Abs_Value										11	11	0	2.83	3.02	1.05 - 4.62	0.04 - 9.53	2.72	0.64 - 3.35	Н/П*	Н/П*
	4СМ+PD1+	Abs_Value										11	11	0	31.8	25.92	16.48 - 47.12	1.57 - 63.6	29.07	8.04 - 60.52	Н/П*	Н/П*
	4СМ+PD1+TIGIT-	Abs_Value										11	11	0	15.07	13.01	7.38 - 22.76	1.16 - 38.18	11.31	4.11 - 26.82	Н/П*	Н/П*
	4СМ+PD1+TIGIT+	Abs_Value										11	11	0	16.73	13.91	8.51 - 24.95	0.41 - 38.43	14.64	3.93 - 27.2	Н/П*	Н/П*
4СМ+TIGIT+	Abs_Value										11	11	0	19.56	16.53	9.79 - 29.33	0.45 - 47.95	18.23	4.45 - 29.99	Н/П*	Н/П*
4ТM_TH1	Abs_Value										11	11	0	8.94	6.31	5.21 - 12.67	2.22 - 23.42	9.6	3.4 - 11.51	Н/П*	Н/П*
4ТM_TH17	Abs_Value										11	11	0	6.69	3.22	4.79 - 8.6	0.67 - 12.4	7.05	5.08 - 7.62	Н/П*	Н/П*
4ТM_Th17TO1	Abs_Value										11	11	0	2.81	1.95	1.66 - 3.97	0.49 - 6.92	2.57	1.31 - 4.11	Н/П*	Н/П*
4ТM_TH2	Abs_Value										11	11	0	3.88	3.58	1.76 - 5.99	0.65 - 10.5	2.91	1.32 - 4.89	Н/П*	Н/П*
4ТM_TH22	Abs_Value										11	11	0	5.01	5.46	1.78 - 8.23	0.36 - 15.88	2.75	1.41 - 5.73	Н/П*	Н/П*
4ТREG	Abs_Value										11	11	0	5.7	5.55	2.42 - 8.98	0.16 - 18.58	5.59	1.05 - 7.72	Н/П*	Н/П*
4ТREG(СТАР2)	Abs_Value										11	11	0	141.67	106.82	78.54 - 204.79	19.25 - 336.13	98.26	74.19 - 184.1	Н/П*	Н/П*
4ТREG_TH1	Abs_Value										11	11	0	0.44	0.39	0.21 - 0.68	0.05 - 1.08	0.37	0.12 - 0.74	Н/П*	Н/П*
4ТREG_TH17	Abs_Value										11	11	0	3.75	2.39	2.34 - 5.17	0.91 - 8.42	3.65	2.01 - 5.1	Н/П*	Н/П*
4ТREG_Th17TO1	Abs_Value										11	11	0	0.2	0.15	0.11 - 0.28	0.01 - 0.39	0.18	0.06 - 0.33	Н/П*	Н/П*
4ТREG_TH2	Abs_Value										11	11	0	2.9	2.9	1.18 - 4.61	0.31 - 8.68	1.15	0.9 - 4.55	Н/П*	Н/П*
4ТREG_TH22	Abs_Value										11	11	0	3.71	3.64	1.56 - 5.86	0.7 - 11.45	2.16	1.2 - 5.39	Н/П*	Н/П*
4ТЕ	Abs_Value										11	11	0	9.12	11.87	2.11 - 16.14	0.42 - 41.3	4.96	1.38 - 12.13	Н/П*	Н/П*
4ТЕ(СТАР2)	Abs_Value										11	11	0	29.57	20.51	17.45 - 41.69	5.39 - 74.77	24.32	19.09 - 31.91	Н/П*	Н/П*
4ТЕ_TH1	Abs_Value										11	11	0	3.99	7.86	-0.65 - 8.64	0.16 - 27.05	0.94	0.23 - 3.48	Н/П*	Н/П*
4ТЕ_TH17	Abs_Value										11	11	0	0.01	0.01	0 - 0.01	0 - 0.03	0	0 - 0.01	Н/П*	Н/П*
4ТЕ_Th17TO1	Abs_Value										11	11	0	0.21	0.56	-0.12 - 0.54	0 - 1.89	0.01	0 - 0.06	Н/П*	Н/П*
4ТЕ_TH2	Abs_Value										11	11	0	0.25	0.4	0.01 - 0.49	0 - 1.33	0.11	0.03 - 0.22	Н/П*	Н/П*
4ТЕ_TH22	Abs_Value										11	11	0	0.01	0.02	0 - 0.02	0 - 0.06	0	0 - 0.01	Н/П*	Н/П*
4ТЕ+226+	Abs_Value										11	11	0	27.32	19.92	15.55 - 39.09	4.64 - 73.35	22.18	16.86 - 29.79	Н/П*	Н/П*
4ТЕ+39+	Abs_Value										11	11	0	5.06	6.29	1.34 - 8.78	0.56 - 20.16	2.04	1.27 - 5.28	Н/П*	Н/П*
4ТЕ+DR+	Abs_Value										11	11	0	14.02	14.93	5.2 - 22.85	0.32 - 51.79	10.36	3.21 - 18.85	Н/П*	Н/П*
4ТЕ+PD-1-TIGIT-	Abs_Value										11	11	0	11.75	8.82	6.54 - 16.96	3.69 - 28.88	8.21	5.44 - 13.73	Н/П*	Н/П*
4ТЕ+PD-1-TIGIT+	Abs_Value										11	11	0	1.44	1.34	0.65 - 2.23	0.1 - 3.76	1.3	0.37 - 2.13	Н/П*	Н/П*
4ТЕ+PD-1+	Abs_Value										11	11	0	16.39	12.56	8.97 - 23.81	1.16 - 45.19	15.93	7.48 - 22.66	Н/П*	Н/П*
4ТЕ+PD-1+TIGIT-	Abs_Value										11	11	0	10.92	10.16	4.92 - 16.92	0.66 - 35.88	6.17	4.48 - 15.07	Н/П*	Н/П*
4ТЕ+PD-1+TIGIT+	Abs_Value										11	11	0	5.47	3.87	3.18 - 7.75	0.5 - 12.65	3.33	2.97 - 7.54	Н/П*	Н/П*
4ТЕ+TIGIT+	Abs_Value										11	11	0	6.9	5.09	3.9 - 9.91	0.6 - 16.41	5.24	3.37 - 9.19	Н/П*	Н/П*
4ТМ	Abs_Value										11	11	0	83.29	28.69	66.34 - 100.24	36.54 - 131.83	82.01	63.66 - 105.58	Н/П*	Н/П*
8+	Abs_Value										11	11	0	578.84	685.07	173.99 - 983.69	30 - 2195.9	217.02	159.23 - 742.49	Н/П*	Н/П*
8+ (IM STAT)	Abs_Value										11	11	0	734.51	779.31	273.97 - 1195.06	32.41 - 2619.95	392.04	231.98 - 846.94	Н/П*	Н/П*
8+226+	Abs_Value										11	11	0	926.56	884.39	403.92 - 1449.2	46.34 - 3173.45	512.62	396.99 - 1064.24	Н/П*	Н/П*
8+39+	Abs_Value										11	11	0	110.84	179.27	4.89 - 216.78	8.23 - 628.04	47.55	32.28 - 73.58	Н/П*	Н/П*
8+DR+	Abs_Value										11	11	0	714.36	823.08	227.95 - 1200.77	71.6 - 2878.79	332.58	275.06 - 883.81	Н/П*	Н/П*
8+PD-1-TIGIT-	Abs_Value										11	11	0	402.69	397.54	167.76 - 637.62	11.43 - 1404.23	233.57	196.53 - 526.23	Н/П*	Н/П*
8+PD-1-TIGIT+	Abs_Value										11	11	0	191.36	216.53	63.4 - 319.32	22.57 - 615.13	126.36	51.13 - 197.78	Н/П*	Н/П*
8+PD-1+	Abs_Value										11	11	0	403.19	372.5	183.06 - 623.32	38.01 - 1266.83	251.83	164.33 - 556.48	Н/П*	Н/П*
8+PD-1+TIGIT-	Abs_Value										11	11	0	198.03	216.01	70.37 - 325.68	3.48 - 749.39	118.32	62.39 - 249.91	Н/П*	Н/П*
8+PD-1+TIGIT+	Abs_Value										11	11	0	205.16	164.35	108.04 - 302.29	34.52 - 517.43	128.21	90.21 - 306.57	Н/П*	Н/П*
8+TIGIT+	Abs_Value										11	11	0	396.52	349.93	189.72 - 603.32	62.49 - 1118.31	272	161.54 - 486.27	Н/П*	Н/П*
8EMTM	Abs_Value										11	11	0	156.08	149.71	67.61 - 244.55	4.67 - 481.44	104.12	57 - 203.48	Н/П*	Н/П*
8EMTM+226+	Abs_Value										11	11	0	142.66	141.53	59.02 - 226.3	2.47 - 469.49	100.18	51.53 - 171.7	Н/П*	Н/П*
8EMTM+39+	Abs_Value										11	11	0	21.87	24.79	7.22 - 36.51	0.5 - 82.84	10.76	3.92 - 33.37	Н/П*	Н/П*
8EMTM+DR+	Abs_Value										11	11	0	124.38	130.01	47.55 - 201.21	4.32 - 412.87	79.07	45.46 - 128.94	Н/П*	Н/П*
8EMTM+PD-1-TIGIT-	Abs_Value										11	11	0	41.89	36.39	20.38 - 63.4	0.24 - 123.49	27.51	18.51 - 52.01	Н/П*	Н/П*
8EMTM+PD-1-TIGIT+	Abs_Value										11	11	0	15.38	20.08	3.52 - 27.25	0.18 - 61.97	7.82	2.29 - 19.7	Н/П*	Н/П*
8EMTM+PD-1+	Abs_Value										11	11	0	98.81	113.49	31.74 - 165.88	4.25 - 396.29	56.28	33.81 - 121.02	Н/П*	Н/П*
8EMTM+PD-1+TIGIT-	Abs_Value										11	11	0	48.74	57.28	14.89 - 82.59	0.45 - 196.08	30.56	13.74 - 63.82	Н/П*	Н/П*
8EMTM+PD-1+TIGIT+	Abs_Value										11	11	0	50.07	57.79	15.92 - 84.22	3.8 - 200.2	36.49	10.63 - 63.03	Н/П*	Н/П*
8EMTM+TIGIT+	Abs_Value										11	11	0	65.45	70.67	23.68 - 107.21	3.98 - 226.37	39.85	12.86 - 86.24	Н/П*	Н/П*
8NV	Abs_Value										11	11	0	35.12	34.31	14.84 - 55.39	3.36 - 103.28	16.56	7.3 - 57.15	Н/П*	Н/П*
8NV(СТАР2)	Abs_Value										11	11	0	54.65	62.03	18 - 91.31	0.85 - 214.03	54.6	8.61 - 74.13	Н/П*	Н/П*
8NV+226+	Abs_Value										11	11	0	48.04	58.86	13.26 - 82.83	0.83 - 205.18	47.85	6.01 - 60.43	Н/П*	Н/П*
8NV+39+	Abs_Value										11	11	0	4.06	5.8	0.63 - 7.49	0.13 - 14.96	0.8	0.41 - 6.58	Н/П*	Н/П*
8NV+DR+	Abs_Value										11	11	0	7.23	6.4	3.44 - 11.01	0.46 - 16.71	4.59	2.16 - 13.91	Н/П*	Н/П*
8NV+PD-1-TIGIT-	Abs_Value										11	11	0	43.46	59.83	8.11 - 78.82	0.2 - 208.28	37.74	5.12 - 57.46	Н/П*	Н/П*
8NV+PD-1-TIGIT+	Abs_Value										11	11	0	4.24	6.3	0.52 - 7.97	0 - 21.7	1.52	0.42 - 5.46	Н/П*	Н/П*
8NV+PD-1+	Abs_Value										11	11	0	6.95	6.26	3.25 - 10.64	0.24 - 19.42	4.65	2.4 - 9.42	Н/П*	Н/П*
8NV+PD-1+TIGIT-	Abs_Value										11	11	0	2.24	2.66	0.67 - 3.81	0 - 8.15	0.95	0.33 - 3.06	Н/П*	Н/П*
8NV+PD-1+TIGIT+	Abs_Value										11	11	0	4.71	4.68	1.94 - 7.47	0.24 - 12.49	2.25	1.27 - 8.82	Н/П*	Н/П*
8NV+TIGIT+	Abs_Value										11	11	0	8.95	9.6	3.28 - 14.62	0.41 - 29.4	3.77	1.65 - 16.06	Н/П*	Н/П*
8TREG	Abs_Value										11	11	0	596	680.43	193.88 - 998.11	29.13 - 2207.38	265.06	199.18 - 720.62	Н/П*	Н/П*
8ЕМ	Abs_Value										11	11	0	142.53	143.35	57.82 - 227.24	4.7 - 435.49	74.23	36.04 - 199.55	Н/П*	Н/П*
8СМ	Abs_Value										11	11	0	13.49	15.47	4.35 - 22.64	0.6 - 51.2	7.36	2.34 - 21.35	Н/П*	Н/П*
8СМ(СТАР2)	Abs_Value										11	11	0	8.6	9.75	2.84 - 14.37	0.04 - 33.96	4.01	2.63 - 12.02	Н/П*	Н/П*
8СМ+226+	Abs_Value										11	11	0	5.99	5.4	2.79 - 9.18	0.04 - 16.8	3.55	2.09 - 8.3	Н/П*	Н/П*
8СМ+39+	Abs_Value										11	11	0	1.55	1.93	0.41 - 2.69	0.02 - 5.23	0.87	0.17 - 2.06	Н/П*	Н/П*
8СМ+DR+	Abs_Value										11	11	0	6.71	8.7	1.57 - 11.85	0.02 - 30.43	3.64	1.84 - 8.99	Н/П*	Н/П*
8СМ+PD-1-TIGIT-	Abs_Value										11	11	0	1.88	2.22	0.56 - 3.19	0.02 - 7.08	0.78	0.29 - 2.73	Н/П*	Н/П*
8СМ+PD-1-TIGIT+	Abs_Value										11	11	0	1.44	2.54	-0.06 - 2.94	0 - 8.77	0.41	0.12 - 1.6	Н/П*	Н/П*
8СМ+PD-1+	Abs_Value										11	11	0	5.28	6.19	1.62 - 8.94	0.02 - 21.78	3.17	1.73 - 7.04	Н/П*	Н/П*
8СМ+PD-1+TIGIT-	Abs_Value										11	11	0	0.77	0.64	0.39 - 1.14	0 - 2.18	0.82	0.24 - 0.98	Н/П*	Н/П*
8СМ+PD-1+TIGIT+	Abs_Value										11	11	0	4.51	6.04	0.94 - 8.09	0.01 - 21.05	2.23	1.12 - 5.47	Н/П*	Н/П*
8СМ+TIGIT+	Abs_Value										11	11	0	5.96	8.52	0.92 - 10.99	0.01 - 29.82	3.21	1.28 - 6.63	Н/П*	Н/П*
8ТЕ	Abs_Value										11	11	0	622.8	761.49	172.78 - 1072.81	23.09 - 2714.05	306.64	199.77 - 658.64	Н/П*	Н/П*
8ТЕ(СТАР2)	Abs_Value										11	11	0	759.66	830.66	268.77 - 1250.55	88.95 - 2905.58	391.48	268.78 - 855.84	Н/П*	Н/П*
8ТЕ+226+	Abs_Value										11	11	0	714.93	813.85	233.98 - 1195.88	37.92 - 2858.44	332.25	262.61 - 814.62	Н/П*	Н/П*
8ТЕ+39+	Abs_Value										11	11	0	74.62	137.84	-6.84 - 156.08	7.19 - 479.15	18.13	15.25 - 46.38	Н/П*	Н/П*
8ТЕ+DR+	Abs_Value										11	11	0	562.06	750.18	118.74 - 1005.39	66.62 - 2623.56	243.25	155.56 - 645.34	Н/П*	Н/П*
8ТЕ+PD-1-TIGIT-	Abs_Value										11	11	0	311.97	376.13	89.69 - 534.25	5.08 - 1283.87	141.19	96.18 - 427.02	Н/П*	Н/П*
8ТЕ+PD-1-TIGIT+	Abs_Value										11	11	0	166.89	194.49	51.96 - 281.83	17.28 - 551.54	100.26	43.13 - 159.9	Н/П*	Н/П*
8ТЕ+PD-1+	Abs_Value										11	11	0	280.8	304.9	100.61 - 460.98	33.55 - 1070.17	158.31	80.8 - 424.72	Н/П*	Н/П*
8ТЕ+PD-1+TIGIT-	Abs_Value										11	11	0	144.03	192.95	30 - 258.05	3.04 - 682.96	61.42	39.01 - 193.3	Н/П*	Н/П*
8ТЕ+PD-1+TIGIT+	Abs_Value										11	11	0	136.77	120.68	65.45 - 208.09	23.32 - 387.21	66.51	40.69 - 225.04	Н/П*	Н/П*
8ТЕ+TIGIT+	Abs_Value										11	11	0	303.66	292.71	130.68 - 476.65	42.68 - 938.75	228.72	82.7 - 354	Н/П*	Н/П*
8ТМ	Abs_Value										11	11	0	33.69	24.31	19.32 - 48.05	5.82 - 76	26.42	14.67 - 52.75	Н/П*	Н/П*
TREG_CM	Abs_Value										11	11	0	3.15	3.31	1.2 - 5.11	0.14 - 9.47	1.57	0.48 - 5.12	Н/П*	Н/П*
TREG_EMTM	Abs_Value										11	11	0	26.34	17.66	15.9 - 36.78	5.79 - 53.46	22.45	10.29 - 42.3	Н/П*	Н/П*
TREG_NV	Abs_Value										11	11	0	3	2.92	1.28 - 4.73	0.01 - 7.25	1.78	0.46 - 5.58	Н/П*	Н/П*
TREG_TE	Abs_Value										11	11	0	4.08	3.56	1.98 - 6.18	0.26 - 10.4	2.85	1.02 - 7.13	Н/П*	Н/П*
TREG+226-TIGIT-	Abs_Value										11	11	0	1.84	1.28	1.08 - 2.59	0.2 - 4.49	1.73	0.89 - 2.34	Н/П*	Н/П*
TREG+226-TIGIT+	Abs_Value										11	11	0	8.56	6.91	4.47 - 12.64	0.73 - 19.26	7.93	2.12 - 13.51	Н/П*	Н/П*
TREG+226+	Abs_Value										11	11	0	26.66	17.13	16.54 - 36.79	5.33 - 51.13	24.99	13.42 - 38.48	Н/П*	Н/П*
TREG+226+TIGIT-	Abs_Value										11	11	0	3.05	1.72	2.04 - 4.07	0.95 - 6.15	3.59	1.37 - 4.12	Н/П*	Н/П*
TREG+226+TIGIT+	Abs_Value										11	11	0	23.61	16.25	14 - 33.21	4.36 - 47.29	23.7	9.63 - 34.4	Н/П*	Н/П*
TREG+39+	Abs_Value										11	11	0	24.66	19.74	13 - 36.33	5.68 - 68.05	19.08	12.11 - 26.92	Н/П*	Н/П*
TREG+DR+	Abs_Value										11	11	0	26.32	19.69	14.68 - 37.95	4.39 - 59.8	25.66	7.96 - 41.74	Н/П*	Н/П*
TREG+PD-1+	Abs_Value										11	11	0	17.43	13.77	9.29 - 25.57	4.68 - 47.96	16.01	6.75 - 18.88	Н/П*	Н/П*
TREG+TIGIT+	Abs_Value										11	11	0	32.16	22.25	19.02 - 45.31	5.35 - 66.55	29.06	12.43 - 50.36	Н/П*	Н/П*
ДЕНЬ ХРРТПХ +90	4_TFH	Abs_Value										16	16	0	35.35	23.89	23.64 - 47.05	3.11 - 96.06	28.78	21.76 - 50.15	Н/П*	Н/П*
	4_TH1	Abs_Value										16	16	0	31.21	29.23	16.89 - 45.54	1.9 - 112.66	21.99	15.62 - 32.29	Н/П*	Н/П*
	4_TH17	Abs_Value										16	16	0	24.13	15.61	16.48 - 31.78	6.93 - 58.39	19.17	12.69 - 32.93	Н/П*	Н/П*
	4_Th17TO1	Abs_Value										16	16	0	6.09	4.39	3.94 - 8.24	0.23 - 16.13	4.89	3.51 - 8.74	Н/П*	Н/П*
	4_TH2	Abs_Value										16	16	0	27.11	18.08	18.25 - 35.97	8.43 - 76.49	20.94	14.14 - 35.85	Н/П*	Н/П*
	4_TH22	Abs_Value										16	16	0	9.15	7.62	5.42 - 12.88	0.67 - 23.59	6.45	3.86 - 12.08	Н/П*	Н/П*
	4+	Abs_Value										16	16	0	132.22	82.34	91.87 - 172.56	20.84 - 298.94	110.26	66.25 - 190.14	Н/П*	Н/П*
	4+ (IM STAT)	Abs_Value										16	16	0	103.84	67.1	70.96 - 136.72	34.32 - 275.92	98.9	52.08 - 129.82	Н/П*	Н/П*
	4+226+	Abs_Value										16	16	0	287.69	154.08	212.19 - 363.19	87.94 - 576.94	257.19	176.03 - 410.75	Н/П*	Н/П*
	4+39+	Abs_Value										16	16	0	55.03	60.37	25.45 - 84.61	1.04 - 246.85	41.24	21.45 - 62.04	Н/П*	Н/П*
	4+DR+	Abs_Value										16	16	0	93.94	80.53	54.48 - 133.4	25.31 - 271.33	51.07	39.47 - 108.97	Н/П*	Н/П*
	4+PD-1-TIGIT-	Abs_Value										16	16	0	141.1	95.38	94.36 - 187.84	37.81 - 332.69	131.49	64.39 - 171.18	Н/П*	Н/П*
	4+PD-1-TIGIT+	Abs_Value										16	16	0	11.6	10.85	6.29 - 16.92	1.69 - 46.7	7.74	5.22 - 15.71	Н/П*	Н/П*
	4+PD-1+	Abs_Value										16	16	0	155.06	104.07	104.07 - 206.05	30.06 - 400.09	125.63	86.15 - 191.77	Н/П*	Н/П*
	4+PD-1+TIGIT-	Abs_Value										16	16	0	85.42	58.08	56.96 - 113.88	15.87 - 247.58	68.49	50 - 101.27	Н/П*	Н/П*
	4+PD-1+TIGIT+	Abs_Value										16	16	0	69.64	53.87	43.24 - 96.04	14.19 - 235.06	56.25	37.41 - 90.5	Н/П*	Н/П*
	4+TIGIT+	Abs_Value										16	16	0	81.25	58.37	52.65 - 109.85	19.56 - 252.76	72.45	40.14 - 98.27	Н/П*	Н/П*
	4NV	Abs_Value										16	16	0	85.71	81.73	45.66 - 125.76	13.04 - 299.61	53.86	31.77 - 101.04	Н/П*	Н/П*
	4NV(СТАР2)	Abs_Value										16	16	0	80.63	80.6	41.14 - 120.12	6.3 - 304.68	47.43	30.78 - 103.91	Н/П*	Н/П*
	4NV_TH1	Abs_Value										16	16	0	5.61	7.86	1.76 - 9.46	0.57 - 30	2.05	0.92 - 6.64	Н/П*	Н/П*
	4NV_TH17	Abs_Value										16	16	0	2.48	2.38	1.31 - 3.64	0.27 - 8.85	1.77	0.71 - 3.14	Н/П*	Н/П*
	4NV_Th17TO1	Abs_Value										16	16	0	0.54	0.61	0.24 - 0.84	0.04 - 2.08	0.34	0.1 - 0.82	Н/П*	Н/П*
	4NV_TH2	Abs_Value										16	16	0	9.6	13.38	3.04 - 16.16	0.58 - 57.11	5.97	3.75 - 10.43	Н/П*	Н/П*
	4NV_TH22	Abs_Value										16	16	0	0.18	0.14	0.11 - 0.25	0.02 - 0.54	0.16	0.11 - 0.2	Н/П*	Н/П*
	4NV+226+	Abs_Value										16	16	0	73.83	78.87	35.18 - 112.47	4.85 - 302.56	41.42	23.72 - 96.07	Н/П*	Н/П*
	4NV+39+	Abs_Value										16	16	0	1.88	2.22	0.79 - 2.96	0.05 - 8	1.49	0.31 - 2.26	Н/П*	Н/П*
	4NV+DR+	Abs_Value										16	16	0	5.04	4.84	2.67 - 7.41	0.13 - 15.82	3.55	1.77 - 6.32	Н/П*	Н/П*
	4NV+PD-1-TIGIT-	Abs_Value										16	16	0	73.63	76.16	36.31 - 110.95	3.6 - 289.92	41.78	27.61 - 96.54	Н/П*	Н/П*
	4NV+PD-1-TIGIT+	Abs_Value										16	16	0	2.24	3.68	0.44 - 4.05	0.04 - 15.6	1.2	0.96 - 1.83	Н/П*	Н/П*
	4NV+PD-1+TIGIT-	Abs_Value										16	16	0	2.88	2.51	1.65 - 4.11	0.07 - 9.06	1.81	0.99 - 4.26	Н/П*	Н/П*
	4NV+PD-1+TIGIT+	Abs_Value										16	16	0	1.87	1.83	0.97 - 2.77	0.08 - 6.13	1.14	0.63 - 2.24	Н/П*	Н/П*
	4NV+PD1+	Abs_Value										16	16	0	4.75	4.08	2.75 - 6.75	0.16 - 15.19	3.55	1.84 - 6.1	Н/П*	Н/П*
	4NV+TIGIT+	Abs_Value										16	16	0	4.11	4.54	1.89 - 6.34	0.13 - 18.1	2.45	1.63 - 4.05	Н/П*	Н/П*
	4ЕМ	Abs_Value										16	16	0	22.06	50.17	-2.52 - 46.64	0.23 - 203.95	4.06	2.05 - 16.96	Н/П*	Н/П*
	4ЕМ_TH1	Abs_Value										16	16	0	3.88	5.53	1.17 - 6.59	0 - 19.39	1.69	0.2 - 4.23	Н/П*	Н/П*
	4ЕМ_TH17	Abs_Value										16	16	0	0.04	0.07	0.01 - 0.08	0 - 0.23	0.01	0 - 0.03	Н/П*	Н/П*
	4ЕМ_Th17TO1	Abs_Value										16	16	0	0.19	0.33	0.03 - 0.35	0 - 1.11	0.06	0.01 - 0.17	Н/П*	Н/П*
	4ЕМ_TH2	Abs_Value										16	16	0	1.01	2.41	-0.16 - 2.19	0 - 9.23	0.11	0.02 - 0.26	Н/П*	Н/П*
	4ЕМ_TH22	Abs_Value										16	16	0	0.03	0.07	-0.01 - 0.06	0 - 0.23	0	0 - 0	Н/П*	Н/П*
	4ЕМ+226+	Abs_Value										16	16	0	121.53	79.15	82.75 - 160.31	19.75 - 301.44	123.64	52.94 - 142.43	Н/П*	Н/П*
	4ЕМ+39+	Abs_Value										16	16	0	30.98	34.27	14.19 - 47.78	0.63 - 139.31	22.37	9.01 - 43.25	Н/П*	Н/П*
	4ЕМ+DR+	Abs_Value										16	16	0	55.87	47.67	32.51 - 79.23	9.62 - 166.88	40.96	19.64 - 71.61	Н/П*	Н/П*
	4ЕМ+PD1-TIGIT-	Abs_Value										16	16	0	31.07	26.51	18.08 - 44.06	1.02 - 100.32	27.71	13.49 - 35.59	Н/П*	Н/П*
	4ЕМ+PD1-TIGIT+	Abs_Value										16	16	0	3.8	3.45	2.11 - 5.49	0.11 - 12.17	2.57	1.75 - 4.65	Н/П*	Н/П*
	4ЕМ+PD1+	Abs_Value										16	16	0	93.56	72.96	57.81 - 129.31	12.61 - 285.99	91.29	38.83 - 108.13	Н/П*	Н/П*
	4ЕМ+PD1+TIGIT-	Abs_Value										16	16	0	54.83	45.16	32.7 - 76.96	7.13 - 195.03	52.87	21.85 - 62.98	Н/П*	Н/П*
	4ЕМ+PD1+TIGIT+	Abs_Value										16	16	0	38.73	32.29	22.91 - 54.55	4.47 - 125.93	36.34	15.02 - 46.71	Н/П*	Н/П*
	4ЕМ+TIGIT+	Abs_Value										16	16	0	42.53	33.2	26.26 - 58.8	5.34 - 130.53	43.38	16.63 - 52.8	Н/П*	Н/П*
	4ЕМTM	Abs_Value										16	16	0	128.43	80.9	88.79 - 168.07	20.66 - 302.94	135.97	56.8 - 149.8	Н/П*	Н/П*
	4СМ	Abs_Value										16	16	0	70.16	37.67	51.7 - 88.61	25.35 - 151.85	63.9	42.04 - 98.93	Н/П*	Н/П*
	4СМ(СТАР2)	Abs_Value										16	16	0	52.13	25.48	39.64 - 64.61	21.2 - 101.25	47.97	31.82 - 65.94	Н/П*	Н/П*
	4СМ_TH1	Abs_Value										16	16	0	3.4	3.07	1.89 - 4.91	0.29 - 9.26	1.83	0.93 - 5.51	Н/П*	Н/П*
	4СМ_TH17	Abs_Value										16	16	0	10.37	7.08	6.9 - 13.84	1.95 - 31.31	8.81	6.44 - 12.39	Н/П*	Н/П*
	4СМ_Th17TO1	Abs_Value										16	16	0	1.16	0.95	0.69 - 1.63	0.11 - 2.67	1.06	0.23 - 1.75	Н/П*	Н/П*
	4СМ_TH2	Abs_Value										16	16	0	7.03	4.75	4.7 - 9.36	1.16 - 18.38	6.35	3.74 - 9.61	Н/П*	Н/П*
	4СМ_TH22	Abs_Value										16	16	0	1.55	1.51	0.81 - 2.29	0.03 - 4.89	0.84	0.61 - 2.35	Н/П*	Н/П*
	4СМ+226+	Abs_Value										16	16	0	49.62	24.87	37.44 - 61.81	19.64 - 97.29	45.45	30.02 - 62.62	Н/П*	Н/П*
	4СМ+39+	Abs_Value										16	16	0	12.83	10.42	7.72 - 17.93	0.16 - 33.92	11.07	6.71 - 18.46	Н/П*	Н/П*
	4СМ+DR+	Abs_Value										16	16	0	10.1	6.87	6.74 - 13.47	1.2 - 24.58	8.29	5.28 - 12.93	Н/П*	Н/П*
	4СМ+PD1-TIGIT-	Abs_Value										16	16	0	19.96	12.91	13.63 - 26.28	2.11 - 50.45	21	11.18 - 27.37	Н/П*	Н/П*
	4СМ+PD1-TIGIT+	Abs_Value										16	16	0	3.18	3.19	1.62 - 4.75	0.21 - 13.54	2.63	1.15 - 4.08	Н/П*	Н/П*
	4СМ+PD1+	Abs_Value										16	16	0	28.99	15.2	21.54 - 36.44	9.67 - 60.98	25.05	18.68 - 37.73	Н/П*	Н/П*
	4СМ+PD1+TIGIT-	Abs_Value										16	16	0	11.22	5.06	8.74 - 13.71	3.55 - 20.95	9.83	7.28 - 14.47	Н/П*	Н/П*
	4СМ+PD1+TIGIT+	Abs_Value										16	16	0	17.76	11.18	12.28 - 23.24	6.08 - 44.81	14.8	8.86 - 24	Н/П*	Н/П*
4СМ+TIGIT+	Abs_Value										16	16	0	20.95	12.85	14.65 - 27.24	7.81 - 49.68	17.47	10.61 - 27.82	Н/П*	Н/П*
4ТM_TH1	Abs_Value										16	16	0	12.57	13.68	5.87 - 19.28	0.08 - 43.91	5.73	4.91 - 14.5	Н/П*	Н/П*
4ТM_TH17	Abs_Value										16	16	0	10.27	7.78	6.46 - 14.08	0.84 - 27.7	7.96	4.34 - 13.61	Н/П*	Н/П*
4ТM_Th17TO1	Abs_Value										16	16	0	3.66	3.12	2.13 - 5.19	0.05 - 10.67	2.76	1.66 - 4.3	Н/П*	Н/П*
4ТM_TH2	Abs_Value										16	16	0	7.39	7.76	3.59 - 11.2	0.56 - 30.18	4.11	1.81 - 11.18	Н/П*	Н/П*
4ТM_TH22	Abs_Value										16	16	0	6.38	5.58	3.64 - 9.11	0.12 - 17.72	4.12	2.47 - 9.31	Н/П*	Н/П*
4ТREG	Abs_Value										16	16	0	2.77	3.73	0.94 - 4.59	0.04 - 13.02	1.12	0.55 - 2.67	Н/П*	Н/П*
4ТREG(СТАР2)	Abs_Value										16	16	0	138.47	81.61	98.48 - 178.45	45.87 - 308.22	118.87	72.38 - 194.27	Н/П*	Н/П*
4ТREG_TH1	Abs_Value										16	16	0	0.37	0.5	0.13 - 0.62	0.02 - 1.73	0.21	0.07 - 0.31	Н/П*	Н/П*
4ТREG_TH17	Abs_Value										16	16	0	4.3	3.2	2.73 - 5.87	0.86 - 13.28	3.51	1.97 - 5.48	Н/П*	Н/П*
4ТREG_Th17TO1	Abs_Value										16	16	0	0.14	0.16	0.06 - 0.22	0 - 0.49	0.05	0.02 - 0.25	Н/П*	Н/П*
4ТREG_TH2	Abs_Value										16	16	0	2.72	1.4	2.03 - 3.41	0.32 - 6.34	2.86	1.58 - 3.38	Н/П*	Н/П*
4ТREG_TH22	Abs_Value										16	16	0	3.67	2.57	2.41 - 4.93	0.84 - 9.32	3.37	1.45 - 5.51	Н/П*	Н/П*
4ТЕ	Abs_Value										16	16	0	12.11	23.09	0.8 - 23.43	0.1 - 86.7	1.66	0.64 - 8.96	Н/П*	Н/П*
4ТЕ(СТАР2)	Abs_Value										16	16	0	46.28	52.68	20.47 - 72.1	10.54 - 179.15	24.72	18.15 - 46.09	Н/П*	Н/П*
4ТЕ_TH1	Abs_Value										16	16	0	2.93	7.7	-0.85 - 6.7	0 - 31.37	0.55	0.13 - 1.75	Н/П*	Н/П*
4ТЕ_TH17	Abs_Value										16	16	0	0	0.01	0 - 0.01	0 - 0.02	0	0 - 0.01	Н/П*	Н/П*
4ТЕ_Th17TO1	Abs_Value										16	16	0	0.09	0.2	0 - 0.19	0 - 0.78	0.01	0 - 0.06	Н/П*	Н/П*
4ТЕ_TH2	Abs_Value										16	16	0	0.25	0.52	0 - 0.51	0 - 2.03	0.05	0.01 - 0.17	Н/П*	Н/П*
4ТЕ_TH22	Abs_Value										16	16	0	0	0.01	0 - 0.01	0 - 0.02	0	0 - 0	Н/П*	Н/П*
4ТЕ+226+	Abs_Value										16	16	0	42.58	49.68	18.24 - 66.92	9.58 - 174.69	20.95	15.78 - 41.84	Н/П*	Н/П*
4ТЕ+39+	Abs_Value										16	16	0	9.58	19.21	0.17 - 18.99	0.11 - 76.01	2.69	1.1 - 6.23	Н/П*	Н/П*
4ТЕ+DR+	Abs_Value										16	16	0	23.14	34.36	6.3 - 39.97	1.71 - 119.56	11.25	3.25 - 19.01	Н/П*	Н/П*
4ТЕ+PD-1-TIGIT-	Abs_Value										16	16	0	15.74	18.58	6.63 - 24.84	1.05 - 77.66	8.83	6.01 - 16.42	Н/П*	Н/П*
4ТЕ+PD-1-TIGIT+	Abs_Value										16	16	0	2.38	2.93	0.95 - 3.82	0.25 - 11.49	1.42	0.72 - 2.58	Н/П*	Н/П*
4ТЕ+PD-1+	Abs_Value										16	16	0	28.16	35.29	10.87 - 45.46	4.45 - 126.54	12.85	9.84 - 22.45	Н/П*	Н/П*
4ТЕ+PD-1+TIGIT-	Abs_Value										16	16	0	16.67	19.57	7.08 - 26.26	1.62 - 67.21	9.04	4.03 - 15.46	Н/П*	Н/П*
4ТЕ+PD-1+TIGIT+	Abs_Value										16	16	0	11.49	19	2.18 - 20.8	1.41 - 78.88	4.87	3.31 - 9.58	Н/П*	Н/П*
4ТЕ+TIGIT+	Abs_Value										16	16	0	13.88	20.94	3.62 - 24.14	2.14 - 85.88	6.14	4.09 - 12.22	Н/П*	Н/П*
4ТМ	Abs_Value										16	16	0	104.08	71.19	69.2 - 138.97	10.27 - 315	108.35	52.94 - 121.85	Н/П*	Н/П*
8+	Abs_Value										16	16	0	483.96	570.83	204.26 - 763.67	14.73 - 2238.8	304.59	68.25 - 709.26	Н/П*	Н/П*
8+ (IM STAT)	Abs_Value										16	16	0	609.74	665.61	283.6 - 935.89	16.62 - 2673.64	442.06	114.75 - 887.6	Н/П*	Н/П*
8+226+	Abs_Value										16	16	0	753.82	776.41	373.38 - 1134.26	86.91 - 3240.63	557.23	173.53 - 1009.04	Н/П*	Н/П*
8+39+	Abs_Value										16	16	0	96.16	122.44	36.16 - 156.15	2.61 - 428.13	46.94	19.91 - 114.27	Н/П*	Н/П*
8+DR+	Abs_Value										16	16	0	541.38	669.73	213.22 - 869.55	40.55 - 2729.41	332.49	144.84 - 628.19	Н/П*	Н/П*
8+PD-1-TIGIT-	Abs_Value										16	16	0	270.21	320.05	113.39 - 427.03	41.92 - 1371.15	169.76	91.78 - 323.43	Н/П*	Н/П*
8+PD-1-TIGIT+	Abs_Value										16	16	0	240.55	333.54	77.12 - 403.98	11.7 - 1209.08	116.12	27.43 - 225.26	Н/П*	Н/П*
8+PD-1+	Abs_Value										16	16	0	350.72	343.07	182.62 - 518.83	32.61 - 1231.92	257.6	106.43 - 493.01	Н/П*	Н/П*
8+PD-1+TIGIT-	Abs_Value										16	16	0	110.21	118.56	52.12 - 168.3	9.56 - 367.72	50.18	38.78 - 140.79	Н/П*	Н/П*
8+PD-1+TIGIT+	Abs_Value										16	16	0	240.51	275.68	105.43 - 375.59	17.7 - 1097.55	156.79	52.92 - 320.3	Н/П*	Н/П*
8+TIGIT+	Abs_Value										16	16	0	481.06	475.3	248.17 - 713.96	38.2 - 1576.95	282.64	65.8 - 759	Н/П*	Н/П*
8EMTM	Abs_Value										16	16	0	107.4	93.5	61.58 - 153.21	2.31 - 329.24	89.66	36.53 - 145.89	Н/П*	Н/П*
8EMTM+226+	Abs_Value										16	16	0	89.77	87.29	47 - 132.55	1.94 - 322.53	62.82	26.16 - 124.81	Н/П*	Н/П*
8EMTM+39+	Abs_Value										16	16	0	16.13	17.42	7.6 - 24.67	0.51 - 52.65	11.57	1.72 - 23.43	Н/П*	Н/П*
8EMTM+DR+	Abs_Value										16	16	0	79.14	65.23	47.18 - 111.11	2.13 - 212.97	66.93	28.12 - 116.1	Н/П*	Н/П*
8EMTM+PD-1-TIGIT-	Abs_Value										16	16	0	23.65	28.49	9.69 - 37.61	0.73 - 96.46	11.24	4.44 - 31.65	Н/П*	Н/П*
8EMTM+PD-1-TIGIT+	Abs_Value										16	16	0	17.07	20.91	6.83 - 27.32	0.22 - 81.95	7.77	3.49 - 27	Н/П*	Н/П*
8EMTM+PD-1+	Abs_Value										16	16	0	66.67	62.9	35.85 - 97.49	1.36 - 255.69	62.14	21.09 - 87.57	Н/П*	Н/П*
8EMTM+PD-1+TIGIT-	Abs_Value										16	16	0	22.19	27.96	8.48 - 35.89	0.69 - 110.4	13.72	6.74 - 21.03	Н/П*	Н/П*
8EMTM+PD-1+TIGIT+	Abs_Value										16	16	0	44.49	43.02	23.41 - 65.56	0.67 - 145.3	31.84	10.28 - 62.94	Н/П*	Н/П*
8EMTM+TIGIT+	Abs_Value										16	16	0	61.56	55.9	34.17 - 88.95	0.89 - 170.16	40.89	15.83 - 105.25	Н/П*	Н/П*
8NV	Abs_Value										16	16	0	45.74	44.53	23.93 - 67.56	9.18 - 184.51	26.4	17.5 - 61.65	Н/П*	Н/П*
8NV(СТАР2)	Abs_Value										16	16	0	54.54	70.98	19.76 - 89.32	3.34 - 298.83	32.85	16.66 - 59.43	Н/П*	Н/П*
8NV+226+	Abs_Value										16	16	0	49.02	69.71	14.87 - 83.18	2.97 - 293.94	30.66	15.35 - 51.92	Н/П*	Н/П*
8NV+39+	Abs_Value										16	16	0	3.23	3.32	1.6 - 4.85	0.06 - 10.69	2.17	0.62 - 4.34	Н/П*	Н/П*
8NV+DR+	Abs_Value										16	16	0	5.83	4.64	3.56 - 8.11	0.39 - 16.08	3.75	2.54 - 8.79	Н/П*	Н/П*
8NV+PD-1-TIGIT-	Abs_Value										16	16	0	45	69.44	10.98 - 79.03	0.89 - 288.77	25.56	10.96 - 41.48	Н/П*	Н/П*
8NV+PD-1-TIGIT+	Abs_Value										16	16	0	2.6	2.33	1.46 - 3.74	0.08 - 7.9	1.9	0.73 - 4.47	Н/П*	Н/П*
8NV+PD-1+	Abs_Value										16	16	0	6.94	6.77	3.62 - 10.26	0.58 - 25.65	4.93	2.43 - 8.52	Н/П*	Н/П*
8NV+PD-1+TIGIT-	Abs_Value										16	16	0	2.75	3.28	1.15 - 4.36	0.02 - 11.05	1.5	0.69 - 3.46	Н/П*	Н/П*
8NV+PD-1+TIGIT+	Abs_Value										16	16	0	4.19	4.73	1.87 - 6.5	0.56 - 17.13	2.56	1.14 - 4.17	Н/П*	Н/П*
8NV+TIGIT+	Abs_Value										16	16	0	6.78	5.99	3.85 - 9.72	1.52 - 19.73	3.92	2.49 - 9.77	Н/П*	Н/П*
8TREG	Abs_Value										16	16	0	476.38	546.46	208.61 - 744.14	14 - 2160.15	322.51	70.53 - 695.58	Н/П*	Н/П*
8ЕМ	Abs_Value										16	16	0	101.04	118.3	43.08 - 159.01	2.96 - 350.98	40.04	20.01 - 173.13	Н/П*	Н/П*
8СМ	Abs_Value										16	16	0	18.78	35.01	1.62 - 35.93	0.71 - 142.48	8.33	4.18 - 11.2	Н/П*	Н/П*
8СМ(СТАР2)	Abs_Value										16	16	0	10.74	13.16	4.29 - 17.19	1.43 - 45.99	6.28	5.32 - 8.71	Н/П*	Н/П*
8СМ+226+	Abs_Value										16	16	0	7.26	7.43	3.62 - 10.9	1.17 - 27.65	5.09	4.2 - 6.31	Н/П*	Н/П*
8СМ+39+	Abs_Value										16	16	0	2.72	3.64	0.94 - 4.51	0.08 - 12.25	1.63	0.49 - 3.06	Н/П*	Н/П*
8СМ+DR+	Abs_Value										16	16	0	8.28	10.55	3.11 - 13.45	0.95 - 40.03	4.7	3.28 - 6.65	Н/П*	Н/П*
8СМ+PD-1-TIGIT-	Abs_Value										16	16	0	1.48	1.19	0.9 - 2.07	0.09 - 5.04	1.24	1.01 - 1.78	Н/П*	Н/П*
8СМ+PD-1-TIGIT+	Abs_Value										16	16	0	2	2.86	0.6 - 3.4	0.04 - 9.71	1	0.54 - 1.45	Н/П*	Н/П*
8СМ+PD-1+	Abs_Value										16	16	0	7.26	9.89	2.42 - 12.11	1.14 - 36.67	3.64	2.17 - 5.64	Н/П*	Н/П*
8СМ+PD-1+TIGIT-	Abs_Value										16	16	0	0.8	0.82	0.4 - 1.2	0.1 - 3.03	0.43	0.35 - 0.86	Н/П*	Н/П*
8СМ+PD-1+TIGIT+	Abs_Value										16	16	0	6.46	9.66	1.73 - 11.2	0.84 - 35.27	2.98	1.75 - 5.14	Н/П*	Н/П*
8СМ+TIGIT+	Abs_Value										16	16	0	8.46	12.34	2.41 - 14.5	0.93 - 43.35	4.12	2.65 - 6.7	Н/П*	Н/П*
8ТЕ	Abs_Value										16	16	0	501.34	697.27	159.67 - 843	27.81 - 2935.15	315.6	112.05 - 556.57	Н/П*	Н/П*
8ТЕ(СТАР2)	Abs_Value										16	16	0	685.6	784.62	301.14 - 1070.06	35.46 - 3213.82	506	156.46 - 979.83	Н/П*	Н/П*
8ТЕ+226+	Abs_Value										16	16	0	605.32	757.57	234.11 - 976.53	34.55 - 3154.74	352.23	150.77 - 781.62	Н/П*	Н/П*
8ТЕ+39+	Abs_Value										16	16	0	73.58	111.95	18.72 - 128.44	1.13 - 386.23	25.52	8.98 - 82.36	Н/П*	Н/П*
8ТЕ+DR+	Abs_Value										16	16	0	447.63	655.54	126.41 - 768.84	20.58 - 2669.82	240.49	106.37 - 478.6	Н/П*	Н/П*
8ТЕ+PD-1-TIGIT-	Abs_Value										16	16	0	199.55	318.56	43.46 - 355.65	9.04 - 1323.33	86.53	44.16 - 243.13	Н/П*	Н/П*
8ТЕ+PD-1-TIGIT+	Abs_Value										16	16	0	216.44	317.94	60.65 - 372.23	9.38 - 1190.46	94.42	24.2 - 195.52	Н/П*	Н/П*
8ТЕ+PD-1+	Abs_Value										16	16	0	269.6	303.31	120.98 - 418.23	16.39 - 1104.9	170.5	66.27 - 358.79	Н/П*	Н/П*
8ТЕ+PD-1+TIGIT-	Abs_Value										16	16	0	84.52	100.53	35.26 - 133.78	5.34 - 353.82	34.82	24.87 - 116.83	Н/П*	Н/П*
8ТЕ+PD-1+TIGIT+	Abs_Value										16	16	0	185.09	244.63	65.22 - 304.95	11.05 - 987.9	106.95	40.06 - 235.62	Н/П*	Н/П*
8ТЕ+TIGIT+	Abs_Value										16	16	0	401.52	438.75	186.54 - 616.51	20.43 - 1536.67	234.01	54.74 - 587.2	Н/П*	Н/П*
8ТМ	Abs_Value										16	16	0	43.72	58.64	14.98 - 72.45	0.57 - 244.32	21.85	10.88 - 60.22	Н/П*	Н/П*
TREG_CM	Abs_Value										16	16	0	1.83	1.04	1.32 - 2.34	0.19 - 3.86	1.63	1.35 - 2.2	Н/П*	Н/П*
TREG_EMTM	Abs_Value										16	16	0	19.2	16.73	11 - 27.4	3.24 - 57.99	16.19	6.39 - 22.43	Н/П*	Н/П*
TREG_NV	Abs_Value										16	16	0	2.59	2.52	1.35 - 3.82	0.22 - 7.96	1.22	0.91 - 3.92	Н/П*	Н/П*
TREG_TE	Abs_Value										16	16	0	4.87	8.07	0.92 - 8.82	0.35 - 33.62	2.28	1.42 - 4.96	Н/П*	Н/П*
TREG+226-TIGIT-	Abs_Value										16	16	0	1.77	1.68	0.95 - 2.59	0.09 - 5.76	1.37	0.45 - 2.28	Н/П*	Н/П*
TREG+226-TIGIT+	Abs_Value										16	16	0	6.18	6.1	3.2 - 9.17	0.38 - 18.95	4.4	1.76 - 8.88	Н/П*	Н/П*
TREG+226+	Abs_Value										16	16	0	20.48	17.47	11.92 - 29.04	3.74 - 64.06	15.48	7.87 - 26.26	Н/П*	Н/П*
TREG+226+TIGIT-	Abs_Value										16	16	0	2.6	1.7	1.77 - 3.44	0.37 - 5.6	2.62	0.91 - 3.75	Н/П*	Н/П*
TREG+226+TIGIT+	Abs_Value										16	16	0	17.88	16.73	9.68 - 26.08	3.37 - 58.46	11.88	6.05 - 24.33	Н/П*	Н/П*
TREG+39+	Abs_Value										16	16	0	20.12	20.89	9.88 - 30.35	3.52 - 76.71	12.83	6.64 - 23.81	Н/П*	Н/П*
TREG+DR+	Abs_Value										16	16	0	18.52	17.96	9.72 - 27.32	3.45 - 67.02	16.88	6.22 - 20.21	Н/П*	Н/П*
TREG+PD-1+	Abs_Value										16	16	0	13.74	14.23	6.77 - 20.71	2.61 - 48.13	9.94	4.29 - 14.6	Н/П*	Н/П*
TREG+TIGIT+	Abs_Value										16	16	0	24.06	21.65	13.46 - 34.67	3.75 - 77.23	18.29	7.78 - 31.58	Н/П*	Н/П*

В таблицах столбцы No- для тех, у кого не развилось cGVHD, Yes - у кого развилось

Описательная таблица только для дня анализа 90

# Те же статистики 
statistics <- list(
  `_Количество субъектов` = ~length(.x) %>% as.character(),
  `_Количество (есть данные)` = ~sum(!is.na(.x)) %>% as.character(),
  `_Нет данных` = ~sum(is.na(.x)) %>% as.character(),
  `_Ср. знач.` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", mean(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
  `_Станд. отклон.` = ~ifelse(sum(!is.na(.x)) < 3, "Н/П*", sd(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
  `_95% ДИ для среднего` = ~{
    n <- sum(!is.na(.x))
    ifelse(n < 3, "Н/П*", 
           paste0(round(mean(.x, na.rm = TRUE) - 1.96 * sd(.x, na.rm = TRUE) / sqrt(n), 2), " - ", round(mean(.x, na.rm = TRUE) + 1.96 * sd(.x, na.rm = TRUE) / sqrt(n), 2))
    )
  },
  `_мин. - макс.` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", paste0(min(.x, na.rm = TRUE) %>% round(2), " - ", max(.x, na.rm = TRUE) %>% round(2))),
  `_Медиана` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", median(.x, na.rm = TRUE) %>% round(2) %>% as.character()),
  `_Q1 - Q3` = ~ifelse(sum(!is.na(.x)) == 0, "Н/П*", paste0(quantile(.x, 0.25, na.rm = TRUE) %>% round(2), " - ", quantile(.x, 0.75, na.rm = TRUE) %>% round(2)))
)

# Фильтруем данные только для +90 дней
AI_Tcells_90 <- AI_Tcells_filtered %>%
  filter(Analysis_day == "+90")

# Функция для t-теста 
t_test_wrapper <- function(data, var) {
  n_yes <- sum(!is.na(data$Abs_Value[data$cGVHD_present == "Yes"]))
  n_no <- sum(!is.na(data$Abs_Value[data$cGVHD_present == "No"]))
  
  if(n_yes < 3 || n_no < 3) {
    return("Н/П*")
  }
  
  test_result <- try(
    t.test(Abs_Value ~ cGVHD_present, data = data)$p.value,
    silent = TRUE
  )
  
  if(inherits(test_result, "try-error")) {
    return("Ошибка")
  }
  
  return(as.character(round(test_result, 4)))
}

# Собираем p-values только для данных 90-го дня
p_values_df_90 <- AI_Tcells_90 %>%
  group_by(Сell_population) %>%
  summarise(
    p_value = t_test_wrapper(cur_data(), Abs_Value),
    .groups = "drop"
  )

# Корректируем p-values
p_values_df_90 <- p_values_df_90 %>%
  mutate(
    adj_p_value = p_value
  )

# Находим индексы числовых p-values
numeric_indices <- !p_values_df_90$p_value %in% c("Н/П*", "Ошибка")

if(sum(numeric_indices) > 0) {
  numeric_p_values <- as.numeric(p_values_df_90$p_value[numeric_indices])
  adj_p_values <- p.adjust(numeric_p_values, method = "BH")
  p_values_df_90$adj_p_value[numeric_indices] <- as.character(round(adj_p_values, 4))
}

# Создаем финальную таблицу
result_90 <- AI_Tcells_90 %>%
  select(`Сell_population`, `cGVHD_present`, Abs_Value) %>%
  group_by(`Сell_population`, `cGVHD_present`) %>%
  summarize(across(Abs_Value, statistics), .groups = "drop") %>%
  pivot_longer(cols = -c(`Сell_population`, `cGVHD_present`)) %>%
  separate(name, into = c("Variable", "Statistics"), sep = "__") %>%
  pivot_wider(names_from = c(cGVHD_present, Statistics), values_from = value) %>%
  # Присоединяем p-values
  left_join(p_values_df_90, by = c("Сell_population")) %>%
  rename(
    "t-test, p-value" = p_value,
    "t-test, adj p-value (BH)" = adj_p_value
  ) %>%
  # Создаём финальную таблицу
  arrange(Сell_population) %>%
  flextable() %>%
  theme_box() %>%
  align(align = "center", part = "all")

# Выводим таблицу
result_90

Сell_population	Variable	No_Количество субъектов	No_Количество (есть данные)	No_Нет данных	No_Ср. знач.	No_Станд. отклон.	No_95% ДИ для среднего	No_мин. - макс.	No_Медиана	No_Q1 - Q3	Yes_Количество субъектов	Yes_Количество (есть данные)	Yes_Нет данных	Yes_Ср. знач.	Yes_Станд. отклон.	Yes_95% ДИ для среднего	Yes_мин. - макс.	Yes_Медиана	Yes_Q1 - Q3	t-test, p-value	t-test, adj p-value (BH)
4_TFH	Abs_Value	39	39	0	16.33	13.43	12.11 - 20.55	0 - 61.09	13.26	8.06 - 22.35	28	28	0	14.42	12.25	9.88 - 18.96	1.1 - 45.51	10.81	4.76 - 18.65	0.5483	0.7484
4_TH1	Abs_Value	39	39	0	35.1	96.74	4.74 - 65.47	0.16 - 608.2	10.47	5.84 - 24.35	28	28	0	17.24	24.14	8.3 - 26.19	0.03 - 113.81	9.26	4.29 - 17.68	0.2747	0.6696
4_TH17	Abs_Value	39	39	0	13.84	8.71	11.11 - 16.57	0.02 - 34.84	12.75	6.74 - 18.73	28	28	0	13.49	9.77	9.87 - 17.11	0.86 - 40.22	11.94	6.64 - 20.16	0.8803	0.9621
4_Th17TO1	Abs_Value	39	39	0	3.39	3.17	2.4 - 4.39	0.03 - 17.49	2.3	1.43 - 4.6	28	28	0	3.75	4.89	1.93 - 5.56	0.05 - 18.77	2.09	0.78 - 3.94	0.7375	0.8959
4_TH2	Abs_Value	39	39	0	13.04	22.22	6.06 - 20.01	0.02 - 143.45	8.78	5.17 - 13.6	28	28	0	13.67	9.99	9.97 - 17.37	0.58 - 37.81	10.16	6.22 - 19.3	0.8754	0.9621
4_TH22	Abs_Value	39	39	0	3.91	3.18	2.91 - 4.91	0 - 13.92	3.12	1.51 - 5.85	28	28	0	4.25	3.86	2.82 - 5.68	0.02 - 14.86	3.06	1.61 - 5.72	0.7032	0.8671
4+	Abs_Value	39	39	0	70.84	76.56	46.81 - 94.87	0.01 - 430.92	59.43	20.66 - 92.9	28	28	0	83.71	46.4	66.52 - 100.89	1.65 - 194.52	81.98	48.2 - 121.66	0.3964	0.6762
4+ (IM STAT)	Abs_Value	39	39	0	65.93	72.58	43.14 - 88.71	0 - 397.77	47.44	19.37 - 82.94	28	28	0	74.78	44.66	58.24 - 91.32	2.77 - 186.76	77.26	37.17 - 96.8	0.5398	0.7484
4+226+	Abs_Value	39	39	0	155.71	179.73	99.3 - 212.12	0.31 - 1046.46	128.08	68.58 - 160.33	28	28	0	132.45	73.4	105.26 - 159.64	16.89 - 269.89	131.07	76.06 - 166.98	0.4698	0.6986
4+39+	Abs_Value	39	39	0	39.48	31.48	29.6 - 49.36	0.07 - 135.08	37.22	19.19 - 54.81	28	28	0	40.21	33.36	27.86 - 52.57	0.49 - 110.79	34.79	9.36 - 63.23	0.9278	0.9731
4+DR+	Abs_Value	39	39	0	102.8	170.68	49.23 - 156.37	0.05 - 960.16	65.32	31.43 - 87.28	28	28	0	64.77	56.51	43.84 - 85.71	4.16 - 250.67	51.29	24.28 - 82.42	0.2011	0.6696
4+PD-1-TIGIT-	Abs_Value	39	39	0	48.64	34	37.97 - 59.31	0.03 - 131.28	34.59	25.53 - 75.58	28	28	0	55.29	44.79	38.69 - 71.88	6.67 - 166.24	41.71	22.29 - 76.75	0.5119	0.73
4+PD-1-TIGIT+	Abs_Value	39	39	0	8.16	24.25	0.55 - 15.77	0 - 154.31	3.78	1.76 - 6.59	28	28	0	4.87	3.39	3.61 - 6.12	0.25 - 12.65	3.76	2.29 - 7.19	0.4071	0.6762
4+PD-1+	Abs_Value	39	39	0	108.13	148.15	61.64 - 154.63	0.33 - 789.05	77.82	46.08 - 97.71	28	28	0	82.56	62.59	59.37 - 105.74	7.01 - 256.14	70.45	36.32 - 110.92	0.3389	0.6696
4+PD-1+TIGIT-	Abs_Value	39	39	0	55.79	53.07	39.14 - 72.45	0.28 - 262.81	35.44	26.29 - 61.74	28	28	0	47.04	40.36	32.09 - 61.98	3.7 - 176.04	35.9	21.62 - 63.3	0.4459	0.6834
4+PD-1+TIGIT+	Abs_Value	39	39	0	52.34	100.95	20.66 - 84.03	0.05 - 526.23	28.49	18 - 44.4	28	28	0	35.52	29.85	24.47 - 46.58	3.31 - 119.05	23.88	15.59 - 49.99	0.3309	0.6696
4+TIGIT+	Abs_Value	39	39	0	60.51	121.07	22.51 - 98.51	0.05 - 680.54	31.37	20.51 - 50.09	28	28	0	40.39	31.42	28.75 - 52.03	4.89 - 130.02	28.02	20.05 - 55.79	0.3264	0.6696
4NV	Abs_Value	39	39	0	17.03	15.12	12.28 - 21.78	0 - 55.9	12.73	6.44 - 21.38	28	28	0	28.77	26.38	19 - 38.55	3.15 - 110.75	18.27	8.39 - 39.7	0.0404	0.6696
4NV(СТАР2)	Abs_Value	39	39	0	15.95	15.14	11.2 - 20.7	0 - 54	10.42	6.42 - 18.05	28	28	0	26.63	24.08	17.71 - 35.55	4.36 - 99.11	18.69	7.91 - 35.34	0.0444	0.6696
4NV_TH1	Abs_Value	39	39	0	1.27	1.37	0.84 - 1.7	0 - 6.02	0.92	0.31 - 1.7	28	28	0	1.99	2.02	1.24 - 2.74	0.01 - 7.62	1.39	0.42 - 2.94	0.1094	0.6696
4NV_TH17	Abs_Value	39	39	0	0.59	0.58	0.41 - 0.77	0 - 2.9	0.41	0.18 - 0.81	28	28	0	0.92	0.76	0.64 - 1.2	0.12 - 3.24	0.68	0.45 - 1.19	0.0582	0.6696
4NV_Th17TO1	Abs_Value	39	39	0	0.11	0.12	0.08 - 0.15	0 - 0.43	0.07	0.02 - 0.17	28	28	0	0.21	0.25	0.12 - 0.3	0.01 - 1.08	0.12	0.04 - 0.24	0.0737	0.6696
4NV_TH2	Abs_Value	39	39	0	1.99	2.41	1.23 - 2.74	0 - 11.34	1.09	0.62 - 2.33	28	28	0	4.1	4.56	2.41 - 5.79	0.14 - 20.02	2.86	1.01 - 5.49	0.0312	0.6696
4NV_TH22	Abs_Value	39	39	0	0.05	0.08	0.03 - 0.08	0 - 0.32	0.02	0.01 - 0.06	28	28	0	0.09	0.12	0.05 - 0.14	0 - 0.55	0.04	0.01 - 0.15	0.1106	0.6696
4NV+226+	Abs_Value	39	39	0	13.74	13.09	9.63 - 17.84	0 - 43.3	9.21	6.11 - 15.8	28	28	0	23.13	21.19	15.28 - 30.98	3.48 - 85.04	16.11	7.06 - 29.98	0.044	0.6696
4NV+39+	Abs_Value	39	39	0	0.7	0.89	0.42 - 0.98	0 - 3.98	0.4	0.1 - 0.87	28	28	0	0.98	0.98	0.61 - 1.34	0.01 - 4.69	0.75	0.48 - 1.13	0.2396	0.6696
4NV+DR+	Abs_Value	39	39	0	1.96	3.25	0.94 - 2.98	0 - 17.28	0.83	0.41 - 1.75	28	28	0	1.75	1.95	1.03 - 2.47	0.25 - 10.14	1.16	0.7 - 1.82	0.7485	0.9026
4NV+PD-1-TIGIT-	Abs_Value	39	39	0	14.19	14.36	9.69 - 18.7	0 - 47.46	9.27	4.44 - 17.37	28	28	0	24.61	23.7	15.84 - 33.39	2.32 - 98.02	16.98	6.11 - 33.64	0.0448	0.6696
4NV+PD-1-TIGIT+	Abs_Value	39	39	0	0.46	0.79	0.22 - 0.71	0 - 4.58	0.26	0.11 - 0.41	28	28	0	0.61	0.55	0.4 - 0.81	0.07 - 2.14	0.44	0.25 - 0.7	0.3928	0.6762
4NV+PD-1+TIGIT-	Abs_Value	39	39	0	0.87	1.14	0.51 - 1.23	0 - 4.56	0.35	0.23 - 0.96	28	28	0	0.93	0.76	0.65 - 1.21	0.1 - 3.04	0.72	0.34 - 1.24	0.7927	0.9228
4NV+PD-1+TIGIT+	Abs_Value	39	39	0	0.42	0.56	0.25 - 0.6	0 - 2.84	0.19	0.08 - 0.57	28	28	0	0.48	0.35	0.35 - 0.61	0.05 - 1.27	0.4	0.23 - 0.62	0.5964	0.7825
4NV+PD1+	Abs_Value	39	39	0	1.29	1.54	0.81 - 1.77	0 - 6.69	0.63	0.33 - 1.84	28	28	0	1.41	0.95	1.06 - 1.76	0.25 - 3.76	1.16	0.64 - 1.95	0.6939	0.8621
4NV+TIGIT+	Abs_Value	39	39	0	0.88	1.11	0.54 - 1.23	0 - 5.34	0.5	0.24 - 1.04	28	28	0	1.08	0.76	0.8 - 1.37	0.19 - 3.42	0.91	0.5 - 1.39	0.3839	0.6762
4ЕМ	Abs_Value	39	39	0	29.18	89.5	1.09 - 57.27	0.01 - 428.8	3.42	0.63 - 16.48	28	28	0	7.64	17.2	1.27 - 14.01	0 - 67.92	0.8	0.19 - 3.72	0.1502	0.6696
4ЕМ_TH1	Abs_Value	39	39	0	11.29	43.51	-2.37 - 24.94	0 - 267.92	1.06	0.16 - 3.75	28	28	0	1.94	5.86	-0.23 - 4.11	0 - 30.53	0.2	0.03 - 0.92	0.1925	0.6696
4ЕМ_TH17	Abs_Value	39	39	0	0.07	0.19	0.01 - 0.13	0 - 0.9	0.01	0 - 0.03	28	28	0	0.01	0.03	0 - 0.02	0 - 0.15	0	0 - 0.01	0.0572	0.6696
4ЕМ_Th17TO1	Abs_Value	39	39	0	0.29	0.88	0.01 - 0.56	0 - 5.46	0.04	0.01 - 0.32	28	28	0	0.04	0.08	0.01 - 0.07	0 - 0.41	0.01	0 - 0.04	0.0894	0.6696
4ЕМ_TH2	Abs_Value	39	39	0	3.8	21.09	-2.81 - 10.42	0 - 131.99	0.08	0.02 - 0.43	28	28	0	0.3	0.62	0.07 - 0.53	0 - 2.67	0.03	0.01 - 0.2	0.3066	0.6696
4ЕМ_TH22	Abs_Value	39	39	0	0.01	0.03	0 - 0.02	0 - 0.15	0	0 - 0	28	28	0	0.01	0.01	0 - 0.01	0 - 0.05	0	0 - 0	0.3268	0.6696
4ЕМ+226+	Abs_Value	39	39	0	85.97	111.51	50.98 - 120.97	0.28 - 553.6	60.55	31.84 - 87.48	28	28	0	61.27	45.72	44.34 - 78.21	2.92 - 184.9	61.09	24.67 - 85.82	0.2184	0.6696
4ЕМ+39+	Abs_Value	39	39	0	23.58	18.88	17.65 - 29.5	0.07 - 70.57	22.61	9.99 - 38	28	28	0	21.36	18.22	14.61 - 28.11	0.36 - 65.22	19.28	3.74 - 34.53	0.6308	0.8082
4ЕМ+DR+	Abs_Value	39	39	0	64.34	103.15	31.97 - 96.71	0.05 - 497.18	41.66	22.69 - 54.93	28	28	0	39.41	37.3	25.59 - 53.22	1.61 - 158.94	31.55	12.09 - 55.55	0.1711	0.6696
4ЕМ+PD1-TIGIT-	Abs_Value	39	39	0	17.15	17.92	11.53 - 22.78	0.02 - 72.04	10.23	5.61 - 20.32	28	28	0	13.15	14.56	7.75 - 18.54	0.12 - 53.88	6.67	4.26 - 15.63	0.3174	0.6696
4ЕМ+PD1-TIGIT+	Abs_Value	39	39	0	3.48	10.15	0.29 - 6.66	0 - 64.16	1.27	0.67 - 2.64	28	28	0	1.74	1.51	1.18 - 2.3	0.03 - 5.22	1.22	0.61 - 2.92	0.2989	0.6696
4ЕМ+PD1+	Abs_Value	39	39	0	68.62	97.13	38.13 - 99.1	0.31 - 488.16	42.29	29.92 - 67.94	28	28	0	49.55	43.2	33.55 - 65.55	2.85 - 169.81	41.27	18.21 - 65.64	0.2824	0.6696
4ЕМ+PD1+TIGIT-	Abs_Value	39	39	0	36.22	35.42	25.1 - 47.33	0.26 - 163.47	25.02	16.2 - 42.8	28	28	0	29.95	28.72	19.32 - 40.59	1.55 - 118.87	21.16	10.76 - 39.53	0.4278	0.6834
4ЕМ+PD1+TIGIT+	Abs_Value	39	39	0	32.4	66.32	11.58 - 53.22	0.05 - 343.46	16.95	9.28 - 23.66	28	28	0	19.6	19.73	12.29 - 26.9	1.3 - 92.73	14.3	6.25 - 25.74	0.2611	0.6696
4ЕМ+TIGIT+	Abs_Value	39	39	0	35.88	73.29	12.88 - 58.88	0.05 - 349.01	18.54	10.11 - 26.96	28	28	0	21.34	20.59	13.71 - 28.97	1.44 - 97.96	18.46	6.9 - 26.92	0.2457	0.6696
4ЕМTM	Abs_Value	39	39	0	89.25	112.7	53.88 - 124.62	0.33 - 560.51	61.41	33.6 - 92.27	28	28	0	64.44	48.25	46.57 - 82.31	3.5 - 201.17	63.48	25.56 - 91.84	0.225	0.6696
4СМ	Abs_Value	39	39	0	31.42	22.37	24.4 - 38.44	0 - 119.97	27.94	16.69 - 46.26	28	28	0	40.08	23.5	31.38 - 48.79	5.35 - 88.59	43.11	17.54 - 53.18	0.1344	0.6696
4СМ(СТАР2)	Abs_Value	39	39	0	30.02	22.79	22.87 - 37.17	0 - 133.51	26.43	16.63 - 38.84	28	28	0	32.97	19.84	25.62 - 40.32	1.94 - 67.99	34.65	16.28 - 44.77	0.5747	0.7633
4СМ_TH1	Abs_Value	39	39	0	1.56	2.53	0.76 - 2.35	0 - 15.41	1.1	0.34 - 1.69	28	28	0	1.57	1.47	1.03 - 2.12	0 - 4.36	0.9	0.36 - 2.7	0.9785	0.9845
4СМ_TH17	Abs_Value	39	39	0	5.03	3.89	3.81 - 6.25	0 - 15.87	4.24	1.91 - 7.32	28	28	0	6.77	5.73	4.65 - 8.89	0.22 - 20.07	4.4	2 - 10.07	0.17	0.6696
4СМ_Th17TO1	Abs_Value	39	39	0	0.38	0.57	0.21 - 0.56	0 - 3.07	0.24	0.06 - 0.41	28	28	0	0.55	0.73	0.28 - 0.82	0.03 - 3.05	0.25	0.12 - 0.65	0.3224	0.6696
4СМ_TH2	Abs_Value	39	39	0	3.18	2.55	2.38 - 3.98	0 - 11.68	2.61	1.48 - 4.55	28	28	0	5.02	4.33	3.42 - 6.63	0.29 - 18.6	4.09	1.54 - 8.19	0.0505	0.6696
4СМ_TH22	Abs_Value	39	39	0	0.53	0.65	0.33 - 0.74	0 - 3.29	0.32	0.1 - 0.69	28	28	0	0.85	0.79	0.56 - 1.14	0.01 - 2.75	0.79	0.19 - 1.1	0.0902	0.6696
4СМ+226+	Abs_Value	39	39	0	27.75	21.33	21.06 - 34.45	0 - 125.07	23.75	15.53 - 36.02	28	28	0	30.78	18.69	23.86 - 37.71	1.86 - 63.84	32.53	15.09 - 40.76	0.5396	0.7484
4СМ+39+	Abs_Value	39	39	0	10.35	10.02	7.2 - 13.49	0 - 49.38	9.36	1.53 - 13.97	28	28	0	12.32	11.87	7.92 - 16.71	0.01 - 39.63	9.41	1.22 - 17.71	0.479	0.701
4СМ+DR+	Abs_Value	39	39	0	14.08	20.69	7.59 - 20.58	0 - 127.35	9.85	5.25 - 13.14	28	28	0	11.9	10.78	7.91 - 15.89	0.25 - 41.83	8.12	3.91 - 16.05	0.5771	0.7633
4СМ+PD1-TIGIT-	Abs_Value	39	39	0	9.47	6.39	7.46 - 11.47	0 - 23.26	7.52	5.37 - 13.64	28	28	0	11.96	10.31	8.14 - 15.78	0.12 - 41.2	8.6	4.25 - 18.41	0.264	0.6696
4СМ+PD1-TIGIT+	Abs_Value	39	39	0	1.44	2.08	0.78 - 2.09	0 - 12.64	0.77	0.45 - 2.01	28	28	0	1.41	1.22	0.96 - 1.86	0.01 - 4.72	1.1	0.6 - 1.79	0.9483	0.9731
4СМ+PD1+	Abs_Value	39	39	0	19.12	18.7	13.25 - 24.99	0 - 111.86	16.09	9.77 - 23.86	28	28	0	19.6	14.8	14.12 - 25.08	0.46 - 61.96	17.76	10.26 - 23.57	0.9061	0.9731
4СМ+PD1+TIGIT-	Abs_Value	39	39	0	8.47	5.96	6.6 - 10.34	0 - 23.93	7.21	4.23 - 13.21	28	28	0	8.74	6.04	6.5 - 10.98	0.31 - 24.42	8.55	5.14 - 11.06	0.855	0.9574
4СМ+PD1+TIGIT+	Abs_Value	39	39	0	10.65	14.71	6.04 - 15.27	0 - 90.89	7.63	3.58 - 11.64	28	28	0	10.86	9.95	7.18 - 14.55	0.15 - 37.55	8.88	5.08 - 12.27	0.9441	0.9731
4СМ+TIGIT+	Abs_Value	39	39	0	12.09	16.62	6.87 - 17.31	0 - 103.53	9	4.03 - 13.68	28	28	0	12.28	10.32	8.45 - 16.1	0.27 - 38.44	10.69	5.63 - 14.57	0.9553	0.9731
4ТM_TH1	Abs_Value	39	39	0	12.66	19.35	6.58 - 18.73	0.14 - 107.61	5.15	2.95 - 13.84	28	28	0	9.75	16.05	3.8 - 15.69	0.01 - 69.74	3.11	1.28 - 9.12	0.5047	0.7261
4ТM_TH17	Abs_Value	39	39	0	7.59	5.69	5.8 - 9.37	0.02 - 20.47	5.91	3.82 - 10.49	28	28	0	5.4	4.24	3.83 - 6.97	0.07 - 17.72	4.87	2.86 - 7.51	0.0761	0.6696
4ТM_Th17TO1	Abs_Value	39	39	0	2.19	1.71	1.65 - 2.72	0.03 - 6.88	1.88	0.98 - 3.01	28	28	0	2.64	3.74	1.26 - 4.02	0 - 13.42	1.26	0.4 - 2.99	0.5522	0.7484
4ТM_TH2	Abs_Value	39	39	0	3.2	3.01	2.26 - 4.15	0.02 - 13.03	2.17	1.45 - 3.93	28	28	0	3.69	4.82	1.91 - 5.48	0.07 - 25.5	2.9	0.95 - 4.16	0.6371	0.81
4ТM_TH22	Abs_Value	39	39	0	3.03	2.8	2.15 - 3.91	0 - 11.23	1.9	1.07 - 4.73	28	28	0	2.99	3.07	1.85 - 4.12	0 - 11.35	2.21	0.77 - 4.02	0.9515	0.9731
4ТREG	Abs_Value	39	39	0	1.24	1.42	0.79 - 1.69	0 - 5.79	0.69	0.23 - 1.75	28	28	0	2.41	6.03	0.18 - 4.64	0.03 - 32.72	1.27	0.48 - 2.01	0.3225	0.6696
4ТREG(СТАР2)	Abs_Value	39	39	0	73	75.81	49.2 - 96.79	0.01 - 424.27	59.76	24.03 - 94.33	28	28	0	85.58	47.59	67.95 - 103.2	1.89 - 193.24	83.08	45.45 - 117.11	0.4082	0.6762
4ТREG_TH1	Abs_Value	39	39	0	0.2	0.24	0.12 - 0.28	0 - 0.92	0.14	0.03 - 0.2	28	28	0	0.22	0.24	0.13 - 0.31	0 - 1	0.15	0.07 - 0.3	0.7316	0.8954
4ТREG_TH17	Abs_Value	39	39	0	2.82	2.61	2 - 3.64	0.01 - 11.98	1.98	0.91 - 4.27	28	28	0	3.49	3.54	2.17 - 4.8	0.06 - 15.96	2.59	1.19 - 4.07	0.4005	0.6762
4ТREG_Th17TO1	Abs_Value	39	39	0	0.07	0.1	0.04 - 0.1	0 - 0.44	0.04	0.01 - 0.08	28	28	0	0.1	0.14	0.05 - 0.15	0 - 0.47	0.04	0.02 - 0.1	0.3475	0.6701
4ТREG_TH2	Abs_Value	39	39	0	1.54	1.37	1.11 - 1.97	0 - 5.88	1.46	0.53 - 2.34	28	28	0	2.23	2.84	1.18 - 3.28	0.22 - 14.5	1.3	0.74 - 3.06	0.2427	0.6696
4ТREG_TH22	Abs_Value	39	39	0	1.69	2.05	1.05 - 2.33	0.01 - 11.04	1.01	0.55 - 2.04	28	28	0	1.82	1.85	1.14 - 2.51	0 - 8.31	1.47	0.4 - 2.49	0.7863	0.9228
4ТЕ	Abs_Value	39	39	0	11.59	46.78	-3.09 - 26.27	0.01 - 293.46	0.64	0.2 - 5.63	28	28	0	2.37	3.82	0.96 - 3.78	0.03 - 14.73	0.88	0.24 - 2.04	0.2278	0.6696
4ТЕ(СТАР2)	Abs_Value	39	39	0	27.59	51.5	11.43 - 43.76	0.03 - 310.52	13.13	6.43 - 23.4	28	28	0	17.96	16.22	11.95 - 23.97	1.53 - 73.6	12.4	8.11 - 26.72	0.279	0.6696
4ТЕ_TH1	Abs_Value	39	39	0	5.91	29.66	-3.4 - 15.22	0 - 185.79	0.13	0.02 - 1.02	28	28	0	0.47	1.02	0.09 - 0.85	0 - 4.5	0.14	0.01 - 0.33	0.2599	0.6696
4ТЕ_TH17	Abs_Value	39	39	0	0.01	0.03	0 - 0.02	0 - 0.17	0	0 - 0	28	28	0	0.01	0.02	0 - 0.01	0 - 0.07	0	0 - 0	0.4728	0.6986
4ТЕ_Th17TO1	Abs_Value	39	39	0	0.13	0.65	-0.08 - 0.33	0 - 4.08	0.01	0 - 0.03	28	28	0	0.01	0.02	0 - 0.02	0 - 0.07	0	0 - 0.01	0.2706	0.6696
4ТЕ_TH2	Abs_Value	39	39	0	0.42	1.36	-0.01 - 0.84	0 - 6.25	0.01	0 - 0.12	28	28	0	0.08	0.13	0.04 - 0.13	0 - 0.51	0.02	0 - 0.12	0.1315	0.6696
4ТЕ_TH22	Abs_Value	39	39	0	0.01	0.01	0 - 0.01	0 - 0.06	0	0 - 0.01	28	28	0	0	0.01	0 - 0.01	0 - 0.05	0	0 - 0	0.4354	0.6834
4ТЕ+226+	Abs_Value	39	39	0	26.34	51.15	10.28 - 42.39	0.03 - 307.76	11.03	6.12 - 22.51	28	28	0	16.66	15.37	10.97 - 22.35	1.33 - 71.49	11.51	7.18 - 22.78	0.271	0.6696
4ТЕ+39+	Abs_Value	39	39	0	4.33	3.99	3.08 - 5.59	0 - 17.63	3.24	0.79 - 6.09	28	28	0	5.45	6.64	2.99 - 7.91	0.05 - 29.5	3.18	1.51 - 6.83	0.4309	0.6834
4ТЕ+DR+	Abs_Value	39	39	0	20.75	45.95	6.33 - 35.17	0 - 273.14	8.21	4.06 - 17.59	28	28	0	11.62	15.22	5.98 - 17.26	0.27 - 71.42	7.25	3.38 - 11.19	0.2534	0.6696
4ТЕ+PD-1-TIGIT-	Abs_Value	39	39	0	7.42	9.57	4.42 - 10.42	0 - 48.37	3.79	2.16 - 8.9	28	28	0	5.1	4.7	3.36 - 6.84	0.27 - 20.57	4.19	2.35 - 5.99	0.1945	0.6696
4ТЕ+PD-1-TIGIT+	Abs_Value	39	39	0	2.5	10.09	-0.67 - 5.67	0 - 63.72	0.68	0.29 - 1.27	28	28	0	1.05	0.99	0.68 - 1.42	0.02 - 4.29	0.78	0.36 - 1.29	0.3773	0.6762
4ТЕ+PD-1+	Abs_Value	39	39	0	17.67	35.09	6.66 - 28.68	0.02 - 198.43	7.84	3.82 - 16	28	28	0	11.81	14.43	6.47 - 17.16	0.53 - 65.87	7.14	3.15 - 12.28	0.3527	0.6701
4ТЕ+PD-1+TIGIT-	Abs_Value	39	39	0	9.85	14.26	5.38 - 14.33	0.02 - 68.31	3.85	2.12 - 11.01	28	28	0	7.28	9.7	3.69 - 10.88	0.31 - 45.47	3.94	1.99 - 7.31	0.3832	0.6762
4ТЕ+PD-1+TIGIT+	Abs_Value	39	39	0	7.82	22.22	0.84 - 14.79	0 - 130.12	2.71	1.56 - 4.95	28	28	0	4.53	5.52	2.49 - 6.58	0.23 - 21.97	2.11	1.41 - 5.09	0.3806	0.6762
4ТЕ+TIGIT+	Abs_Value	39	39	0	10.32	31.7	0.37 - 20.27	0 - 193.84	3.7	2.22 - 6.07	28	28	0	5.58	6.07	3.33 - 7.83	0.34 - 22.91	3.11	2.07 - 5.82	0.3679	0.6762
4ТМ	Abs_Value	39	39	0	68.73	44.83	54.66 - 82.8	0.29 - 206.37	59.16	36.36 - 89.43	28	28	0	60.2	43.52	44.08 - 76.32	2.7 - 156.95	59.02	21.18 - 93.81	0.4377	0.6834
8+	Abs_Value	39	39	0	338.23	532.81	171.01 - 505.45	3.6 - 2131.88	94.25	33.79 - 338.12	28	28	0	163.88	420.4	8.16 - 319.59	0.65 - 2174.4	32.02	7.98 - 107.38	0.1397	0.6696
8+ (IM STAT)	Abs_Value	39	39	0	367.88	552.6	194.44 - 541.31	3.93 - 2176.1	99.73	39.92 - 499.23	28	28	0	190.71	457.37	21.29 - 360.12	0.71 - 2351.17	40.68	13.82 - 116.25	0.1569	0.6696
8+226+	Abs_Value	39	39	0	470.53	618.71	276.35 - 664.71	19.73 - 2309.79	182.21	83.91 - 662.23	28	28	0	254.15	484.55	74.67 - 433.63	7.76 - 2484.23	93.15	40.59 - 227.28	0.1136	0.6696
8+39+	Abs_Value	39	39	0	50.88	78.12	26.36 - 75.39	0.09 - 418.95	23.41	8.89 - 61.49	28	28	0	47.44	107.14	7.75 - 87.13	0.2 - 562.33	12.38	3.76 - 49.88	0.8858	0.9621
8+DR+	Abs_Value	39	39	0	367.32	527.47	201.78 - 532.87	4.94 - 2168.46	142.83	62.61 - 414.98	28	28	0	216.12	474.09	40.51 - 391.73	2.26 - 2431.19	63.22	19.15 - 162.93	0.2241	0.6696
8+PD-1-TIGIT-	Abs_Value	39	39	0	135.49	198.3	73.25 - 197.72	5.63 - 815.7	39.97	17.51 - 139.58	28	28	0	76.66	134.27	26.93 - 126.39	1.36 - 704.51	40.59	10.93 - 84.58	0.1526	0.6696
8+PD-1-TIGIT+	Abs_Value	39	39	0	144.2	244.69	67.4 - 221	1.37 - 1271.22	31.04	10.46 - 209.95	28	28	0	65.97	141.78	13.46 - 118.49	1 - 719.74	15.57	7.8 - 62.55	0.1044	0.6696
8+PD-1+	Abs_Value	39	39	0	217.19	328.31	114.15 - 320.23	7.78 - 1736.81	95	38.06 - 229.28	28	28	0	133.94	258.59	38.15 - 229.72	1.8 - 1201.16	35.47	16.3 - 80.32	0.2504	0.6696
8+PD-1+TIGIT-	Abs_Value	39	39	0	71.54	104.23	38.83 - 104.25	1.45 - 448.19	26.52	4.16 - 106.41	28	28	0	41.87	87.52	9.45 - 74.29	0.7 - 428.96	12.39	3.78 - 32.22	0.2113	0.6696
8+PD-1+TIGIT+	Abs_Value	39	39	0	145.65	238.86	70.69 - 220.62	5.05 - 1288.62	68.95	21.04 - 122.68	28	28	0	92.07	178.77	25.85 - 158.28	0.99 - 772.2	19.64	11.2 - 49.28	0.2976	0.6696
8+TIGIT+	Abs_Value	39	39	0	289.85	431.67	154.37 - 425.33	6.42 - 1840.75	94.56	43.22 - 313.01	28	28	0	158.04	314.31	41.62 - 274.46	1.99 - 1491.94	43.96	19.14 - 109.1	0.1529	0.6696
8EMTM	Abs_Value	39	39	0	77.74	115.56	41.47 - 114	2.95 - 582.56	29.11	9.7 - 91.47	28	28	0	70.04	204.35	-5.65 - 145.73	0.4 - 1077.88	11.45	3.34 - 45.52	0.8582	0.9574
8EMTM+226+	Abs_Value	39	39	0	72.96	112.94	37.51 - 108.41	2.29 - 577.84	28.32	7.48 - 83.22	28	28	0	64.24	192.62	-7.11 - 135.59	0.36 - 1020.79	10.3	2.38 - 43.16	0.8312	0.9533
8EMTM+39+	Abs_Value	39	39	0	14.47	23.42	7.12 - 21.82	0.04 - 99.93	4.62	1.73 - 15.46	28	28	0	15.07	51.88	-4.14 - 34.29	0.03 - 277.35	1.72	0.75 - 9.77	0.9544	0.9731
8EMTM+DR+	Abs_Value	39	39	0	64.68	100.49	33.15 - 96.22	1.79 - 474.38	25.43	8.16 - 71.87	28	28	0	62.31	194.49	-9.73 - 134.35	0.28 - 1026.67	6.98	1.25 - 30.94	0.9532	0.9731
8EMTM+PD-1-TIGIT-	Abs_Value	39	39	0	16.56	28.57	7.59 - 25.52	0.1 - 131.33	4.96	1.16 - 19.06	28	28	0	14.71	44.65	-1.83 - 31.25	0.1 - 237.98	2.42	0.29 - 9.52	0.8481	0.9574
8EMTM+PD-1-TIGIT+	Abs_Value	39	39	0	18.89	47.24	4.06 - 33.71	0.12 - 275.2	4.85	0.88 - 12.82	28	28	0	12.87	39.42	-1.74 - 27.47	0.04 - 206	0.93	0.23 - 7.56	0.5727	0.7633
8EMTM+PD-1+	Abs_Value	39	39	0	42.29	57.22	24.33 - 60.25	2.21 - 240.61	17.22	6.99 - 48.08	28	28	0	42.46	121.77	-2.64 - 87.57	0.27 - 633.9	6.11	1.59 - 25.15	0.9945	0.9945
8EMTM+PD-1+TIGIT-	Abs_Value	39	39	0	13	16.61	7.78 - 18.21	0.2 - 74.77	5.86	1.15 - 19.09	28	28	0	13.87	44.21	-2.5 - 30.25	0.08 - 235.25	2.36	0.47 - 7.78	0.9209	0.9731
8EMTM+PD-1+TIGIT+	Abs_Value	39	39	0	29.3	44.1	15.46 - 43.14	0.71 - 188.94	11.73	3.71 - 27.49	28	28	0	28.59	79.29	-0.78 - 57.96	0.12 - 398.65	3.64	1.15 - 13.56	0.9662	0.9781
8EMTM+TIGIT+	Abs_Value	39	39	0	48.18	86.13	21.15 - 75.22	0.83 - 464.14	17.79	5.39 - 42.69	28	28	0	41.46	118.34	-2.38 - 85.29	0.16 - 604.65	4.85	1.71 - 21.19	0.799	0.9228
8NV	Abs_Value	39	39	0	7.64	9.28	4.73 - 10.56	0.02 - 46.45	5.08	1.98 - 8.98	28	28	0	11.62	11.65	7.31 - 15.94	0.67 - 55.43	7.91	5.17 - 17.08	0.1405	0.6696
8NV(СТАР2)	Abs_Value	39	39	0	9.6	11.35	6.04 - 13.16	0.03 - 49.35	5.19	2.26 - 10.73	28	28	0	11.25	10.66	7.3 - 15.19	1.05 - 48.26	6.76	4.77 - 14.25	0.5468	0.7484
8NV+226+	Abs_Value	39	39	0	8.68	10.74	5.31 - 12.05	0.03 - 49.26	4.68	1.99 - 10.06	28	28	0	9.91	9.3	6.47 - 13.36	0.95 - 40.2	5.96	4.28 - 12.51	0.6174	0.7973
8NV+39+	Abs_Value	39	39	0	0.6	0.97	0.29 - 0.9	0 - 5.17	0.3	0.06 - 0.64	28	28	0	0.67	0.81	0.36 - 0.97	0.01 - 3.73	0.44	0.13 - 0.8	0.7558	0.9048
8NV+DR+	Abs_Value	39	39	0	2.56	4.43	1.17 - 3.96	0.01 - 16.54	0.66	0.3 - 1.9	28	28	0	1.37	2.02	0.62 - 2.12	0.03 - 9.92	0.6	0.44 - 1.22	0.1426	0.6696
8NV+PD-1-TIGIT-	Abs_Value	39	39	0	7.04	9.42	4.09 - 10	0 - 43.98	3.81	1.03 - 8.78	28	28	0	9.61	10.56	5.7 - 13.52	0.23 - 47.12	5.74	3.06 - 12.31	0.3088	0.6696
8NV+PD-1-TIGIT+	Abs_Value	39	39	0	1.11	1.92	0.51 - 1.72	0 - 9.21	0.49	0.22 - 0.85	28	28	0	0.73	0.83	0.42 - 1.03	0.05 - 3.77	0.46	0.23 - 0.72	0.2655	0.6696
8NV+PD-1+	Abs_Value	39	39	0	1.45	2.12	0.78 - 2.11	0.02 - 10	0.52	0.2 - 1.5	28	28	0	0.91	1.11	0.5 - 1.32	0.05 - 3.96	0.44	0.23 - 1.06	0.1836	0.6696
8NV+PD-1+TIGIT-	Abs_Value	39	39	0	0.5	0.92	0.21 - 0.79	0 - 4.91	0.15	0.03 - 0.5	28	28	0	0.31	0.36	0.18 - 0.45	0 - 1.26	0.2	0.08 - 0.4	0.2527	0.6696
8NV+PD-1+TIGIT+	Abs_Value	39	39	0	0.95	1.35	0.52 - 1.37	0.01 - 5.16	0.39	0.15 - 1.12	28	28	0	0.6	0.89	0.27 - 0.92	0.04 - 3.31	0.25	0.17 - 0.38	0.2056	0.6696
8NV+TIGIT+	Abs_Value	39	39	0	2.06	3.05	1.1 - 3.02	0.01 - 12.72	0.88	0.45 - 2.26	28	28	0	1.32	1.63	0.72 - 1.93	0.11 - 6.55	0.64	0.46 - 1.05	0.2063	0.6696
8TREG	Abs_Value	39	39	0	334.51	529.5	168.33 - 500.7	3.32 - 2109.36	93.76	33.11 - 326.8	28	28	0	166.61	430.63	7.1 - 326.11	0.67 - 2227.15	31.77	8.02 - 102.77	0.158	0.6696
8ЕМ	Abs_Value	39	39	0	79.03	128.38	38.73 - 119.32	0.46 - 668.2	28.95	7.36 - 99.94	28	28	0	67.68	206.05	-8.64 - 144	0.11 - 1084.06	7.04	1.01 - 34.8	0.7979	0.9228
8СМ	Abs_Value	39	39	0	2.88	6.14	0.95 - 4.81	0.01 - 37.25	0.94	0.56 - 2.43	28	28	0	5.32	12.63	0.64 - 9.99	0.08 - 67.57	2.36	0.34 - 5.01	0.351	0.6701
8СМ(СТАР2)	Abs_Value	39	39	0	6	19.68	-0.18 - 12.17	0.02 - 118.92	1.16	0.72 - 3.09	28	28	0	3.83	5.57	1.77 - 5.9	0.02 - 19.92	1.88	0.27 - 4.27	0.5181	0.7325
8СМ+226+	Abs_Value	39	39	0	5.61	19.33	-0.46 - 11.67	0.02 - 118.25	1.08	0.6 - 2.93	28	28	0	3.33	4.75	1.57 - 5.09	0.02 - 16.84	1.68	0.22 - 3.34	0.483	0.701
8СМ+39+	Abs_Value	39	39	0	0.93	1.62	0.43 - 1.44	0 - 9.34	0.47	0.18 - 0.76	28	28	0	1.27	1.93	0.55 - 1.98	0 - 6.95	0.2	0.07 - 1.77	0.4626	0.6986
8СМ+DR+	Abs_Value	39	39	0	5.16	17.97	-0.48 - 10.8	0.01 - 107.27	0.96	0.51 - 2.09	28	28	0	2.81	5.22	0.87 - 4.74	0.01 - 19.49	0.69	0.13 - 1.93	0.4428	0.6834
8СМ+PD-1-TIGIT-	Abs_Value	39	39	0	1.23	2.88	0.32 - 2.13	0 - 15.65	0.25	0.11 - 0.88	28	28	0	1.12	1.58	0.54 - 1.71	0 - 5.79	0.49	0.11 - 1.24	0.8486	0.9574
8СМ+PD-1-TIGIT+	Abs_Value	39	39	0	2.1	9.31	-0.83 - 5.02	0 - 58.16	0.2	0.1 - 0.58	28	28	0	0.69	1.18	0.25 - 1.12	0 - 5.17	0.2	0.05 - 0.61	0.3555	0.6701
8СМ+PD-1+	Abs_Value	39	39	0	2.67	7.9	0.2 - 5.15	0.02 - 45.11	0.74	0.28 - 1.51	28	28	0	2.03	3.93	0.57 - 3.48	0.01 - 15.63	0.52	0.1 - 1.43	0.6598	0.8324
8СМ+PD-1+TIGIT-	Abs_Value	39	39	0	0.68	1.95	0.07 - 1.29	0 - 9.81	0.15	0.03 - 0.35	28	28	0	0.49	1	0.12 - 0.86	0.01 - 4.45	0.11	0.04 - 0.38	0.6059	0.7886
8СМ+PD-1+TIGIT+	Abs_Value	39	39	0	1.99	6.19	0.05 - 3.94	0.01 - 37.26	0.62	0.21 - 1.18	28	28	0	1.53	2.99	0.43 - 2.64	0 - 11.18	0.39	0.06 - 1.08	0.6889	0.8621
8СМ+TIGIT+	Abs_Value	39	39	0	4.09	15.41	-0.75 - 8.93	0.01 - 95.42	0.8	0.34 - 1.64	28	28	0	2.22	3.86	0.79 - 3.65	0 - 12.71	0.7	0.13 - 2.13	0.4714	0.6986
8ТЕ	Abs_Value	39	39	0	340.55	488.28	187.3 - 493.79	4.38 - 1891.65	72.89	27.04 - 523.74	28	28	0	135.07	228.34	50.49 - 219.65	0.46 - 1033.99	42.13	12.61 - 131.19	0.0251	0.6696
8ТЕ(СТАР2)	Abs_Value	39	39	0	399.82	532.76	232.61 - 567.03	7.72 - 2117.62	121.61	53.59 - 623.55	28	28	0	190.71	317.08	73.26 - 308.16	2.04 - 1520.64	74.98	26.84 - 165.62	0.0492	0.6696
8ТЕ+226+	Abs_Value	39	39	0	380.04	511.32	219.56 - 540.51	6.99 - 1998.95	102.32	50.26 - 599.53	28	28	0	176.1	299.7	65.09 - 287.11	1.84 - 1441.91	61.81	24.47 - 147.36	0.0447	0.6696
8ТЕ+39+	Abs_Value	39	39	0	34.3	57.18	16.35 - 52.25	0.05 - 321.3	13.22	3.65 - 43.95	28	28	0	30.36	56.92	9.27 - 51.44	0.07 - 278.04	7.6	2.95 - 34.51	0.781	0.9228
8ТЕ+DR+	Abs_Value	39	39	0	291.49	426.01	157.79 - 425.2	2.61 - 1916.64	93.22	40.64 - 361.39	28	28	0	149.34	282.01	44.88 - 253.8	1.18 - 1379.51	39.48	15.08 - 122	0.1054	0.6696
8ТЕ+PD-1-TIGIT-	Abs_Value	39	39	0	109.69	170.26	56.25 - 163.13	2.07 - 692.88	26.6	9.18 - 117.4	28	28	0	50.89	89.3	17.81 - 83.97	0.56 - 459.76	20.6	5.05 - 62.44	0.0716	0.6696
8ТЕ+PD-1-TIGIT+	Abs_Value	39	39	0	121.05	193.14	60.43 - 181.66	0.99 - 921.44	24.4	8.44 - 190.13	28	28	0	51.55	101.85	13.82 - 89.27	0.45 - 504.62	14.1	4.74 - 55.63	0.0612	0.6696
8ТЕ+PD-1+	Abs_Value	39	39	0	169.08	280.68	80.99 - 257.17	3.69 - 1526.37	67.37	26.03 - 170.51	28	28	0	88.27	149.38	32.94 - 143.6	1.03 - 556.25	29.97	12.58 - 69.83	0.1331	0.6696
8ТЕ+PD-1+TIGIT-	Abs_Value	39	39	0	56.8	90.76	28.31 - 85.28	0.82 - 403.46	18.56	2.45 - 72.41	28	28	0	27.18	48.92	9.06 - 45.3	0.47 - 190.87	7.59	2.07 - 25.75	0.0906	0.6696
8ТЕ+PD-1+TIGIT+	Abs_Value	39	39	0	112.28	201.35	49.09 - 175.48	2.85 - 1122.91	47.52	13.89 - 97.11	28	28	0	61.09	106.19	21.76 - 100.43	0.56 - 365.38	14.54	8.69 - 41.59	0.1827	0.6696
8ТЕ+TIGIT+	Abs_Value	39	39	0	233.33	346.67	124.53 - 342.13	3.84 - 1498.44	77.37	26.2 - 269.88	28	28	0	112.64	198.57	39.09 - 186.19	1.01 - 870	29.7	14.87 - 94.69	0.0765	0.6696
8ТМ	Abs_Value	39	39	0	20.92	28	12.13 - 29.7	0.43 - 149.26	12.18	4.59 - 22.53	28	28	0	20.26	37.21	6.47 - 34.04	0.34 - 179.51	5.25	1.36 - 17.61	0.9375	0.9731
TREG_CM	Abs_Value	39	39	0	0.81	0.88	0.54 - 1.09	0 - 4.33	0.5	0.26 - 1.08	28	28	0	1.48	2.72	0.47 - 2.49	0.02 - 14.66	0.92	0.32 - 1.56	0.2223	0.6696
TREG_EMTM	Abs_Value	39	39	0	8.82	8.27	6.22 - 11.41	0.05 - 40.11	7.21	2.95 - 12.43	28	28	0	11.9	17.5	5.42 - 18.38	0.05 - 93.26	6.51	3.01 - 13.22	0.3923	0.6762
TREG_NV	Abs_Value	39	39	0	0.93	0.89	0.65 - 1.21	0 - 3.03	0.71	0.21 - 1.47	28	28	0	1.21	0.82	0.91 - 1.52	0.01 - 3.4	1.13	0.63 - 1.75	0.1786	0.6696
TREG_TE	Abs_Value	39	39	0	2.37	1.78	1.81 - 2.93	0 - 6.11	2.06	1.15 - 3.5	28	28	0	3.04	2.65	2.06 - 4.02	0.19 - 8.97	2.17	0.97 - 4.09	0.2505	0.6696
TREG+226-TIGIT-	Abs_Value	39	39	0	0.85	0.78	0.61 - 1.1	0 - 2.66	0.63	0.17 - 1.39	28	28	0	0.88	0.74	0.61 - 1.15	0.04 - 3.18	0.69	0.34 - 1.18	0.8825	0.9621
TREG+226-TIGIT+	Abs_Value	39	39	0	3.39	3.18	2.39 - 4.39	0.01 - 13.35	2.67	0.95 - 4.88	28	28	0	4.62	7.57	1.82 - 7.43	0.22 - 40.78	2.82	1.46 - 4.13	0.4216	0.6834
TREG+226+	Abs_Value	39	39	0	8.82	7.4	6.49 - 11.14	0.04 - 38.28	9.02	3.48 - 11.72	28	28	0	12.15	14.13	6.92 - 17.38	0.85 - 72.45	7.91	3.79 - 14.59	0.2615	0.6696
TREG+226+TIGIT-	Abs_Value	39	39	0	1.36	1.22	0.98 - 1.75	0.01 - 4.82	0.92	0.52 - 1.82	28	28	0	1.67	1.7	1.04 - 2.3	0.06 - 7.96	1.15	0.6 - 1.92	0.413	0.6773
TREG+226+TIGIT+	Abs_Value	39	39	0	7.46	6.55	5.4 - 9.51	0.02 - 33.46	6.06	2.41 - 10.44	28	28	0	10.48	13.51	5.47 - 15.48	0.25 - 70.7	6.52	3.05 - 13.06	0.2811	0.6696
TREG+39+	Abs_Value	39	39	0	9.7	9.56	6.7 - 12.7	0.03 - 45.27	6.69	3.41 - 11.8	28	28	0	13.81	20.79	6.11 - 21.52	0.18 - 111.4	8.3	3.67 - 15.91	0.336	0.6696
TREG+DR+	Abs_Value	39	39	0	9.7	8.49	7.03 - 12.36	0.02 - 39.81	8.49	3.47 - 13.01	28	28	0	13.29	19.64	6.01 - 20.56	0.59 - 105.25	8.1	3.56 - 14.05	0.3701	0.6762
TREG+PD-1+	Abs_Value	39	39	0	4.45	3.85	3.25 - 5.66	0.04 - 18.35	3.67	1.4 - 6.2	28	28	0	7.17	13.16	2.29 - 12.04	0.13 - 69.61	3.88	1.6 - 7.43	0.2978	0.6696
TREG+TIGIT+	Abs_Value	39	39	0	10.84	9.27	7.93 - 13.75	0.03 - 42.48	10.53	3.55 - 14.81	28	28	0	15.1	20.74	7.42 - 22.78	0.47 - 111.49	9.01	5.36 - 17.63	0.3169	0.6696

#Графики без логарифмирования

Без группировки, день 90

# 2. Построение графиков 
analysis_days <- c("+90")  # Фиксируем день +90
cell_populations <- unique(AI_Tcells_filtered$Сell_population)

# Функция для создания одного графика
create_plot <- function(day, cell_pop, data) {
  data_subset <- data %>%
    filter(Analysis_day == day, Сell_population == cell_pop)

  if (nrow(data_subset) > 0) {
    p <- ggplot(data_subset, aes(x = cGVHD_present, y = Abs_Value, fill = cGVHD_present)) +
      geom_boxplot() +
      ggpubr::stat_compare_means(method = "t.test", label.y = 0.8 * max(data_subset$Abs_Value, na.rm = TRUE), label.x = 1.5) +
      labs(title = paste("Abs_Value by cGVHD_present\n(Analysis_day =", day, ", Cell Pop =", cell_pop, ")"),
           x = "cGVHD_present", y = "Abs_Value") +
      theme_bw() +
      theme(axis.text.x = element_text(angle = 45, hjust = 1),
            plot.title = element_text(hjust = 0.5)) +
      scale_y_continuous(limits = function(x) {
        range_x <- max(x) - min(x)
        c(min(x) - 0.1 * range_x, max(x) + 0.1 * range_x)
      })
    
    return(p)
  } else {
    return(NULL) # Возвращаем NULL, если нет данных
  }
}

# Создание всех графиков
plots <- list()
for (cell_pop in cell_populations) {
  p <- create_plot("+90", cell_pop, AI_Tcells_filtered)
  if (!is.null(p)) {
    print(p)
    plots[[paste0("plot_90_", cell_pop)]] <- p
    #ggsave(paste0("plot_90_", cell_pop, ".png"), plot = p, width = 10, height = 7)
  }
}

Графики с логарифмированием

# 1. Добавление группирующей переменной для facet_wrap)
AI_Tcells_filtered_facet <- AI_Tcells_filtered %>%
  mutate(group = paste0("Group ", (as.numeric(Сell_population) -1) %/% 5 +1))


# 2. Построение графиков с использованием facet_wrap

analysis_days <- unique(AI_Tcells_filtered_facet$Analysis_day)
groups <- unique(AI_Tcells_filtered_facet$group)

for (day in analysis_days) {
  for (grp in groups) {
    data_subset <- AI_Tcells_filtered_facet %>%
      filter(Analysis_day == day, group == grp)

    if (nrow(data_subset) > 0) {
      # Логарифмирование значений Abs_Value
      data_subset <- data_subset %>%
        mutate(log_Abs_Value = log1p(Abs_Value)) # log1p для обработки нулей

       max_val <- max(data_subset$log_Abs_Value, na.rm = TRUE)

      p <- ggplot(data_subset, aes(x = cGVHD_present, y = log_Abs_Value, fill = cGVHD_present)) + 
        geom_boxplot() +
        ggpubr::stat_compare_means(method = "t.test", label.y = max_val - 0.1 * max_val) +
        labs(title = paste("log(Abs_Value + 1) by cGVHD_present\n(Analysis_day =", day, ", Group =", grp, ")"), 
             x = "cGVHD_present", y = "log(Abs_Value + 1)") + 
        theme_bw() +
        theme(axis.text.x = element_text(angle = 45, hjust = 1),
              plot.title = element_text(hjust = 0.5)) +
        facet_wrap(~Сell_population, scales = "free_x")

      print(p)
      #ggsave(paste0("plot_log_", day, "_group_", grp, ".png"), plot = p, width = 12, height = 8)
    }
  }
}

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

## Warning: Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Computation failed in `stat_compare_means()`.
## Caused by error:
## ! аргумент "x" пропущен, умолчаний нет

#GLM wide data

##Подготовка данных

data_day90 <- filter(AI_Tcells_filtered, Analysis_day == "+90")

data_day180 <- filter(AI_Tcells_filtered, Analysis_day == "+180")

data_wide_90 <- data_day90 %>%
  pivot_wider(names_from = Сell_population, values_from = Abs_Value)

data_90 <- data_wide_90 %>%
  select(-ID, -Time_OS, -cGVHD_time, -Analysis_day, -Analysis_time)


data_wide_180 <- data_day180 %>%
  pivot_wider(names_from = Сell_population, values_from = Abs_Value)

data_180 <- data_wide_180 %>%
  select(-ID, -Time_OS, -cGVHD_time, -Analysis_day, -Analysis_time)

Первая модель, aliased coefficients

model_90 <- glm(cGVHD_present ~ ., data = data_90, family = binomial)

# Модель для 180-го дня
model_180 <- glm(cGVHD_present ~ ., data = data_180, family = binomial)

summary(model_90)

## 
## Call:
## glm(formula = cGVHD_present ~ ., family = binomial, data = data_90)
## 
## Coefficients: (98 not defined because of singularities)
##                       Estimate Std. Error z value Pr(>|z|)
## (Intercept)         -2.478e+01  3.493e+05       0        1
## `4_TFH`              2.814e+00  1.169e+05       0        1
## `4_TH1`              1.197e+01  2.993e+05       0        1
## `4_TH17`            -2.102e+01  2.303e+05       0        1
## `4_Th17TO1`         -4.085e-01  1.115e+05       0        1
## `4_TH2`              6.069e+01  7.583e+05       0        1
## `4_TH22`             3.035e+01  3.068e+05       0        1
## `4+ (IM STAT)`      -2.700e+00  3.472e+04       0        1
## `4+`                 1.901e+00  2.483e+04       0        1
## `4+226+`            -9.562e+01  1.002e+06       0        1
## `4+39+`              8.119e+00  1.808e+05       0        1
## `4+DR+`             -6.441e+00  1.808e+05       0        1
## `4+PD-1+`            2.392e+09  4.572e+13       0        1
## `4+PD-1+TIGIT-`     -2.392e+09  4.572e+13       0        1
## `4+PD-1+TIGIT+`     -2.369e+08  5.477e+13       0        1
## `4+PD-1-TIGIT-`      7.296e+01  8.486e+05       0        1
## `4+PD-1-TIGIT+`      2.155e+09  8.382e+13       0        1
## `4+TIGIT+`          -2.155e+09  8.382e+13       0        1
## `4NV(СТАР2)`         3.651e+09  9.226e+13       0        1
## `4NV`               -1.696e+01  2.263e+05       0        1
## `4NV_TH1`           -4.673e+01  1.095e+06       0        1
## `4NV_TH17`          -6.398e+01  1.775e+06       0        1
## `4NV_Th17TO1`        8.650e+01  5.334e+06       0        1
## `4NV_TH2`           -3.296e+01  5.916e+05       0        1
## `4NV_TH22`           2.725e+02  2.957e+06       0        1
## `4NV+226+`           1.107e+02  1.253e+06       0        1
## `4NV+39+`            4.507e+01  1.144e+06       0        1
## `4NV+DR+`           -1.925e+01  5.060e+05       0        1
## `4NV+PD1+`           1.273e+09  6.849e+14       0        1
## `4NV+PD-1+TIGIT-`   -4.924e+09  6.852e+14       0        1
## `4NV+PD-1+TIGIT+`   -2.167e+11  3.916e+15       0        1
## `4NV+PD-1-TIGIT-`   -3.651e+09  9.226e+13       0        1
## `4NV+PD-1-TIGIT+`   -2.154e+11  4.110e+15       0        1
## `4NV+TIGIT+`         2.117e+11  4.058e+15       0        1
## `4ЕМ`               -7.693e+00  1.312e+05       0        1
## `4ЕМ_TH1`            9.051e+00  5.941e+05       0        1
## `4ЕМ_TH17`           6.029e+02  7.161e+06       0        1
## `4ЕМ_Th17TO1`        7.375e+01  2.839e+06       0        1
## `4ЕМ_TH2`           -4.820e+01  6.447e+05       0        1
## `4ЕМ_TH22`           2.975e+03  4.646e+07       0        1
## `4ЕМ+226+`           1.163e+02  1.340e+06       0        1
## `4ЕМ+39+`           -7.999e+00  1.989e+05       0        1
## `4ЕМ+DR+`            8.134e+00  2.964e+05       0        1
## `4ЕМ+PD1+`           1.167e+09  5.108e+13       0        1
## `4ЕМ+PD1+TIGIT-`    -8.231e+09  9.278e+13       0        1
## `4ЕМ+PD1+TIGIT+`    -5.654e+09  1.127e+14       0        1
## `4ЕМ+PD1-TIGIT-`    -7.064e+09  7.265e+13       0        1
## `4ЕМ+PD1-TIGIT+`    -4.487e+09  1.366e+14       0        1
## `4ЕМ+TIGIT+`        -2.578e+09  1.365e+14       0        1
## `4ЕМTM`              7.064e+09  7.265e+13       0        1
## `4СМ(СТАР2)`        -5.354e+09  1.173e+14       0        1
## `4СМ`               -1.240e+00  2.015e+05       0        1
## `4СМ_TH1`           -2.607e+01  1.087e+06       0        1
## `4СМ_TH17`           3.976e+01  7.140e+05       0        1
## `4СМ_Th17TO1`        9.995e+01  1.573e+06       0        1
## `4СМ_TH2`           -7.502e+01  9.984e+05       0        1
## `4СМ_TH22`          -3.550e+01  1.285e+06       0        1
## `4СМ+226+`           1.126e+02  1.124e+06       0        1
## `4СМ+39+`           -1.046e+01  2.979e+05       0        1
## `4СМ+DR+`            9.785e+00  1.619e+05       0        1
## `4СМ+PD1+`           5.137e+09  1.271e+14       0        1
## `4СМ+PD1+TIGIT-`     2.173e+08  9.713e+13       0        1
## `4СМ+PD1+TIGIT+`    -1.778e+10  2.012e+14       0        1
## `4СМ+PD1-TIGIT-`     5.354e+09  1.173e+14       0        1
## `4СМ+PD1-TIGIT+`    -1.264e+10  1.672e+14       0        1
## `4СМ+TIGIT+`         1.800e+10  2.468e+14       0        1
## `4ТM_TH1`           -1.488e+01  3.306e+05       0        1
## `4ТM_TH17`                  NA         NA      NA       NA
## `4ТM_Th17TO1`               NA         NA      NA       NA
## `4ТM_TH2`                   NA         NA      NA       NA
## `4ТM_TH22`                  NA         NA      NA       NA
## `4ТREG(СТАР2)`              NA         NA      NA       NA
## `4ТREG`                     NA         NA      NA       NA
## `4ТREG_TH1`                 NA         NA      NA       NA
## `4ТREG_TH17`                NA         NA      NA       NA
## `4ТREG_Th17TO1`             NA         NA      NA       NA
## `4ТREG_TH2`                 NA         NA      NA       NA
## `4ТREG_TH22`                NA         NA      NA       NA
## `4ТЕ(СТАР2)`                NA         NA      NA       NA
## `4ТЕ`                       NA         NA      NA       NA
## `4ТЕ_TH1`                   NA         NA      NA       NA
## `4ТЕ_TH17`                  NA         NA      NA       NA
## `4ТЕ_Th17TO1`               NA         NA      NA       NA
## `4ТЕ_TH2`                   NA         NA      NA       NA
## `4ТЕ_TH22`                  NA         NA      NA       NA
## `4ТЕ+226+`                  NA         NA      NA       NA
## `4ТЕ+39+`                   NA         NA      NA       NA
## `4ТЕ+DR+`                   NA         NA      NA       NA
## `4ТЕ+PD-1+`                 NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `4ТЕ+TIGIT+`                NA         NA      NA       NA
## `4ТМ`                       NA         NA      NA       NA
## `8+ (IM STAT)`              NA         NA      NA       NA
## `8+`                        NA         NA      NA       NA
## `8+226+`                    NA         NA      NA       NA
## `8+39+`                     NA         NA      NA       NA
## `8+DR+`                     NA         NA      NA       NA
## `8+PD-1+`                   NA         NA      NA       NA
## `8+PD-1+TIGIT-`             NA         NA      NA       NA
## `8+PD-1+TIGIT+`             NA         NA      NA       NA
## `8+PD-1-TIGIT-`             NA         NA      NA       NA
## `8+PD-1-TIGIT+`             NA         NA      NA       NA
## `8+TIGIT+`                  NA         NA      NA       NA
## `8EMTM`                     NA         NA      NA       NA
## `8EMTM+226+`                NA         NA      NA       NA
## `8EMTM+39+`                 NA         NA      NA       NA
## `8EMTM+DR+`                 NA         NA      NA       NA
## `8EMTM+PD-1+`               NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT+`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT+`         NA         NA      NA       NA
## `8EMTM+TIGIT+`              NA         NA      NA       NA
## `8NV(СТАР2)`                NA         NA      NA       NA
## `8NV`                       NA         NA      NA       NA
## `8NV+226+`                  NA         NA      NA       NA
## `8NV+39+`                   NA         NA      NA       NA
## `8NV+DR+`                   NA         NA      NA       NA
## `8NV+PD-1+`                 NA         NA      NA       NA
## `8NV+PD-1+TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1+TIGIT+`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT+`           NA         NA      NA       NA
## `8NV+TIGIT+`                NA         NA      NA       NA
## `8TREG`                     NA         NA      NA       NA
## `8ЕМ`                       NA         NA      NA       NA
## `8СМ(СТАР2)`                NA         NA      NA       NA
## `8СМ`                       NA         NA      NA       NA
## `8СМ+226+`                  NA         NA      NA       NA
## `8СМ+39+`                   NA         NA      NA       NA
## `8СМ+DR+`                   NA         NA      NA       NA
## `8СМ+PD-1+`                 NA         NA      NA       NA
## `8СМ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8СМ+TIGIT+`                NA         NA      NA       NA
## `8ТЕ(СТАР2)`                NA         NA      NA       NA
## `8ТЕ`                       NA         NA      NA       NA
## `8ТЕ+226+`                  NA         NA      NA       NA
## `8ТЕ+39+`                   NA         NA      NA       NA
## `8ТЕ+DR+`                   NA         NA      NA       NA
## `8ТЕ+PD-1+`                 NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8ТЕ+TIGIT+`                NA         NA      NA       NA
## `8ТМ`                       NA         NA      NA       NA
## TREG_CM                     NA         NA      NA       NA
## TREG_EMTM                   NA         NA      NA       NA
## TREG_NV                     NA         NA      NA       NA
## TREG_TE                     NA         NA      NA       NA
## `TREG+226+`                 NA         NA      NA       NA
## `TREG+226+TIGIT-`           NA         NA      NA       NA
## `TREG+226+TIGIT+`           NA         NA      NA       NA
## `TREG+226-TIGIT-`           NA         NA      NA       NA
## `TREG+226-TIGIT+`           NA         NA      NA       NA
## `TREG+39+`                  NA         NA      NA       NA
## `TREG+DR+`                  NA         NA      NA       NA
## `TREG+PD-1+`                NA         NA      NA       NA
## `TREG+TIGIT+`               NA         NA      NA       NA
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 9.1068e+01  on 66  degrees of freedom
## Residual deviance: 3.8871e-10  on  0  degrees of freedom
## AIC: 134
## 
## Number of Fisher Scoring iterations: 25

summary(model_180)

## 
## Call:
## glm(formula = cGVHD_present ~ ., family = binomial, data = data_180)
## 
## Coefficients: (123 not defined because of singularities)
##                       Estimate Std. Error z value Pr(>|z|)
## (Intercept)         -2.139e+01  8.538e+05       0        1
## `4_TFH`              9.432e-02  4.383e+04       0        1
## `4_TH1`              1.968e+00  5.945e+04       0        1
## `4_TH17`            -1.234e+00  1.196e+05       0        1
## `4_Th17TO1`         -2.081e+00  1.644e+05       0        1
## `4_TH2`             -3.419e+00  7.776e+04       0        1
## `4_TH22`             7.887e+00  2.891e+05       0        1
## `4+ (IM STAT)`      -4.519e-01  3.940e+04       0        1
## `4+`                 1.518e+00  3.746e+04       0        1
## `4+226+`            -3.920e+00  1.053e+05       0        1
## `4+39+`             -2.813e-01  1.057e+05       0        1
## `4+DR+`              4.347e-02  3.146e+04       0        1
## `4+PD-1+`           -9.565e+08  2.509e+13       0        1
## `4+PD-1+TIGIT-`      9.565e+08  2.509e+13       0        1
## `4+PD-1+TIGIT+`      1.508e+08  3.255e+13       0        1
## `4+PD-1-TIGIT-`      3.759e+00  1.165e+05       0        1
## `4+PD-1-TIGIT+`     -8.057e+08  1.597e+13       0        1
## `4+TIGIT+`           8.057e+08  1.597e+13       0        1
## `4NV(СТАР2)`         2.940e+09  4.100e+13       0        1
## `4NV`               -3.941e+00  1.597e+05       0        1
## `4NV_TH1`            1.105e+00  3.562e+05       0        1
## `4NV_TH17`          -5.061e+00  1.356e+06       0        1
## `4NV_Th17TO1`       -4.550e+01  6.278e+06       0        1
## `4NV_TH2`            2.648e+00  1.768e+05       0        1
## `4NV_TH22`          -1.653e+01  5.084e+06       0        1
## `4NV+226+`           5.451e+00  2.154e+05       0        1
## `4NV+39+`            3.068e+01  1.403e+06       0        1
## `4NV+DR+`            8.034e+00  1.962e+05       0        1
## `4NV+PD1+`          -4.005e+10  1.110e+15       0        1
## `4NV+PD-1+TIGIT-`    3.711e+10  1.086e+15       0        1
## `4NV+PD-1+TIGIT+`   -1.309e+10  1.119e+15       0        1
## `4NV+PD-1-TIGIT-`   -2.940e+09  4.100e+13       0        1
## `4NV+PD-1-TIGIT+`   -5.314e+10  1.279e+15       0        1
## `4NV+TIGIT+`         5.021e+10  1.249e+15       0        1
## `4ЕМ`               -1.272e+00  1.459e+05       0        1
## `4ЕМ_TH1`           -2.770e+00  2.901e+05       0        1
## `4ЕМ_TH17`           2.145e+02  1.343e+07       0        1
## `4ЕМ_Th17TO1`        1.317e+01  8.963e+05       0        1
## `4ЕМ_TH2`            2.101e+01  1.147e+06       0        1
## `4ЕМ_TH22`          -3.374e+03  6.507e+07       0        1
## `4ЕМ+226+`           1.086e+00  5.482e+04       0        1
## `4ЕМ+39+`           -6.593e-01  1.766e+05       0        1
## `4ЕМ+DR+`                   NA         NA      NA       NA
## `4ЕМ+PD1+`                  NA         NA      NA       NA
## `4ЕМ+PD1+TIGIT-`            NA         NA      NA       NA
## `4ЕМ+PD1+TIGIT+`            NA         NA      NA       NA
## `4ЕМ+PD1-TIGIT-`            NA         NA      NA       NA
## `4ЕМ+PD1-TIGIT+`            NA         NA      NA       NA
## `4ЕМ+TIGIT+`                NA         NA      NA       NA
## `4ЕМTM`                     NA         NA      NA       NA
## `4СМ(СТАР2)`                NA         NA      NA       NA
## `4СМ`                       NA         NA      NA       NA
## `4СМ_TH1`                   NA         NA      NA       NA
## `4СМ_TH17`                  NA         NA      NA       NA
## `4СМ_Th17TO1`               NA         NA      NA       NA
## `4СМ_TH2`                   NA         NA      NA       NA
## `4СМ_TH22`                  NA         NA      NA       NA
## `4СМ+226+`                  NA         NA      NA       NA
## `4СМ+39+`                   NA         NA      NA       NA
## `4СМ+DR+`                   NA         NA      NA       NA
## `4СМ+PD1+`                  NA         NA      NA       NA
## `4СМ+PD1+TIGIT-`            NA         NA      NA       NA
## `4СМ+PD1+TIGIT+`            NA         NA      NA       NA
## `4СМ+PD1-TIGIT-`            NA         NA      NA       NA
## `4СМ+PD1-TIGIT+`            NA         NA      NA       NA
## `4СМ+TIGIT+`                NA         NA      NA       NA
## `4ТM_TH1`                   NA         NA      NA       NA
## `4ТM_TH17`                  NA         NA      NA       NA
## `4ТM_Th17TO1`               NA         NA      NA       NA
## `4ТM_TH2`                   NA         NA      NA       NA
## `4ТM_TH22`                  NA         NA      NA       NA
## `4ТREG(СТАР2)`              NA         NA      NA       NA
## `4ТREG`                     NA         NA      NA       NA
## `4ТREG_TH1`                 NA         NA      NA       NA
## `4ТREG_TH17`                NA         NA      NA       NA
## `4ТREG_Th17TO1`             NA         NA      NA       NA
## `4ТREG_TH2`                 NA         NA      NA       NA
## `4ТREG_TH22`                NA         NA      NA       NA
## `4ТЕ(СТАР2)`                NA         NA      NA       NA
## `4ТЕ`                       NA         NA      NA       NA
## `4ТЕ_TH1`                   NA         NA      NA       NA
## `4ТЕ_TH17`                  NA         NA      NA       NA
## `4ТЕ_Th17TO1`               NA         NA      NA       NA
## `4ТЕ_TH2`                   NA         NA      NA       NA
## `4ТЕ_TH22`                  NA         NA      NA       NA
## `4ТЕ+226+`                  NA         NA      NA       NA
## `4ТЕ+39+`                   NA         NA      NA       NA
## `4ТЕ+DR+`                   NA         NA      NA       NA
## `4ТЕ+PD-1+`                 NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `4ТЕ+TIGIT+`                NA         NA      NA       NA
## `4ТМ`                       NA         NA      NA       NA
## `8+ (IM STAT)`              NA         NA      NA       NA
## `8+`                        NA         NA      NA       NA
## `8+226+`                    NA         NA      NA       NA
## `8+39+`                     NA         NA      NA       NA
## `8+DR+`                     NA         NA      NA       NA
## `8+PD-1+`                   NA         NA      NA       NA
## `8+PD-1+TIGIT-`             NA         NA      NA       NA
## `8+PD-1+TIGIT+`             NA         NA      NA       NA
## `8+PD-1-TIGIT-`             NA         NA      NA       NA
## `8+PD-1-TIGIT+`             NA         NA      NA       NA
## `8+TIGIT+`                  NA         NA      NA       NA
## `8EMTM`                     NA         NA      NA       NA
## `8EMTM+226+`                NA         NA      NA       NA
## `8EMTM+39+`                 NA         NA      NA       NA
## `8EMTM+DR+`                 NA         NA      NA       NA
## `8EMTM+PD-1+`               NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT+`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT+`         NA         NA      NA       NA
## `8EMTM+TIGIT+`              NA         NA      NA       NA
## `8NV(СТАР2)`                NA         NA      NA       NA
## `8NV`                       NA         NA      NA       NA
## `8NV+226+`                  NA         NA      NA       NA
## `8NV+39+`                   NA         NA      NA       NA
## `8NV+DR+`                   NA         NA      NA       NA
## `8NV+PD-1+`                 NA         NA      NA       NA
## `8NV+PD-1+TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1+TIGIT+`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT+`           NA         NA      NA       NA
## `8NV+TIGIT+`                NA         NA      NA       NA
## `8TREG`                     NA         NA      NA       NA
## `8ЕМ`                       NA         NA      NA       NA
## `8СМ(СТАР2)`                NA         NA      NA       NA
## `8СМ`                       NA         NA      NA       NA
## `8СМ+226+`                  NA         NA      NA       NA
## `8СМ+39+`                   NA         NA      NA       NA
## `8СМ+DR+`                   NA         NA      NA       NA
## `8СМ+PD-1+`                 NA         NA      NA       NA
## `8СМ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8СМ+TIGIT+`                NA         NA      NA       NA
## `8ТЕ(СТАР2)`                NA         NA      NA       NA
## `8ТЕ`                       NA         NA      NA       NA
## `8ТЕ+226+`                  NA         NA      NA       NA
## `8ТЕ+39+`                   NA         NA      NA       NA
## `8ТЕ+DR+`                   NA         NA      NA       NA
## `8ТЕ+PD-1+`                 NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8ТЕ+TIGIT+`                NA         NA      NA       NA
## `8ТМ`                       NA         NA      NA       NA
## TREG_CM                     NA         NA      NA       NA
## TREG_EMTM                   NA         NA      NA       NA
## TREG_NV                     NA         NA      NA       NA
## TREG_TE                     NA         NA      NA       NA
## `TREG+226+`                 NA         NA      NA       NA
## `TREG+226+TIGIT-`           NA         NA      NA       NA
## `TREG+226+TIGIT+`           NA         NA      NA       NA
## `TREG+226-TIGIT-`           NA         NA      NA       NA
## `TREG+226-TIGIT+`           NA         NA      NA       NA
## `TREG+39+`                  NA         NA      NA       NA
## `TREG+DR+`                  NA         NA      NA       NA
## `TREG+PD-1+`                NA         NA      NA       NA
## `TREG+TIGIT+`               NA         NA      NA       NA
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 5.3467e+01  on 41  degrees of freedom
## Residual deviance: 2.4369e-10  on  0  degrees of freedom
## AIC: 84
## 
## Number of Fisher Scoring iterations: 25

Диагностика

#{r} car::vif(model_90) car::vif(model_180)

#Корреляции

data_90_num <- data_90 %>%
  select(-cGVHD_present) 

data_90_cor <- cor(data_90_num)

corrplot(data_90_cor, method = "circle", type = "upper", tl.col = "black", tl.cex = 0.7)

corrplot(data_90_cor, method = 'number')

correlation_matrix <- cor(model.matrix(model_90))

## Warning in cor(model.matrix(model_90)): стандартное отклонение нулевое

# Визуализация тепловой карты

melted_cor <- reshape2::melt(correlation_matrix)

ggplot(data = melted_cor, aes(x = Var1, y = Var2, fill = value)) +
  geom_tile() +
  scale_fill_gradient2(low = "blue", mid = "white", high = "red") +  
  theme(axis.text.x = element_text(angle = 90, hjust = 1)) +  
  labs(title = "Матрица корреляций", fill = "Коэффициент корреляции")

#LASSO применяет L1-регуляризацию, которая добавляет штрафной член к функции потерь. Этот штраф уменьшает коэффициенты некоторых предикторов до нуля, эффективно исключая их из модели.

##90

# Подготовка данных: X - матрица предикторов, y - вектор отклика
X <- model.matrix(cGVHD_present ~ ., data = data_90)
y <- data_90$cGVHD_present

# Построение модели LASSO
lasso_model <- glmnet(X, y, family = "binomial", alpha = 1) # alpha = 1 для LASSO

# Выбор наилучшего lambda с помощью кросс-валидации
cv_lasso <- cv.glmnet(X, y, family = "binomial", alpha = 1)
best_lambda <- cv_lasso$lambda.min

# Модель с наилучшим lambda
lasso_model_best <- glmnet(X, y, family = "binomial", alpha = 1, lambda = best_lambda)

# Коэффициенты
coef(lasso_model_best)

## 166 x 1 sparse Matrix of class "dgCMatrix"
##                               s0
## (Intercept)         -0.352883859
## (Intercept)          .          
## `4_TFH`              .          
## `4_TH1`              .          
## `4_TH17`             .          
## `4_Th17TO1`          .          
## `4_TH2`              .          
## `4_TH22`             .          
## `4+ (IM STAT)`       .          
## `4+`                 .          
## `4+226+`             .          
## `4+39+`              .          
## `4+DR+`              .          
## `4+PD-1+`            .          
## `4+PD-1+TIGIT-`      .          
## `4+PD-1+TIGIT+`      .          
## `4+PD-1-TIGIT-`      .          
## `4+PD-1-TIGIT+`      .          
## `4+TIGIT+`           .          
## `4NV(СТАР2)`         .          
## `4NV`                .          
## `4NV_TH1`            .          
## `4NV_TH17`           .          
## `4NV_Th17TO1`        .          
## `4NV_TH2`            0.007483848
## `4NV_TH22`           .          
## `4NV+226+`           .          
## `4NV+39+`            .          
## `4NV+DR+`            .          
## `4NV+PD1+`           .          
## `4NV+PD-1+TIGIT-`    .          
## `4NV+PD-1+TIGIT+`    .          
## `4NV+PD-1-TIGIT-`    .          
## `4NV+PD-1-TIGIT+`    .          
## `4NV+TIGIT+`         .          
## `4ЕМ`                .          
## `4ЕМ_TH1`            .          
## `4ЕМ_TH17`           .          
## `4ЕМ_Th17TO1`        .          
## `4ЕМ_TH2`            .          
## `4ЕМ_TH22`           .          
## `4ЕМ+226+`           .          
## `4ЕМ+39+`            .          
## `4ЕМ+DR+`            .          
## `4ЕМ+PD1+`           .          
## `4ЕМ+PD1+TIGIT-`     .          
## `4ЕМ+PD1+TIGIT+`     .          
## `4ЕМ+PD1-TIGIT-`     .          
## `4ЕМ+PD1-TIGIT+`     .          
## `4ЕМ+TIGIT+`         .          
## `4ЕМTM`              .          
## `4СМ(СТАР2)`         .          
## `4СМ`                .          
## `4СМ_TH1`            .          
## `4СМ_TH17`           .          
## `4СМ_Th17TO1`        .          
## `4СМ_TH2`            .          
## `4СМ_TH22`           .          
## `4СМ+226+`           .          
## `4СМ+39+`            .          
## `4СМ+DR+`            .          
## `4СМ+PD1+`           .          
## `4СМ+PD1+TIGIT-`     .          
## `4СМ+PD1+TIGIT+`     .          
## `4СМ+PD1-TIGIT-`     .          
## `4СМ+PD1-TIGIT+`     .          
## `4СМ+TIGIT+`         .          
## `4ТM_TH1`            .          
## `4ТM_TH17`           .          
## `4ТM_Th17TO1`        .          
## `4ТM_TH2`            .          
## `4ТM_TH22`           .          
## `4ТREG(СТАР2)`       .          
## `4ТREG`              .          
## `4ТREG_TH1`          .          
## `4ТREG_TH17`         .          
## `4ТREG_Th17TO1`      .          
## `4ТREG_TH2`          .          
## `4ТREG_TH22`         .          
## `4ТЕ(СТАР2)`         .          
## `4ТЕ`                .          
## `4ТЕ_TH1`            .          
## `4ТЕ_TH17`           .          
## `4ТЕ_Th17TO1`        .          
## `4ТЕ_TH2`            .          
## `4ТЕ_TH22`           .          
## `4ТЕ+226+`           .          
## `4ТЕ+39+`            .          
## `4ТЕ+DR+`            .          
## `4ТЕ+PD-1+`          .          
## `4ТЕ+PD-1+TIGIT-`    .          
## `4ТЕ+PD-1+TIGIT+`    .          
## `4ТЕ+PD-1-TIGIT-`    .          
## `4ТЕ+PD-1-TIGIT+`    .          
## `4ТЕ+TIGIT+`         .          
## `4ТМ`                .          
## `8+ (IM STAT)`       .          
## `8+`                 .          
## `8+226+`             .          
## `8+39+`              .          
## `8+DR+`              .          
## `8+PD-1+`            .          
## `8+PD-1+TIGIT-`      .          
## `8+PD-1+TIGIT+`      .          
## `8+PD-1-TIGIT-`      .          
## `8+PD-1-TIGIT+`      .          
## `8+TIGIT+`           .          
## `8EMTM`              .          
## `8EMTM+226+`         .          
## `8EMTM+39+`          .          
## `8EMTM+DR+`          .          
## `8EMTM+PD-1+`        .          
## `8EMTM+PD-1+TIGIT-`  .          
## `8EMTM+PD-1+TIGIT+`  .          
## `8EMTM+PD-1-TIGIT-`  .          
## `8EMTM+PD-1-TIGIT+`  .          
## `8EMTM+TIGIT+`       .          
## `8NV(СТАР2)`         .          
## `8NV`                .          
## `8NV+226+`           .          
## `8NV+39+`            .          
## `8NV+DR+`            .          
## `8NV+PD-1+`          .          
## `8NV+PD-1+TIGIT-`    .          
## `8NV+PD-1+TIGIT+`    .          
## `8NV+PD-1-TIGIT-`    .          
## `8NV+PD-1-TIGIT+`    .          
## `8NV+TIGIT+`         .          
## `8TREG`              .          
## `8ЕМ`                .          
## `8СМ(СТАР2)`         .          
## `8СМ`                .          
## `8СМ+226+`           .          
## `8СМ+39+`            .          
## `8СМ+DR+`            .          
## `8СМ+PD-1+`          .          
## `8СМ+PD-1+TIGIT-`    .          
## `8СМ+PD-1+TIGIT+`    .          
## `8СМ+PD-1-TIGIT-`    .          
## `8СМ+PD-1-TIGIT+`    .          
## `8СМ+TIGIT+`         .          
## `8ТЕ(СТАР2)`         .          
## `8ТЕ`                .          
## `8ТЕ+226+`           .          
## `8ТЕ+39+`            .          
## `8ТЕ+DR+`            .          
## `8ТЕ+PD-1+`          .          
## `8ТЕ+PD-1+TIGIT-`    .          
## `8ТЕ+PD-1+TIGIT+`    .          
## `8ТЕ+PD-1-TIGIT-`    .          
## `8ТЕ+PD-1-TIGIT+`    .          
## `8ТЕ+TIGIT+`         .          
## `8ТМ`                .          
## TREG_CM              .          
## TREG_EMTM            .          
## TREG_NV              .          
## TREG_TE              .          
## `TREG+226+`          .          
## `TREG+226+TIGIT-`    .          
## `TREG+226+TIGIT+`    .          
## `TREG+226-TIGIT-`    .          
## `TREG+226-TIGIT+`    .          
## `TREG+39+`           .          
## `TREG+DR+`           .          
## `TREG+PD-1+`         .          
## `TREG+TIGIT+`        .

##180

# Подготовка данных: X - матрица предикторов, y - вектор отклика
X <- model.matrix(cGVHD_present ~ ., data = data_180)
y <- data_180$cGVHD_present

# Построение модели LASSO
lasso_model <- glmnet(X, y, family = "binomial", alpha = 1) # alpha = 1 для LASSO

# Выбор наилучшего lambda с помощью кросс-валидации
cv_lasso <- cv.glmnet(X, y, family = "binomial", alpha = 1)
best_lambda <- cv_lasso$lambda.min

# Модель с наилучшим lambda
lasso_model_best <- glmnet(X, y, family = "binomial", alpha = 1, lambda = best_lambda)

# Коэффициенты
coef(lasso_model_best)

## 166 x 1 sparse Matrix of class "dgCMatrix"
##                                s0
## (Intercept)         -6.931472e-01
## (Intercept)          .           
## `4_TFH`              .           
## `4_TH1`              .           
## `4_TH17`             .           
## `4_Th17TO1`          .           
## `4_TH2`              .           
## `4_TH22`             .           
## `4+ (IM STAT)`       .           
## `4+`                 .           
## `4+226+`             .           
## `4+39+`              .           
## `4+DR+`              .           
## `4+PD-1+`            .           
## `4+PD-1+TIGIT-`      .           
## `4+PD-1+TIGIT+`      .           
## `4+PD-1-TIGIT-`      .           
## `4+PD-1-TIGIT+`      .           
## `4+TIGIT+`           .           
## `4NV(СТАР2)`         .           
## `4NV`                .           
## `4NV_TH1`            .           
## `4NV_TH17`           .           
## `4NV_Th17TO1`        8.628088e-16
## `4NV_TH2`            .           
## `4NV_TH22`           .           
## `4NV+226+`           .           
## `4NV+39+`            .           
## `4NV+DR+`            .           
## `4NV+PD1+`           .           
## `4NV+PD-1+TIGIT-`    .           
## `4NV+PD-1+TIGIT+`    .           
## `4NV+PD-1-TIGIT-`    .           
## `4NV+PD-1-TIGIT+`    .           
## `4NV+TIGIT+`         .           
## `4ЕМ`                .           
## `4ЕМ_TH1`            .           
## `4ЕМ_TH17`           .           
## `4ЕМ_Th17TO1`        .           
## `4ЕМ_TH2`            .           
## `4ЕМ_TH22`           .           
## `4ЕМ+226+`           .           
## `4ЕМ+39+`            .           
## `4ЕМ+DR+`            .           
## `4ЕМ+PD1+`           .           
## `4ЕМ+PD1+TIGIT-`     .           
## `4ЕМ+PD1+TIGIT+`     .           
## `4ЕМ+PD1-TIGIT-`     .           
## `4ЕМ+PD1-TIGIT+`     .           
## `4ЕМ+TIGIT+`         .           
## `4ЕМTM`              .           
## `4СМ(СТАР2)`         .           
## `4СМ`                .           
## `4СМ_TH1`            .           
## `4СМ_TH17`           .           
## `4СМ_Th17TO1`        .           
## `4СМ_TH2`            .           
## `4СМ_TH22`           .           
## `4СМ+226+`           .           
## `4СМ+39+`            .           
## `4СМ+DR+`            .           
## `4СМ+PD1+`           .           
## `4СМ+PD1+TIGIT-`     .           
## `4СМ+PD1+TIGIT+`     .           
## `4СМ+PD1-TIGIT-`     .           
## `4СМ+PD1-TIGIT+`     .           
## `4СМ+TIGIT+`         .           
## `4ТM_TH1`            .           
## `4ТM_TH17`           .           
## `4ТM_Th17TO1`        .           
## `4ТM_TH2`            .           
## `4ТM_TH22`           .           
## `4ТREG(СТАР2)`       .           
## `4ТREG`              .           
## `4ТREG_TH1`          .           
## `4ТREG_TH17`         .           
## `4ТREG_Th17TO1`      .           
## `4ТREG_TH2`          .           
## `4ТREG_TH22`         .           
## `4ТЕ(СТАР2)`         .           
## `4ТЕ`                .           
## `4ТЕ_TH1`            .           
## `4ТЕ_TH17`           .           
## `4ТЕ_Th17TO1`        .           
## `4ТЕ_TH2`            .           
## `4ТЕ_TH22`           .           
## `4ТЕ+226+`           .           
## `4ТЕ+39+`            .           
## `4ТЕ+DR+`            .           
## `4ТЕ+PD-1+`          .           
## `4ТЕ+PD-1+TIGIT-`    .           
## `4ТЕ+PD-1+TIGIT+`    .           
## `4ТЕ+PD-1-TIGIT-`    .           
## `4ТЕ+PD-1-TIGIT+`    .           
## `4ТЕ+TIGIT+`         .           
## `4ТМ`                .           
## `8+ (IM STAT)`       .           
## `8+`                 .           
## `8+226+`             .           
## `8+39+`              .           
## `8+DR+`              .           
## `8+PD-1+`            .           
## `8+PD-1+TIGIT-`      .           
## `8+PD-1+TIGIT+`      .           
## `8+PD-1-TIGIT-`      .           
## `8+PD-1-TIGIT+`      .           
## `8+TIGIT+`           .           
## `8EMTM`              .           
## `8EMTM+226+`         .           
## `8EMTM+39+`          .           
## `8EMTM+DR+`          .           
## `8EMTM+PD-1+`        .           
## `8EMTM+PD-1+TIGIT-`  .           
## `8EMTM+PD-1+TIGIT+`  .           
## `8EMTM+PD-1-TIGIT-`  .           
## `8EMTM+PD-1-TIGIT+`  .           
## `8EMTM+TIGIT+`       .           
## `8NV(СТАР2)`         .           
## `8NV`                .           
## `8NV+226+`           .           
## `8NV+39+`            .           
## `8NV+DR+`            .           
## `8NV+PD-1+`          .           
## `8NV+PD-1+TIGIT-`    .           
## `8NV+PD-1+TIGIT+`    .           
## `8NV+PD-1-TIGIT-`    .           
## `8NV+PD-1-TIGIT+`    .           
## `8NV+TIGIT+`         .           
## `8TREG`              .           
## `8ЕМ`                .           
## `8СМ(СТАР2)`         .           
## `8СМ`                .           
## `8СМ+226+`           .           
## `8СМ+39+`            .           
## `8СМ+DR+`            .           
## `8СМ+PD-1+`          .           
## `8СМ+PD-1+TIGIT-`    .           
## `8СМ+PD-1+TIGIT+`    .           
## `8СМ+PD-1-TIGIT-`    .           
## `8СМ+PD-1-TIGIT+`    .           
## `8СМ+TIGIT+`         .           
## `8ТЕ(СТАР2)`         .           
## `8ТЕ`                .           
## `8ТЕ+226+`           .           
## `8ТЕ+39+`            .           
## `8ТЕ+DR+`            .           
## `8ТЕ+PD-1+`          .           
## `8ТЕ+PD-1+TIGIT-`    .           
## `8ТЕ+PD-1+TIGIT+`    .           
## `8ТЕ+PD-1-TIGIT-`    .           
## `8ТЕ+PD-1-TIGIT+`    .           
## `8ТЕ+TIGIT+`         .           
## `8ТМ`                .           
## TREG_CM              .           
## TREG_EMTM            .           
## TREG_NV              .           
## TREG_TE              .           
## `TREG+226+`          .           
## `TREG+226+TIGIT-`    .           
## `TREG+226+TIGIT+`    .           
## `TREG+226-TIGIT-`    .           
## `TREG+226-TIGIT+`    .           
## `TREG+39+`           .           
## `TREG+DR+`           .           
## `TREG+PD-1+`         .           
## `TREG+TIGIT+`        .

##несколько попыток отобрать предикторы в модель, везде aliased coefficient

model_90_filter <- glm(cGVHD_present ~ . - `4+ (IM STAT)` - `4+` - `4NV(СТАР2)` - `4NV` - `4ЕМ` - `4СМ(СТАР2)` - `4СМ` - `4ТREG(СТАР2)` - `4ТREG` - `4ТЕ(СТАР2)` - `4ТЕ` - `8+ (IM STAT)` - `8+` - `8EMTM` - `8NV(СТАР2)` - `8NV` - `8СМ(СТАР2)` - `8СМ` - `8ТЕ(СТАР2)` - `8ТЕ`, data = data_90, family = binomial)


summary(model_90_filter)

## 
## Call:
## glm(formula = cGVHD_present ~ . - `4+ (IM STAT)` - `4+` - `4NV(СТАР2)` - 
##     `4NV` - `4ЕМ` - `4СМ(СТАР2)` - `4СМ` - `4ТREG(СТАР2)` - 
##     `4ТREG` - `4ТЕ(СТАР2)` - `4ТЕ` - `8+ (IM STAT)` - 
##     `8+` - `8EMTM` - `8NV(СТАР2)` - `8NV` - `8СМ(СТАР2)` - 
##     `8СМ` - `8ТЕ(СТАР2)` - `8ТЕ`, family = binomial, 
##     data = data_90)
## 
## Coefficients: (78 not defined because of singularities)
##                       Estimate Std. Error z value Pr(>|z|)
## (Intercept)         -2.776e+01  3.605e+05       0        1
## `4_TFH`             -5.818e+00  8.031e+04       0        1
## `4_TH1`              2.656e+01  9.467e+05       0        1
## `4_TH17`            -9.898e+01  1.504e+06       0        1
## `4_Th17TO1`         -9.482e+01  5.141e+06       0        1
## `4_TH2`             -7.014e+01  7.237e+05       0        1
## `4_TH22`            -4.085e+00  4.450e+06       0        1
## `4+226+`             2.066e+01  1.107e+06       0        1
## `4+39+`              3.786e+01  9.003e+05       0        1
## `4+DR+`             -7.175e+00  1.271e+05       0        1
## `4+PD-1+`            1.388e+09  7.014e+13       0        1
## `4+PD-1+TIGIT-`     -1.388e+09  7.014e+13       0        1
## `4+PD-1+TIGIT+`     -2.926e+09  3.248e+13       0        1
## `4+PD-1-TIGIT-`     -2.752e+01  5.302e+05       0        1
## `4+PD-1-TIGIT+`     -1.538e+09  8.709e+13       0        1
## `4+TIGIT+`           1.538e+09  8.709e+13       0        1
## `4NV_TH1`           -8.685e+01  2.563e+06       0        1
## `4NV_TH17`           1.218e+02  1.464e+06       0        1
## `4NV_Th17TO1`        4.724e+02  1.482e+07       0        1
## `4NV_TH2`            7.191e+01  8.991e+05       0        1
## `4NV_TH22`          -3.069e+02  1.039e+07       0        1
## `4NV+226+`          -2.714e+01  1.126e+06       0        1
## `4NV+39+`            1.268e+01  2.072e+06       0        1
## `4NV+DR+`           -2.711e+00  1.230e+06       0        1
## `4NV+PD1+`          -1.076e+11  3.701e+15       0        1
## `4NV+PD-1+TIGIT-`    1.076e+11  3.701e+15       0        1
## `4NV+PD-1+TIGIT+`   -2.395e+11  1.201e+16       0        1
## `4NV+PD-1-TIGIT-`    3.541e+01  5.552e+05       0        1
## `4NV+PD-1-TIGIT+`   -3.471e+11  1.564e+16       0        1
## `4NV+TIGIT+`         3.471e+11  1.564e+16       0        1
## `4ЕМ_TH1`           -4.077e+01  1.075e+06       0        1
## `4ЕМ_TH17`          -1.992e+02  7.594e+06       0        1
## `4ЕМ_Th17TO1`        3.540e+02  6.738e+06       0        1
## `4ЕМ_TH2`            9.196e+01  1.220e+06       0        1
## `4ЕМ_TH22`           1.020e+03  9.990e+07       0        1
## `4ЕМ+226+`          -3.620e+01  1.314e+06       0        1
## `4ЕМ+39+`           -4.022e+01  8.473e+05       0        1
## `4ЕМ+DR+`            7.334e+00  3.289e+05       0        1
## `4ЕМ+PD1+`          -3.490e+09  7.280e+13       0        1
## `4ЕМ+PD1+TIGIT-`     1.190e+09  1.597e+14       0        1
## `4ЕМ+PD1+TIGIT+`     1.519e+09  2.640e+14       0        1
## `4ЕМ+PD1-TIGIT-`    -2.301e+09  1.057e+14       0        1
## `4ЕМ+PD1-TIGIT+`    -1.972e+09  2.074e+14       0        1
## `4ЕМ+TIGIT+`        -3.291e+08  1.137e+14       0        1
## `4ЕМTM`              2.301e+09  1.057e+14       0        1
## `4СМ_TH1`            1.176e+01  6.180e+05       0        1
## `4СМ_TH17`           1.031e+02  1.787e+06       0        1
## `4СМ_Th17TO1`        2.113e+01  2.776e+06       0        1
## `4СМ_TH2`            7.338e+01  7.548e+05       0        1
## `4СМ_TH22`           1.180e+02  1.024e+07       0        1
## `4СМ+226+`          -4.553e+01  1.911e+06       0        1
## `4СМ+39+`           -4.747e+01  1.396e+06       0        1
## `4СМ+DR+`           -9.300e-01  2.872e+05       0        1
## `4СМ+PD1+`           6.314e+09  2.271e+14       0        1
## `4СМ+PD1+TIGIT-`    -6.314e+09  2.271e+14       0        1
## `4СМ+PD1+TIGIT+`     2.295e+09  2.751e+14       0        1
## `4СМ+PD1-TIGIT-`     4.609e+01  1.600e+06       0        1
## `4СМ+PD1-TIGIT+`     8.609e+09  2.957e+14       0        1
## `4СМ+TIGIT+`        -8.609e+09  2.957e+14       0        1
## `4ТM_TH1`           -4.046e+01  1.141e+06       0        1
## `4ТM_TH17`           1.119e+02  1.767e+06       0        1
## `4ТM_Th17TO1`        1.064e+02  6.304e+06       0        1
## `4ТM_TH2`            6.166e+01  1.313e+06       0        1
## `4ТM_TH22`          -2.066e+01  5.232e+06       0        1
## `4ТREG_TH1`          3.298e+02  8.226e+06       0        1
## `4ТREG_TH17`         9.210e+00  7.521e+05       0        1
## `4ТREG_Th17TO1`     -5.297e+02  1.103e+07       0        1
## `4ТREG_TH2`                 NA         NA      NA       NA
## `4ТREG_TH22`                NA         NA      NA       NA
## `4ТЕ_TH1`                   NA         NA      NA       NA
## `4ТЕ_TH17`                  NA         NA      NA       NA
## `4ТЕ_Th17TO1`               NA         NA      NA       NA
## `4ТЕ_TH2`                   NA         NA      NA       NA
## `4ТЕ_TH22`                  NA         NA      NA       NA
## `4ТЕ+226+`                  NA         NA      NA       NA
## `4ТЕ+39+`                   NA         NA      NA       NA
## `4ТЕ+DR+`                   NA         NA      NA       NA
## `4ТЕ+PD-1+`                 NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `4ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `4ТЕ+TIGIT+`                NA         NA      NA       NA
## `4ТМ`                       NA         NA      NA       NA
## `8+226+`                    NA         NA      NA       NA
## `8+39+`                     NA         NA      NA       NA
## `8+DR+`                     NA         NA      NA       NA
## `8+PD-1+`                   NA         NA      NA       NA
## `8+PD-1+TIGIT-`             NA         NA      NA       NA
## `8+PD-1+TIGIT+`             NA         NA      NA       NA
## `8+PD-1-TIGIT-`             NA         NA      NA       NA
## `8+PD-1-TIGIT+`             NA         NA      NA       NA
## `8+TIGIT+`                  NA         NA      NA       NA
## `8EMTM+226+`                NA         NA      NA       NA
## `8EMTM+39+`                 NA         NA      NA       NA
## `8EMTM+DR+`                 NA         NA      NA       NA
## `8EMTM+PD-1+`               NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1+TIGIT+`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT-`         NA         NA      NA       NA
## `8EMTM+PD-1-TIGIT+`         NA         NA      NA       NA
## `8EMTM+TIGIT+`              NA         NA      NA       NA
## `8NV+226+`                  NA         NA      NA       NA
## `8NV+39+`                   NA         NA      NA       NA
## `8NV+DR+`                   NA         NA      NA       NA
## `8NV+PD-1+`                 NA         NA      NA       NA
## `8NV+PD-1+TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1+TIGIT+`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT-`           NA         NA      NA       NA
## `8NV+PD-1-TIGIT+`           NA         NA      NA       NA
## `8NV+TIGIT+`                NA         NA      NA       NA
## `8TREG`                     NA         NA      NA       NA
## `8ЕМ`                       NA         NA      NA       NA
## `8СМ+226+`                  NA         NA      NA       NA
## `8СМ+39+`                   NA         NA      NA       NA
## `8СМ+DR+`                   NA         NA      NA       NA
## `8СМ+PD-1+`                 NA         NA      NA       NA
## `8СМ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8СМ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8СМ+TIGIT+`                NA         NA      NA       NA
## `8ТЕ+226+`                  NA         NA      NA       NA
## `8ТЕ+39+`                   NA         NA      NA       NA
## `8ТЕ+DR+`                   NA         NA      NA       NA
## `8ТЕ+PD-1+`                 NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1+TIGIT+`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT-`           NA         NA      NA       NA
## `8ТЕ+PD-1-TIGIT+`           NA         NA      NA       NA
## `8ТЕ+TIGIT+`                NA         NA      NA       NA
## `8ТМ`                       NA         NA      NA       NA
## TREG_CM                     NA         NA      NA       NA
## TREG_EMTM                   NA         NA      NA       NA
## TREG_NV                     NA         NA      NA       NA
## TREG_TE                     NA         NA      NA       NA
## `TREG+226+`                 NA         NA      NA       NA
## `TREG+226+TIGIT-`           NA         NA      NA       NA
## `TREG+226+TIGIT+`           NA         NA      NA       NA
## `TREG+226-TIGIT-`           NA         NA      NA       NA
## `TREG+226-TIGIT+`           NA         NA      NA       NA
## `TREG+39+`                  NA         NA      NA       NA
## `TREG+DR+`                  NA         NA      NA       NA
## `TREG+PD-1+`                NA         NA      NA       NA
## `TREG+TIGIT+`               NA         NA      NA       NA
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 9.1068e+01  on 66  degrees of freedom
## Residual deviance: 3.8883e-10  on  0  degrees of freedom
## AIC: 134
## 
## Number of Fisher Scoring iterations: 25

model_90_filter_2 <- glm(cGVHD_present ~ `4+ (IM STAT)` + `4NV(СТАР2)` + `4NV` + `4NV_TH17` + `4NV_Th17TO1` + `4NV_TH2` + `4NV+226+` + `4NV+PD-1-TIGIT-` + `4NV+TIGIT+` + `4ЕМ_TH1` + `4ЕМ_TH17` + `4ЕМ_Th17TO1` + `4СМ` + `4СМ_TH22` + `4ТЕ+PD-1+TIGIT-` + `8+ (IM STAT)` + `8+` + `8+DR+` + `8+PD-1+` + `8+PD-1+TIGIT+` + `8+TIGIT+` + `8EMTM` + `8EMTM+226+` + `8EMTM+39+` + `8EMTM+DR+` + `8EMTM+PD-1+` +  `8EMTM+PD-1+TIGIT-` + `8EMTM+PD-1+TIGIT+` + `8EMTM+PD-1-TIGIT+` + `8EMTM+TIGIT+` + `8NV` + `8TREG` + `8ТЕ(СТАР2)` + `8ТЕ+226+` + `8ТЕ+DR+` + `8ТЕ+PD-1+` + `8ТЕ+PD-1+TIGIT+` + `8ТМ`, data = data_90, family = binomial)                          

## Warning: glm.fit: возникли подогнанные вероятности 0 или 1

model_90_filter_2 <- glm(cGVHD_present ~ `4NV_TH17` + `4NV_TH2` + `4NV+226+` + `4NV+PD-1-TIGIT-` + `4ЕМ_TH17` + `4ЕМ_Th17TO1` + `8+DR+` + `8+PD-1+` + `8+PD-1+TIGIT+` + `8EMTM+39+` + `8EMTM+DR+` + `8EMTM+PD-1+` +  `8EMTM+PD-1+TIGIT-` + `8EMTM+TIGIT+` + `8NV` + `8TREG` + `8ТЕ+DR+` +   `8ТЕ+PD-1+TIGIT+`, data = data_90, family = binomial) 

## Warning: glm.fit: возникли подогнанные вероятности 0 или 1

summary(model_90_filter_2)

## 
## Call:
## glm(formula = cGVHD_present ~ `4NV_TH17` + `4NV_TH2` + `4NV+226+` + 
##     `4NV+PD-1-TIGIT-` + `4ЕМ_TH17` + `4ЕМ_Th17TO1` + `8+DR+` + 
##     `8+PD-1+` + `8+PD-1+TIGIT+` + `8EMTM+39+` + `8EMTM+DR+` + 
##     `8EMTM+PD-1+` + `8EMTM+PD-1+TIGIT-` + `8EMTM+TIGIT+` + `8NV` + 
##     `8TREG` + `8ТЕ+DR+` + `8ТЕ+PD-1+TIGIT+`, family = binomial, 
##     data = data_90)
## 
## Coefficients:
##                       Estimate Std. Error z value Pr(>|z|)  
## (Intercept)          -0.562595   0.674208  -0.834   0.4040  
## `4NV_TH17`            0.600160   0.797564   0.752   0.4518  
## `4NV_TH2`             0.191467   0.193999   0.987   0.3237  
## `4NV+226+`           -0.162948   0.213486  -0.763   0.4453  
## `4NV+PD-1-TIGIT-`     0.155361   0.181271   0.857   0.3914  
## `4ЕМ_TH17`          -11.998866   9.866320  -1.216   0.2239  
## `4ЕМ_Th17TO1`        -5.845051   3.428431  -1.705   0.0882 .
## `8+DR+`              -0.436723   0.224706  -1.944   0.0520 .
## `8+PD-1+`             0.007366   0.019088   0.386   0.6996  
## `8+PD-1+TIGIT+`       0.794734   0.444771   1.787   0.0740 .
## `8EMTM+39+`          -0.059645   0.050367  -1.184   0.2363  
## `8EMTM+DR+`           0.486709   0.233585   2.084   0.0372 *
## `8EMTM+PD-1+`        -0.979300   0.513995  -1.905   0.0567 .
## `8EMTM+PD-1+TIGIT-`   0.988064   0.584346   1.691   0.0909 .
## `8EMTM+TIGIT+`        0.096118   0.087828   1.094   0.2738  
## `8NV`                 0.010953   0.052602   0.208   0.8351  
## `8TREG`              -0.011642   0.008210  -1.418   0.1562  
## `8ТЕ+DR+`             0.440618   0.228786   1.926   0.0541 .
## `8ТЕ+PD-1+TIGIT+`    -0.798576   0.445109  -1.794   0.0728 .
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 91.068  on 66  degrees of freedom
## Residual deviance: 58.630  on 48  degrees of freedom
## AIC: 96.63
## 
## Number of Fisher Scoring iterations: 7

#Heat map

# Создание корреляционной матрицы
correlation_matrix <- cor(data_90_num, method = "spearman")

# Иерархическая кластеризация
cor_hclust <- hclust(dist((1-correlation_matrix)), method = "complete")

# Создание тепловой карты 
pheatmap(
  correlation_matrix,
  cluster_rows = cor_hclust,
  cluster_cols = cor_hclust,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица",
  annotation_col = NULL,
  annotation_row = NULL,
  fontsize = 10
)

##кластеры

# Функция для расчета SSE
wss <- function(k) {
  km <- kmeans(data_90_num, centers = k, nstart = 25)
  return(km$tot.withinss)
}

# Расчет SSE для k от 1 до 10
k.values <- 1:10
SSE <- sapply(k.values, wss)

# Построение графика
plot(k.values, SSE, type = "b", xlab = "Число кластеров", ylab = "Сумма квадратов ошибок (SSE)", 
     main = "Метод локтя")
lines(k.values, SSE, col = "red")

library(cluster)

silhouette_scores <- sapply(2:10, function(k) {
  km <- kmeans(data_90_num, centers = k, nstart = 25)
  sil <- silhouette(km$cluster, dist(data_90_num))
  mean(sil[, 3])
})

# Построение графика
plot(2:10, silhouette_scores, type = "b", xlab = "Число кластеров", ylab = "Средний силуэтный коэффициент", 
     main = "Критерий силуэта")
lines(2:10, silhouette_scores, col = "red")

#Деление на 10 кластеров + отдельные матрицы

clusters <- cutree(cor_hclust, k = 10)

table(clusters)

## clusters
##  1  2  3  4  5  6  7  8  9 10 
## 29 27 14 13  9  9 38  9  6 10

cluster_1_vars <- names(which(clusters == 1))
cluster_2_vars <- names(which(clusters == 2))
cluster_3_vars <- names(which(clusters == 3))
cluster_4_vars <- names(which(clusters == 4))
cluster_5_vars <- names(which(clusters == 5))
cluster_6_vars <- names(which(clusters == 6))
cluster_7_vars <- names(which(clusters == 7))
cluster_8_vars <- names(which(clusters == 8))
cluster_9_vars <- names(which(clusters == 9))
cluster_10_vars <- names(which(clusters == 10))

cluster_1_matrix <- correlation_matrix[cluster_1_vars, cluster_1_vars]

pheatmap(
  cluster_1_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для первого кластера"
)

cluster_2_matrix <- correlation_matrix[cluster_2_vars, cluster_2_vars]

pheatmap(
  cluster_2_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для второго кластера"
)

cluster_3_matrix <- correlation_matrix[cluster_3_vars, cluster_3_vars]

pheatmap(
  cluster_3_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для третьего кластера"
)

cluster_4_matrix <- correlation_matrix[cluster_4_vars, cluster_4_vars]

pheatmap(
  cluster_4_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для четвертого кластера"
)

cluster_5_matrix <- correlation_matrix[cluster_5_vars, cluster_5_vars]

pheatmap(
  cluster_5_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для пятого кластера"
)

cluster_6_matrix <- correlation_matrix[cluster_6_vars, cluster_6_vars]

pheatmap(
  cluster_6_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для шестого кластера"
)

cluster_7_matrix <- correlation_matrix[cluster_7_vars, cluster_7_vars]

pheatmap(
  cluster_7_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для седьмого кластера"
)

cluster_8_matrix <- correlation_matrix[cluster_8_vars, cluster_8_vars]

pheatmap(
  cluster_8_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для восьмого кластера"
)

cluster_9_matrix <- correlation_matrix[cluster_9_vars, cluster_9_vars]

pheatmap(
  cluster_9_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для девятого кластера"
)

cluster_10_matrix <- correlation_matrix[cluster_10_vars, cluster_10_vars]

pheatmap(
  cluster_10_matrix,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для десятого кластера"
)

#Деление на 5 кластеров + корреляционные матрицы

clusters_2 <- cutree(cor_hclust, k = 5)

table(clusters_2)

## clusters_2
##  1  2  3  4  5 
## 52 27 23 24 38

cluster_1 <- names(which(clusters_2 == 1))
cluster_2 <- names(which(clusters_2 == 2))
cluster_3 <- names(which(clusters_2 == 3))
cluster_4 <- names(which(clusters_2 == 4))
cluster_5 <- names(which(clusters_2 == 5))

cluster_matrix_1 <- correlation_matrix[cluster_1, cluster_1]

pheatmap(
  cluster_matrix_1,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для первого кластера"
)

cluster_matrix_2 <- correlation_matrix[cluster_2, cluster_2]

pheatmap(
  cluster_matrix_2,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для второго кластера"
)

cluster_matrix_3 <- correlation_matrix[cluster_3, cluster_3]

pheatmap(
  cluster_matrix_3,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для третьего кластера"
)

cluster_matrix_4 <- correlation_matrix[cluster_4, cluster_4]

pheatmap(
  cluster_matrix_4,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для четвертого кластера"
)

cluster_matrix_5 <- correlation_matrix[cluster_5, cluster_5]

pheatmap(
  cluster_matrix_5,
  cluster_rows = F,
  cluster_cols = F,
  color = colorRampPalette(c("blue", "white", "red"))(100),
  main = "Корреляционная матрица для пятого кластера"
)

Модель по результатам heat map (отобранные предикторы), 90 день

model_90_filter_finish <- glm(cGVHD_present ~ `4СМ_TH1` + `4_TH22`+ `TREG+PD-1+` + `4ЕМ_TH17` + `4ЕМ+39+` + `4ТREG_TH1` + `8ТЕ` + `4NV_TH2` + `TREG+226-TIGIT-` + `8NV+DR+` + `4NV+PD-1+TIGIT-` + `8EMTM+39+` + `8СМ+TIGIT+`, data = data_90, family = binomial) 


summary(model_90_filter_finish)

## 
## Call:
## glm(formula = cGVHD_present ~ `4СМ_TH1` + `4_TH22` + `TREG+PD-1+` + 
##     `4ЕМ_TH17` + `4ЕМ+39+` + `4ТREG_TH1` + `8ТЕ` + `4NV_TH2` + 
##     `TREG+226-TIGIT-` + `8NV+DR+` + `4NV+PD-1+TIGIT-` + `8EMTM+39+` + 
##     `8СМ+TIGIT+`, family = binomial, data = data_90)
## 
## Coefficients:
##                     Estimate Std. Error z value Pr(>|z|)  
## (Intercept)        -0.700678   0.653080  -1.073   0.2833  
## `4СМ_TH1`           0.200270   0.213659   0.937   0.3486  
## `4_TH22`            0.199067   0.117592   1.693   0.0905 .
## `TREG+PD-1+`        0.085986   0.069854   1.231   0.2183  
## `4ЕМ_TH17`        -10.781745  11.975131  -0.900   0.3679  
## `4ЕМ+39+`          -0.039620   0.024450  -1.620   0.1051  
## `4ТREG_TH1`         1.861241   1.718133   1.083   0.2787  
## `8ТЕ`              -0.002228   0.001679  -1.327   0.1845  
## `4NV_TH2`           0.400092   0.175911   2.274   0.0229 *
## `TREG+226-TIGIT-`  -0.890614   0.608079  -1.465   0.1430  
## `8NV+DR+`          -0.327920   0.166921  -1.965   0.0495 *
## `4NV+PD-1+TIGIT-`  -0.251259   0.410354  -0.612   0.5403  
## `8EMTM+39+`         0.026298   0.012307   2.137   0.0326 *
## `8СМ+TIGIT+`        0.025814   0.066322   0.389   0.6971  
## ---
## Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 91.068  on 66  degrees of freedom
## Residual deviance: 64.971  on 53  degrees of freedom
## AIC: 92.971
## 
## Number of Fisher Scoring iterations: 7

##Корреляции в model_90_filter_finish

data_90_num_model <- data_90 %>%
  select(`4СМ_TH1`, `4_TH22`,`TREG+PD-1+`, `4ЕМ_TH17`, `4ЕМ+39+`, `4ТREG_TH1`, `8ТЕ`, `4NV_TH2`, `TREG+226-TIGIT-`, `8NV+DR+`, `4NV+PD-1+TIGIT-`, `8EMTM+39+`, `8СМ+TIGIT+`) 


data_90_num_model_cor <- cor(data_90_num_model)

corrplot(data_90_num_model_cor, method = "circle", type = "upper", tl.col = "black", tl.cex = 0.7)

corrplot(data_90_num_model_cor, method = 'number')

##Диагностика model_90_filter_finish 90 день

Проверка формы зависимости логита от \(X\) на линейность:

df_check <- model_90_filter_finish %>% broom::augment() %>% 
  dplyr::select(-starts_with("."), .fitted) %>% 
  dplyr::select(where(is.numeric)) %>% 
  pivot_longer(-.fitted) %>% 
  rename(logit = .fitted)
  
ggplot() +
  geom_point(aes(x = value, y = logit), df_check) +
  geom_smooth(aes(x = value, y = logit), df_check, color = "red", se = FALSE) +
  facet_wrap(~ name, scales = "free") +
  theme_bw()

## `geom_smooth()` using method = 'loess' and formula = 'y ~ x'

Мультиколлинеарность:

car::vif(model_90_filter_finish)

##         `4СМ_TH1`          `4_TH22`      `TREG+PD-1+`        `4ЕМ_TH17` 
##          2.465438          1.849622          1.444725          1.581198 
##         `4ЕМ+39+`       `4ТREG_TH1`             `8ТЕ`         `4NV_TH2` 
##          2.088637          1.915383          2.578817          2.311035 
## `TREG+226-TIGIT-`         `8NV+DR+` `4NV+PD-1+TIGIT-`       `8EMTM+39+` 
##          2.353237          2.167347          1.463771          2.204821 
##      `8СМ+TIGIT+` 
##          1.736319

Выбросы

resid_panel(model_90_filter_finish, plots = c("lev", "cookd"))

## Warning in helper_plotly_label(model): в результате преобразования созданы NA
## Warning in helper_plotly_label(model): в результате преобразования созданы NA

Модель по результатам heat map (отобранные предикторы), 180 день

model_180_filter_finish <- glm(cGVHD_present ~ `4СМ_TH1` + `4_TH22`+ `TREG+PD-1+` + `4ЕМ_TH17` + `4ЕМ+39+` + `4ТREG_TH1` + `8ТЕ` + `4NV_TH2` + `4NV_Th17TO1` + `8NV+DR+` + `4NV+PD-1+TIGIT-` + `8EMTM+39+` + `8СМ+TIGIT+`, data = data_180, family = binomial) 


summary(model_180_filter_finish)

## 
## Call:
## glm(formula = cGVHD_present ~ `4СМ_TH1` + `4_TH22` + `TREG+PD-1+` + 
##     `4ЕМ_TH17` + `4ЕМ+39+` + `4ТREG_TH1` + `8ТЕ` + `4NV_TH2` + 
##     `4NV_Th17TO1` + `8NV+DR+` + `4NV+PD-1+TIGIT-` + `8EMTM+39+` + 
##     `8СМ+TIGIT+`, family = binomial, data = data_180)
## 
## Coefficients:
##                     Estimate Std. Error z value Pr(>|z|)
## (Intercept)       -1.1419914  1.0702854  -1.067    0.286
## `4СМ_TH1`          0.4745997  0.3242301   1.464    0.143
## `4_TH22`           0.1368453  0.1165034   1.175    0.240
## `TREG+PD-1+`       0.0362640  0.0585317   0.620    0.536
## `4ЕМ_TH17`         2.5650151  5.8451669   0.439    0.661
## `4ЕМ+39+`          0.0020392  0.0207330   0.098    0.922
## `4ТREG_TH1`       -2.6278044  4.0082651  -0.656    0.512
## `8ТЕ`             -0.0008452  0.0016178  -0.522    0.601
## `4NV_TH2`         -0.1621211  0.1268905  -1.278    0.201
## `4NV_Th17TO1`      0.5616999  2.7822101   0.202    0.840
## `8NV+DR+`         -0.1235626  0.1251563  -0.987    0.324
## `4NV+PD-1+TIGIT-`  0.0462197  0.1847806   0.250    0.802
## `8EMTM+39+`       -0.0036416  0.0074200  -0.491    0.624
## `8СМ+TIGIT+`       0.0725012  0.0858565   0.844    0.398
## 
## (Dispersion parameter for binomial family taken to be 1)
## 
##     Null deviance: 53.467  on 41  degrees of freedom
## Residual deviance: 37.070  on 28  degrees of freedom
## AIC: 65.07
## 
## Number of Fisher Scoring iterations: 6

df_check <- model_180_filter_finish %>% broom::augment() %>% 
  dplyr::select(-starts_with("."), .fitted) %>% 
  dplyr::select(where(is.numeric)) %>% 
  pivot_longer(-.fitted) %>% 
  rename(logit = .fitted)
  
ggplot() +
  geom_point(aes(x = value, y = logit), df_check) +
  geom_smooth(aes(x = value, y = logit), df_check, color = "red", se = FALSE) +
  facet_wrap(~ name, scales = "free") +
  theme_bw()

## `geom_smooth()` using method = 'loess' and formula = 'y ~ x'

#Множественный регрессионный анализ, поправка на множественное сравнение, Forrest plot и Vulcano plot

# Копируем данные для переименования
data_90_copy <- data_90

# Функция для безопасных имен переменных
make_safe_names <- function(names) {
  # Заменяем недопустимые символы на '_'
  safe_names <- make.names(names, unique = TRUE)
  return(safe_names)
}

# Функция для выполнения регрессии и коррекции p-значений
perform_multiple_regression <- function(data) {
  # Находим числовые колонки, исключая целевую
  numeric_cols <- names(data)[sapply(data, is.numeric) & names(data) != "cGVHD_present"]
  
  # Создаем копию данных с безопасными именами
  data_safe <- data
  names(data_safe) <- make_safe_names(names(data))
  
  # Обновляем список числовых колонок с безопасными именами
  numeric_cols_safe <- make_safe_names(numeric_cols)
  
  # Список для хранения результатов
  regression_results <- list()
  
  # Цикл по всем числовым переменным
  for (i in seq_along(numeric_cols_safe)) {
    col <- numeric_cols_safe[i]
    original_col <- numeric_cols[i]
    
    formula <- as.formula(paste("cGVHD_present ~", col))
    model <- glm(formula, data = data_safe, family = binomial())
    
    # Извлечение результатов
    tidy_model <- tidy(model, conf.int = TRUE)
    tidy_model$original_variable <- original_col
    regression_results[[original_col]] <- tidy_model
  }
  
  # Коррекция p-значений методом Бенджамини-Хохберга
  p_values <- sapply(regression_results, function(x) x$p.value[2])
  adjusted_p_values <- p.adjust(p_values, method = "BH")
  
  # Обновление результатов скорректированными p-значениями
  for (i in seq_along(regression_results)) {
    regression_results[[names(regression_results)[i]]]$p.adj <- adjusted_p_values[i]
  }
  
  return(regression_results)
}

# Выполнение регрессионного анализа
results <- perform_multiple_regression(data_90_copy)

## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1
## Warning: glm.fit: возникли подогнанные вероятности 0 или 1

# Подготовка данных для Forest Plot
forest_data <- do.call(rbind, lapply(names(results), function(col) {
  res <- results[[col]]
  data.frame(
    variable = col,
    estimate = res$estimate[2],
    conf.low = res$conf.low[2],
    conf.high = res$conf.high[2],
    p.adj = res$p.adj[2]
  )
}))

# Forest Plot
forest_plot_1 <- ggplot(forest_data, aes(y = reorder(variable, estimate), x = estimate)) +
  geom_point(size = 3) +
  geom_errorbarh(aes(xmin = conf.low, xmax = conf.high), height = 0.2) +
  geom_vline(xintercept = 0, linetype = "dashed") +
  theme_minimal() +
  labs(title = "Forest Plot of Regression Coefficients", 
       x = "Coefficient Estimate", 
       y = "Variables") +
  theme(axis.text.x = element_blank()) + #убрали текст с вертикальной оси после coord_flip()
   scale_x_continuous(limits = c(-75, 25)) +
    coord_flip()

forest_plot_2 <- ggplot(forest_data, aes(y = reorder(variable, estimate), x = estimate, color = p.adj < 0.05)) +
  geom_point(size = 2) +
  geom_errorbarh(aes(xmin = conf.low, xmax = conf.high), height = 0.1) +
  geom_vline(xintercept = 0, linetype = "dashed") +
  theme_minimal() +
  labs(title = "Forest Plot of Regression Coefficients (p-adjust)", 
       x = "Coefficient Estimate", 
       y = "Variables") +
  theme(axis.text.x = element_blank()) +
  scale_x_continuous(limits = c(-75, 50)) +
  coord_flip() +
  scale_color_manual(values = c("TRUE" = "red", "FALSE" = "black"))


# Volcano Plot 
volcano_plot_1 <- ggplot(forest_data, aes(x = estimate, y = -log10(p.adj))) +
  geom_point(aes(color = p.adj < 0.05)) +
  geom_text_repel(aes(label = variable),
                  box.padding = 0.5,
                  max.overlaps = Inf,
                  size = 2,
                  segment.size = 0.2,
                   segment.linetype = "solid",
                   segment.alpha = 0.5) + # Управляем толщиной линий
    scale_color_manual(values = c("TRUE" = "red", "FALSE" = "black")) +
  theme_minimal() +
  labs(title = "Volcano Plot",
       x = "Coefficient Estimate",
       y = "-log10(Adjusted p-value)") +
  scale_x_continuous(limits = c(-20, 8)) +
   scale_y_continuous(limits = c(0, 0.18))

# Вывод результатов
print(forest_data)

##                            variable      estimate      conf.low     conf.high
## 4_TFH                         4_TFH -1.192789e-02  -0.053208193  2.624051e-02
## 4_TH1                         4_TH1 -6.601313e-03  -0.029766044  3.009291e-03
## 4_TH17                       4_TH17 -4.308347e-03  -0.059739379  4.966030e-02
## 4_Th17TO1                 4_Th17TO1  2.286947e-02  -0.104923124  1.506918e-01
## 4_TH2                         4_TH2  1.955833e-03  -0.030201781  3.313621e-02
## 4_TH22                       4_TH22  2.880987e-02  -0.114728565  1.723961e-01
## 4+ (IM STAT)           4+ (IM STAT)  2.306123e-03  -0.005734818  1.087413e-02
## 4+                               4+  3.052174e-03  -0.004529199  1.154683e-02
## 4+226+                       4+226+ -1.272667e-03  -0.006287738  2.261703e-03
## 4+39+                         4+39+  7.264395e-04  -0.014854194  1.610321e-02
## 4+DR+                         4+DR+ -3.213373e-03  -0.011929145  1.353236e-03
## 4+PD-1+                     4+PD-1+ -2.169453e-03  -0.009020198  2.232934e-03
## 4+PD-1+TIGIT-         4+PD-1+TIGIT- -4.085288e-03  -0.016292979  6.297043e-03
## 4+PD-1+TIGIT+         4+PD-1+TIGIT+ -3.446140e-03  -0.016352915  3.378383e-03
## 4+PD-1-TIGIT-         4+PD-1-TIGIT-  4.482373e-03  -0.008223370  1.747532e-02
## 4+PD-1-TIGIT+         4+PD-1-TIGIT+ -1.456310e-02  -0.114348491  1.672480e-02
## 4+TIGIT+                   4+TIGIT+ -3.040573e-03  -0.014932729  2.816980e-03
## 4NV(СТАР2)               4NV(СТАР2)  2.946307e-02   0.003157308  6.032737e-02
## 4NV                             4NV  2.931199e-02   0.004010783  5.954912e-02
## 4NV_TH1                     4NV_TH1  2.607140e-01  -0.034348791  5.983811e-01
## 4NV_TH17                   4NV_TH17  7.844828e-01   0.020829753  1.691711e+00
## 4NV_Th17TO1             4NV_Th17TO1  2.933089e+00   0.121140037  6.421601e+00
## 4NV_TH2                     4NV_TH2  2.024009e-01   0.038313652  4.147739e-01
## 4NV_TH22                   4NV_TH22  4.699992e+00  -0.533238620  1.102395e+01
## 4NV+226+                   4NV+226+  3.406572e-02   0.003808529  6.984789e-02
## 4NV+39+                     4NV+39+  3.264935e-01  -0.201775887  9.173007e-01
## 4NV+DR+                     4NV+DR+ -2.811586e-02  -0.242749162  1.519534e-01
## 4NV+PD1+                   4NV+PD1+  6.997821e-02  -0.311046372  4.508367e-01
## 4NV+PD-1+TIGIT-     4NV+PD-1+TIGIT-  6.282884e-02  -0.448499366  5.643206e-01
## 4NV+PD-1+TIGIT+     4NV+PD-1+TIGIT+  2.583120e-01  -0.785509150  1.337379e+00
## 4NV+PD-1-TIGIT-     4NV+PD-1-TIGIT-  3.059930e-02   0.003400347  6.257681e-02
## 4NV+PD-1-TIGIT+     4NV+PD-1-TIGIT+  2.939970e-01  -0.419933981  1.122351e+00
## 4NV+TIGIT+               4NV+TIGIT+  2.120261e-01  -0.293119036  7.530865e-01
## 4ЕМ                             4ЕМ -9.706025e-03  -0.044487015  1.930841e-03
## 4ЕМ_TH1                     4ЕМ_TH1 -4.551469e-02  -0.160400164  4.438920e-03
## 4ЕМ_TH17                   4ЕМ_TH17 -1.135250e+01 -33.830606874 -7.104417e-01
## 4ЕМ_Th17TO1             4ЕМ_Th17TO1 -5.644614e+00 -11.867157882 -1.471248e+00
## 4ЕМ_TH2                     4ЕМ_TH2 -2.109105e-01  -1.011913703  3.109271e-02
## 4ЕМ_TH22                   4ЕМ_TH22 -1.026784e+01 -41.521216241  1.044726e+01
## 4ЕМ+226+                   4ЕМ+226+ -3.986835e-03  -0.013845678  2.204190e-03
## 4ЕМ+39+                     4ЕМ+39+ -6.625632e-03  -0.034215574  1.989209e-02
## 4ЕМ+DR+                     4ЕМ+DR+ -5.474407e-03  -0.019228845  1.944977e-03
## 4ЕМ+PD1+                   4ЕМ+PD1+ -3.824117e-03  -0.014656994  2.990452e-03
## 4ЕМ+PD1+TIGIT-       4ЕМ+PD1+TIGIT- -6.301864e-03  -0.024186629  8.952337e-03
## 4ЕМ+PD1+TIGIT+       4ЕМ+PD1+TIGIT+ -6.607567e-03  -0.029574105  4.371054e-03
## 4ЕМ+PD1-TIGIT-       4ЕМ+PD1-TIGIT- -1.566218e-02  -0.050425049  1.453703e-02
## 4ЕМ+PD1-TIGIT+       4ЕМ+PD1-TIGIT+ -6.474996e-02  -0.350919775  3.146187e-02
## 4ЕМ+TIGIT+               4ЕМ+TIGIT+ -6.276076e-03  -0.028181875  3.810628e-03
## 4ЕМTM                         4ЕМTM -3.829029e-03  -0.013268465  2.213791e-03
## 4СМ(СТАР2)               4СМ(СТАР2)  6.453075e-03  -0.016663598  3.062525e-02
## 4СМ                             4СМ  1.691211e-02  -0.004638123  4.056495e-02
## 4СМ_TH1                     4СМ_TH1  2.942211e-03  -0.260373957  2.465506e-01
## 4СМ_TH17                   4СМ_TH17  7.781370e-02  -0.025064358  1.880996e-01
## 4СМ_Th17TO1             4СМ_Th17TO1  4.089293e-01  -0.361590570  1.280204e+00
## 4СМ_TH2                     4СМ_TH2  1.645319e-01   0.015139493  3.403715e-01
## 4СМ_TH22                   4СМ_TH22  6.297697e-01  -0.064865270  1.424744e+00
## 4СМ+226+                   4СМ+226+  7.529372e-03  -0.017057480  3.342749e-02
## 4СМ+39+                     4СМ+39+  1.703792e-02  -0.028542819  6.416434e-02
## 4СМ+DR+                     4СМ+DR+ -8.241032e-03  -0.048732330  2.137218e-02
## 4СМ+PD1+                   4СМ+PD1+  1.684060e-03  -0.029116091  3.146615e-02
## 4СМ+PD1+TIGIT-       4СМ+PD1+TIGIT-  7.812635e-03  -0.075864739  9.073960e-02
## 4СМ+PD1+TIGIT+       4СМ+PD1+TIGIT+  1.298687e-03  -0.041652816  4.169538e-02
## 4СМ+PD1-TIGIT-       4СМ+PD1-TIGIT-  3.707706e-02  -0.022283090  1.008015e-01
## 4СМ+PD1-TIGIT+       4СМ+PD1-TIGIT+ -8.665034e-03  -0.333056389  2.823657e-01
## 4СМ+TIGIT+               4СМ+TIGIT+  9.266205e-04  -0.038311784  3.761018e-02
## 4ТM_TH1                     4ТM_TH1 -9.890246e-03  -0.045154865  1.803704e-02
## 4ТM_TH17                   4ТM_TH17 -8.974865e-02  -0.205328221  1.018344e-02
## 4ТM_Th17TO1             4ТM_Th17TO1  6.128490e-02  -0.120536423  2.541365e-01
## 4ТM_TH2                     4ТM_TH2  3.326909e-02  -0.098463743  1.743657e-01
## 4ТM_TH22                   4ТM_TH22 -5.450642e-03  -0.180917563  1.638927e-01
## 4ТREG(СТАР2)           4ТREG(СТАР2)  2.992617e-03  -0.004600390  1.140269e-02
## 4ТREG                         4ТREG  9.974799e-02  -0.047338058  4.299644e-01
## 4ТREG_TH1                 4ТREG_TH1  3.594778e-01  -1.730241399  2.429116e+00
## 4ТREG_TH17               4ТREG_TH17  7.377884e-02  -0.088605508  2.474507e-01
## 4ТREG_Th17TO1         4ТREG_Th17TO1  2.194209e+00  -2.110730531  6.882077e+00
## 4ТREG_TH2                 4ТREG_TH2  1.697747e-01  -0.074402815  4.920320e-01
## 4ТREG_TH22               4ТREG_TH22  3.438166e-02  -0.226874367  2.932528e-01
## 4ТЕ(СТАР2)               4ТЕ(СТАР2) -8.666494e-03  -0.035327664  5.813436e-03
## 4ТЕ                             4ТЕ -6.458256e-02  -0.179692196  1.563777e-03
## 4ТЕ_TH1                     4ТЕ_TH1 -2.360022e-01  -0.703718076 -1.551099e-02
## 4ТЕ_TH17                   4ТЕ_TH17 -7.299372e+00 -38.649479175  1.256012e+01
## 4ТЕ_Th17TO1             4ТЕ_Th17TO1 -1.774795e+01 -47.695632249 -2.146875e+00
## 4ТЕ_TH2                     4ТЕ_TH2 -9.320401e-01  -4.039935135  1.086067e-01
## 4ТЕ_TH22                   4ТЕ_TH22 -1.744097e+01 -69.999146488  2.468971e+01
## 4ТЕ+226+                   4ТЕ+226+ -9.094341e-03  -0.037043399  5.750676e-03
## 4ТЕ+39+                     4ТЕ+39+  4.119643e-02  -0.052867455  1.435782e-01
## 4ТЕ+DR+                     4ТЕ+DR+ -1.088313e-02  -0.044530700  5.989214e-03
## 4ТЕ+PD-1+                 4ТЕ+PD-1+ -9.216858e-03  -0.040543357  9.699847e-03
## 4ТЕ+PD-1+TIGIT-     4ТЕ+PD-1+TIGIT- -1.818962e-02  -0.069199553  2.217053e-02
## 4ТЕ+PD-1+TIGIT+     4ТЕ+PD-1+TIGIT+ -1.476146e-02  -0.082082005  1.697998e-02
## 4ТЕ+PD-1-TIGIT-     4ТЕ+PD-1-TIGIT- -4.504298e-02  -0.136808132  2.288264e-02
## 4ТЕ+PD-1-TIGIT+     4ТЕ+PD-1-TIGIT+ -4.235761e-02            NA  3.792714e-02
## 4ТЕ+TIGIT+               4ТЕ+TIGIT+ -1.177285e-02  -0.072042248  1.181967e-02
## 4ТМ                             4ТМ -4.554485e-03  -0.016581118  6.621550e-03
## 8+ (IM STAT)           8+ (IM STAT) -8.047779e-04  -0.002256401  2.481918e-04
## 8+                               8+ -8.944099e-04  -0.002496242  2.313553e-04
## 8+226+                       8+226+ -8.073626e-04  -0.002101420  1.552208e-04
## 8+39+                         8+39+ -4.310858e-04  -0.006878449  5.114558e-03
## 8+DR+                         8+DR+ -6.945413e-04  -0.002101746  3.503550e-04
## 8+PD-1+                     8+PD-1+ -1.101171e-03  -0.003517477  6.643026e-04
## 8+PD-1+TIGIT-         8+PD-1+TIGIT- -3.644808e-03  -0.010843644  1.763569e-03
## 8+PD-1+TIGIT+         8+PD-1+TIGIT+ -1.363957e-03  -0.004677822  1.068784e-03
## 8+PD-1-TIGIT-         8+PD-1-TIGIT- -2.301747e-03  -0.006480818  7.790071e-04
## 8+PD-1-TIGIT+         8+PD-1-TIGIT+ -2.512063e-03  -0.006777948  3.856124e-04
## 8+TIGIT+                   8+TIGIT+ -1.065960e-03  -0.003003019  3.387724e-04
## 8EMTM                         8EMTM -3.231769e-04  -0.004234766  2.900799e-03
## 8EMTM+226+               8EMTM+226+ -4.047680e-04  -0.004571004  2.966600e-03
## 8EMTM+39+                 8EMTM+39+  4.300058e-04  -0.015196125  1.477788e-02
## 8EMTM+DR+                 8EMTM+DR+ -1.139179e-04  -0.004205662  3.433143e-03
## 8EMTM+PD-1+             8EMTM+PD-1+  2.177711e-05  -0.006481992  5.891883e-03
## 8EMTM+PD-1+TIGIT- 8EMTM+PD-1+TIGIT-  9.189195e-04  -0.017978415  1.883762e-02
## 8EMTM+PD-1+TIGIT+ 8EMTM+PD-1+TIGIT+ -1.950759e-04  -0.009559274  8.179936e-03
## 8EMTM+PD-1-TIGIT- 8EMTM+PD-1-TIGIT- -1.496974e-03  -0.018576070  1.258540e-02
## 8EMTM+PD-1-TIGIT+ 8EMTM+PD-1-TIGIT+ -3.489338e-03  -0.020174930  8.028849e-03
## 8EMTM+TIGIT+           8EMTM+TIGIT+ -7.032457e-04  -0.006781974  4.290054e-03
## 8NV(СТАР2)               8NV(СТАР2)  1.361576e-02  -0.031288953  5.944562e-02
## 8NV                             8NV  3.849184e-02  -0.009713654  9.576209e-02
## 8NV+226+                   8NV+226+  1.213997e-02  -0.037077835  6.187507e-02
## 8NV+39+                     8NV+39+  8.379380e-02  -0.483143494  6.490125e-01
## 8NV+DR+                     8NV+DR+ -1.120911e-01  -0.334406160  3.887328e-02
## 8NV+PD-1+                 8NV+PD-1+ -2.042232e-01  -0.606927612  9.675565e-02
## 8NV+PD-1+TIGIT-     8NV+PD-1+TIGIT- -4.352068e-01  -1.520287462  2.999592e-01
## 8NV+PD-1+TIGIT+     8NV+PD-1+TIGIT+ -2.866860e-01  -0.850054256  1.536046e-01
## 8NV+PD-1-TIGIT-     8NV+PD-1-TIGIT-  2.646975e-02  -0.023067033  8.053411e-02
## 8NV+PD-1-TIGIT+     8NV+PD-1-TIGIT+ -1.908475e-01  -0.677642461  1.470535e-01
## 8NV+TIGIT+               8NV+TIGIT+ -1.334034e-01  -0.416613832  7.339542e-02
## 8TREG                         8TREG -8.475997e-04  -0.002415032  2.632552e-04
## 8ЕМ                             8ЕМ -4.441537e-04  -0.004279948  2.626299e-03
## 8СМ(СТАР2)               8СМ(СТАР2) -1.105947e-02  -0.073664981  2.308438e-02
## 8СМ                             8СМ  3.062386e-02  -0.024549124  1.195902e-01
## 8СМ+226+                   8СМ+226+ -1.280425e-02  -0.085594550  2.278949e-02
## 8СМ+39+                     8СМ+39+  1.087545e-01  -0.174149816  4.149762e-01
## 8СМ+DR+                     8СМ+DR+ -1.523045e-02  -0.090736043  2.286988e-02
## 8СМ+PD-1+                 8СМ+PD-1+ -1.668810e-02  -0.124634528  6.114210e-02
## 8СМ+PD-1+TIGIT-     8СМ+PD-1+TIGIT- -7.915222e-02  -0.508316957  2.312430e-01
## 8СМ+PD-1+TIGIT+     8СМ+PD-1+TIGIT+ -1.939491e-02  -0.161747057  8.132773e-02
## 8СМ+PD-1-TIGIT-     8СМ+PD-1-TIGIT- -1.876911e-02  -0.264661639  1.902866e-01
## 8СМ+PD-1-TIGIT+     8СМ+PD-1-TIGIT+ -4.969508e-02  -0.394095492  3.928102e-02
## 8СМ+TIGIT+               8СМ+TIGIT+ -1.699291e-02  -0.116894240  2.816586e-02
## 8ТЕ(СТАР2)               8ТЕ(СТАР2) -1.228451e-03  -0.002890620  7.762858e-06
## 8ТЕ                             8ТЕ -1.642412e-03  -0.003730554 -1.551474e-04
## 8ТЕ+226+                   8ТЕ+226+ -1.318327e-03  -0.003085873 -1.576719e-05
## 8ТЕ+39+                     8ТЕ+39+ -1.280958e-03  -0.011644917  7.485492e-03
## 8ТЕ+DR+                     8ТЕ+DR+ -1.256611e-03  -0.003283363  2.311296e-04
## 8ТЕ+PD-1+                 8ТЕ+PD-1+ -2.052920e-03  -0.005812765  4.932080e-04
## 8ТЕ+PD-1+TIGIT-     8ТЕ+PD-1+TIGIT- -6.626415e-03  -0.017358858  9.545961e-04
## 8ТЕ+PD-1+TIGIT+     8ТЕ+PD-1+TIGIT+ -2.475322e-03  -0.007600324  9.657084e-04
## 8ТЕ+PD-1-TIGIT-     8ТЕ+PD-1-TIGIT- -3.624402e-03  -0.009212732  3.529961e-04
## 8ТЕ+PD-1-TIGIT+     8ТЕ+PD-1-TIGIT+ -3.607313e-03  -0.008909730  1.300236e-04
## 8ТЕ+TIGIT+               8ТЕ+TIGIT+ -1.769967e-03  -0.004468783  1.750598e-04
## 8ТМ                             8ТМ -6.597081e-04  -0.017889012  1.495558e-02
## TREG_CM                     TREG_CM  2.699803e-01  -0.060875348  8.322506e-01
## TREG_EMTM                 TREG_EMTM  1.963620e-02  -0.019606176  7.123463e-02
## TREG_NV                     TREG_NV  3.893276e-01  -0.176951123  9.853837e-01
## TREG_TE                     TREG_TE  1.417832e-01  -0.081908776  3.780830e-01
## TREG+226+                 TREG+226+  3.105693e-02  -0.016258837  9.091851e-02
## TREG+226+TIGIT-     TREG+226+TIGIT-  1.520811e-01  -0.190878573  5.207239e-01
## TREG+226+TIGIT+     TREG+226+TIGIT+  3.270098e-02  -0.018358487  1.002788e-01
## TREG+226-TIGIT-     TREG+226-TIGIT-  4.902853e-02  -0.609246111  6.974801e-01
## TREG+226-TIGIT+     TREG+226-TIGIT+  4.460158e-02  -0.049181155  1.734679e-01
## TREG+39+                   TREG+39+  1.934120e-02  -0.014326261  6.597026e-02
## TREG+DR+                   TREG+DR+  1.926575e-02  -0.016732736  6.872729e-02
## TREG+PD-1+               TREG+PD-1+  4.150195e-02  -0.019923457  1.440264e-01
## TREG+TIGIT+             TREG+TIGIT+  2.059914e-02  -0.013561723  6.793911e-02
##                       p.adj
## 4_TFH             0.7746926
## 4_TH1             0.7527201
## 4_TH17            0.9627693
## 4_Th17TO1         0.8772403
## 4_TH2             0.9627693
## 4_TH22            0.8626506
## 4+ (IM STAT)      0.7746926
## 4+                0.7508243
## 4+226+            0.7746926
## 4+39+             0.9741645
## 4+DR+             0.7508243
## 4+PD-1+           0.7508243
## 4+PD-1+TIGIT-     0.7527201
## 4+PD-1+TIGIT+     0.7508243
## 4+PD-1-TIGIT-     0.7746173
## 4+PD-1-TIGIT+     0.7746926
## 4+TIGIT+          0.7508243
## 4NV(СТАР2)        0.7508243
## 4NV               0.7508243
## 4NV_TH1           0.7508243
## 4NV_TH17          0.7508243
## 4NV_Th17TO1       0.7508243
## 4NV_TH2           0.7508243
## 4NV_TH22          0.7508243
## 4NV+226+          0.7508243
## 4NV+39+           0.7508243
## 4NV+DR+           0.9141400
## 4NV+PD1+          0.8772403
## 4NV+PD-1+TIGIT-   0.9262301
## 4NV+PD-1+TIGIT+   0.8015183
## 4NV+PD-1-TIGIT-   0.7508243
## 4NV+PD-1-TIGIT+   0.7508243
## 4NV+TIGIT+        0.7508243
## 4ЕМ               0.7508243
## 4ЕМ_TH1           0.7508243
## 4ЕМ_TH17          0.7508243
## 4ЕМ_Th17TO1       0.7508243
## 4ЕМ_TH2           0.7746926
## 4ЕМ_TH22          0.7508243
## 4ЕМ+226+          0.7508243
## 4ЕМ+39+           0.8033715
## 4ЕМ+DR+           0.7508243
## 4ЕМ+PD1+          0.7508243
## 4ЕМ+PD1+TIGIT-    0.7508243
## 4ЕМ+PD1+TIGIT+    0.7508243
## 4ЕМ+PD1-TIGIT-    0.7508243
## 4ЕМ+PD1-TIGIT+    0.7746926
## 4ЕМ+TIGIT+        0.7508243
## 4ЕМTM             0.7508243
## 4СМ(СТАР2)        0.7814361
## 4СМ               0.7508243
## 4СМ_TH1           0.9858508
## 4СМ_TH17          0.7508243
## 4СМ_Th17TO1       0.7508243
## 4СМ_TH2           0.7508243
## 4СМ_TH22          0.7508243
## 4СМ+226+          0.7746926
## 4СМ+39+           0.7527201
## 4СМ+DR+           0.8015183
## 4СМ+PD1+          0.9736931
## 4СМ+PD1+TIGIT-    0.9569874
## 4СМ+PD1+TIGIT+    0.9741645
## 4СМ+PD1-TIGIT-    0.7508243
## 4СМ+PD1-TIGIT+    0.9741645
## 4СМ+TIGIT+        0.9741645
## 4ТM_TH1           0.7746926
## 4ТM_TH17          0.7508243
## 4ТM_Th17TO1       0.7746926
## 4ТM_TH2           0.8015183
## 4ТM_TH22          0.9741645
## 4ТREG(СТАР2)      0.7508243
## 4ТREG             0.7508243
## 4ТREG_TH1         0.8842108
## 4ТREG_TH17        0.7508243
## 4ТREG_Th17TO1     0.7508243
## 4ТREG_TH2         0.7508243
## 4ТREG_TH22        0.9144398
## 4ТЕ(СТАР2)        0.7508243
## 4ТЕ               0.7508243
## 4ТЕ_TH1           0.7508243
## 4ТЕ_TH17          0.7746926
## 4ТЕ_Th17TO1       0.7508243
## 4ТЕ_TH2           0.7508243
## 4ТЕ_TH22          0.7508243
## 4ТЕ+226+          0.7508243
## 4ТЕ+39+           0.7508243
## 4ТЕ+DR+           0.7508243
## 4ТЕ+PD-1+         0.7508243
## 4ТЕ+PD-1+TIGIT-   0.7508243
## 4ТЕ+PD-1+TIGIT+   0.7727447
## 4ТЕ+PD-1-TIGIT-   0.7508243
## 4ТЕ+PD-1-TIGIT+   0.7746926
## 4ТЕ+TIGIT+        0.7746926
## 4ТМ               0.7508243
## 8+ (IM STAT)      0.7508243
## 8+                0.7508243
## 8+226+            0.7508243
## 8+39+             0.9627693
## 8+DR+             0.7508243
## 8+PD-1+           0.7508243
## 8+PD-1+TIGIT-     0.7508243
## 8+PD-1+TIGIT+     0.7508243
## 8+PD-1-TIGIT-     0.7508243
## 8+PD-1-TIGIT+     0.7508243
## 8+TIGIT+          0.7508243
## 8EMTM             0.9531593
## 8EMTM+226+        0.9335033
## 8EMTM+39+         0.9741645
## 8EMTM+DR+         0.9741645
## 8EMTM+PD-1+       0.9937872
## 8EMTM+PD-1+TIGIT- 0.9736931
## 8EMTM+PD-1+TIGIT+ 0.9741645
## 8EMTM+PD-1-TIGIT- 0.9501433
## 8EMTM+PD-1-TIGIT+ 0.7814361
## 8EMTM+TIGIT+      0.9144398
## 8NV(СТАР2)        0.7746926
## 8NV               0.7508243
## 8NV+226+          0.8015183
## 8NV+39+           0.9141400
## 8NV+DR+           0.7508243
## 8NV+PD-1+         0.7508243
## 8NV+PD-1+TIGIT-   0.7508243
## 8NV+PD-1+TIGIT+   0.7508243
## 8NV+PD-1-TIGIT-   0.7508243
## 8NV+PD-1-TIGIT+   0.7508243
## 8NV+TIGIT+        0.7508243
## 8TREG             0.7508243
## 8ЕМ               0.9144398
## 8СМ(СТАР2)        0.7814361
## 8СМ               0.7508243
## 8СМ+226+          0.7746926
## 8СМ+39+           0.7508243
## 8СМ+DR+           0.7746926
## 8СМ+PD-1+         0.8626506
## 8СМ+PD-1+TIGIT-   0.8116272
## 8СМ+PD-1+TIGIT+   0.8772403
## 8СМ+PD-1-TIGIT-   0.9584098
## 8СМ+PD-1-TIGIT+   0.7746926
## 8СМ+TIGIT+        0.7746926
## 8ТЕ(СТАР2)        0.7508243
## 8ТЕ               0.7508243
## 8ТЕ+226+          0.7508243
## 8ТЕ+39+           0.9144398
## 8ТЕ+DR+           0.7508243
## 8ТЕ+PD-1+         0.7508243
## 8ТЕ+PD-1+TIGIT-   0.7508243
## 8ТЕ+PD-1+TIGIT+   0.7508243
## 8ТЕ+PD-1-TIGIT-   0.7508243
## 8ТЕ+PD-1-TIGIT+   0.7508243
## 8ТЕ+TIGIT+        0.7508243
## 8ТМ               0.9741645
## TREG_CM           0.7508243
## TREG_EMTM         0.7508243
## TREG_NV           0.7508243
## TREG_TE           0.7508243
## TREG+226+         0.7508243
## TREG+226+TIGIT-   0.7508243
## TREG+226+TIGIT+   0.7508243
## TREG+226-TIGIT-   0.9627693
## TREG+226-TIGIT+   0.7508243
## TREG+39+          0.7508243
## TREG+DR+          0.7508243
## TREG+PD-1+        0.7508243
## TREG+TIGIT+       0.7508243

forest_plot_1

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_errorbarh()`).

forest_plot_2

## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_errorbarh()`).

volcano_plot_1

# Volcano Plot 
volcano_plot_2 <- ggplot(forest_data, aes(x = estimate, y = -log10(p.adj))) +
  # Добавляем прозрачность точкам через alpha
  geom_point(aes(color = p.adj < 0.05), alpha = 0.5) +
  # Добавляем условие для отображения подписей
  geom_text_repel(data = subset(forest_data, estimate < -5 | estimate > 1),
                  aes(label = variable),
                  box.padding = 0.5,
                  max.overlaps = Inf,
                  size = 4,
                  segment.size = 0.2,
                  segment.linetype = "solid",
                  segment.alpha = 0.5) +
  scale_color_manual(values = c("TRUE" = "red", "FALSE" = "black")) +
  theme_minimal() +
  labs(title = "Volcano Plot",
       x = "Coefficient Estimate",
       y = "-log10(Adjusted p-value)") +
  scale_x_continuous(limits = c(-20, 8)) +
  scale_y_continuous(limits = c(0, 0.18))

volcano_plot_2

volcano_plot_3 <- ggplot(forest_data, aes(x = estimate, y = -log10(p.adj))) +
  # Добавляем логику для трех цветов на основе estimate
  geom_point(aes(color = case_when(
    estimate < -5 ~ "below_threshold",
    estimate > 1 ~ "above_threshold",
    TRUE ~ "within_threshold"
  )),
  size = 3,  
  alpha = 0.7) + 
  
  # Добавляем подписи для выбросов
  geom_text_repel(data = subset(forest_data, estimate < -5 | estimate > 1),
                  aes(label = variable),
                  box.padding = 0.5,
                  max.overlaps = Inf,
                  size = 4,
                  segment.size = 0.2,
                  segment.linetype = "solid",
                  segment.alpha = 0.5) +
  
  # Применяем цветовую палитру 
  scale_color_manual(
    values = c(
      "below_threshold" = "#304289",  # Синий для точек ниже -5
      "above_threshold" = "#893056",  # Красный для точек выше 1
      "within_threshold" = "#898889"  # Серый для точек между порогами
    ),
    guide = "none"  # Убираем легенду
  ) +
  
  theme_minimal() +
  labs(title = "Volcano Plot",
       x = "Coefficient Estimate",
       y = "-log10(Adjusted p-value)") +
  scale_x_continuous(limits = c(-20, 8)) +
  scale_y_continuous(limits = c(0, 0.18))

volcano_plot_3